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Domain combination pairs in Chlamydia trachomatis L2b/Canada1

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Adjacent domain pairs graph

Graph of adjacent domain pairs.


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Domain combination pairs

283 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N) Superfamily (C) Number of occurrances Number unique
P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases 139
Nucleotidylyl transferase Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 66
NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 52
Phospholipase D/nuclease Phospholipase D/nuclease 53
Thiamin diphosphate-binding fold (THDP-binding) TK C-terminal domain-like 43
MurD-like peptide ligases, catalytic domain MurD-like peptide ligases, peptide-binding domain 43
Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) 43
P-loop containing nucleoside triphosphate hydrolases Translation proteins 44
Nucleic acid-binding proteins Nucleic acid-binding proteins 43
Translation proteins SH3-like domain Nucleic acid-binding proteins 32
ValRS/IleRS/LeuRS editing domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 33
GroEL equatorial domain-like GroEL apical domain-like 32
ValRS/IleRS/LeuRS editing domain Nucleotidylyl transferase 33
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Ribosomal protein S5 domain 2-like 33
Class II aaRS and biotin synthetases Class II aaRS ABD-related 33
CBS-domain pair FAD-binding/transporter-associated domain-like 31
Nucleic acid-binding proteins Class II aaRS and biotin synthetases 33
Single hybrid motif CoA-dependent acyltransferases 33
P-loop containing nucleoside triphosphate hydrolases Ribosomal protein S5 domain 2-like 33
Aminoacid dehydrogenase-like, N-terminal domain NAD(P)-binding Rossmann-fold domains 32
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 22
N-terminal domain of DnaB helicase P-loop containing nucleoside triphosphate hydrolases 21
MurCD N-terminal domain MurD-like peptide ligases, peptide-binding domain 22
E set domains (Trans)glycosidases 22
Single hybrid motif Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 22
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex CoA-dependent acyltransferases 22
Translation proteins EF-G C-terminal domain-like 22
Sigma3 and sigma4 domains of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 22
Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like 22
P-loop containing nucleoside triphosphate hydrolases post-AAA+ oligomerization domain-like 22
EF-G C-terminal domain-like EF-G C-terminal domain-like 22
Actin-like ATPase domain Actin-like ATPase domain 22
LuxS/MPP-like metallohydrolase LuxS/MPP-like metallohydrolase 22
P-loop containing nucleoside triphosphate hydrolases "Winged helix" DNA-binding domain 22
Phosphoglucomutase, first 3 domains Phosphoglucomutase, C-terminal domain 22
Alpha-L RNA-binding motif Pseudouridine synthase 21
Riboflavin synthase domain-like Ferredoxin reductase-like, C-terminal NADP-linked domain 22
Ribosomal protein S5 domain 2-like Type II DNA topoisomerase 22
MurE/MurF N-terminal domain MurD-like peptide ligases, peptide-binding domain 21
NAD(P)-binding Rossmann-fold domains 6-phosphogluconate dehydrogenase C-terminal domain-like 22
Penicillin binding protein dimerisation domain beta-lactamase/transpeptidase-like 22
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Type II DNA topoisomerase 22
Sigma2 domain of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 22
Class II aaRS and biotin synthetases ThrRS/AlaRS common domain 22
PreATP-grasp domain Glutathione synthetase ATP-binding domain-like 22
Double Clp-N motif P-loop containing nucleoside triphosphate hydrolases 21
Phosphoglucomutase, first 3 domains Phosphoglucomutase, first 3 domains 22
P-loop containing nucleoside triphosphate hydrolases Restriction endonuclease-like 22
Nucleic acid-binding proteins RuvA domain 2-like 22
MurE/MurF N-terminal domain MurD-like peptide ligases, catalytic domain 21
