All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.
The links below permit the addition or removal of specific sets of domain combination pairs.
Change the list of genome two-letter codes in the 'Include genomes' box to include domain-pairs from those genomes.
Change the list of genomes in the 'Exclude genomes' box to exclude domain-pairs from those genomes.
List of all two-letter genome codes.
Superfamily (N) | Superfamily (C) | Number of occurrances | Number unique | |
P-loop containing nucleoside triphosphate hydrolases | P-loop containing nucleoside triphosphate hydrolases | 9 | 8 | |
NAD(P)-binding Rossmann-fold domains | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 8 | 3 | |
PurM N-terminal domain-like | PurM C-terminal domain-like | 8 | 3 | |
NAD(P)-binding Rossmann-fold domains | 6-phosphogluconate dehydrogenase C-terminal domain-like | 8 | 3 | |
Thiamin diphosphate-binding fold (THDP-binding) | TK C-terminal domain-like | 7 | 4 | |
Nucleotidylyl transferase | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 7 | 5 | |
PreATP-grasp domain | Glutathione synthetase ATP-binding domain-like | 5 | 4 | |
Composite domain of metallo-dependent hydrolases | Metallo-dependent hydrolases | 5 | 3 | |
Homodimeric domain of signal transducing histidine kinase | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 5 | 4 | |
P-loop containing nucleoside triphosphate hydrolases | Translation proteins | 5 | 4 | |
4Fe-4S ferredoxins | 4Fe-4S ferredoxins | 5 | 4 | |
Class II aaRS and biotin synthetases | Class II aaRS ABD-related | 4 | 4 | |
Zinc beta-ribbon | Cyclin-like | 4 | 1 | |
Class I glutamine amidotransferase-like | P-loop containing nucleoside triphosphate hydrolases | 4 | 3 | |
Cyclin-like | Cyclin-like | 4 | 1 | |
Thiamin diphosphate-binding fold (THDP-binding) | Thiamin diphosphate-binding fold (THDP-binding) | 4 | 3 | |
Sm-like ribonucleoproteins | Mechanosensitive channel protein MscS (YggB), C-terminal domain | 3 | 2 | |
Nucleic acid-binding proteins | P-loop containing nucleoside triphosphate hydrolases | 3 | 3 | |
PreATP-grasp domain | Rudiment single hybrid motif | 3 | 2 | |
HAMP domain-like | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 3 | 2 | |
Sensory domain-like | HAMP domain-like | 3 | 2 | |
6-phosphogluconate dehydrogenase C-terminal domain-like | UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 3 | 1 | |
NAD(P)-binding Rossmann-fold domains | UDP-glucose/GDP-mannose dehydrogenase C-terminal domain | 3 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 3 | 2 | |
ValRS/IleRS/LeuRS editing domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 3 | 2 | |
ACT-like | ACT-like | 3 | 2 | |
NAD(P)-linked oxidoreductase | alpha-helical ferredoxin | 3 | 1 | |
MoeA N-terminal region -like | MoeA C-terminal domain-like | 3 | 2 | |
Metallo-hydrolase/oxidoreductase | Flavoproteins | 3 | 1 | |
Mechanosensitive channel protein MscS (YggB), transmembrane region | Mechanosensitive channel protein MscS (YggB), C-terminal domain | 3 | 2 | |
Sensory domain-like | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 3 | 2 | |
Calcium ATPase, transduction domain A | HAD-like | 3 | 3 | |
Nucleic acid-binding proteins | Nucleic acid-binding proteins | 3 | 3 | |
Homeodomain-like | Tetracyclin repressor-like, C-terminal domain | 3 | 1 | |
Sensory domain-like | Homodimeric domain of signal transducing histidine kinase | 3 | 2 | |
Ribosomal protein S5 domain 2-like | GHMP Kinase, C-terminal domain | 3 | 1 | |
Glutathione synthetase ATP-binding domain-like | Rudiment single hybrid motif | 3 | 2 | |
Molybdenum cofactor biosynthesis proteins | MoeA C-terminal domain-like | 3 | 2 | |
lambda repressor-like DNA-binding domains | RmlC-like cupins | 3 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Restriction endonuclease-like | 3 | 3 | |
HAD-like | Calcium ATPase, transmembrane domain M | 3 | 3 | |
