Domain combination pairs in Aspergillus versicolor v1.0

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Domain combination pairs

1481 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N)	Superfamily (C)	Number of occurrances	Number unique
GroES-like	NAD(P)-binding Rossmann-fold domains	132	15
P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	115	41
FAD/NAD(P)-binding domain	FAD-linked reductases, C-terminal domain	91	13
FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	54	10
Acetyl-CoA synthetase-like	ACP-like	46	37
NAD(P)-binding Rossmann-fold domains	6-phosphogluconate dehydrogenase C-terminal domain-like	42	8
Actin-like ATPase domain	Actin-like ATPase domain	39	15
CoA-dependent acyltransferases	CoA-dependent acyltransferases	39	32
ACP-like	CoA-dependent acyltransferases	36	30
(Trans)glycosidases	Glycosyl hydrolase domain	35	12
TPR-like	TPR-like	35	20
Acetyl-CoA synthetase-like	CoA-dependent acyltransferases	34	28
ABC transporter transmembrane region	P-loop containing nucleoside triphosphate hydrolases	32	6
Thiolase-like	FabD/lysophospholipase-like	31	23
Riboflavin synthase domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	31	15
ACP-like	NAD(P)-binding Rossmann-fold domains	30	24
NAD(P)-binding Rossmann-fold domains	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	30	6
ABC transporter transmembrane region	ABC transporter transmembrane region	28	4
Thioredoxin-like	GST C-terminal domain-like	28	5
ACP-like	ACP-like	28	23
FabD/lysophospholipase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	27	20
Purine and uridine phosphorylases	P-loop containing nucleoside triphosphate hydrolases	27	20
(Trans)glycosidases	Beta-D-glucan exohydrolase, C-terminal domain	27	6
Calcium ATPase, transduction domain A	Calcium ATPase, transmembrane domain M	26	9
Calcium ATPase, transduction domain A	HAD-like	26	9
Thiolase-like	Probable ACP-binding domain of malonyl-CoA ACP transacylase	26	19
HAD-like	Calcium ATPase, transmembrane domain M	25	8
FabD/lysophospholipase-like	ACP-like	25	18
Thiolase-like	ACP-like	25	18
Probable ACP-binding domain of malonyl-CoA ACP transacylase	ACP-like	24	17
Thiolase-like	NAD(P)-binding Rossmann-fold domains	23	17
RNA-binding domain, RBD	RNA-binding domain, RBD	23	13
Acyl-CoA dehydrogenase NM domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	23	8
FabD/lysophospholipase-like	NAD(P)-binding Rossmann-fold domains	23	17
Acetyl-CoA synthetase-like	Acetyl-CoA synthetase-like	22	18
Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	21	8
"Winged helix" DNA-binding domain	S-adenosyl-L-methionine-dependent methyltransferases	21	2
Zn-dependent exopeptidases	Bacterial exopeptidase dimerisation domain	21	6
Composite domain of metallo-dependent hydrolases	Metallo-dependent hydrolases	21	11
ARM repeat	ARM repeat	20	15
Probable ACP-binding domain of malonyl-CoA ACP transacylase	NAD(P)-binding Rossmann-fold domains	19	14
Metal cation-transporting ATPase, ATP-binding domain N	Calcium ATPase, transmembrane domain M	19	4
Metal cation-transporting ATPase, ATP-binding domain N	HAD-like	19	4
NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	19	14
Formate/glycerate dehydrogenase catalytic domain-like	NAD(P)-binding Rossmann-fold domains	19	6
Calcium ATPase, transduction domain A	Metal cation-transporting ATPase, ATP-binding domain N	19	4
MFS general substrate transporter	MFS general substrate transporter	18	5
Galactose-binding domain-like	(Trans)glycosidases	18	9
Thiolase-like	Thiolase-like	18	7
Ankyrin repeat	Ankyrin repeat	17	14
Thioesterase/thiol ester dehydrase-isomerase	Thioesterase/thiol ester dehydrase-isomerase	16	8
beta-beta-alpha zinc fingers	Zn2/Cys6 DNA-binding domain	16	3
Thiolase-like	S-adenosyl-L-methionine-dependent methyltransferases	15	11
Arabinanase/levansucrase/invertase	Concanavalin A-like lectins/glucanases	15	3
Aminoacid dehydrogenase-like, N-terminal domain	NAD(P)-binding Rossmann-fold domains	15	7
Probable ACP-binding domain of malonyl-CoA ACP transacylase	S-adenosyl-L-methionine-dependent methyltransferases	15	11
P-loop containing nucleoside triphosphate hydrolases	Ankyrin repeat	15	13
WD40 repeat-like	WD40 repeat-like	15	9
FabD/lysophospholipase-like	S-adenosyl-L-methionine-dependent methyltransferases	15	11
P-loop containing nucleoside triphosphate hydrolases	TPR-like	14	10
P-loop containing nucleoside triphosphate hydrolases	Translation proteins	14	10
S-adenosyl-L-methionine-dependent methyltransferases	NAD(P)-binding Rossmann-fold domains	14	10
(Trans)glycosidases	Chitinase insertion domain	14	7
beta-beta-alpha zinc fingers	beta-beta-alpha zinc fingers	14	8
Acetyl-CoA synthetase-like	NAD(P)-binding Rossmann-fold domains	14	13
Galactose mutarotase-like	(Trans)glycosidases	13	5
Galactose-binding domain-like	beta-Galactosidase/glucuronidase domain	13	7
beta-Galactosidase/glucuronidase domain	(Trans)glycosidases	13	7
Probable ACP-binding domain of malonyl-CoA ACP transacylase	GroES-like	13	8
S-adenosyl-L-methionine-dependent methyltransferases	ACP-like	13	9
Thiolase-like	GroES-like	13	8
FabD/lysophospholipase-like	GroES-like	13	8
Homodimeric domain of signal transducing histidine kinase	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	12	10
GroES-like	ACP-like	12	7
Ypt/Rab-GAP domain of gyp1p	Ypt/Rab-GAP domain of gyp1p	12	4
Plant lectins/antimicrobial peptides	(Trans)glycosidases	12	7
PreATP-grasp domain	Glutathione synthetase ATP-binding domain-like	12	11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	CheY-like	12	10
Enolase N-terminal domain-like	Enolase C-terminal domain-like	12	3
FAD-binding/transporter-associated domain-like	FAD-linked oxidases, C-terminal domain	12	4
Homodimeric domain of signal transducing histidine kinase	CheY-like	12	10
Plant lectins/antimicrobial peptides	Chitinase insertion domain	11	6
Cupredoxins	Cupredoxins	11	9
Purine and uridine phosphorylases	Ankyrin repeat	11	9
Nucleotidylyl transferase	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	11	6
S-adenosyl-L-methionine-dependent methyltransferases	GroES-like	10	6
alpha/beta-Hydrolases	Galactose-binding domain-like	10	3
Thiamin diphosphate-binding fold (THDP-binding)	DHS-like NAD/FAD-binding domain	10	2
Cyclin-like	Cyclin-like	10	7
F-box domain	WD40 repeat-like	9	6
FAD-linked reductases, C-terminal domain	Thioredoxin-like	9	4
Amine oxidase N-terminal region	Amine oxidase N-terminal region	9	1
GroEL equatorial domain-like	GroEL-intermediate domain like	9	2
GroEL-intermediate domain like	GroEL apical domain-like	9	2
Amine oxidase N-terminal region	Amine oxidase catalytic domain	9	1
Galactose mutarotase-like	Glycosyl hydrolase domain	9	3
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	9	4
CRAL/TRIO N-terminal domain	CRAL/TRIO domain	9	5
FAD/NAD(P)-binding domain	Thioredoxin-like	9	4
Homeodomain-like	Homeodomain-like	9	6
GroEL equatorial domain-like	GroEL apical domain-like	9	2
Thiamin diphosphate-binding fold (THDP-binding)	TK C-terminal domain-like	9	5
Phospholipase D/nuclease	Phospholipase D/nuclease	9	6
ARM repeat	Protein kinase-like (PK-like)	9	9
NAD(P)-binding Rossmann-fold domains	CoA-dependent acyltransferases	8	8
P-loop containing nucleoside triphosphate hydrolases	"Winged helix" DNA-binding domain	8	6
Nucleotide-binding domain	FAD-linked reductases, C-terminal domain	8	3
ISP domain	Bet v1-like	8	3
Glutathione synthetase ATP-binding domain-like	Rudiment single hybrid motif	8	7
PreATP-grasp domain	Rudiment single hybrid motif	8	7
Creatinase/prolidase N-terminal domain	Creatinase/aminopeptidase	8	4
RING/U-box	RING/U-box	8	8
P-loop containing nucleoside triphosphate hydrolases	NAD(P)-binding Rossmann-fold domains	7	5
Galactose mutarotase-like	Galactose-binding domain-like	7	2
LysM domain	LysM domain	7	6
P-loop containing nucleoside triphosphate hydrolases	Ribosomal protein S5 domain 2-like	7	6
Cation efflux protein transmembrane domain-like	Cation efflux protein cytoplasmic domain-like	7	4
P-loop containing nucleoside triphosphate hydrolases	RING/U-box	7	2
P-loop containing nucleoside triphosphate hydrolases	ARM repeat	7	7
Aconitase iron-sulfur domain	LeuD/IlvD-like	7	2
Class II aaRS and biotin synthetases	Class II aaRS ABD-related	7	6
beta-Galactosidase/glucuronidase domain	beta-Galactosidase/glucuronidase domain	7	3
ACP-like	alpha/beta-Hydrolases	7	4
Nucleic acid-binding proteins	P-loop containing nucleoside triphosphate hydrolases	7	1
Nucleic acid-binding proteins	Class II aaRS and biotin synthetases	7	3
ValRS/IleRS/LeuRS editing domain	Nucleotidylyl transferase	6	2
Translation proteins	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	6	2
Cytochrome b5-like heme/steroid binding domain	FMN-linked oxidoreductases	6	1
Glutathione synthetase ATP-binding domain-like	Single hybrid motif	6	5
UBA-like	Ubiquitin-like	6	5
P-loop containing nucleoside triphosphate hydrolases	EF-G C-terminal domain-like	6	6
IlvD/EDD N-terminal domain-like	LeuD/IlvD-like	6	1
Zn2/Cys6 DNA-binding domain	Zn2/Cys6 DNA-binding domain	6	1
GAF domain-like	Homodimeric domain of signal transducing histidine kinase	6	4
Flavoproteins	Ferredoxin reductase-like, C-terminal NADP-linked domain	6	3
LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	6	6
Translation proteins	EF-G C-terminal domain-like	6	6
PreATP-grasp domain	Single hybrid motif	6	5
GAF domain-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	6	4
Purine and uridine phosphorylases	TPR-like	6	3
CoA-transferase family III (CaiB/BaiF)	CoA-transferase family III (CaiB/BaiF)	6	2
ValRS/IleRS/LeuRS editing domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	6	2
Rudiment single hybrid motif	Single hybrid motif	6	5
Flavoproteins	Riboflavin synthase domain-like	6	3
GAF domain-like	CheY-like	6	4
DNA repair protein MutS, domain III	P-loop containing nucleoside triphosphate hydrolases	6	6
EF-G C-terminal domain-like	EF-G C-terminal domain-like	6	6
P-loop containing nucleoside triphosphate hydrolases	EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	6	2
F-box domain	RNI-like	6	5
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Adenine nucleotide alpha hydrolases-like	5	2
LysM domain	Plant lectins/antimicrobial peptides	5	3
HSP40/DnaJ peptide-binding domain	HSP40/DnaJ peptide-binding domain	5	3
Ribosomal protein S5 domain 2-like	GHMP Kinase, C-terminal domain	5	4
Nucleic acid-binding proteins	Nucleic acid-binding proteins	5	5
Plant lectins/antimicrobial peptides	Plant lectins/antimicrobial peptides	5	4
LysM domain	(Trans)glycosidases	5	3
PYP-like sensor domain (PAS domain)	CheY-like	5	5
CorA soluble domain-like	Magnesium transport protein CorA, transmembrane region	5	3
LysM domain	Chitinase insertion domain	5	3
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Ribosomal protein S5 domain 2-like	5	4
Thioredoxin-like	Thioredoxin-like	5	5
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), peptide-binding domain	5	3
Chaperone J-domain	HSP40/DnaJ peptide-binding domain	5	3
P-loop containing nucleoside triphosphate hydrolases	Aminoacid dehydrogenase-like, N-terminal domain	5	3
Eukaryotic type KH-domain (KH-domain type I)	Eukaryotic type KH-domain (KH-domain type I)	5	5
DNA ligase/mRNA capping enzyme, catalytic domain	Nucleic acid-binding proteins	5	4
DPP6 N-terminal domain-like	alpha/beta-Hydrolases	5	2
