All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.
The links below permit the addition or removal of specific sets of domain combination pairs.
Change the list of genome two-letter codes in the 'Include genomes' box to include domain-pairs from those genomes.
Change the list of genomes in the 'Exclude genomes' box to exclude domain-pairs from those genomes.
List of all two-letter genome codes.
Superfamily (N) | Superfamily (C) | Number of occurrances | Number unique | |
P-loop containing nucleoside triphosphate hydrolases | P-loop containing nucleoside triphosphate hydrolases | 10 | 6 | |
Methionine synthase domain | Cobalamin (vitamin B12)-binding domain | 9 | 2 | |
Type I dockerin domain | "Helical backbone" metal receptor | 9 | 1 | |
Thiamin diphosphate-binding fold (THDP-binding) | TK C-terminal domain-like | 6 | 3 | |
ACT-like | ACT-like | 6 | 4 | |
Nucleotidylyl transferase | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 6 | 5 | |
NAD(P)-binding Rossmann-fold domains | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | 6 | 2 | |
PreATP-grasp domain | Glutathione synthetase ATP-binding domain-like | 5 | 4 | |
NAD(P)-binding Rossmann-fold domains | 6-phosphogluconate dehydrogenase C-terminal domain-like | 5 | 2 | |
PurM N-terminal domain-like | PurM C-terminal domain-like | 5 | 2 | |
"Winged helix" DNA-binding domain | Dimeric alpha+beta barrel | 5 | 1 | |
Class II aaRS and biotin synthetases | Class II aaRS ABD-related | 4 | 4 | |
Nucleotide-diphospho-sugar transferases | Trimeric LpxA-like enzymes | 4 | 1 | |
Ribosomal protein S5 domain 2-like | GHMP Kinase, C-terminal domain | 4 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Translation proteins | 4 | 3 | |
P-loop containing nucleoside triphosphate hydrolases | "Winged helix" DNA-binding domain | 4 | 3 | |
Tubulin nucleotide-binding domain-like | Tubulin C-terminal domain-like | 4 | 2 | |
P-loop containing nucleoside triphosphate hydrolases | Class I glutamine amidotransferase-like | 4 | 2 | |
"Winged helix" DNA-binding domain | GAD domain-like | 3 | 2 | |
ValRS/IleRS/LeuRS editing domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 3 | 2 | |
Actin-like ATPase domain | Actin-like ATPase domain | 3 | 3 | |
Formate/glycerate dehydrogenase catalytic domain-like | NAD(P)-binding Rossmann-fold domains | 3 | 2 | |
L domain-like | L domain-like | 3 | 2 | |
ADC-like | Cdc48 domain 2-like | 3 | 1 | |
Thiamin diphosphate-binding fold (THDP-binding) | Thiamin diphosphate-binding fold (THDP-binding) | 3 | 3 | |
Sm-like ribonucleoproteins | Mechanosensitive channel protein MscS (YggB), C-terminal domain | 3 | 2 | |
Aminoacid dehydrogenase-like, N-terminal domain | NAD(P)-binding Rossmann-fold domains | 3 | 2 | |
Composite domain of metallo-dependent hydrolases | Metallo-dependent hydrolases | 3 | 2 | |
ValRS/IleRS/LeuRS editing domain | Nucleotidylyl transferase | 3 | 2 | |
Phospholipase D/nuclease | Phospholipase D/nuclease | 3 | 2 | |
Cdc48 domain 2-like | P-loop containing nucleoside triphosphate hydrolases | 3 | 1 | |
Thiolase-like | Thiolase-like | 3 | 1 | |
ADC-like | P-loop containing nucleoside triphosphate hydrolases | 3 | 1 | |
Actin-like ATPase domain | 4Fe-4S ferredoxins | 3 | 1 | |
Iron-dependent repressor protein, dimerization domain | C-terminal domain of transcriptional repressors | 2 | 1 | |
Pectin lyase-like | Pectin lyase-like | 2 | 1 | |
Adenine nucleotide alpha hydrolases-like | 4Fe-4S ferredoxins | 2 | 2 | |
Translational machinery components | L30e-like | 2 | 2 | |
Pre-PUA domain | PUA domain-like | 2 | 2 | |
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | 2 | 2 | |
lambda repressor-like DNA-binding domains | CBS-domain pair | 2 | 1 | |
Nucleic acid-binding proteins | Class II aaRS and biotin synthetases | 2 | 2 | |
Periplasmic binding protein-like II | Periplasmic binding protein-like II | 2 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Restriction endonuclease-like | 2 | 2 | |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | Ribosomal protein S5 domain 2-like | 2 | 2 | |
P-loop containing nucleoside triphosphate hydrolases | vWA-like | 2 | 1 | |