ValRS/IleRS/LeuRS editing domain | Nucleotidylyl transferase | 3 | 2 | |
Calcium ATPase, transduction domain A | Calcium ATPase, transmembrane domain M | 3 | 3 | |
Translation proteins | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 3 | 2 | |
MoeA N-terminal region -like | Molybdenum cofactor biosynthesis proteins | 3 | 2 | |
Sensory domain-like | Methyl-accepting chemotaxis protein (MCP) signaling domain | 3 | 1 | |
PLP-binding barrel | Alanine racemase C-terminal domain-like | 3 | 2 | |
Formate/glycerate dehydrogenase catalytic domain-like | NAD(P)-binding Rossmann-fold domains | 3 | 2 | |
Mechanosensitive channel protein MscS (YggB), transmembrane region | Sm-like ribonucleoproteins | 3 | 2 | |
HAMP domain-like | Homodimeric domain of signal transducing histidine kinase | 3 | 2 | |
Aminoacid dehydrogenase-like, N-terminal domain | NAD(P)-binding Rossmann-fold domains | 2 | 1 | |
Translational machinery components | L30e-like | 2 | 2 | |
P-loop containing nucleoside triphosphate hydrolases | C-terminal domain of alpha and beta subunits of F1 ATP synthase | 2 | 2 | |
ARM repeat | ARM repeat | 2 | 1 | |
Tubulin nucleotide-binding domain-like | Tubulin C-terminal domain-like | 2 | 1 | |
Multidrug resistance efflux transporter EmrE | Multidrug resistance efflux transporter EmrE | 2 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | TGS-like | 2 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | "Winged helix" DNA-binding domain | 2 | 2 | |
Pre-PUA domain | PUA domain-like | 2 | 2 | |
Nicotinate/Quinolinate PRTase N-terminal domain-like | Nicotinate/Quinolinate PRTase C-terminal domain-like | 2 | 1 | |
Domain of the SRP/SRP receptor G-proteins | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 | |
Phosphoglucomutase, first 3 domains | Phosphoglucomutase, C-terminal domain | 2 | 1 | |
Succinyl-CoA synthetase domains | Glutathione synthetase ATP-binding domain-like | 2 | 2 | |
tRNA-guanine transglycosylase | Pre-PUA domain | 2 | 2 | |
Thiolase-like | Thiolase-like | 2 | 1 | |
HMA, heavy metal-associated domain | Calcium ATPase, transmembrane domain M | 2 | 2 | |
HMA, heavy metal-associated domain | Calcium ATPase, transduction domain A | 2 | 2 | |
P-loop containing nucleoside triphosphate hydrolases | Ribosomal protein S5 domain 2-like | 2 | 2 | |
Glutamine synthetase/guanido kinase | GatB/YqeY motif | 2 | 2 | |
FAD/NAD(P)-binding domain | 4Fe-4S ferredoxins | 2 | 1 | |
NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | 2 | 2 | |
CBS-domain pair | CBS-domain pair | 2 | 2 | |
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 2 | 2 | |
TPR-like | TPR-like | 2 | 2 | |
Thiamin diphosphate-binding fold (THDP-binding) | Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | 2 | 2 | |
NAD(P)-binding Rossmann-fold domains | Succinyl-CoA synthetase domains | 2 | 2 | |
Nucleic acid-binding proteins | Translation proteins SH3-like domain | 2 | 2 | |
Ribbon-helix-helix | ACT-like | 2 | 1 | |
EF-G C-terminal domain-like | Ribosomal protein S5 domain 2-like | 2 | 2 | |
Composite domain of metallo-dependent hydrolases | Composite domain of metallo-dependent hydrolases | 2 | 2 | |
Thiamin diphosphate-binding fold (THDP-binding) | DHS-like NAD/FAD-binding domain | 2 | 1 | |
PRTase-like | PRTase-like | 2 | 1 | |
Methyl-coenzyme M reductase subunits | Methyl-coenzyme M reductase alpha and beta chain C-terminal domain | 2 | 1 | |
Phosphoglucomutase, first 3 domains | Phosphoglucomutase, first 3 domains | 2 | 1 | |
tRNA-guanine transglycosylase | PUA domain-like | 2 | 2 | |
"Winged helix" DNA-binding domain | S-adenosyl-L-methionine-dependent methyltransferases | 2 | 1 | |
Aldolase | 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain | 2 | 1 | |
HMA, heavy metal-associated domain | HAD-like | 2 | 2 | |
DNA methylase specificity domain | DNA methylase specificity domain | 2 | 1 | |