P-loop containing nucleoside triphosphate hydrolases	post-AAA+ oligomerization domain-like	5	3
ENTH/VHS domain	GAT-like domain	5	5
P-loop containing nucleoside triphosphate hydrolases	WD40 repeat-like	5	5
Translation proteins	Ribosomal protein S5 domain 2-like	5	5
Ribonuclease H-like	DNA/RNA polymerases	5	4
Composite domain of metallo-dependent hydrolases	Composite domain of metallo-dependent hydrolases	5	2
Actin-like ATPase domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	5	3
EF-G C-terminal domain-like	Ribosomal protein S5 domain 2-like	5	5
Metallo-dependent phosphatases	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	5	3
Probable ACP-binding domain of malonyl-CoA ACP transacylase	CoA-dependent acyltransferases	4	4
Oxidoreductase molybdopterin-binding domain	E set domains	4	4
Beta-galactosidase LacA, domain 3	Galactose-binding domain-like	4	1
ADC-like	Cdc48 domain 2-like	4	4
Cullin homology domain	"Winged helix" DNA-binding domain	4	3
Tubulin nucleotide-binding domain-like	Tubulin C-terminal domain-like	4	1
FYVE/PHD zinc finger	FYVE/PHD zinc finger	4	4
PAZ domain	Ribonuclease H-like	4	2
Ribosomal protein S5 domain 2-like	Ribonuclease PH domain 2-like	4	2
SH3-domain	SH3-domain	4	4
Glycosyl hydrolase domain	Beta-galactosidase LacA, domain 3	4	1
ARM repeat	WD40 repeat-like	4	4
Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	4	3
HMA, heavy metal-associated domain	Calcium ATPase, transduction domain A	4	4
PYP-like sensor domain (PAS domain)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	4	4
alpha/beta-Hydrolases	alpha/beta-Hydrolases	4	3
Nucleotidylyl transferase	Ribosomal protein L25-like	4	3
FabD/lysophospholipase-like	CoA-dependent acyltransferases	4	4
P-loop containing nucleoside triphosphate hydrolases	Smc hinge domain	4	3
Thiolase-like	CoA-dependent acyltransferases	4	4
NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	4	3
PUA domain-like	P-loop containing nucleoside triphosphate hydrolases	4	3
P-loop containing nucleoside triphosphate hydrolases	Sec63 N-terminal domain-like	4	3
Aldolase	Aminoacid dehydrogenase-like, N-terminal domain	4	2
Galactose-binding domain-like	Galactose-binding domain-like	4	1
Aldolase	NAD(P)-binding Rossmann-fold domains	4	2
SNARE-like	Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	4	3
Galactose mutarotase-like	Starch-binding domain-like	4	1
BAR/IMD domain-like	SH3-domain	4	2
DnaJ/Hsp40 cysteine-rich domain	HSP40/DnaJ peptide-binding domain	4	2
FabD/lysophospholipase-like	FabD/lysophospholipase-like	4	3
Cysteine proteinases	RING/U-box	4	4
ADC-like	P-loop containing nucleoside triphosphate hydrolases	4	4
HMA, heavy metal-associated domain	HAD-like	4	4
P-loop containing nucleoside triphosphate hydrolases	Aldolase	4	2
Glycosyl hydrolase domain	Galactose-binding domain-like	4	1
Purine and uridine phosphorylases	WD40 repeat-like	4	4
PA domain	Zn-dependent exopeptidases	4	3
Translation proteins SH3-like domain	Nucleic acid-binding proteins	4	4
FabD/lysophospholipase-like	Thioesterase/thiol ester dehydrase-isomerase	4	3
Starch-binding domain-like	Galactose-binding domain-like	4	1
Leukotriene A4 hydrolase N-terminal domain	Metalloproteases ("zincins"), catalytic domain	4	2
NAD(P)-binding Rossmann-fold domains	MFS general substrate transporter	4	4
(Trans)glycosidases	Beta-galactosidase LacA, domain 3	4	1
Chaperone J-domain	DnaJ/Hsp40 cysteine-rich domain	4	2
PYP-like sensor domain (PAS domain)	Homodimeric domain of signal transducing histidine kinase	4	4
beta-N-acetylhexosaminidase-like domain	(Trans)glycosidases	4	3
Protease propeptides/inhibitors	Subtilisin-like	4	3
Heat shock protein 70kD (HSP70), peptide-binding domain	Heat shock protein 70kD (HSP70), C-terminal subdomain	4	2
PIN domain-like	5' to 3' exonuclease, C-terminal subdomain	4	2
"Winged helix" DNA-binding domain	Sec63 N-terminal domain-like	4	3
Galactose-binding domain-like	Six-hairpin glycosidases	4	3
Acetyl-CoA synthetase-like	alpha/beta-Hydrolases	4	2
Single hybrid motif	CoA-dependent acyltransferases	4	3
ClpP/crotonase	ClpP/crotonase	4	4
C2 domain (Calcium/lipid-binding domain, CaLB)	Protein kinase-like (PK-like)	3	3
GroES-like	CoA-dependent acyltransferases	3	3
Protein kinase-like (PK-like)	WD40 repeat-like	3	3
Cytochrome b5-like heme/steroid binding domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	3
Riboflavin synthase domain-like	2Fe-2S ferredoxin-like	3	3
WW domain	WW domain	3	3
Pectin lyase-like	Pectin lyase-like	3	2
vWA-like	Helical domain of Sec23/24	3	2
F-box domain	Ankyrin repeat	3	2
alpha-ketoacid dehydrogenase kinase, N-terminal domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	3	3
Cdc48 domain 2-like	P-loop containing nucleoside triphosphate hydrolases	3	3
6-phosphogluconate dehydrogenase C-terminal domain-like	6-phosphogluconate dehydrogenase C-terminal domain-like	3	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, C-terminal domain	3	3
FAD/NAD(P)-binding domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	3	2
Ferredoxin reductase-like, C-terminal NADP-linked domain	2Fe-2S ferredoxin-like	3	3
Zn-finger domain of Sec23/24	beta-sandwich domain of Sec23/24	3	2
DNA repair protein MutS, domain I	P-loop containing nucleoside triphosphate hydrolases	3	3
BAR/IMD domain-like	PH domain-like	3	3
BRCT domain	BRCT domain	3	3
Cytochrome P450	Riboflavin synthase domain-like	3	2
beta-sandwich domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	3	2
NAD(P)-binding Rossmann-fold domains	Zn2/Cys6 DNA-binding domain	3	3
GST C-terminal domain-like	Nucleotidylyl transferase	3	2
L domain-like	L domain-like	3	3
DNA repair protein MutS, domain II	P-loop containing nucleoside triphosphate hydrolases	3	3
vWA-like	C-terminal, gelsolin-like domain of Sec23/24	3	2
Thioredoxin-like	Ubiquitin-like	3	2
FabD/lysophospholipase-like	Inosine monophosphate dehydrogenase (IMPDH)	3	2
Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	3	3
Calcium ATPase, transduction domain A	Calcium ATPase, transduction domain A	3	1
Multidrug resistance efflux transporter EmrE	Multidrug resistance efflux transporter EmrE	3	1
Clc chloride channel	CBS-domain pair	3	2
Chromo domain-like	P-loop containing nucleoside triphosphate hydrolases	3	3
Thiolase-like	4'-phosphopantetheinyl transferase	3	2
MurD-like peptide ligases, catalytic domain	MurD-like peptide ligases, peptide-binding domain	3	2
C2 domain (Calcium/lipid-binding domain, CaLB)	C2 domain (Calcium/lipid-binding domain, CaLB)	3	3
CBS-domain pair	CBS-domain pair	3	3
P-loop containing nucleoside triphosphate hydrolases	C-terminal domain of alpha and beta subunits of F1 ATP synthase	3	3
ARM repeat	Clathrin adaptor appendage domain	3	3
Thiolase-like	alpha/beta-Hydrolases	3	2
SNARE-like	SNARE fusion complex	3	2
Zn-finger domain of Sec23/24	Helical domain of Sec23/24	3	2
Actin depolymerizing proteins	Actin depolymerizing proteins	3	3
FabD/lysophospholipase-like	alpha/beta-Hydrolases	3	2
Probable ACP-binding domain of malonyl-CoA ACP transacylase	alpha/beta-Hydrolases	3	2
NAD(P)-binding Rossmann-fold domains	LDH C-terminal domain-like	3	1
Acyl-CoA dehydrogenase C-terminal domain-like	Acyl-CoA dehydrogenase C-terminal domain-like	3	2
TPR-like	Chaperone J-domain	3	3
Transducin (alpha subunit), insertion domain	P-loop containing nucleoside triphosphate hydrolases	3	1
DNA repair protein MutS, domain II	DNA repair protein MutS, domain III	3	3
alpha/beta-Hydrolases	TPR-like	3	3
cAMP-binding domain-like	cAMP-binding domain-like	3	3
Heme-dependent peroxidases	Cytochrome P450	3	2
Glutamine synthetase, N-terminal domain	Glutamine synthetase/guanido kinase	3	1
Cullin repeat-like	"Winged helix" DNA-binding domain	3	2
EF-hand	Sm-like ribonucleoproteins	3	1
DNA repair protein MutS, domain I	DNA repair protein MutS, domain III	3	3
Aldolase	post-HMGL domain-like	3	2
Fumarylacetoacetate hydrolase, FAH, N-terminal domain	FAH	3	1
TPR-like	HCP-like	3	3
P-loop containing nucleoside triphosphate hydrolases	Tropomyosin	3	2
beta-sandwich domain of Sec23/24	Helical domain of Sec23/24	3	2
SMAD/FHA domain	Protein kinase-like (PK-like)	3	2
Succinyl-CoA synthetase domains	Glutathione synthetase ATP-binding domain-like	3	2
Zn-finger domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	3	2
Zn-finger domain of Sec23/24	vWA-like	3	2
Cytochrome b5-like heme/steroid binding domain	Riboflavin synthase domain-like	3	3
Cullin repeat-like	Cullin homology domain	3	2
HMA, heavy metal-associated domain	Calcium ATPase, transmembrane domain M	3	3
Fe,Mn superoxide dismutase (SOD), N-terminal domain	Fe,Mn superoxide dismutase (SOD), C-terminal domain	3	2
alpha/beta-Hydrolases	P-loop containing nucleoside triphosphate hydrolases	3	3
beta-Galactosidase/glucuronidase domain	Galactose mutarotase-like	3	1
Cytochrome P450	Ferredoxin reductase-like, C-terminal NADP-linked domain	3	2
DNA/RNA polymerases	Lesion bypass DNA polymerase (Y-family), little finger domain	3	2
Six-hairpin glycosidases	(Trans)glycosidases	3	3
Nucleotidyltransferase	PAP/OAS1 substrate-binding domain	3	2
Creatinase/aminopeptidase	"Winged helix" DNA-binding domain	3	2
P-loop containing nucleoside triphosphate hydrolases	Phosphoglycerate mutase-like	3	3
vWA-like	beta-sandwich domain of Sec23/24	3	2
"Winged helix" DNA-binding domain	"Winged helix" DNA-binding domain	3	3
Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	3	3
P-loop containing nucleoside triphosphate hydrolases	TGS-like	3	2
Phosphoglucomutase, first 3 domains	Phosphoglucomutase, first 3 domains	3	3
RNase III domain-like	RNase III domain-like	3	3
FabD/lysophospholipase-like	4'-phosphopantetheinyl transferase	3	2
BRCT domain	WGR domain-like	3	3
NAD(P)-binding Rossmann-fold domains	4'-phosphopantetheinyl transferase	3	2
Helical domain of Sec23/24	C-terminal, gelsolin-like domain of Sec23/24	3	2
S-adenosyl-L-methionine-dependent methyltransferases	CoA-dependent acyltransferases	3	3
EF-hand	EF-hand	3	3
(Trans)glycosidases	UDP-Glycosyltransferase/glycogen phosphorylase	3	1
Inosine monophosphate dehydrogenase (IMPDH)	Thioesterase/thiol ester dehydrase-isomerase	3	2
Sec63 N-terminal domain-like	E set domains	2	2
PK beta-barrel domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	2	2
E set domains	Riboflavin synthase domain-like	2	2
RNA-binding domain, RBD	Ran binding protein zinc finger-like	2	2
PurM N-terminal domain-like	PurM C-terminal domain-like	2	2
WGR domain-like	Domain of poly(ADP-ribose) polymerase	2	2
RING/U-box	WD40 repeat-like	2	2
2Fe-2S ferredoxin-like	CO dehydrogenase flavoprotein C-terminal domain-like	2	1
Translational machinery components	L30e-like	2	2
Galactose-binding domain-like	E set domains	2	2
DNA-binding domain of Mlu1-box binding protein MBP1	Ankyrin repeat	2	2
TRAF domain-like	Cysteine proteinases	2	2
RraA-like	RraA-like	2	1
P-loop containing nucleoside triphosphate hydrolases	FtsH protease domain-like	2	2
TPR-like	SET domain	2	1
RNase III domain-like	dsRNA-binding domain-like	2	2
Molybdenum cofactor biosynthesis proteins	MoeA N-terminal region -like	2	2
Cytochrome b5-like heme/steroid binding domain	DEK C-terminal domain	2	1
WW domain	FF domain	2	2
E set domains	Ferredoxin reductase-like, C-terminal NADP-linked domain	2	2
dsRNA-binding domain-like	Ribosomal protein S5 domain 2-like	2	1