MurCD N-terminal domain MurD-like peptide ligases, catalytic domain 22
P-loop containing nucleoside triphosphate hydrolases EF-G C-terminal domain-like 22
P-loop containing nucleoside triphosphate hydrolases TrpR-like 21
Nucleotidyltransferase Poly A polymerase C-terminal region-like 21
tRNA-binding arm Class II aaRS and biotin synthetases 21
Pectin lyase-like Autotransporter 22
Glutamine synthetase/guanido kinase GatB/YqeY motif 11
Prokaryotic type KH domain (KH-domain type II) Ribosomal protein S3 C-terminal domain 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) SIS domain 11
Transcription factor NusA, N-terminal domain Nucleic acid-binding proteins 11
NAD(P)-binding Rossmann-fold domains Succinyl-CoA synthetase domains 11
PheT/TilS domain Anticodon-binding domain of PheRS 11
CheY-like C-terminal effector domain of the bipartite response regulators 11
Formyltransferase FMT C-terminal domain-like 11
FAD-binding/transporter-associated domain-like Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain 11
Diaminopimelate epimerase-like Diaminopimelate epimerase-like 11
DNA repair protein MutS, domain II P-loop containing nucleoside triphosphate hydrolases 11
lambda integrase-like, N-terminal domain DNA breaking-rejoining enzymes 11
CheY-like P-loop containing nucleoside triphosphate hydrolases 11
Phosphoenolpyruvate/pyruvate domain PK C-terminal domain-like 11
Nucleic acid-binding proteins Prokaryotic type KH domain (KH-domain type II) 11
E set domains E set domains 11
DNA ligase/mRNA capping enzyme, catalytic domain Nucleic acid-binding proteins 11
Nucleic acid-binding proteins Rad51 N-terminal domain-like 11
YrdC/RibB RibA-like 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
PIN domain-like DNA/RNA polymerases 11
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain Phosphohistidine domain 11
PDZ domain-like ClpP/crotonase 11
PUA domain-like Ribosomal protein S5 domain 2-like 11
P-loop containing nucleoside triphosphate hydrolases Helical scaffold and wing domains of SecA 11
R1 subunit of ribonucleotide reductase, N-terminal domain PFL-like glycyl radical enzymes 11
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 Nucleic acid-binding proteins 11
Zinc beta-ribbon SWIB/MDM2 domain 11
PDZ domain-like PDZ domain-like 11
C-terminal UvrC-binding domain of UvrB RuvA domain 2-like 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) Translation proteins 11
RNase III domain-like dsRNA-binding domain-like 11
E set domains Glycosyl hydrolase domain 11
Calcium ATPase, transduction domain A HAD-like 11
Thiolase-like Thiolase-like 11
P-loop containing nucleoside triphosphate hydrolases CarD-like 11
Trypsin-like serine proteases PDZ domain-like 11
RuvA domain 2-like BRCT domain 11
Glutathione synthetase ATP-binding domain-like Rudiment single hybrid motif 11
Domain of the SRP/SRP receptor G-proteins Signal peptide-binding domain 11
Nucleic acid-binding proteins ArfGap/RecO-like zinc finger 11
Ribosomal protein S5 domain 2-like Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 11
Translation proteins EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 11
Nucleotide-diphospho-sugar transferases Trimeric LpxA-like enzymes 11
NagB/RpiA/CoA transferase-like D-ribose-5-phosphate isomerase (RpiA), lid domain 11
MFS general substrate transporter ARM repeat 11
Rho N-terminal domain-like P-loop containing nucleoside triphosphate hydrolases 11
MurD-like peptide ligases, peptide-binding domain Glutathione synthetase ATP-binding domain-like 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) ThrRS/AlaRS common domain 11
alpha/beta knot Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 11
2Fe-2S ferredoxin-like alpha-helical ferredoxin 11
PreATP-grasp domain Rudiment single hybrid motif 11
Domain of the SRP/SRP receptor G-proteins P-loop containing nucleoside triphosphate hydrolases 11
EF-G C-terminal domain-like Ribosomal protein S5 domain 2-like 11
Ribonuclease PH domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK Dihydropteroate synthetase-like 11