GroEL equatorial domain-like | GroEL apical domain-like | 2 | 2 | |
FAD/NAD(P)-binding domain | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 1 | 1 | |
2Fe-2S ferredoxin-like | alpha-helical ferredoxin | 1 | 1 | |
"Winged helix" DNA-binding domain | PhoU-like | 1 | 1 | |
Cdc48 domain 2-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
Adenine nucleotide alpha hydrolases-like | Argininosuccinate synthetase, C-terminal domain | 1 | 1 | |
Aldolase | Ribulose-phoshate binding barrel | 1 | 1 | |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | PRTase-like | 1 | 1 | |
NagB/RpiA/CoA transferase-like | D-ribose-5-phosphate isomerase (RpiA), lid domain | 1 | 1 | |
Insert subdomain of RNA polymerase alpha subunit | RBP11-like subunits of RNA polymerase | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | Phosphohistidine domain | 1 | 1 | |
FAD/NAD(P)-binding domain | Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | 1 | 1 | |
Ferritin-like | Rubredoxin-like | 1 | 1 | |
Carbamoyl phosphate synthetase, large subunit connection domain | Methylglyoxal synthase-like | 1 | 1 | |
"Winged helix" DNA-binding domain | Periplasmic binding protein-like II | 1 | 1 | |
Ribosomal protein S5 domain 2-like | Ribosomal protein S5 domain 2-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | NAD(P)-binding Rossmann-fold domains | 1 | 1 | |
Prokaryotic type I DNA topoisomerase | Zinc beta-ribbon | 1 | 1 | |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | SIS domain | 1 | 1 | |
Ribosomal protein L6 | Ribosomal protein L6 | 1 | 1 | |
Nucleic acid-binding proteins | DHH phosphoesterases | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | Carbamoyl phosphate synthetase, large subunit connection domain | 1 | 1 | |
TPR-like | Protein prenylyltransferase | 1 | 1 | |
RuvA domain 2-like | Nucleic acid-binding proteins | 1 | 1 | |
Dom34/Pelota N-terminal domain-like | L30e-like | 1 | 1 | |
Formate dehydrogenase/DMSO reductase, domains 1-3 | ADC-like | 1 | 1 | |
Tex N-terminal region-like | RuvA domain 2-like | 1 | 1 | |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | C-terminal domain of alpha and beta subunits of F1 ATP synthase | 1 | 1 | |
DNA ligase/mRNA capping enzyme, catalytic domain | Nucleic acid-binding proteins | 1 | 1 | |
PK beta-barrel domain-like | Phosphoenolpyruvate/pyruvate domain | 1 | 1 | |
Ribonuclease H-like | DNA/RNA polymerases | 1 | 1 | |
Homodimeric domain of signal transducing histidine kinase | CheW-like | 1 | 1 | |
"Winged helix" DNA-binding domain | Nucleotidyltransferase | 1 | 1 | |
Thioredoxin-like | Six-hairpin glycosidases | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | Serine metabolism enzymes domain | 1 | 1 | |
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | ThrRS/AlaRS common domain | 1 | 1 | |
Prokaryotic type KH domain (KH-domain type II) | Prokaryotic type KH domain (KH-domain type II) | 1 | 1 | |
MgtE N-terminal domain-like | MgtE membrane domain-like | 1 | 1 | |
Translation proteins | EF-G C-terminal domain-like | 1 | 1 | |
CheY-binding domain of CheA | CheY-binding domain of CheA | 1 | 1 | |
MoeA N-terminal region -like | Periplasmic binding protein-like II | 1 | 1 | |
Radical SAM enzymes | Acyl-CoA N-acyltransferases (Nat) | 1 | 1 | |
Translation initiation factor 2 beta, aIF2beta, N-terminal domain | Zinc-binding domain of translation initiation factor 2 beta | 1 | 1 | |
tRNA-guanine transglycosylase | Uracil-DNA glycosylase-like | 1 | 1 | |
Prismane protein-like | alpha-helical ferredoxin | 1 | 1 | |
Enolase N-terminal domain-like | Enolase C-terminal domain-like | 1 | 1 | |
"Winged helix" DNA-binding domain | ACT-like | 1 | 1 | |
EF-G C-terminal domain-like | EF-G C-terminal domain-like | 1 | 1 | |
CheY-binding domain of CheA | CheW-like | 1 | 1 | |
NAD-binding domain of HMG-CoA reductase | Substrate-binding domain of HMG-CoA reductase | 1 | 1 | |