Insert subdomain of RNA polymerase alpha subunit	RBP11-like subunits of RNA polymerase	2	2
ISP domain	FAD/NAD(P)-binding domain	2	2
Acetyl-CoA synthetase-like	Zn2/Cys6 DNA-binding domain	2	2
Ribulose-phoshate binding barrel	Tryptophan synthase beta subunit-like PLP-dependent enzymes	2	2
P-loop containing nucleoside triphosphate hydrolases	DEK C-terminal domain	2	1
Metalloproteases ("zincins"), catalytic domain	Blood coagulation inhibitor (disintegrin)	2	1
Protein kinase-like (PK-like)	CheY-like	2	2
Sec7 domain	PH domain-like	2	1
UBA-like	Thioredoxin-like	2	1
Oxidoreductase molybdopterin-binding domain	Riboflavin synthase domain-like	2	2
Domain of poly(ADP-ribose) polymerase	ADP-ribosylation	2	2
Single hybrid motif	ClpP/crotonase	2	2
CO dehydrogenase molybdoprotein N-domain-like	Molybdenum cofactor-binding domain	2	1
GST C-terminal domain-like	Ribosomal protein L25-like	2	1
BAR/IMD domain-like	GTPase activation domain, GAP	2	2
Sec63 N-terminal domain-like	Sec63 N-terminal domain-like	2	2
DNA polymerase beta, N-terminal domain-like	PsbU/PolX domain-like	2	2
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DNA mismatch repair protein MutL	2	2
P-loop containing nucleoside triphosphate hydrolases	Bromodomain	2	2
WGR domain-like	ADP-ribosylation	2	2
tRNA-binding arm	Class II aaRS and biotin synthetases	2	2
PK beta-barrel domain-like	Riboflavin synthase domain-like	2	2
CO dehydrogenase ISP C-domain like	FAD-binding/transporter-associated domain-like	2	1
Globin-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	2	1
SH3-domain	Ras GEF	2	1
ACT-like	ACT-like	2	2
PA domain	Transferrin receptor-like dimerisation domain	2	1
FAD-binding/transporter-associated domain-like	CO dehydrogenase molybdoprotein N-domain-like	2	1
PH domain-like	Oxysterol-binding protein-like	2	2
Ankyrin repeat	RING/U-box	2	2
FAS1 domain	FAS1 domain	2	1
ARM repeat	Hect, E3 ligase catalytic domain	2	1
HCP-like	HCP-like	2	2
Galactose oxidase, central domain	E set domains	2	2
Quinoprotein alcohol dehydrogenase-like	WD40 repeat-like	2	2
P-loop containing nucleoside triphosphate hydrolases	Initiation factor IF2/eIF5b, domain 3	2	2
PX domain	BAR/IMD domain-like	2	1
Purine and uridine phosphorylases	Quinoprotein alcohol dehydrogenase-like	2	2
Cytochrome b5-like heme/steroid binding domain	Nucleotide-diphospho-sugar transferases	2	1
Bromodomain	Bromodomain	2	2
2Fe-2S ferredoxin-like	CO dehydrogenase ISP C-domain like	2	1
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	CoA-dependent acyltransferases	2	2
Protein kinase-like (PK-like)	KA1-like	2	1
t-snare proteins	SNARE fusion complex	2	2
Cytochrome b5-like heme/steroid binding domain	Acyl-CoA dehydrogenase C-terminal domain-like	2	2
TPR-like	Protein kinase-like (PK-like)	2	2
Carbamoyl phosphate synthetase, large subunit connection domain	Methylglyoxal synthase-like	2	2
ATP-dependent DNA ligase DNA-binding domain	DNA ligase/mRNA capping enzyme, catalytic domain	2	1
N-terminal domain of alpha and beta subunits of F1 ATP synthase	P-loop containing nucleoside triphosphate hydrolases	2	2
Rudiment single hybrid motif	ClpP/crotonase	2	2
PYP-like sensor domain (PAS domain)	Glucocorticoid receptor-like (DNA-binding domain)	2	2
HMA, heavy metal-associated domain	HMA, heavy metal-associated domain	2	2
PRTase-like	PRTase-like	2	1
MFS general substrate transporter	ALDH-like	2	1
Oxidoreductase molybdopterin-binding domain	Cytochrome b5-like heme/steroid binding domain	2	2
RING/U-box	vWA-like	2	2
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	NAD(P)-linked oxidoreductase	2	1
Ubiquitin-like	Ubiquitin-like	2	2
BRCT domain	Domain of poly(ADP-ribose) polymerase	2	2
MOSC N-terminal domain-like	PK beta-barrel domain-like	2	2
ATP-dependent DNA ligase DNA-binding domain	Nucleic acid-binding proteins	2	1
NAD(P)-binding Rossmann-fold domains	NAD(P)-linked oxidoreductase	2	1
Zinc beta-ribbon	Cyclin-like	2	2
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	Zinc-binding domain of translation initiation factor 2 beta	2	2
NAD-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	2	1
PriA/YqbF domain	GINS helical bundle-like	2	2
Class I glutamine amidotransferase-like	Ribulose-phoshate binding barrel	2	2
CO dehydrogenase ISP C-domain like	CO dehydrogenase molybdoprotein N-domain-like	2	1
Zn-dependent exopeptidases	Transferrin receptor-like dimerisation domain	2	1
SAM/Pointed domain	PH domain-like	2	2
ARM repeat	PH domain-like	2	2
MoeA N-terminal region -like	MoeA C-terminal domain-like	2	2
EF-hand	Mitochondrial carrier	2	2
CO dehydrogenase ISP C-domain like	CO dehydrogenase flavoprotein C-terminal domain-like	2	1
Mss4-like	Mss4-like	2	1
Zn-dependent exopeptidases	(Trans)glycosidases	2	2
BRCT domain	ADP-ribosylation	2	2
PreATP-grasp domain	Methylglyoxal synthase-like	2	2
DNA repair protein MutS, domain I	DNA repair protein MutS, domain II	2	2
PreATP-grasp domain	ClpP/crotonase	2	2
Class II aaRS and biotin synthetases	ThrRS/AlaRS common domain	2	2
alpha/beta-Hydrolases	Magnesium transport protein CorA, transmembrane region	2	2
CO dehydrogenase flavoprotein C-terminal domain-like	Molybdenum cofactor-binding domain	2	1
FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	2	1
Urease, gamma-subunit	Metallo-dependent hydrolases	2	2
DNA polymerase beta, N-terminal domain-like	Nucleotidyltransferase	2	2
Purine and uridine phosphorylases	ARM repeat	2	2
P-loop containing nucleoside triphosphate hydrolases	RNase III domain-like	2	2
RING/U-box	FYVE/PHD zinc finger	2	2
FYVE/PHD zinc finger	Clavaminate synthase-like	2	2
Galactose-binding domain-like	Galactose oxidase, central domain	2	2
Ribosomal L27 protein-like	Nucleic acid-binding proteins	2	2
Urease, gamma-subunit	Urease, beta-subunit	2	2
Nucleotide-diphospho-sugar transferases	DEK C-terminal domain	2	1
P-loop containing nucleoside triphosphate hydrolases	PRTase-like	2	2
P-loop containing nucleoside triphosphate hydrolases	HAD-like	2	2
FAD-binding/transporter-associated domain-like	Molybdenum cofactor-binding domain	2	1
Metallo-hydrolase/oxidoreductase	Cytochrome P450	2	2
Restriction endonuclease-like	RuvA domain 2-like	2	2
Globin-like	Riboflavin synthase domain-like	2	1
PYP-like sensor domain (PAS domain)	PYP-like sensor domain (PAS domain)	2	2
GroES-like	GroES-like	2	1
FabD/lysophospholipase-like	Acetyl-CoA synthetase-like	2	2
Arabinanase/levansucrase/invertase	Galactose-binding domain-like	2	1
Transcription factor IIA (TFIIA), alpha-helical domain	Transcription factor IIA (TFIIA), beta-barrel domain	2	2
NAD(P)-binding Rossmann-fold domains	Siroheme synthase middle domains-like	2	2
SMAD/FHA domain	"Winged helix" DNA-binding domain	2	1
(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	2	2
Urease, beta-subunit	Composite domain of metallo-dependent hydrolases	2	2
YjgF-like	YjgF-like	2	2
N-terminal, heterodimerisation domain of RBP7 (RpoE)	Nucleic acid-binding proteins	2	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Class I glutamine amidotransferase-like	2	2
Thiolase-like	Acetyl-CoA synthetase-like	2	2
N-terminal domain of alpha and beta subunits of F1 ATP synthase	C-terminal domain of alpha and beta subunits of F1 ATP synthase	2	2
Glutathione synthetase ATP-binding domain-like	Methylglyoxal synthase-like	2	2
NTF2-like	FAD/NAD(P)-binding domain	2	1
NAD(P)-binding Rossmann-fold domains	Succinyl-CoA synthetase domains	2	2
GTPase activation domain, GAP	RGC domain-like	2	2
CCCH zinc finger	CCCH zinc finger	2	2
Initiation factor IF2/eIF5b, domain 3	Translation proteins	2	2
NAD(P)-binding Rossmann-fold domains	Thioesterase/thiol ester dehydrase-isomerase	2	2
ARM repeat	Sec7 domain	2	2
Diaminopimelate epimerase-like	Diaminopimelate epimerase-like	2	1
TPR-like	HIT/MYND zinc finger-like	2	2
Single hybrid motif	Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	2	2
Clathrin adaptor appendage domain	Subdomain of clathrin and coatomer appendage domain	2	2
Folate-binding domain	Aminomethyltransferase beta-barrel domain	2	2
Glutathione synthetase ATP-binding domain-like	Carbamoyl phosphate synthetase, large subunit connection domain	2	2
Molybdenum cofactor biosynthesis proteins	MoeA C-terminal domain-like	2	2
PsbU/PolX domain-like	Nucleotidyltransferase	2	2
Bacterial exopeptidase dimerisation domain	(Trans)glycosidases	2	2
Voltage-gated potassium channels	Voltage-gated potassium channels	2	2
RNA-binding domain, RBD	PWI domain	2	2
E set domains	Cytochrome b5-like heme/steroid binding domain	2	2
post-HMGL domain-like	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	2	1
Urease, beta-subunit	Metallo-dependent hydrolases	2	2
Translation proteins	ThrRS/AlaRS common domain	2	2
Periplasmic binding protein-like II	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain	2	1
Aminopeptidase/glucanase lid domain	Zn-dependent exopeptidases	2	1
Acyl-CoA N-acyltransferases (Nat)	Bromodomain	2	2
ACP-like	Zn2/Cys6 DNA-binding domain	2	2
Protein kinase-like (PK-like)	Ankyrin repeat	2	2
vWA-like	SPOC domain-like	2	2
Tropomyosin	Smc hinge domain	2	1
TRAF domain-like	RING/U-box	2	2
beta-beta-alpha zinc fingers	S-adenosyl-L-methionine-dependent methyltransferases	2	2
PLC-like phosphodiesterases	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	2	2
Subtilisin-like	Galactose-binding domain-like	2	1
Urease, gamma-subunit	Composite domain of metallo-dependent hydrolases	2	2
UDP-Glycosyltransferase/glycogen phosphorylase	HAD-like	2	1
2Fe-2S ferredoxin-like	CO dehydrogenase molybdoprotein N-domain-like	2	1
Purple acid phosphatase, N-terminal domain	Metallo-dependent phosphatases	2	2
2Fe-2S ferredoxin-like	FAD-binding/transporter-associated domain-like	2	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	Acetyl-CoA synthetase-like	2	2
Dimeric alpha+beta barrel	Dimeric alpha+beta barrel	2	2
P-loop containing nucleoside triphosphate hydrolases	beta-beta-alpha zinc fingers	2	2
Metallo-hydrolase/oxidoreductase	SCP-like	2	1
Glutathione synthetase ATP-binding domain-like	ClpP/crotonase	2	2
2Fe-2S ferredoxin-like	Molybdenum cofactor-binding domain	2	1
Ankyrin repeat	POZ domain	2	2
P-loop containing nucleoside triphosphate hydrolases	Cytochrome b5-like heme/steroid binding domain	2	1
CO dehydrogenase ISP C-domain like	Molybdenum cofactor-binding domain	2	1
PUA domain-like	Ribosomal protein S5 domain 2-like	2	1
Glutathione synthetase ATP-binding domain-like	Glutathione synthetase ATP-binding domain-like	2	2
Cytochrome b5-like heme/steroid binding domain	Acyl-CoA dehydrogenase NM domain-like	2	2
EF-hand	C2 domain (Calcium/lipid-binding domain, CaLB)	2	2
Nucleotide-diphospho-sugar transferases	Trimeric LpxA-like enzymes	2	2
Ribosomal L11/L12e N-terminal domain	Ribosomal protein L11, C-terminal domain	2	1
DBL homology domain (DH-domain)	PH domain-like	2	1
Ribosomal protein L6	Ribosomal protein L6	2	2
Aldolase	2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain	2	1
Oligoxyloglucan reducing end-specific cellobiohydrolase	Oligoxyloglucan reducing end-specific cellobiohydrolase	2	2
F1F0 ATP synthase subunit C	F1F0 ATP synthase subunit C	2	1
PreATP-grasp domain	Carbamoyl phosphate synthetase, large subunit connection domain	2	2
Oxidoreductase molybdopterin-binding domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	2	2
Nucleic acid-binding proteins	Eukaryotic type KH-domain (KH-domain type I)	2	2