UbiD C-terminal domain-like UbiD C-terminal domain-like 11
Chaperone J-domain DnaJ/Hsp40 cysteine-rich domain 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Nucleotidylyl transferase 11
FMN-binding split barrel UbiD C-terminal domain-like 11
Thioredoxin-like Six-hairpin glycosidases 11
SufE/NifU Fe-S cluster assembly (FSCA) domain-like 11
LysM domain LysM domain 11
FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 11
Ribosomal protein S5 domain 2-like GHMP Kinase, C-terminal domain 11
PK beta-barrel domain-like Phosphoenolpyruvate/pyruvate domain 11
PUA domain-like P-loop containing nucleoside triphosphate hydrolases 11
Heat shock protein 70kD (HSP70), peptide-binding domain Heat shock protein 70kD (HSP70), C-terminal subdomain 11
FabD/lysophospholipase-like Probable ACP-binding domain of malonyl-CoA ACP transacylase 11
Ribosomal L11/L12e N-terminal domain Ribosomal protein L11, C-terminal domain 11
RBP11-like subunits of RNA polymerase C-terminal domain of RNA polymerase alpha subunit 11
SMAD/FHA domain SMAD/FHA domain 11
S-adenosyl-L-methionine-dependent methyltransferases Putative methyltransferase TM0872, insert domain 11
Protein kinase-like (PK-like) C-type lectin-like 11
MurCD N-terminal domain PreATP-grasp domain 11
P-loop containing nucleoside triphosphate hydrolases Rubredoxin-like 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase DNA mismatch repair protein MutL 11
DNA clamp DNA clamp 11
MgtE N-terminal domain-like CBS-domain pair 11
PYP-like sensor domain (PAS domain) Homodimeric domain of signal transducing histidine kinase 11
Riboflavin synthase domain-like Riboflavin synthase domain-like 11
Prokaryotic type KH domain (KH-domain type II) Prokaryotic type KH domain (KH-domain type II) 11
NAD(P)-binding Rossmann-fold domains LDH C-terminal domain-like 11
PIN domain-like Ribonuclease H-like 11
Nucleic acid-binding proteins BRCT domain 11
Translation proteins Initiation factor IF2/eIF5b, domain 3 11
P-loop containing nucleoside triphosphate hydrolases FtsH protease domain-like 11
P-loop containing nucleoside triphosphate hydrolases EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 11
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 11
Prokaryotic type I DNA topoisomerase Zinc beta-ribbon 11
PK beta-barrel domain-like PK C-terminal domain-like 11
RuvA domain 2-like P-loop containing nucleoside triphosphate hydrolases 11
Aldolase NAD(P)-binding Rossmann-fold domains 11
MurD-like peptide ligases, peptide-binding domain PreATP-grasp domain 11
DNA-glycosylase Nudix 11
EspE N-terminal domain-like P-loop containing nucleoside triphosphate hydrolases 11
PEP carboxykinase N-terminal domain PEP carboxykinase-like 11
Glutathione synthetase ATP-binding domain-like Succinyl-CoA synthetase domains 11
Creatinase/prolidase N-terminal domain Creatinase/aminopeptidase 11
PheT/TilS domain Class II aaRS and biotin synthetases 11
Putative DNA-binding domain Class II aaRS and biotin synthetases 11
Putative DNA-binding domain Phoshotransferase/anion transport protein 11
P-loop containing nucleoside triphosphate hydrolases TRCF domain-like 11
Coiled-coil domain of nucleotide exchange factor GrpE Head domain of nucleotide exchange factor GrpE 11
dsRNA-binding domain-like Ribosomal protein S5 domain 2-like 11
Multidrug resistance efflux transporter EmrE Multidrug resistance efflux transporter EmrE 11
DNA repair protein MutS, domain III P-loop containing nucleoside triphosphate hydrolases 11
Nucleic acid-binding proteins P-loop containing nucleoside triphosphate hydrolases 11
Insert subdomain of RNA polymerase alpha subunit C-terminal domain of RNA polymerase alpha subunit 11
DnaJ/Hsp40 cysteine-rich domain HSP40/DnaJ peptide-binding domain 11
GIY-YIG endonuclease RuvA domain 2-like 11
MetI-like Periplasmic binding protein-like II 11
DNA ligase/mRNA capping enzyme, catalytic domain BRCT domain 11
FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain 11