Zn-dependent exopeptidases | Bacterial exopeptidase dimerisation domain | 1 | 1 | |
HD-domain/PDEase-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 | |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | CheW-like | 1 | 1 | |
EPT/RTPC-like | RNA 3'-terminal phosphate cyclase, RPTC, insert domain | 1 | 1 | |
L9 N-domain-like | Ribonuclease H-like | 1 | 1 | |
PAP/OAS1 substrate-binding domain | PAP/Archaeal CCA-adding enzyme, C-terminal domain | 1 | 1 | |
Hypothetical protein AF0491, middle domain | EF-G C-terminal domain-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | post-AAA+ oligomerization domain-like | 1 | 1 | |
Class II aaRS and biotin synthetases | Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | 1 | 1 | |
Alpha subunit of glutamate synthase, C-terminal domain | ADC-like | 1 | 1 | |
F1F0 ATP synthase subunit B, membrane domain | V-type ATPase subunit E-like | 1 | 1 | |
Putative DNA-binding domain | Putative DNA-binding domain | 1 | 1 | |
Type I dockerin domain | "Helical backbone" metal receptor | 1 | 1 | |
Eukaryotic type KH-domain (KH-domain type I) | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 | |
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 | L30e-like | 1 | 1 | |
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | Translation proteins | 1 | 1 | |
Formate/glycerate dehydrogenase catalytic domain-like | ACT-like | 1 | 1 | |
"Winged helix" DNA-binding domain | Iron-dependent repressor protein, dimerization domain | 1 | 1 | |
Histidine-containing phosphotransfer domain, HPT domain | CheW-like | 1 | 1 | |
CbiG N-terminal domain-like | CobE/GbiG C-terminal domain-like | 1 | 1 | |
Formylmethanofuran:tetrahydromethanopterin formyltransferase | Formylmethanofuran:tetrahydromethanopterin formyltransferase | 1 | 1 | |
F1F0 ATP synthase subunit C | F1F0 ATP synthase subunit C | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | Glutathione synthetase ATP-binding domain-like | 1 | 1 | |
PurM N-terminal domain-like | PurM N-terminal domain-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | CBS-domain pair | 1 | 1 | |
PK beta-barrel domain-like | PK C-terminal domain-like | 1 | 1 | |
Creatinase/prolidase N-terminal domain | Creatinase/aminopeptidase | 1 | 1 | |
alpha/beta-Hydrolases | CBS-domain pair | 1 | 1 | |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | Ribosomal protein S5 domain 2-like | 1 | 1 | |
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | Nucleotidylyl transferase | 1 | 1 | |
FMN-binding split barrel | UbiD C-terminal domain-like | 1 | 1 | |
Class II aaRS and biotin synthetases | ThrRS/AlaRS common domain | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | MOP-like | 1 | 1 | |
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 | Translational machinery components | 1 | 1 | |
CBS-domain pair | MgtE membrane domain-like | 1 | 1 | |
Aminopeptidase/glucanase lid domain | Zn-dependent exopeptidases | 1 | 1 | |
Creatinase/aminopeptidase | "Winged helix" DNA-binding domain | 1 | 1 | |
CorA soluble domain-like | Magnesium transport protein CorA, transmembrane region | 1 | 1 | |
RNase III domain-like | dsRNA-binding domain-like | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | Glutathione synthetase ATP-binding domain-like | 1 | 1 | |
Formate/glycerate dehydrogenase catalytic domain-like | Serine metabolism enzymes domain | 1 | 1 | |
THUMP domain-like | Adenine nucleotide alpha hydrolases-like | 1 | 1 | |
Nucleotidylyl transferase | Nucleic acid-binding proteins | 1 | 1 | |
Zinc beta-ribbon | Zinc beta-ribbon | 1 | 1 | |
ADC-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
PYP-like sensor domain (PAS domain) | PYP-like sensor domain (PAS domain) | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | RuvA domain 2-like | 1 | 1 | |
ACT-like | CheY-like | 1 | 1 | |