PK beta-barrel domain-like	2Fe-2S ferredoxin-like	2	2
P-loop containing nucleoside triphosphate hydrolases	Nucleotide-diphospho-sugar transferases	2	1
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	2	2
Nicotinate/Quinolinate PRTase N-terminal domain-like	Nicotinate/Quinolinate PRTase C-terminal domain-like	2	2
Cytochrome P450	Flavoproteins	2	1
PreATP-grasp domain	PreATP-grasp domain	2	2
Beta-D-glucan exohydrolase, C-terminal domain	Beta-D-glucan exohydrolase, C-terminal domain	2	1
EF-hand	Calponin-homology domain, CH-domain	2	2
E set domains	(Trans)glycosidases	2	2
Chromo domain-like	Chromo domain-like	2	2
P-loop containing nucleoside triphosphate hydrolases	Hypothetical protein YjiA, C-terminal domain	2	2
CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase molybdoprotein N-domain-like	2	1
Homeodomain-like	beta-beta-alpha zinc fingers	2	1
ARM repeat	Subdomain of clathrin and coatomer appendage domain	2	2
Ribokinase-like	Nucleotidylyl transferase	1	1
Glutathione synthetase ATP-binding domain-like	Aldolase	1	1
Ada DNA repair protein, N-terminal domain (N-Ada 10)	Homeodomain-like	1	1
Chaperone J-domain	beta-beta-alpha zinc fingers	1	1
Class I glutamine amidotransferase-like	Metallo-dependent hydrolases	1	1
PH domain-like	"Winged helix" DNA-binding domain	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	ThrRS/AlaRS common domain	1	1
post-HMGL domain-like	Single hybrid motif	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Cytochrome P450	1	1
SH3-domain	PH domain-like	1	1
UBA-like	XPC-binding domain	1	1
Class II aaRS ABD-related	C-terminal domain of ProRS	1	1
FAD/NAD(P)-binding domain	EF-hand	1	1
ARM repeat	Chromo domain-like	1	1
CHY zinc finger-like	RING/U-box	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Nucleotide-binding domain	1	1
(Trans)glycosidases	Acyl-CoA N-acyltransferases (Nat)	1	1
Protein kinase-like (PK-like)	Cyclin-like	1	1
Carbamoyl phosphate synthetase, large subunit connection domain	Aspartate/ornithine carbamoyltransferase	1	1
Obg GTP-binding protein N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
HLH, helix-loop-helix DNA-binding domain	ITPase-like	1	1
FYVE/PHD zinc finger	Rabenosyn-5 Rab-binding domain-like	1	1
FGAM synthase PurL, linker domain	PurM C-terminal domain-like	1	1
WD40 repeat-like	alpha/beta-Hydrolases	1	1
Rhodanese/Cell cycle control phosphatase	Cysteine proteinases	1	1
cAMP-binding domain-like	F-box domain	1	1
P-loop containing nucleoside triphosphate hydrolases	GroES-like	1	1
"Winged helix" DNA-binding domain	Regulator of G-protein signaling, RGS	1	1
Methylglyoxal synthase-like	Metallo-dependent hydrolases	1	1
beta-beta-alpha zinc fingers	Ribonuclease H-like	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	Bacterial exopeptidase dimerisation domain	1	1
Purine and uridine phosphorylases	beta-beta-alpha zinc fingers	1	1
NAD(P)-binding Rossmann-fold domains	Purine and uridine phosphorylases	1	1
PLP-dependent transferases	MoaD/ThiS	1	1
Trypsin-like serine proteases	PDZ domain-like	1	1
Cytochrome P450	Calcium-dependent phosphotriesterase	1	1
ACP-like	beta-lactamase/transpeptidase-like	1	1
Nitrous oxide reductase, N-terminal domain	Quinoprotein alcohol dehydrogenase-like	1	1
Class I glutamine amidotransferase-like	Glutathione synthetase ATP-binding domain-like	1	1
Cysteine proteinases	Ribonuclease H-like	1	1
Activator of Hsp90 ATPase, Aha1	Bet v1-like	1	1
Thiamin diphosphate-binding fold (THDP-binding)	Flavoproteins	1	1
Nucleic acid-binding proteins	eIF2alpha middle domain-like	1	1
RING/U-box	PH domain-like	1	1
Class I glutamine amidotransferase-like	PreATP-grasp domain	1	1
Ubiquitin-like	BAG domain	1	1
(Trans)glycosidases	Class I glutamine amidotransferase-like	1	1
NagB/RpiA/CoA transferase-like	CoA-transferase family III (CaiB/BaiF)	1	1
SurE-like	Glutathione synthetase ATP-binding domain-like	1	1
Zn2/Cys6 DNA-binding domain	Trimeric LpxA-like enzymes	1	1
"Winged helix" DNA-binding domain	E set domains	1	1
WW domain	FKBP-like	1	1
P-loop containing nucleoside triphosphate hydrolases	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Glutathione synthetase ATP-binding domain-like	Cyclophilin-like	1	1
Putative DNA-binding domain	Putative DNA-binding domain	1	1
HR1 repeat	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
WD40 repeat-like	Ribonuclease H-like	1	1
Calponin-homology domain, CH-domain	RGC domain-like	1	1
SNARE-like	P-loop containing nucleoside triphosphate hydrolases	1	1
P-loop containing nucleoside triphosphate hydrolases	Ras GEF	1	1
Ribonuclease H-like	HRDC-like	1	1
BRCT domain	P-loop containing nucleoside triphosphate hydrolases	1	1
Chitinase insertion domain	FAH	1	1
GAT-like domain	Clathrin adaptor appendage domain	1	1
Nucleotidyltransferase	Poly A polymerase C-terminal region-like	1	1
PX domain	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Rudiment single hybrid motif	PurM C-terminal domain-like	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	Rhodanese/Cell cycle control phosphatase	1	1
Rudiment single hybrid motif	post-HMGL domain-like	1	1
Phosphofructokinase	Phosphofructokinase	1	1
PurS-like	Class I glutamine amidotransferase-like	1	1
L domain-like	Nucleotide cyclase	1	1
Glycerol-3-phosphate (1)-acyltransferase	TPR-like	1	1
Barwin-like endoglucanases	PHL pollen allergen	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Thiamin diphosphate-binding fold (THDP-binding)	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	HSP90 C-terminal domain	1	1
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	1	1
PRP4-like	Functional domain of the splicing factor Prp18	1	1
BAR/IMD domain-like	"Winged helix" DNA-binding domain	1	1
YjeF N-terminal domain-like	Cyclophilin-like	1	1
Ubiquitin-like	Zn-binding ribosomal proteins	1	1
Galactose oxidase, central domain	Galactose oxidase, central domain	1	1
SAM/Pointed domain	Metallo-dependent phosphatases	1	1
PurM C-terminal domain-like	PurM C-terminal domain-like	1	1
Chaperone J-domain	HSC20 (HSCB), C-terminal oligomerisation domain	1	1
YjgF-like	FAD/NAD(P)-binding domain	1	1
TPR-like	HSP20-like chaperones	1	1
Clavaminate synthase-like	HAD-like	1	1
Glucocorticoid receptor-like (DNA-binding domain)	GTPase activation domain, GAP	1	1
Ankyrin repeat	RCC1/BLIP-II	1	1
Carbamate kinase-like	NAD(P)-binding Rossmann-fold domains	1	1
PAH2 domain	PAH2 domain	1	1
EF-hand	UBA-like	1	1
Glycoside hydrolase/deacetylase	Families 57/38 glycoside transferase middle domain	1	1
Domain of the SRP/SRP receptor G-proteins	P-loop containing nucleoside triphosphate hydrolases	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
"Winged helix" DNA-binding domain	CheY-like	1	1
Carbamate kinase-like	ACT-like	1	1
SRP19	Zn2/Cys6 DNA-binding domain	1	1
dsRNA-binding domain-like	UBC-like	1	1
Thioesterase/thiol ester dehydrase-isomerase	Ankyrin repeat	1	1
GAT-like domain	Ubiquitin-like	1	1
PH domain-like	WD40 repeat-like	1	1
RNI-like	Zn-dependent exopeptidases	1	1
FMN-linked oxidoreductases	Nucleotide-binding domain	1	1
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	1	1
NAD(P)-binding Rossmann-fold domains	Tetrapyrrole methylase	1	1
Nucleotidyltransferase	ARM repeat	1	1
L domain-like	PP2C-like	1	1
Class II aaRS and biotin synthetases	Anticodon-binding domain of PheRS	1	1
RuvA domain 2-like	RuvA domain 2-like	1	1
Ran binding protein zinc finger-like	"Winged helix" DNA-binding domain	1	1
Magnesium transport protein CorA, transmembrane region	PLP-dependent transferases	1	1
TGS-like	Class II aaRS ABD-related	1	1
TK C-terminal domain-like	Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	1	1
S-adenosyl-L-methionine-dependent methyltransferases	beta-lactamase/transpeptidase-like	1	1
L domain-like	UBA-like	1	1
PP2C-like	Nucleotide cyclase	1	1
Formate dehydrogenase/DMSO reductase, domains 1-3	ADC-like	1	1
P-loop containing nucleoside triphosphate hydrolases	vWA-like	1	1
Ankyrin repeat	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Thioredoxin-like	ERP29 C domain-like	1	1
Translation proteins	Translation proteins	1	1
Plant lectins/antimicrobial peptides	Glycoside hydrolase/deacetylase	1	1
MFS general substrate transporter	alpha/beta-Hydrolases	1	1
CBD9-like	FAD-linked reductases, C-terminal domain	1	1
Isochorismatase-like hydrolases	GST C-terminal domain-like	1	1
FYVE/PHD zinc finger	Acyl-CoA N-acyltransferases (Nat)	1	1
ARM repeat	"Winged helix" DNA-binding domain	1	1
EF-hand	PLC-like phosphodiesterases	1	1
Zn-dependent exopeptidases	Homeodomain-like	1	1
Class I glutamine amidotransferase-like	Glycosyl hydrolase domain	1	1
Tex N-terminal region-like	Nucleic acid-binding proteins	1	1
PH domain-like	Protein kinase-like (PK-like)	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	Hect, E3 ligase catalytic domain	1	1
TGS-like	ThrRS/AlaRS common domain	1	1
FAD/NAD(P)-binding domain	Nitrite/Sulfite reductase N-terminal domain-like	1	1
Periplasmic binding protein-like II	GlnB-like	1	1
MFS general substrate transporter	beta-beta-alpha zinc fingers	1	1
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	Translation proteins	1	1
Thioredoxin-like	Six-hairpin glycosidases	1	1
eIF2alpha middle domain-like	eIF-2-alpha, C-terminal domain	1	1
S-adenosyl-L-methionine-dependent methyltransferases	FAD-binding/transporter-associated domain-like	1	1
Metallo-dependent hydrolases	Glutamine synthetase/guanido kinase	1	1
PX domain	beta-sandwich domain of Sec23/24	1	1
"Winged helix" DNA-binding domain	Phosphoglycerate mutase-like	1	1
Methyl-accepting chemotaxis protein (MCP) signaling domain	Homodimeric domain of signal transducing histidine kinase	1	1
Concanavalin A-like lectins/glucanases	P-domain of calnexin/calreticulin	1	1
Phosphoglycerate mutase-like	Metallo-dependent phosphatases	1	1
DEK C-terminal domain	SWIB/MDM2 domain	1	1
Zn2/Cys6 DNA-binding domain	DHS-like NAD/FAD-binding domain	1	1
Supernatant protein factor (SPF), C-terminal domain	Oxysterol-binding protein-like	1	1
PX domain	Phospholipase D/nuclease	1	1
PH domain-like	Ran binding protein zinc finger-like	1	1
Translation initiation factor 2 beta, aIF2beta, N-terminal domain	ARM repeat	1	1
Thioredoxin-like	eEF1-gamma domain	1	1
GST C-terminal domain-like	eEF-1beta-like	1	1
Thermostable phytase (3-phytase)	Thermostable phytase (3-phytase)	1	1
Formate/glycerate dehydrogenase catalytic domain-like	ACT-like	1	1
FAD/NAD(P)-binding domain	alpha/beta-Hydrolases	1	1
HAD-like	Translational machinery components	1	1
Formate/glycerate dehydrogenase catalytic domain-like	Cysteine proteinases	1	1
DNase I-like	Mannose-binding lectins	1	1
P-loop containing nucleoside triphosphate hydrolases	PH domain-like	1	1
L domain-like	DNase I-like	1	1
SNARE fusion complex	SNARE fusion complex	1	1
Chaperone J-domain	Sec63 N-terminal domain-like	1	1
TK C-terminal domain-like	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
Ribonuclease H-like	SH2 domain	1	1
Nucleic acid-binding proteins	SH2 domain	1	1
ENTH/VHS domain	SH3-domain	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	PRTase-like	1	1
NSFL1 (p97 ATPase) cofactor p47, SEP domain	Ubiquitin-like	1	1
ACP-like	Trimeric LpxA-like enzymes	1	1
PreATP-grasp domain	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
Calpain large subunit, middle domain (domain III)	Calpain large subunit, middle domain (domain III)	1	1