MurD-like peptide ligases, catalytic domain Glutathione synthetase ATP-binding domain-like 11
GreA transcript cleavage protein, N-terminal domain FKBP-like 11
Translation initiation factor IF3, N-terminal domain Translation initiation factor IF3, C-terminal domain 11
Translation proteins Ribosomal protein S5 domain 2-like 11
Calcium ATPase, transmembrane domain M HAD-like 11
P-loop containing nucleoside triphosphate hydrolases TGS-like 11
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
5' to 3' exonuclease, C-terminal subdomain Ribonuclease H-like 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Nucleotidylyl transferase 11
Ribonuclease PH domain 2-like Ribonuclease PH domain 2-like 11
2Fe-2S ferredoxin-like Ferredoxin reductase-like, C-terminal NADP-linked domain 11
P-loop containing nucleoside triphosphate hydrolases Class I glutamine amidotransferase-like 11
Multidrug efflux transporter AcrB transmembrane domain Multidrug efflux transporter AcrB transmembrane domain 11
Nucleic acid-binding proteins Anticodon-binding domain of PheRS 11
PIN domain-like 5' to 3' exonuclease, C-terminal subdomain 11
2Fe-2S ferredoxin-like Riboflavin synthase domain-like 11
Ribosomal protein L7/12, oligomerisation (N-terminal) domain ClpS-like 11
ValRS/IleRS/LeuRS editing domain tRNA-binding arm 11
MgtE N-terminal domain-like MgtE membrane domain-like 11
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 Eukaryotic type KH-domain (KH-domain type I) 11
P-loop containing nucleoside triphosphate hydrolases Pre-protein crosslinking domain of SecA 11
Ribonuclease PH domain 2-like Nucleic acid-binding proteins 11
PIN domain-like P-loop containing nucleoside triphosphate hydrolases 11
Nucleic acid-binding proteins GAD domain-like 11
Phosphohistidine domain Phosphoenolpyruvate/pyruvate domain 11
Transcription factor NusA, N-terminal domain Prokaryotic type KH domain (KH-domain type II) 11
FAD/NAD(P)-binding domain FAD-linked reductases, C-terminal domain 11
UBA-like Elongation factor Ts (EF-Ts), dimerisation domain 11
DNA repair protein MutS, domain II DNA repair protein MutS, domain III 11
Trigger factor ribosome-binding domain Triger factor/SurA peptide-binding domain-like 11
Nucleotidylyl transferase Riboflavin kinase-like 11
P-loop containing nucleoside triphosphate hydrolases Initiation factor IF2/eIF5b, domain 3 11
Fe,Mn superoxide dismutase (SOD), N-terminal domain Fe,Mn superoxide dismutase (SOD), C-terminal domain 11
DNA repair protein MutS, domain I P-loop containing nucleoside triphosphate hydrolases 11
PYP-like sensor domain (PAS domain) ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 11
Nucleic acid-binding proteins PheT/TilS domain 11
Prokaryotic type I DNA topoisomerase SWIB/MDM2 domain 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
YbaK/ProRS associated domain Class II aaRS ABD-related 11
Actin-like ATPase domain Heat shock protein 70kD (HSP70), C-terminal subdomain 11
"Winged helix" DNA-binding domain GAF domain-like 11
CarD-like TRCF domain-like 11
GroEL equatorial domain-like GroEL-intermediate domain like 11
Actin-like ATPase domain Heat shock protein 70kD (HSP70), peptide-binding domain 11
L30e-like alpha/beta knot 11
FAD/NAD(P)-binding domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain 11
Eukaryotic type KH-domain (KH-domain type I) Nucleic acid-binding proteins 11
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases tRNA-binding arm 11
Insert subdomain of RNA polymerase alpha subunit RBP11-like subunits of RNA polymerase 11
P-loop containing nucleoside triphosphate hydrolases C-terminal UvrC-binding domain of UvrB 11
ABC transporter transmembrane region P-loop containing nucleoside triphosphate hydrolases 11
DnaK suppressor protein DksA, alpha-hairpin domain Glucocorticoid receptor-like (DNA-binding domain) 11
Nucleotidylyl transferase Alpha-L RNA-binding motif 11
MurD-like peptide ligases, catalytic domain PreATP-grasp domain 11
Ribosomal protein S5 domain 2-like Nucleic acid-binding proteins 11