CheY-like | Methylesterase CheB, C-terminal domain | 1 | 1 | |
Acyl-CoA N-acyltransferases (Nat) | Acyl-CoA N-acyltransferases (Nat) | 1 | 1 | |
Carbohydrate phosphatase | NAD kinase/diacylglycerol kinase-like | 1 | 1 | |
TK C-terminal domain-like | 4Fe-4S ferredoxins | 1 | 1 | |
Histidine-containing phosphotransfer domain, HPT domain | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | 1 | |
IlvD/EDD N-terminal domain-like | LeuD/IlvD-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Sec63 N-terminal domain-like | 1 | 1 | |
Nucleic acid-binding proteins | Class II aaRS and biotin synthetases | 1 | 1 | |
DnaJ/Hsp40 cysteine-rich domain | Nucleic acid-binding proteins | 1 | 1 | |
FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain | 1 | 1 | |
Aldolase | Single hybrid motif | 1 | 1 | |
Nucleotidylyl transferase | An anticodon-binding domain of class I aminoacyl-tRNA synthetases | 1 | 1 | |
Actin-like ATPase domain | Heat shock protein 70kD (HSP70), peptide-binding domain | 1 | 1 | |
PIN domain-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
PYP-like sensor domain (PAS domain) | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | 1 | |
PUA domain-like | Adenine nucleotide alpha hydrolases-like | 1 | 1 | |
Diaminopimelate epimerase-like | Diaminopimelate epimerase-like | 1 | 1 | |
PYP-like sensor domain (PAS domain) | Homodimeric domain of signal transducing histidine kinase | 1 | 1 | |
Molybdenum cofactor biosynthesis proteins | Periplasmic binding protein-like II | 1 | 1 | |
GAD domain-like | GatB/YqeY motif | 1 | 1 | |
Periplasmic binding protein-like II | ACT-like | 1 | 1 | |
FAD/NAD(P)-binding domain | FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 1 | 1 | |
Acylphosphatase/BLUF domain-like | YrdC/RibB | 1 | 1 | |
Phosphohistidine domain | Phosphoenolpyruvate/pyruvate domain | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | Phosphoenolpyruvate/pyruvate domain | 1 | 1 | |
GroEL-intermediate domain like | GroEL apical domain-like | 1 | 1 | |
4Fe-4S ferredoxins | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
"Winged helix" DNA-binding domain | CBS-domain pair | 1 | 1 | |
Uracil-DNA glycosylase-like | PUA domain-like | 1 | 1 | |
Tex N-terminal region-like | Ribonuclease H-like | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | ACT-like | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | Siroheme synthase middle domains-like | 1 | 1 | |
Initiation factor IF2/eIF5b, domain 3 | Translation proteins | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | C-terminal UvrC-binding domain of UvrB | 1 | 1 | |
MgtE N-terminal domain-like | CBS-domain pair | 1 | 1 | |
CBS-domain pair | Inosine monophosphate dehydrogenase (IMPDH) | 1 | 1 | |
Nucleic acid-binding proteins | eIF2alpha middle domain-like | 1 | 1 | |
Glutamine synthetase, N-terminal domain | Glutamine synthetase/guanido kinase | 1 | 1 | |
tRNA-intron endonuclease N-terminal domain-like | tRNA-intron endonuclease catalytic domain-like | 1 | 1 | |
Ribokinase-like | AraD/HMP-PK domain-like | 1 | 1 | |
CheY-binding domain of CheA | Homodimeric domain of signal transducing histidine kinase | 1 | 1 | |
Class II aaRS and biotin synthetases | Translation proteins | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | TrkA C-terminal domain-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Smc hinge domain | 1 | 1 | |
Class II aaRS and biotin synthetases | C-terminal domain of ProRS | 1 | 1 | |
Histidine-containing phosphotransfer domain, HPT domain | CheY-binding domain of CheA | 1 | 1 | |
PreATP-grasp domain | Methylglyoxal synthase-like | 1 | 1 | |
Ribonuclease H-like | RuvA domain 2-like | 1 | 1 | |
Glutamyl tRNA-reductase catalytic, N-terminal domain | Glutamyl tRNA-reductase dimerization domain | 1 | 1 | |
Sensory domain-like | Sensory domain-like | 1 | 1 | |
Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain | Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Initiation factor IF2/eIF5b, domain 3 | 1 | 1 | |
Histidine-containing phosphotransfer domain, HPT domain | Homodimeric domain of signal transducing histidine kinase | 1 | 1 | |
Serine metabolism enzymes domain | ACT-like | 1 | 1 | |
Restriction endonuclease-like | RuvA domain 2-like | 1 | 1 | |
Thiamin diphosphate-binding fold (THDP-binding) | 4Fe-4S ferredoxins | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | LDH C-terminal domain-like | 1 | 1 | |
Putative DNA-binding domain | Class II aaRS and biotin synthetases | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | Glutamyl tRNA-reductase dimerization domain | 1 | 1 | |
Carbohydrate-binding domain | PKD domain | 1 | 1 | |
DNA clamp | DNA clamp | 1 | 1 | |
Class II aaRS ABD-related | C-terminal domain of ProRS | 1 | 1 | |
Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | Pyrimidine nucleoside phosphorylase C-terminal domain | 1 | 1 | |
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Signal peptide-binding domain | 1 | 1 | |
Fic-like | "Winged helix" DNA-binding domain | 1 | 1 | |
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III | TK C-terminal domain-like | 1 | 1 | |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | Adenine nucleotide alpha hydrolases-like | 1 | 1 | |
S-adenosyl-L-methionine-dependent methyltransferases | DNA methylase specificity domain | 1 | 1 | |
Phosphoenolpyruvate/pyruvate domain | PK C-terminal domain-like | 1 | 1 | |
PIN domain-like | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 | |
PurM C-terminal domain-like | PurM C-terminal domain-like | 1 | 1 | |
Methionyl-tRNA synthetase (MetRS), Zn-domain | Nucleic acid-binding proteins | 1 | 1 | |
Pseudouridine synthase | PUA domain-like | 1 | 1 | |
GIY-YIG endonuclease | C-terminal UvrC-binding domain of UvrB | 1 | 1 | |
Periplasmic binding protein-like II | GlnB-like | 1 | 1 | |
YjeF N-terminal domain-like | Ribokinase-like | 1 | 1 | |
Translation proteins | Ribosomal protein S5 domain 2-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Rad50 coiled-coil Zn hook | 1 | 1 | |
4Fe-4S ferredoxins | FMN-linked oxidoreductases | 1 | 1 | |
Aldolase | post-HMGL domain-like | 1 | 1 | |
ADC-like | Cdc48 domain 2-like | 1 | 1 | |
Methionyl-tRNA synthetase (MetRS), Zn-domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 1 | 1 | |
dsRNA-binding domain-like | Ribosomal protein S5 domain 2-like | 1 | 1 | |
Nucleotidyltransferase | PAP/Archaeal CCA-adding enzyme, C-terminal domain | 1 | 1 | |
GatD N-terminal domain-like | Glutaminase/Asparaginase | 1 | 1 | |
GroEL equatorial domain-like | GroEL-intermediate domain like | 1 | 1 | |
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | CoaB-like | 1 | 1 | |
Flavoproteins | 4Fe-4S ferredoxins | 1 | 1 | |
Uracil-DNA glycosylase-like | Pre-PUA domain | 1 | 1 | |
THUMP domain-like | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 | |
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | Nucleic acid-binding proteins | 1 | 1 | |
MoeA C-terminal domain-like | Periplasmic binding protein-like II | 1 | 1 | |
Ribosomal L11/L12e N-terminal domain | Ribosomal protein L11, C-terminal domain | 1 | 1 | |
Riboflavin synthase domain-like | Ferredoxin reductase-like, C-terminal NADP-linked domain | 1 | 1 | |
TPR-like | Chaperone J-domain | 1 | 1 | |
Dom34/Pelota N-terminal domain-like | Translational machinery components | 1 | 1 | |
PreATP-grasp domain | PreATP-grasp domain | 1 | 1 | |
ACT-like | 4Fe-4S ferredoxins | 1 | 1 | |
Carbamate kinase-like | ACT-like | 1 | 1 | |
Quinoprotein alcohol dehydrogenase-like | Quinoprotein alcohol dehydrogenase-like | 1 | 1 | |
RuvA domain 2-like | RuvA domain 2-like | 1 | 1 | |
Succinyl-CoA synthetase domains | Succinyl-CoA synthetase domains | 1 | 1 | |
Ribulose-phoshate binding barrel | RraA-like | 1 | 1 | |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