P-loop containing nucleoside triphosphate hydrolases	Retrovirus zinc finger-like domains	1	1
RuvA domain 2-like	Nucleic acid-binding proteins	1	1
P-loop containing nucleoside triphosphate hydrolases	PX domain	1	1
Flavoproteins	Adenine nucleotide alpha hydrolases-like	1	1
Quinoprotein alcohol dehydrogenase-like	Quinoprotein alcohol dehydrogenase-like	1	1
Thiamin phosphate synthase	GST C-terminal domain-like	1	1
HR1 repeat	Cysteine-rich domain	1	1
4'-phosphopantetheinyl transferase	4'-phosphopantetheinyl transferase	1	1
Dimeric alpha+beta barrel	Acetyl-CoA synthetase-like	1	1
Aldolase	ClpP/crotonase	1	1
Metallo-dependent hydrolases	Metallo-dependent hydrolases	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Sm-like ribonucleoproteins	1	1
Formate/glycerate dehydrogenase catalytic domain-like	MFS general substrate transporter	1	1
UBC-like	UBC-like	1	1
RCC1/BLIP-II	ARM repeat	1	1
SIS domain	Actin-like ATPase domain	1	1
FGAM synthase PurL, linker domain	PurM N-terminal domain-like	1	1
Obg GTP-binding protein N-terminal domain	Clavaminate synthase-like	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	ACT-like	1	1
WD40 repeat-like	Cyclophilin-like	1	1
Dom34/Pelota N-terminal domain-like	Translational machinery components	1	1
Nitrite/Sulfite reductase N-terminal domain-like	Nitrite/Sulfite reductase N-terminal domain-like	1	1
"Winged helix" DNA-binding domain	GTPase activation domain, GAP	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	L30e-like	1	1
Dcp2 domain-like	Folate-binding domain	1	1
Kelch motif	Kelch motif	1	1
Nucleotide-binding domain	Nucleotide-binding domain	1	1
Actin depolymerizing proteins	SH3-domain	1	1
RING/U-box	Composite domain of metallo-dependent hydrolases	1	1
Protein kinase-like (PK-like)	Class II aaRS ABD-related	1	1
alpha-ketoacid dehydrogenase kinase, N-terminal domain	DHS-like NAD/FAD-binding domain	1	1
alpha/beta-Hydrolases	ALDH-like	1	1
Riboflavin synthase domain-like	Riboflavin synthase domain-like	1	1
Histone-fold	Histone-fold	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	PreATP-grasp domain	1	1
FAD/NAD(P)-binding domain	Acetoacetate decarboxylase-like	1	1
UROD/MetE-like	UROD/MetE-like	1	1
Glutathione synthetase ATP-binding domain-like	Aspartate/ornithine carbamoyltransferase	1	1
P-loop containing nucleoside triphosphate hydrolases	Clavaminate synthase-like	1	1
Trypsin-like serine proteases	Trypsin-like serine proteases	1	1
2Fe-2S ferredoxin-like	alpha-helical ferredoxin	1	1
lambda repressor-like DNA-binding domains	Cyanase C-terminal domain	1	1
Spectrin repeat	EF-hand	1	1
Cyclophilin-like	TPR-like	1	1
Ribonuclease H-like	Ribonuclease H-like	1	1
HAMP domain-like	CheY-like	1	1
(Trans)glycosidases	Invasin/intimin cell-adhesion fragments	1	1
Zn2/Cys6 DNA-binding domain	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	1	1
Class I glutamine amidotransferase-like	GMP synthetase C-terminal dimerisation domain	1	1
FGAM synthase PurL, linker domain	Class I glutamine amidotransferase-like	1	1
Dehydroquinate synthase-like	Aminoacid dehydrogenase-like, N-terminal domain	1	1
RNA-binding domain, RBD	Class II aaRS ABD-related	1	1
HR1 repeat	Protein kinase-like (PK-like)	1	1
ARM repeat	PLP-dependent transferases	1	1
Chromo domain-like	Acyl-CoA N-acyltransferases (Nat)	1	1
UBA-like	NSFL1 (p97 ATPase) cofactor p47, SEP domain	1	1
Radical SAM enzymes	Molybdenum cofactor biosynthesis protein C, MoaC	1	1
NagB/RpiA/CoA transferase-like	D-ribose-5-phosphate isomerase (RpiA), lid domain	1	1
P-loop containing nucleoside triphosphate hydrolases	EF-hand	1	1
Quinoprotein alcohol dehydrogenase-like	Nucleoporin domain	1	1
Alpha subunit of glutamate synthase, C-terminal domain	Nucleotide-binding domain	1	1
TK C-terminal domain-like	Riboflavin synthase domain-like	1	1
PreATP-grasp domain	Aspartate/ornithine carbamoyltransferase	1	1
Ribonuclease H-like	Ribokinase-like	1	1
Staphylococcal nuclease	Staphylococcal nuclease	1	1
RNA-binding domain, RBD	ARM repeat	1	1
Clavaminate synthase-like	MFS general substrate transporter	1	1
CHY zinc finger-like	Zinc hairpin stack	1	1
Surp module (SWAP domain)	Surp module (SWAP domain)	1	1
P-loop containing nucleoside triphosphate hydrolases	Homeodomain-like	1	1
FAD-linked reductases, C-terminal domain	HMG-box	1	1
HAD-like	BRCT domain	1	1
EPT/RTPC-like	P-loop containing nucleoside triphosphate hydrolases	1	1
SPOC domain-like	C-terminal domain of Ku80	1	1
Nucleic acid-binding proteins	Nucleotidylyl transferase	1	1
Cytochrome P450	NAD(P)-binding Rossmann-fold domains	1	1
TPR-like	RNA-binding domain, RBD	1	1
beta-Galactosidase/glucuronidase domain	Bacterial exopeptidase dimerisation domain	1	1
Homeodomain-like	Chromo domain-like	1	1
Prokaryotic type KH domain (KH-domain type II)	Ribosomal protein S3 C-terminal domain	1	1
Actin-like ATPase domain	Uracil-DNA glycosylase-like	1	1
Kelch motif	POZ domain	1	1
Bet v1-like	Zn2/Cys6 DNA-binding domain	1	1
Isochorismatase-like hydrolases	Clavaminate synthase-like	1	1
Clavaminate synthase-like	Quinoprotein alcohol dehydrogenase-like	1	1
Rap30/74 interaction domains	"Winged helix" DNA-binding domain	1	1
FAD/NAD(P)-binding domain	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain	1	1
Magnesium transport protein CorA, transmembrane region	Amidase signature (AS) enzymes	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	CCCH zinc finger	1	1
Nucleic acid-binding proteins	eIF-2-alpha, C-terminal domain	1	1
Ribosomal L27 protein-like	Eukaryotic type KH-domain (KH-domain type I)	1	1
FAD-linked reductases, C-terminal domain	4Fe-4S ferredoxins	1	1
HAMP domain-like	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
P-loop containing nucleoside triphosphate hydrolases	SH3-domain	1	1
FYVE/PHD zinc finger	SAICAR synthase-like	1	1
NAD(P)-binding Rossmann-fold domains	DHS-like NAD/FAD-binding domain	1	1
Coiled-coil domain of nucleotide exchange factor GrpE	Head domain of nucleotide exchange factor GrpE	1	1
Ankyrin repeat	Subtilisin-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Cytidine deaminase-like	1	1
UBA-like	UBA-like	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	Calcium-dependent phosphotriesterase	1	1
NAD(P)-binding Rossmann-fold domains	FAD-linked reductases, C-terminal domain	1	1
HMA, heavy metal-associated domain	Metal cation-transporting ATPase, ATP-binding domain N	1	1
TATA-box binding protein-like	TATA-box binding protein-like	1	1
Zn2/Cys6 DNA-binding domain	Glycosyl hydrolase domain	1	1
DNA/RNA polymerases	Heme oxygenase-like	1	1
Indigoidine synthase A-like	Ribokinase-like	1	1
Aldolase	alpha/beta-Hydrolases	1	1
Enolase C-terminal domain-like	Zn2/Cys6 DNA-binding domain	1	1
Staphylococcal nuclease	Tudor/PWWP/MBT	1	1
all-alpha NTP pyrophosphatases	ALDH-like	1	1
Hypothetical protein c14orf129, hspc210	TPR-like	1	1
Phosphoglycerate mutase-like	5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain	1	1
PreATP-grasp domain	PurM C-terminal domain-like	1	1
Nucleic acid-binding proteins	"Winged helix" DNA-binding domain	1	1
DPP6 N-terminal domain-like	DPP6 N-terminal domain-like	1	1
Ankyrin repeat	Pseudo ankyrin repeat-like	1	1
Mitochondrial carrier	WD40 repeat-like	1	1
beta-Galactosidase/glucuronidase domain	Invasin/intimin cell-adhesion fragments	1	1
Flavoproteins	Nitrite and sulphite reductase 4Fe-4S domain-like	1	1
Concanavalin A-like lectins/glucanases	PH domain-like	1	1
WD40 repeat-like	Zn-dependent exopeptidases	1	1
TPR-like	F-box domain	1	1
2Fe-2S ferredoxin-like	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
NAD(P)-binding Rossmann-fold domains	Nucleotide-diphospho-sugar transferases	1	1
Rudiment single hybrid motif	PurM N-terminal domain-like	1	1
alpha/beta-Hydrolases	(Phosphotyrosine protein) phosphatases II	1	1
Cyclophilin-like	Single hybrid motif	1	1
Class I glutamine amidotransferase-like	ADC synthase	1	1
Nucleic acid-binding proteins	BRCT domain	1	1
Class II aaRS and biotin synthetases	C-terminal domain of ProRS	1	1
Families 57/38 glycoside transferase middle domain	Galactose mutarotase-like	1	1
GroES-like	beta-lactamase/transpeptidase-like	1	1
Cytochrome P450	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
Calponin-homology domain, CH-domain	Spectrin repeat	1	1
TATA-box binding protein-like	DNA-glycosylase	1	1
BRCT domain	Lesion bypass DNA polymerase (Y-family), little finger domain	1	1
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	RING/U-box	1	1
PLP-dependent transferases	alpha/beta-Hydrolases	1	1
TPR-like	CAD & PB1 domains	1	1
RCC1/BLIP-II	PLP-dependent transferases	1	1
BRCT domain	Homeodomain-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Alpha subunit of glutamate synthase, C-terminal domain	1	1
FYSH domain	Hypothetical protein AF0491, middle domain	1	1
Six-hairpin glycosidases	GroES-like	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Nucleotidylyl transferase	1	1
Cysteine proteinases	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	1	1
Glutathione synthetase ATP-binding domain-like	Metallo-dependent hydrolases	1	1
Inhibitor of apoptosis (IAP) repeat	Inhibitor of apoptosis (IAP) repeat	1	1
beta-beta-alpha zinc fingers	Cytochrome P450	1	1
FAD-linked reductases, C-terminal domain	Folate-binding domain	1	1
PLP-dependent transferases	MOSC N-terminal domain-like	1	1
MIT domain	P-loop containing nucleoside triphosphate hydrolases	1	1
PH domain-like	BEACH domain	1	1
HAD-like	Metallo-dependent phosphatases	1	1
SET domain	RuBisCo LSMT C-terminal, substrate-binding domain	1	1
Ribosomal protein L16p/L10e	Ribosomal protein L16p/L10e	1	1
RmlC-like cupins	alpha/beta-Hydrolases	1	1
tRNA-guanine transglycosylase	Thymidylate synthase/dCMP hydroxymethylase	1	1
Ankyrin repeat	Oxysterol-binding protein-like	1	1
Myosin S1 fragment, N-terminal domain	P-loop containing nucleoside triphosphate hydrolases	1	1
FMN-linked oxidoreductases	Thioesterase/thiol ester dehydrase-isomerase	1	1
FYVE/PHD zinc finger	P-loop containing nucleoside triphosphate hydrolases	1	1
Metallo-dependent hydrolases	Aspartate/ornithine carbamoyltransferase	1	1
P-loop containing nucleoside triphosphate hydrolases	Signal peptide-binding domain	1	1
Conserved domain common to transcription factors TFIIS, elongin A, CRSP70	Elongation factor TFIIS domain 2	1	1
Glutamine synthetase/guanido kinase	GatB/YqeY motif	1	1
Methyl-accepting chemotaxis protein (MCP) signaling domain	CheY-like	1	1
DBL homology domain (DH-domain)	BAR/IMD domain-like	1	1
TRAF domain-like	Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain	1	1
PH0987 N-terminal domain-like	Single hybrid motif	1	1
TGS-like	PUA domain-like	1	1
Ankyrin repeat	PLC-like phosphodiesterases	1	1
PIN domain-like	Nucleotide-binding domain	1	1
Riboflavin synthase domain-like	Adenine nucleotide alpha hydrolases-like	1	1
Dcp2 domain-like	Nudix	1	1
Glycosyl hydrolase domain	Ricin B-like lectins	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	GTPase activation domain, GAP	1	1
Nucleic acid-binding proteins	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Zn2/Cys6 DNA-binding domain	Zn-dependent exopeptidases	1	1
Glutathione synthetase ATP-binding domain-like	post-HMGL domain-like	1	1
FabD/lysophospholipase-like	beta-lactamase/transpeptidase-like	1	1
GST C-terminal domain-like	eEF1-gamma domain	1	1
SET domain	WW domain	1	1
Glutaminase/Asparaginase	Ankyrin repeat	1	1