UDP-Glycosyltransferase/glycogen phosphorylase Autotransporter 11
Ribosomal protein L6 Ribosomal protein L6 11
P-loop containing nucleoside triphosphate hydrolases Signal peptide-binding domain 11
DNA repair protein MutS, domain I DNA repair protein MutS, domain III 11
Ribonuclease PH domain 2-like Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 11
ThrRS/AlaRS common domain Class II aaRS ABD-related 11
CBS-domain pair MgtE membrane domain-like 11
Chaperone J-domain HSP40/DnaJ peptide-binding domain 11
MurCD N-terminal domain Glutathione synthetase ATP-binding domain-like 11
Nucleotidylyl transferase An anticodon-binding domain of class I aminoacyl-tRNA synthetases 11
Nucleic acid-binding proteins Putative DNA-binding domain 11
(Trans)glycosidases Glycosyl hydrolase domain 11
beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like 11
Ribosomal protein S5 domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
DNA repair protein MutS, domain I DNA repair protein MutS, domain II 11
ABC transporter involved in vitamin B12 uptake, BtuC Iron-dependent repressor protein, dimerization domain 11
Class II aaRS and biotin synthetases Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 11
Translation proteins ThrRS/AlaRS common domain 11
L9 N-domain-like Ribosomal protein L9 C-domain 11
Ribosomal protein S5 domain 2-like Ribonuclease PH domain 2-like 11
N-utilization substance G protein NusG, N-terminal domain Translation proteins SH3-like domain 11
Rho N-terminal domain-like Nucleic acid-binding proteins 11
Prokaryotic type KH domain (KH-domain type II) Rad51 N-terminal domain-like 11
P-loop containing nucleoside triphosphate hydrolases Probable GTPase Der, C-terminal domain 11
Pre-protein crosslinking domain of SecA Helical scaffold and wing domains of SecA 11
Ribosomal protein S5 domain 2-like DNA mismatch repair protein MutL 11
F1F0 ATP synthase subunit C F1F0 ATP synthase subunit C 11
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain Phosphoenolpyruvate/pyruvate domain 11
Sec-C motif Creatinase/aminopeptidase 11
Thymidylate synthase-complementing protein Thy1 Thymidylate synthase-complementing protein Thy1 11
Class II aaRS and biotin synthetases YbaK/ProRS associated domain 11
Obg GTP-binding protein N-terminal domain P-loop containing nucleoside triphosphate hydrolases 11
5' to 3' exonuclease, C-terminal subdomain DNA/RNA polymerases 11
PHP domain-like RuvA domain 2-like 11
Zinc beta-ribbon DNA primase core 11
Putative DNA-binding domain Anticodon-binding domain of PheRS 11
Calcium ATPase, transduction domain A Calcium ATPase, transmembrane domain M 11
Cytidine deaminase-like Dihydrofolate reductase-like 11
PheT/TilS domain Putative DNA-binding domain 11
Class II aaRS and biotin synthetases Translation proteins 11
Enolase N-terminal domain-like Enolase C-terminal domain-like 11
DNA ligase/mRNA capping enzyme, catalytic domain RuvA domain 2-like 11
Nucleotidylyl transferase tRNA-binding arm 11
Type II DNA topoisomerase GyrA/ParC C-terminal domain-like 11
HSP40/DnaJ peptide-binding domain HSP40/DnaJ peptide-binding domain 11
Class II aaRS and biotin synthetases GAD domain-like 11
GIY-YIG endonuclease C-terminal UvrC-binding domain of UvrB 11
Ribonuclease H-like DNA/RNA polymerases 11
Translation proteins Translation proteins 11
Macro domain-like Zn-dependent exopeptidases 11
Class II aaRS and biotin synthetases Phospholipase D/nuclease 11
GroEL-intermediate domain like GroEL apical domain-like 11
Transcription factor NusA, N-terminal domain Rad51 N-terminal domain-like 11
P-loop containing nucleoside triphosphate hydrolases RecA protein, C-terminal domain 11
Class II aaRS and biotin synthetases Anticodon-binding domain of PheRS 11
Glucocorticoid receptor-like (DNA-binding domain) P-loop containing nucleoside triphosphate hydrolases 11
Homodimeric domain of signal transducing histidine kinase ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 11
Aldolase Aminoacid dehydrogenase-like, N-terminal domain 11

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