Domain of the SRP/SRP receptor G-proteins | Signal peptide-binding domain | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | DHH phosphoesterases | 1 | 1 | |
Methionyl-tRNA synthetase (MetRS), Zn-domain | Nucleotidylyl transferase | 1 | 1 | |
ATP-dependent DNA ligase DNA-binding domain | Nucleic acid-binding proteins | 1 | 1 | |
"Winged helix" DNA-binding domain | Dimeric alpha+beta barrel | 1 | 1 | |
Alpha subunit of glutamate synthase, C-terminal domain | Alpha subunit of glutamate synthase, C-terminal domain | 1 | 1 | |
Nucleotidyltransferase | PAP/OAS1 substrate-binding domain | 1 | 1 | |
Nucleotidylyl transferase | Ribosomal protein L25-like | 1 | 1 | |
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | Pyrimidine nucleoside phosphorylase C-terminal domain | 1 | 1 | |
Chemotaxis receptor methyltransferase CheR, N-terminal domain | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 | |
Ribonuclease H-like | Nucleic acid-binding proteins | 1 | 1 | |
Nucleotide-diphospho-sugar transferases | Trimeric LpxA-like enzymes | 1 | 1 | |
eIF2alpha middle domain-like | eIF-2-alpha, C-terminal domain | 1 | 1 | |
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain | 1 | 1 | |
Actin-like ATPase domain | Actin-like ATPase domain | 1 | 1 | |
Translation proteins | Translation proteins | 1 | 1 | |
DnaJ/Hsp40 cysteine-rich domain | DHH phosphoesterases | 1 | 1 | |
PreATP-grasp domain | Carbamoyl phosphate synthetase, large subunit connection domain | 1 | 1 | |
Nucleic acid-binding proteins | eIF-2-alpha, C-terminal domain | 1 | 1 | |
N-terminal, heterodimerisation domain of RBP7 (RpoE) | Nucleic acid-binding proteins | 1 | 1 | |
FYSH domain | Hypothetical protein AF0491, middle domain | 1 | 1 | |
Carbohydrate-binding domain | Carbohydrate-binding domain | 1 | 1 | |
"Winged helix" DNA-binding domain | Sec63 N-terminal domain-like | 1 | 1 | |
L domain-like | L domain-like | 1 | 1 | |
CheY-binding domain of CheA | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | 1 | |
Glutamyl tRNA-reductase catalytic, N-terminal domain | NAD(P)-binding Rossmann-fold domains | 1 | 1 | |
Prokaryotic type KH domain (KH-domain type II) | Ribosomal protein S3 C-terminal domain | 1 | 1 | |
Rad51 N-terminal domain-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
Tex N-terminal region-like | Nucleic acid-binding proteins | 1 | 1 | |
Periplasmic binding protein-like II | Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain | 1 | 1 | |
FYSH domain | EF-G C-terminal domain-like | 1 | 1 | |
"Winged helix" DNA-binding domain | Protein kinase-like (PK-like) | 1 | 1 | |
Cation efflux protein transmembrane domain-like | Cation efflux protein cytoplasmic domain-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | EF-G C-terminal domain-like | 1 | 1 | |
GroEL equatorial domain-like | GroEL equatorial domain-like | 1 | 1 | |
Carbamoyl phosphate synthetase, small subunit N-terminal domain | Class I glutamine amidotransferase-like | 1 | 1 | |
post-HMGL domain-like | Single hybrid motif | 1 | 1 | |
PIN domain-like | 5' to 3' exonuclease, C-terminal subdomain | 1 | 1 | |
Glutamine synthetase/guanido kinase | GAD domain-like | 1 | 1 | |
CBS-domain pair | ParB/Sulfiredoxin | 1 | 1 | |
Actin-like ATPase domain | Protein kinase-like (PK-like) | 1 | 1 | |
Translation proteins | ThrRS/AlaRS common domain | 1 | 1 | |
ATP-dependent DNA ligase DNA-binding domain | DNA ligase/mRNA capping enzyme, catalytic domain | 1 | 1 | |
Aldehyde ferredoxin oxidoreductase, N-terminal domain | Aldehyde ferredoxin oxidoreductase, C-terminal domains | 1 | 1 | |
C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase | ICP-like | 1 | 1 | |
TATA-box binding protein-like | TATA-box binding protein-like | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | Methylglyoxal synthase-like | 1 | 1 | |