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1	Translational machinery components	1	1
NTF2-like	Phosphoglycerate mutase-like	1	1
RING/U-box	Cyclophilin-like	1	1
Pectin lyase-like	Six-hairpin glycosidases	1	1
Six-hairpin glycosidases	Metallo-dependent phosphatases	1	1
Protein kinase-like (PK-like)	Class II aaRS and biotin synthetases	1	1
alpha-ketoacid dehydrogenase kinase, N-terminal domain	Thiamin diphosphate-binding fold (THDP-binding)	1	1
Myosin S1 fragment, N-terminal domain	Tropomyosin	1	1
Zn-dependent exopeptidases	Carbohydrate phosphatase	1	1
SET domain	alpha/beta-Hydrolases	1	1
Cyclin-like	MFS general substrate transporter	1	1
Class I glutamine amidotransferase-like	Carbamoyl phosphate synthetase, large subunit connection domain	1	1
VPS9 domain	Ankyrin repeat	1	1
Arp2/3 complex subunits	Arp2/3 complex subunits	1	1
POZ domain	Skp1 dimerisation domain-like	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	ARM repeat	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
WD40 repeat-like	DNase I-like	1	1
HIT-like	HIT-like	1	1
PDZ domain-like	PDZ domain-like	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	DNA-glycosylase	1	1
Fibronectin type III	BRCT domain	1	1
ISP transmembrane anchor	ISP domain	1	1
"Winged helix" DNA-binding domain	Terpenoid synthases	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	WW domain	1	1
Putative isomerase YbhE	WD40 repeat-like	1	1
P-loop containing nucleoside triphosphate hydrolases	Apolipoprotein A-I	1	1
(Trans)glycosidases	Metallo-dependent phosphatases	1	1
Zn2/Cys6 DNA-binding domain	Isochorismatase-like hydrolases	1	1
Macro domain-like	DHS-like NAD/FAD-binding domain	1	1
PLP-binding barrel	Alanine racemase C-terminal domain-like	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Clavaminate synthase-like	1	1
Protein kinase-like (PK-like)	Cytochrome P450	1	1
Nucleotidylyl transferase	Alpha-L RNA-binding motif	1	1
Probable ACP-binding domain of malonyl-CoA ACP transacylase	beta-lactamase/transpeptidase-like	1	1
N-acetylmuramoyl-L-alanine amidase-like	LysM domain	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Aspartate/ornithine carbamoyltransferase	1	1
6-phosphogluconate dehydrogenase C-terminal domain-like	Purine and uridine phosphorylases	1	1
HAD-like	PRTase-like	1	1
RING/U-box	PUA domain-like	1	1
Phosphoglycerate mutase-like	WD40 repeat-like	1	1
ARM repeat	Rap/Ran-GAP	1	1
Thiolase-like	beta-lactamase/transpeptidase-like	1	1
Ribosomal protein L7/12, oligomerisation (N-terminal) domain	ClpS-like	1	1
Methyl-accepting chemotaxis protein (MCP) signaling domain	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
Cysteine-rich domain	SH3-domain	1	1
POZ domain	POZ domain	1	1
Ribonuclease H-like	Nudix	1	1
S-adenosyl-L-methionine-dependent methyltransferases	HRDC-like	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Amidase signature (AS) enzymes	1	1
PLP-dependent transferases	NAD(P)-binding Rossmann-fold domains	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	CBS-domain pair	1	1
Nucleotidylyl transferase	P-loop containing nucleoside triphosphate hydrolases	1	1
Cytochrome P450	Zn2/Cys6 DNA-binding domain	1	1
Terpenoid cyclases/Protein prenyltransferases	Terpenoid cyclases/Protein prenyltransferases	1	1
Galactose-binding domain-like	Invasin/intimin cell-adhesion fragments	1	1
Clavaminate synthase-like	GST C-terminal domain-like	1	1
Zn2/Cys6 DNA-binding domain	MFS general substrate transporter	1	1
RibA-like	Aldolase	1	1
Polo-box domain	Polo-box domain	1	1
Glutathione synthetase ATP-binding domain-like	PH0987 N-terminal domain-like	1	1
Methylglyoxal synthase-like	Cytidine deaminase-like	1	1
AN1-like Zinc finger	AN1-like Zinc finger	1	1
GST C-terminal domain-like	Nucleic acid-binding proteins	1	1
Protein kinase-like (PK-like)	GAF domain-like	1	1
R1 subunit of ribonucleotide reductase, N-terminal domain	PFL-like glycyl radical enzymes	1	1
BRCT domain	Nucleotidyltransferase	1	1
Acetyl-CoA synthetase-like	Trimeric LpxA-like enzymes	1	1
S-adenosyl-L-methionine-dependent methyltransferases	SET domain	1	1
cAMP-binding domain-like	RNI-like	1	1
MIT domain	Cysteine proteinases	1	1
HAND domain of the nucleosome remodeling ATPase ISWI	Homeodomain-like	1	1
Ribosomal protein S5 domain 2-like	DNA mismatch repair protein MutL	1	1
Glycoside hydrolase/deacetylase	Galactose mutarotase-like	1	1
GroES-like	Acetyl-CoA synthetase-like	1	1
Galactose-binding domain-like	Bacterial exopeptidase dimerisation domain	1	1
Protein kinase-like (PK-like)	Homodimeric domain of signal transducing histidine kinase	1	1
SMAD/FHA domain	RING/U-box	1	1
Endosomal sorting complex assembly domain	VPS28 C-terminal domain-like	1	1
Cysteine proteinases	alpha/beta-Hydrolases	1	1
DinB/YfiT-like putative metalloenzymes	C-type lectin-like	1	1
FMN-binding split barrel	Class II aaRS and biotin synthetases	1	1
WD40 repeat-like	Calcium-dependent phosphotriesterase	1	1
Phosphoenolpyruvate/pyruvate domain	PK C-terminal domain-like	1	1
Ubiquitin-like	PH domain-like	1	1
NTF2-like	Zn2/Cys6 DNA-binding domain	1	1
ARID-like	Clavaminate synthase-like	1	1
Ubiquitin-like	Cysteine proteinases	1	1
PIN domain-like	FAD-linked reductases, C-terminal domain	1	1
PH domain-like	ArfGap/RecO-like zinc finger	1	1
alpha/beta-Hydrolases	Nucleotide-diphospho-sugar transferases	1	1
FYVE/PHD zinc finger	Homeodomain-like	1	1
Protein kinase-like (PK-like)	Polo-box domain	1	1
ARM repeat	BEACH domain	1	1
Ribonuclease H-like	RNA-binding domain, RBD	1	1
PK beta-barrel domain-like	FabD/lysophospholipase-like	1	1
Ribosomal protein S5 domain 2-like	HSP90 C-terminal domain	1	1
Ankyrin repeat	DHS-like NAD/FAD-binding domain	1	1
FabD/lysophospholipase-like	FMN-linked oxidoreductases	1	1
FYVE/PHD zinc finger	Chromo domain-like	1	1
Ribokinase-like	GST C-terminal domain-like	1	1
Homeodomain-like	FAD/NAD(P)-binding domain	1	1
BRCT domain	DNA/RNA polymerases	1	1
UBC-like	Protein kinase-like (PK-like)	1	1
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain	Cytochrome b5-like heme/steroid binding domain	1	1
PRP4-like	WD40 repeat-like	1	1
ACT-like	Formyltransferase	1	1
Nqo1 middle domain-like	Nqo1C-terminal domain-like	1	1
Protein kinase-like (PK-like)	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	1	1
P-loop containing nucleoside triphosphate hydrolases	Class I glutamine amidotransferase-like	1	1
PurS-like	PurM N-terminal domain-like	1	1
Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain	ARM repeat	1	1
Periplasmic binding protein-like II	ACT-like	1	1
Translation proteins SH3-like domain	Translation proteins SH3-like domain	1	1
Trimeric LpxA-like enzymes	ARM repeat	1	1
Protein kinase-like (PK-like)	Mitochondrial carrier	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	Homeodomain-like	1	1
Thiamin pyrophosphokinase, catalytic domain	Thiamin pyrophosphokinase, substrate-binding domain	1	1
F-box domain	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
GroES-like	GlcG-like	1	1
Calponin-homology domain, CH-domain	GTPase activation domain, GAP	1	1
RNA-binding domain, RBD	SET domain	1	1
Cap-Gly domain	L domain-like	1	1
Clavaminate synthase-like	RING/U-box	1	1
Cyclin-like	TPR-like	1	1
PLP-dependent transferases	PK beta-barrel domain-like	1	1
Cyclophilin-like	Cyclophilin-like	1	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Riboflavin synthase domain-like	1	1
FAD/NAD(P)-binding domain	Nitrite and sulphite reductase 4Fe-4S domain-like	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Metallo-hydrolase/oxidoreductase	1	1
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain	Alkaline phosphatase-like	1	1
PUA domain-like	eIF1-like	1	1
Clathrin heavy-chain terminal domain	ARM repeat	1	1
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	DNA breaking-rejoining enzymes	1	1
Nudix	NagB/RpiA/CoA transferase-like	1	1
PX domain	HRDC-like	1	1
Siroheme synthase middle domains-like	Tetrapyrrole methylase	1	1
FAH	alpha/beta-Hydrolases	1	1
DNA polymerase beta, N-terminal domain-like	Restriction endonuclease-like	1	1
vWA-like	C-terminal domain of Ku80	1	1
UBA-like	Chaperone J-domain	1	1
P-loop containing nucleoside triphosphate hydrolases	HAND domain of the nucleosome remodeling ATPase ISWI	1	1
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
SH3-domain	PX domain	1	1
UBC-like	Class II aaRS ABD-related	1	1
Concanavalin A-like lectins/glucanases	AbfB domain	1	1
Carbamate kinase-like	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	1	1
SMAD/FHA domain	PH domain-like	1	1
Putative DNA-binding domain	PheT/TilS domain	1	1
HAMP domain-like	Homodimeric domain of signal transducing histidine kinase	1	1
Class I glutamine amidotransferase-like	Methylglyoxal synthase-like	1	1
Zinc hairpin stack	RING/U-box	1	1
MFS general substrate transporter	NAD(P)-linked oxidoreductase	1	1
Sm-like ribonucleoproteins	Cytochrome P450	1	1
P-loop containing nucleoside triphosphate hydrolases	Pseudo ankyrin repeat-like	1	1
Tetrahydrobiopterin biosynthesis enzymes-like	Tetrahydrobiopterin biosynthesis enzymes-like	1	1
TK C-terminal domain-like	Flavoproteins	1	1
Flavoproteins	Radical SAM enzymes	1	1
Class II aaRS and biotin synthetases	Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	FMN-linked oxidoreductases	1	1
Ubiquitin-like	Cap-Gly domain	1	1
AraD/HMP-PK domain-like	Galactose mutarotase-like	1	1
Calcium-dependent phosphotriesterase	YWTD domain	1	1
Leukotriene A4 hydrolase N-terminal domain	ARM repeat	1	1
Hypothetical protein SAV1430	Fe-S cluster assembly (FSCA) domain-like	1	1
Radical SAM enzymes	Acyl-CoA N-acyltransferases (Nat)	1	1
RNA-binding domain, RBD	Cytochrome P450	1	1
Ran binding protein zinc finger-like	Ran binding protein zinc finger-like	1	1
PRTase-like	DNA-glycosylase	1	1
USP8 N-terminal domain-like	JAB1/MPN domain	1	1
DAK1/DegV-like	DhaL-like	1	1
PreATP-grasp domain	Metallo-dependent hydrolases	1	1
Heme-dependent catalase-like	Class I glutamine amidotransferase-like	1	1
UBC-like	Ribosomal protein S5 domain 2-like	1	1
Class II aaRS and biotin synthetases	Translation proteins	1	1
YgfY-like	WD40 repeat-like	1	1
FAD-binding/transporter-associated domain-like	Pseudouridine synthase	1	1
NAD(P)-binding Rossmann-fold domains	FAD/NAD(P)-binding domain	1	1
PEP carboxykinase N-terminal domain	PEP carboxykinase-like	1	1
NAD(P)-binding Rossmann-fold domains	ACT-like	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Metallo-dependent hydrolases	1	1
BRCT domain	post-AAA+ oligomerization domain-like	1	1
Methylglyoxal synthase-like	Aspartate/ornithine carbamoyltransferase	1	1
RING/U-box	Formyltransferase	1	1
Retrovirus zinc finger-like domains	Retrovirus zinc finger-like domains	1	1
CBS-domain pair	CAD & PB1 domains	1	1
Protein kinase-like (PK-like)	P-loop containing nucleoside triphosphate hydrolases	1	1
Protein kinase-like (PK-like)	AttH-like	1	1
HisI-like	ALDH-like	1	1
Galactose mutarotase-like	Six-hairpin glycosidases	1	1
RING/U-box	Homeodomain-like	1	1
DNA ligase/mRNA capping enzyme, catalytic domain	BRCT domain	1	1
PA domain	RING/U-box	1	1
L30e-like	alpha/beta knot	1	1
NAD(P)-binding Rossmann-fold domains	beta-lactamase/transpeptidase-like	1	1
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	MFS general substrate transporter	1	1
Ribokinase-like	Nucleic acid-binding proteins	1	1
DNA/RNA polymerases	Ribokinase-like	1	1
YjgF-like	FAD-linked reductases, C-terminal domain	1	1
(Trans)glycosidases	Ricin B-like lectins	1	1
F-box domain	Protein kinase-like (PK-like)	1	1
NAD(P)-binding Rossmann-fold domains	LuxS/MPP-like metallohydrolase	1	1
FMN-binding split barrel	PTPA-like	1	1
S-adenosyl-L-methionine-dependent methyltransferases	PRTase-like	1	1
Mitochondrial carrier	Nucleotide-diphospho-sugar transferases	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	alpha-helical ferredoxin	1	1
P-loop containing nucleoside triphosphate hydrolases	HCP-like	1	1
Alpha subunit of glutamate synthase, C-terminal domain	alpha-helical ferredoxin	1	1
Glycerol-3-phosphate (1)-acyltransferase	Glycerol-3-phosphate (1)-acyltransferase	1	1
LexA/Signal peptidase	UBC-like	1	1
BAR/IMD domain-like	Cysteine-rich domain	1	1
Thiamin diphosphate-binding fold (THDP-binding)	Nitrite and sulphite reductase 4Fe-4S domain-like	1	1
Spectrin repeat	Spectrin repeat	1	1
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	SIS domain	1	1
F-box domain	Clavaminate synthase-like	1	1
Succinyl-CoA synthetase domains	Succinyl-CoA synthetase domains	1	1
FAD-linked reductases, C-terminal domain	Acetoacetate decarboxylase-like	1	1
2Fe-2S ferredoxin-like	4Fe-4S ferredoxins	1	1
ACP-like	P-loop containing nucleoside triphosphate hydrolases	1	1
VPS28 C-terminal domain-like	S-adenosyl-L-methionine-dependent methyltransferases	1	1
NAD(P)-binding Rossmann-fold domains	Calcium-dependent phosphotriesterase	1	1
TPR-like	RNI-like	1	1
Galactose-binding domain-like	Zn-dependent exopeptidases	1	1
Tex N-terminal region-like	RuvA domain 2-like	1	1
Rudiment single hybrid motif	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
YgbK-like	NAD(P)-linked oxidoreductase	1	1
Adenine nucleotide alpha hydrolases-like	YjgF-like	1	1
Ankyrin repeat	PH domain-like	1	1
Nucleotidylyl transferase	An anticodon-binding domain of class I aminoacyl-tRNA synthetases	1	1
TRAF domain-like	TRAF domain-like	1	1
PH domain-like	PH domain-like	1	1
Zn2/Cys6 DNA-binding domain	Macro domain-like	1	1
"Winged helix" DNA-binding domain	Protein kinase-like (PK-like)	1	1
MIT domain	Calpain large subunit, middle domain (domain III)	1	1
Cysteine proteinases	RraA-like	1	1
Thiamin diphosphate-binding fold (THDP-binding)	Nitrite/Sulfite reductase N-terminal domain-like	1	1
Taf5 N-terminal domain-like	WD40 repeat-like	1	1
PLP-dependent transferases	PLP-dependent transferases	1	1
Activating enzymes of the ubiquitin-like proteins	Activating enzymes of the ubiquitin-like proteins	1	1
TGS-like	Class II aaRS and biotin synthetases	1	1
Acetyl-CoA synthetase-like	P-loop containing nucleoside triphosphate hydrolases	1	1
DUSP-like	Cysteine proteinases	1	1
BEACH domain	WD40 repeat-like	1	1
Thioredoxin-like	Galactose-binding domain-like	1	1
Actin-like ATPase domain	CV3147-like	1	1
dsRNA-binding domain-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Leucine zipper domain	YAP1 redox domain	1	1
Class I glutamine amidotransferase-like	Class II aaRS and biotin synthetases	1	1
SGNH hydrolase	Integrin alpha N-terminal domain	1	1
C2 domain (Calcium/lipid-binding domain, CaLB)	Cysteine-rich domain	1	1
Glycerol-3-phosphate (1)-acyltransferase	RNI-like	1	1
Concanavalin A-like lectins/glucanases	BEACH domain	1	1
Concanavalin A-like lectins/glucanases	WD40 repeat-like	1	1
Cytochrome P450	2Fe-2S ferredoxin-like	1	1
E set domains	AMPKBI-like	1	1
ARM repeat	RING/U-box	1	1
Cysteine proteinases	UBA-like	1	1
Methyl-accepting chemotaxis protein (MCP) signaling domain	HAMP domain-like	1	1
TrmE connector domain	P-loop containing nucleoside triphosphate hydrolases	1	1
HAD-like	FAD/NAD(P)-binding domain	1	1
Actin depolymerizing proteins	C-terminal, gelsolin-like domain of Sec23/24	1	1
Aldolase	Single hybrid motif	1	1
Aldolase	MFS general substrate transporter	1	1
SMAD/FHA domain	Cytochrome P450	1	1
PYP-like sensor domain (PAS domain)	GAF domain-like	1	1
Tex N-terminal region-like	Ribonuclease H-like	1	1
Protein kinase-like (PK-like)	DPP6 N-terminal domain-like	1	1
ENTH/VHS domain	RNA-binding domain, RBD	1	1
SPOC domain-like	SAP domain	1	1
NTF2-like	UBA-like	1	1
Class I glutamine amidotransferase-like	Adenine nucleotide alpha hydrolases-like	1	1
Alkaline phosphatase-like	Zn2/Cys6 DNA-binding domain	1	1
UBC-like	P-loop containing nucleoside triphosphate hydrolases	1	1
Supernatant protein factor (SPF), C-terminal domain	PH domain-like	1	1
Multidrug efflux transporter AcrB transmembrane domain	Multidrug efflux transporter AcrB transmembrane domain	1	1
MFS general substrate transporter	Actin-like ATPase domain	1	1
PurM N-terminal domain-like	PurM N-terminal domain-like	1	1
beta-beta-alpha zinc fingers	Isochorismatase-like hydrolases	1	1
PH domain-like	C2 domain (Calcium/lipid-binding domain, CaLB)	1	1
PK beta-barrel domain-like	PK C-terminal domain-like	1	1
PH domain-like	UDP-Glycosyltransferase/glycogen phosphorylase	1	1
Nitrite and sulphite reductase 4Fe-4S domain-like	ISP domain	1	1
Rudiment single hybrid motif	PH0987 N-terminal domain-like	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Nucleotidylyl transferase	1	1
PH domain-like	GTPase activation domain, GAP	1	1
UBC-like	UBA-like	1	1
RING/U-box	SH3-domain	1	1
NTF2-like	"Winged helix" DNA-binding domain	1	1
EF-G C-terminal domain-like	beta and beta-prime subunits of DNA dependent RNA-polymerase	1	1
VPS9 domain	PX domain	1	1
S-adenosyl-L-methionine-dependent methyltransferases	P-loop containing nucleoside triphosphate hydrolases	1	1
FYVE/PHD zinc finger	SET domain	1	1
PUA domain-like	Nucleotidylyl transferase	1	1
Glutathione synthetase ATP-binding domain-like	PurM N-terminal domain-like	1	1
Metallo-dependent phosphatases	Acyl-CoA dehydrogenase NM domain-like	1	1
UBC-like	RING/U-box	1	1
SAM/Pointed domain	P-loop containing nucleoside triphosphate hydrolases	1	1
PurS-like	PurM C-terminal domain-like	1	1
Thioredoxin-like	Kelch motif	1	1
Methionyl-tRNA synthetase (MetRS), Zn-domain	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	1
EPT/RTPC-like	NAD(P)-binding Rossmann-fold domains	1	1
Six-hairpin glycosidases	NAD(P)-binding Rossmann-fold domains	1	1
FAD/NAD(P)-binding domain	MFS general substrate transporter	1	1
PreATP-grasp domain	PH0987 N-terminal domain-like	1	1
RING/U-box	Metallo-dependent hydrolases	1	1
Zn2/Cys6 DNA-binding domain	Bacterial exopeptidase dimerisation domain	1	1
PLP-dependent transferases	FabD/lysophospholipase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	SMAD/FHA domain	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Methylglyoxal synthase-like	1	1
4Fe-4S ferredoxins	Formate dehydrogenase/DMSO reductase, domains 1-3	1	1
Ankyrin repeat	Magnesium transport protein CorA, transmembrane region	1	1
ARM repeat	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	1	1
Amidase signature (AS) enzymes	"Winged helix" DNA-binding domain	1	1
Bacterial exopeptidase dimerisation domain	Glycosyl hydrolase domain	1	1
TK C-terminal domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	1	1
RING/U-box	UBA-like	1	1
Chaperone J-domain	E set domains	1	1
vWA-like	SAP domain	1	1
NAD(P)-binding Rossmann-fold domains	Cysteine proteinases	1	1
Cysteine-rich domain	Protein kinase-like (PK-like)	1	1
HAD-like	Terpenoid cyclases/Protein prenyltransferases	1	1
Nqo1 FMN-binding domain-like	Nqo1 middle domain-like	1	1
ThrRS/AlaRS common domain	Class II aaRS ABD-related	1	1
Dehydroquinate synthase-like	NAD(P)-binding Rossmann-fold domains	1	1
EPT/RTPC-like	Aminoacid dehydrogenase-like, N-terminal domain	1	1
RNA-binding domain, RBD	R3H domain	1	1
ARM repeat	Formin homology 2 domain (FH2 domain)	1	1
Metalloproteases ("zincins"), catalytic domain	PDZ domain-like	1	1
Sm-like ribonucleoproteins	Metallo-hydrolase/oxidoreductase	1	1
Ribonuclease H-like	Nucleic acid-binding proteins	1	1
DPP6 N-terminal domain-like	Galactose oxidase, central domain	1	1
beta-sandwich domain of Sec23/24	ARM repeat	1	1
PH domain-like	vWA-like	1	1
PreATP-grasp domain	Cyclophilin-like	1	1
Concanavalin A-like lectins/glucanases	ARM repeat	1	1
Zinc beta-ribbon	MFS general substrate transporter	1	1
VPS9 domain	UBA-like	1	1
Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	1	1
SpoIIaa-like	cAMP-binding domain-like	1	1
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	Protein kinase-like (PK-like)	1	1
Bacterial exopeptidase dimerisation domain	Homeodomain-like	1	1
Amidase signature (AS) enzymes	PH domain-like	1	1
Enolase N-terminal domain-like	Zn2/Cys6 DNA-binding domain	1	1
Trimeric LpxA-like enzymes	Trimeric LpxA-like enzymes	1	1
Tryptophan synthase beta subunit-like PLP-dependent enzymes	Zn-dependent exopeptidases	1	1
Ypt/Rab-GAP domain of gyp1p	EF-hand	1	1
Dehydroquinate synthase-like	P-loop containing nucleoside triphosphate hydrolases	1	1
The spindle assembly checkpoint protein mad2	FYVE/PHD zinc finger	1	1
HR1 repeat	ARM repeat	1	1
HisI-like	all-alpha NTP pyrophosphatases	1	1
ISP domain	Zn2/Cys6 DNA-binding domain	1	1
NAD(P)-binding Rossmann-fold domains	GlcG-like	1	1
PreATP-grasp domain	post-HMGL domain-like	1	1
Cysteine-rich domain	Cysteine-rich domain	1	1
ARID-like	FYVE/PHD zinc finger	1	1
Adenine nucleotide alpha hydrolases-like	Argininosuccinate synthetase, C-terminal domain	1	1
Lysozyme-like	LysM domain	1	1
F-box domain	DPP6 N-terminal domain-like	1	1
Rhodanese/Cell cycle control phosphatase	(Phosphotyrosine protein) phosphatases II	1	1
ISP domain	FAD/NAD-linked reductases, dimerisation (C-terminal) domain	1	1
Calponin-homology domain, CH-domain	EB1 dimerisation domain-like	1	1
Quinoprotein alcohol dehydrogenase-like	Protein kinase-like (PK-like)	1	1
WW domain	Hect, E3 ligase catalytic domain	1	1
FF domain	FF domain	1	1
CBD9-like	FAD/NAD(P)-binding domain	1	1
Nucleic acid-binding proteins	TPR-like	1	1
Nqo1 FMN-binding domain-like	Nqo1C-terminal domain-like	1	1
PH domain-like	(Phosphotyrosine protein) phosphatases II	1	1
Poly A polymerase C-terminal region-like	ARM repeat	1	1
ADP-ribosylation	UBC-like	1	1
ARM repeat	TPR-like	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	NAD(P)-binding Rossmann-fold domains	1	1
Class I glutamine amidotransferase-like	Aspartate/ornithine carbamoyltransferase	1	1
PheT/TilS domain	Class II aaRS and biotin synthetases	1	1
P-loop containing nucleoside triphosphate hydrolases	Annexin	1	1
Protein kinase-like (PK-like)	FYVE/PHD zinc finger	1	1
RuvA domain 2-like	SH2 domain	1	1
Ferredoxin reductase-like, C-terminal NADP-linked domain	Adenine nucleotide alpha hydrolases-like	1	1
CBS-domain pair	Inosine monophosphate dehydrogenase (IMPDH)	1	1
Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain	WD40 repeat-like	1	1
Phosphohistidine domain	Phosphoenolpyruvate/pyruvate domain	1	1
Flavoproteins	Nitrite/Sulfite reductase N-terminal domain-like	1	1
Nudix	Folate-binding domain	1	1
NAD(P)-binding Rossmann-fold domains	Citrate synthase	1	1
L domain-like	NTF2-like	1	1
HMA, heavy metal-associated domain	Cu,Zn superoxide dismutase-like	1	1
Thiamin phosphate synthase	Nucleotidylyl transferase	1	1
Nucleotide-diphospho-sugar transferases	Cytochrome P450	1	1
HMG-box	HMG-box	1	1
PH domain-like	PLC-like phosphodiesterases	1	1
Cadherin-like	Cadherin-like	1	1
FAD-linked reductases, C-terminal domain	Aminomethyltransferase beta-barrel domain	1	1
Tricorn protease N-terminal domain	DPP6 N-terminal domain-like	1	1
Regulator of G-protein signaling, RGS	PX domain	1	1
CCCH zinc finger	RING/U-box	1	1
Cyclophilin-like	PH0987 N-terminal domain-like	1	1
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III	Ferredoxin reductase-like, C-terminal NADP-linked domain	1	1
Nucleotidyltransferase	PAP/Archaeal CCA-adding enzyme, C-terminal domain	1	1
Pre-PUA domain	PUA domain-like	1	1
Six-hairpin glycosidases	Starch-binding domain-like	1	1
E set domains	Glycosyl hydrolase domain	1	1
Sialidases	Oligoxyloglucan reducing end-specific cellobiohydrolase	1	1
Dehydroquinate synthase-like	Aldolase	1	1
FMN-linked oxidoreductases	Alpha subunit of glutamate synthase, C-terminal domain	1	1
Translation proteins	beta and beta-prime subunits of DNA dependent RNA-polymerase	1	1
"Winged helix" DNA-binding domain	DBL homology domain (DH-domain)	1	1
FYVE/PHD zinc finger	Elongation factor TFIIS domain 2	1	1
BRCT domain	PsbU/PolX domain-like	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	DHS-like NAD/FAD-binding domain	1	1
SAM/Pointed domain	Ubiquitin-like	1	1
Rudiment single hybrid motif	Aldolase	1	1
Ribosomal protein S5 domain 2-like	Type II DNA topoisomerase	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Kelch motif	1	1
Metalloproteases ("zincins"), catalytic domain	ARM repeat	1	1
Heme-dependent peroxidases	Heme-dependent peroxidases	1	1
PurM N-terminal domain-like	Class I glutamine amidotransferase-like	1	1
UDP-Glycosyltransferase/glycogen phosphorylase	6-phosphogluconate dehydrogenase C-terminal domain-like	1	1
beta-Galactosidase/glucuronidase domain	Zn-dependent exopeptidases	1	1
LCCL domain	t-snare proteins	1	1
alpha/beta-Hydrolases	NAD(P)-binding Rossmann-fold domains	1	1
Cytochrome c	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	1	1
Zinc-binding domain of translation initiation factor 2 beta	ARM repeat	1	1
ENTH/VHS domain	I/LWEQ domain	1	1
FMN-binding split barrel	UbiD C-terminal domain-like	1	1
SAM/Pointed domain	Protein kinase-like (PK-like)	1	1
Ubiquitin-like	XPC-binding domain	1	1
PIN domain-like	Nucleic acid-binding proteins	1	1
Chaperone J-domain	CSL zinc finger	1	1
PurS-like	FGAM synthase PurL, linker domain	1	1
Adenine nucleotide alpha hydrolases-like	GMP synthetase C-terminal dimerisation domain	1	1
SH3-domain	Metallo-dependent phosphatases	1	1
PreATP-grasp domain	PurM N-terminal domain-like	1	1
"Winged helix" DNA-binding domain	RNA-binding domain, RBD	1	1
FAD/NAD(P)-binding domain	HMG-box	1	1
PK beta-barrel domain-like	Phosphoenolpyruvate/pyruvate domain	1	1
PH domain-like	EF-hand	1	1
tRNA-intron endonuclease catalytic domain-like	BRCT domain	1	1
YjeF N-terminal domain-like	RING/U-box	1	1
CCCH zinc finger	SMR domain-like	1	1
Cysteine proteinases	Calpain large subunit, middle domain (domain III)	1	1
P-loop containing nucleoside triphosphate hydrolases	PLP-dependent transferases	1	1
PH domain-like	Metallo-dependent phosphatases	1	1
Integrin alpha N-terminal domain	Integrin alpha N-terminal domain	1	1
Metallo-dependent phosphatases	Acyl-CoA dehydrogenase C-terminal domain-like	1	1
Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	1	1
ENTH/VHS domain	Ubiquitin-like	1	1
ENTH/VHS domain	FYVE/PHD zinc finger	1	1
Concanavalin A-like lectins/glucanases	Zn2/Cys6 DNA-binding domain	1	1
TPR-like	RING/U-box	1	1
PX domain	SNARE fusion complex	1	1
SNARE-like	L30e-like	1	1
Thiamin phosphate synthase	Ribokinase-like	1	1
Double Clp-N motif	P-loop containing nucleoside triphosphate hydrolases	1	1
GroEL apical domain-like	SAICAR synthase-like	1	1
SNARE-like	Domain of the SRP/SRP receptor G-proteins	1	1
N-terminal domain of MutM-like DNA repair proteins	S13-like H2TH domain	1	1
Homeodomain-like	FAD-linked reductases, C-terminal domain	1	1
PLP-dependent transferases	Zn2/Cys6 DNA-binding domain	1	1
"Winged helix" DNA-binding domain	SWIB/MDM2 domain	1	1
Dehydroquinate synthase-like	EPT/RTPC-like	1	1
S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	1	1
NTF2-like	NTF2-like	1	1
Homeodomain-like	Acyl-CoA N-acyltransferases (Nat)	1	1
ENTH/VHS domain	Clathrin adaptor appendage domain	1	1
PAP/OAS1 substrate-binding domain	PAP/Archaeal CCA-adding enzyme, C-terminal domain	1	1
EPT/RTPC-like	Aldolase	1	1
Ribonuclease H-like	RuvA domain 2-like	1	1
Pseudo ankyrin repeat-like	POZ domain	1	1
ALDH-like	ALDH-like	1	1
mRNA decapping enzyme DcpS N-terminal domain	HIT-like	1	1
Glutathione synthetase ATP-binding domain-like	PurM C-terminal domain-like	1	1
Nucleotidylyl transferase	Nucleotidylyl transferase	1	1
Ribulose-phoshate binding barrel	Ribulose-phoshate binding barrel	1	1
Chaperone J-domain	HAD-like	1	1
Nucleotide-diphospho-sugar transferases	ARM repeat	1	1
Cytidine deaminase-like	Thioredoxin-like	1	1
WD40 repeat-like	YVTN repeat-like/Quinoprotein amine dehydrogenase	1	1
FMN-linked oxidoreductases	alpha-helical ferredoxin	1	1
Carbon-nitrogen hydrolase	Adenine nucleotide alpha hydrolases-like	1	1
Regulator of G-protein signaling, RGS	beta-sandwich domain of Sec23/24	1	1
Glutathione synthetase ATP-binding domain-like	Phosphohistidine domain	1	1
SH3-domain	SAM/Pointed domain	1	1
Glycosyl hydrolase domain	Starch-binding domain-like	1	1
E set domains	Ankyrin repeat	1	1
(Trans)glycosidases	Starch-binding domain-like	1	1
Thiamin phosphate synthase	Nucleic acid-binding proteins	1	1
Tex N-terminal region-like	SH2 domain	1	1
NAD(P)-binding Rossmann-fold domains	Thioredoxin-like	1	1
Eukaryotic RPB5 N-terminal domain	RPB5-like RNA polymerase subunit	1	1
SH3-domain	Cysteine proteinases	1	1
FAD/NAD(P)-binding domain	Cytochrome b5-like heme/steroid binding domain	1	1
NAD(P)-binding Rossmann-fold domains	Glutathione synthetase ATP-binding domain-like	1	1
UBA-like	SMR domain-like	1	1
Pseudo ankyrin repeat-like	DHS-like NAD/FAD-binding domain	1	1
Ribosomal protein S5 domain 2-like	Ribosomal protein S5 domain 2-like	1	1
Zn-dependent exopeptidases	Glycosyl hydrolase domain	1	1
TK C-terminal domain-like	Nitrite/Sulfite reductase N-terminal domain-like	1	1
FAD/NAD(P)-binding domain	4Fe-4S ferredoxins	1	1
P-loop containing nucleoside triphosphate hydrolases	RuvA domain 2-like	1	1
MFS general substrate transporter	Phosphoglycerate mutase-like	1	1
Kelch motif	Galactose oxidase, central domain	1	1
Carbamoyl phosphate synthetase, small subunit N-terminal domain	Glutathione synthetase ATP-binding domain-like	1	1
NTF2-like	RNA-binding domain, RBD	1	1
FAD/NAD(P)-binding domain	Folate-binding domain	1	1
Pseudouridine synthase	PUA domain-like	1	1
UBC-like	Endosomal sorting complex assembly domain	1	1
PLP-dependent transferases	Glutathione synthetase ATP-binding domain-like	1	1
Zn2/Cys6 DNA-binding domain	alpha/beta-Hydrolases	1	1
Glutathione synthetase ATP-binding domain-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	1	1
S-adenosyl-L-methionine-dependent methyltransferases	Acetyl-CoA synthetase-like	1	1
PreATP-grasp domain	Aldolase	1	1
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	Type II DNA topoisomerase	1	1
P-loop containing nucleoside triphosphate hydrolases	E set domains	1	1
WD40 repeat-like	Cysteine proteinases	1	1
Mitochondrial carrier	SH3-domain	1	1
Rudiment single hybrid motif	Cyclophilin-like	1	1
Cyclophilin-like	RNA-binding domain, RBD	1	1
Ribonuclease H-like	Heme oxygenase-like	1	1
Kelch motif	Clavaminate synthase-like	1	1
Translation proteins SH3-like domain	P-loop containing nucleoside triphosphate hydrolases	1	1
PX domain	CAD & PB1 domains	1	1
BRCT domain	DNA polymerase beta, N-terminal domain-like	1	1
LmbE-like	Galactose-binding domain-like	1	1
Formate/glycerate dehydrogenase catalytic domain-like	DHS-like NAD/FAD-binding domain	1	1
S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	1	1
Carbamoyl phosphate synthetase, large subunit connection domain	Metallo-dependent hydrolases	1	1
RCC1/BLIP-II	POZ domain	1	1
PurM C-terminal domain-like	Class I glutamine amidotransferase-like	1	1
Endosomal sorting complex assembly domain	S-adenosyl-L-methionine-dependent methyltransferases	1	1
Adenine nucleotide alpha hydrolases-like	DHS-like NAD/FAD-binding domain	1	1
UBC-like	Class II aaRS and biotin synthetases	1	1
HIT/MYND zinc finger-like	SET domain	1	1
Ankyrin repeat	PX domain	1	1
Homeodomain-like	HMG-box	1	1
Kelch motif	Protein kinase-like (PK-like)	1	1
Glutathione synthetase ATP-binding domain-like	Phosphoenolpyruvate/pyruvate domain	1	1
RNI-like	beta-beta-alpha zinc fingers	1	1
MFS general substrate transporter	beta and beta-prime subunits of DNA dependent RNA-polymerase	1	1
Carbamate kinase-like	PUA domain-like	1	1
Undecaprenyl diphosphate synthase	Undecaprenyl diphosphate synthase	1	1
P-loop containing nucleoside triphosphate hydrolases	Homodimeric domain of signal transducing histidine kinase	1	1
Cap-Gly domain	EPT/RTPC-like	1	1
P-loop containing nucleoside triphosphate hydrolases	beta and beta-prime subunits of DNA dependent RNA-polymerase	1	1
P-loop containing nucleoside triphosphate hydrolases	Quinoprotein alcohol dehydrogenase-like	1	1
RING/U-box	RNA-binding domain, RBD	1	1
Zn2/Cys6 DNA-binding domain	PEBP-like	1	1
ISP domain	Ferritin-like	1	1
FYVE/PHD zinc finger	GroEL apical domain-like	1	1
Cryptochrome/photolyase, N-terminal domain	Cryptochrome/photolyase FAD-binding domain	1	1
GAF domain-like	GAF domain-like	1	1
UBA-like	TPR-like	1	1
LCCL domain	SNARE fusion complex	1	1
Putative DNA-binding domain	Class II aaRS and biotin synthetases	1	1
Amidase signature (AS) enzymes	Ran binding protein zinc finger-like	1	1
GAT-like domain	I/LWEQ domain	1	1
PYP-like sensor domain (PAS domain)	Protein kinase-like (PK-like)	1	1
cAMP-binding domain-like	FabD/lysophospholipase-like	1	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK	Dihydropteroate synthetase-like	1	1
P-loop containing nucleoside triphosphate hydrolases	GAF domain-like	1	1
Nitrite and sulphite reductase 4Fe-4S domain-like	Nitrite and sulphite reductase 4Fe-4S domain-like	1	1
N-terminal domain of adenylylcyclase associated protein, CAP	C-terminal domain of adenylylcyclase associated protein	1	1
FAD/NAD(P)-binding domain	Aminomethyltransferase beta-barrel domain	1	1
Clavaminate synthase-like	Zn2/Cys6 DNA-binding domain	1	1
BAR/IMD domain-like	ArfGap/RecO-like zinc finger	1	1
DNA clamp	DNA clamp	1	1
Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	1	1
SH3-domain	CAD & PB1 domains	1	1
RING/U-box	EF-hand	1	1
Dom34/Pelota N-terminal domain-like	L30e-like	1	1
Mitochondrial cytochrome c oxidase subunit VIa	FAD/NAD(P)-binding domain	1	1
Di-copper centre-containing domain	Concanavalin A-like lectins/glucanases	1	1
alpha-helical ferredoxin	Nucleotide-binding domain	1	1
RNA-binding domain, RBD	Tricorn protease domain 2	1	1
Mitochondrial carrier	RING/U-box	1	1
Nitrite/Sulfite reductase N-terminal domain-like	ISP domain	1	1
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD	Pseudo ankyrin repeat-like	1	1
P-loop containing nucleoside triphosphate hydrolases	CheY-like	1	1
FAD-binding/transporter-associated domain-like	PRTase-like	1	1
Ribonuclease H-like	Ran binding protein zinc finger-like	1	1
Ribokinase-like	Heme oxygenase-like	1	1
RNA-binding domain, RBD	PABC (PABP) domain	1	1
ArfGap/RecO-like zinc finger	UBA-like	1	1
Voltage-gated potassium channels	EF-hand	1	1
vWA-like	Cysteine-rich domain	1	1
Zn2/Cys6 DNA-binding domain	FAD/NAD(P)-binding domain	1	1