Multidrug efflux transporter AcrB transmembrane domain | Multidrug efflux transporter AcrB transmembrane domain | 2 | 2 | |
Adenine nucleotide alpha hydrolases-like | GMP synthetase C-terminal dimerisation domain | 2 | 2 | |
Ribosomal L27 protein-like | Nucleic acid-binding proteins | 2 | 2 | |
"Winged helix" DNA-binding domain | Iron-dependent repressor protein, dimerization domain | 2 | 1 | |
lambda repressor-like DNA-binding domains | RmlC-like cupins | 2 | 1 | |
Glutamine synthetase/guanido kinase | GatB/YqeY motif | 2 | 2 | |
P-loop containing nucleoside triphosphate hydrolases | TGS-like | 2 | 1 | |
Phosphoglucomutase, first 3 domains | Phosphoglucomutase, first 3 domains | 2 | 1 | |
"Winged helix" DNA-binding domain | C-terminal domain of transcriptional repressors | 2 | 1 | |
GroEL-intermediate domain like | GroEL apical domain-like | 2 | 1 | |
Aldolase | 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain | 2 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | "Helical backbone" metal receptor | 2 | 1 | |
Nicotinate/Quinolinate PRTase N-terminal domain-like | Nicotinate/Quinolinate PRTase C-terminal domain-like | 2 | 1 | |
FAD-binding/transporter-associated domain-like | FAD-linked oxidases, C-terminal domain | 2 | 1 | |
Ribosomal protein S5 domain 2-like | Ribonuclease PH domain 2-like | 2 | 1 | |
Actin-like ATPase domain | Heat shock protein 70kD (HSP70), peptide-binding domain | 2 | 2 | |
NAD(P)-binding Rossmann-fold domains | NAD(P)-binding Rossmann-fold domains | 2 | 2 | |
Translation proteins SH3-like domain | Nucleic acid-binding proteins | 2 | 2 | |
Ferritin-like | Rubredoxin-like | 2 | 1 | |
GroEL equatorial domain-like | GroEL apical domain-like | 2 | 1 | |
Methyl-coenzyme M reductase subunits | Methyl-coenzyme M reductase alpha and beta chain C-terminal domain | 2 | 1 | |
Calcium ATPase, transduction domain A | HAD-like | 2 | 2 | |
Phosphoglucomutase, first 3 domains | Phosphoglucomutase, C-terminal domain | 2 | 1 | |
PhoU-like | TrkA C-terminal domain-like | 2 | 1 | |
tRNA-guanine transglycosylase | PUA domain-like | 2 | 2 | |
GroEL equatorial domain-like | GroEL-intermediate domain like | 2 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Ribosomal protein S5 domain 2-like | 2 | 2 | |
Ribbon-helix-helix | ACT-like | 2 | 1 | |
Translation proteins | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 2 | 1 | |
tRNA-guanine transglycosylase | Pre-PUA domain | 2 | 2 | |
Nucleic acid-binding proteins | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 | |
Zn-dependent exopeptidases | Bacterial exopeptidase dimerisation domain | 2 | 1 | |
Flavoproteins | 4Fe-4S ferredoxins | 2 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 2 | 1 | |
HAD-like | Calcium ATPase, transmembrane domain M | 2 | 2 | |
HCP-like | HCP-like | 2 | 2 | |
P-loop containing nucleoside triphosphate hydrolases | C-terminal domain of alpha and beta subunits of F1 ATP synthase | 2 | 2 | |
Domain of the SRP/SRP receptor G-proteins | P-loop containing nucleoside triphosphate hydrolases | 2 | 2 | |
Calcium ATPase, transduction domain A | Calcium ATPase, transmembrane domain M | 2 | 2 | |
Quinoprotein alcohol dehydrogenase-like | Quinoprotein alcohol dehydrogenase-like | 2 | 2 | |
CBS-domain pair | CBS-domain pair | 2 | 2 | |
Quinoprotein alcohol dehydrogenase-like | ABC transporter involved in vitamin B12 uptake, BtuC | 1 | 1 | |
Pseudouridine synthase | PUA domain-like | 1 | 1 | |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | SIS domain | 1 | 1 | |
TK C-terminal domain-like | 4Fe-4S ferredoxins | 1 | 1 | |
Aldolase | NAD(P)-binding Rossmann-fold domains | 1 | 1 | |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | C-terminal domain of alpha and beta subunits of F1 ATP synthase | 1 | 1 | |
Translation initiation factor 2 beta, aIF2beta, N-terminal domain | Zinc-binding domain of translation initiation factor 2 beta | 1 | 1 | |
Class I glutamine amidotransferase-like | Adenine nucleotide alpha hydrolases-like | 1 | 1 | |
HSP40/DnaJ peptide-binding domain | HSP40/DnaJ peptide-binding domain | 1 | 1 | |
Thiamin diphosphate-binding fold (THDP-binding) | 4Fe-4S ferredoxins | 1 | 1 | |
HMA, heavy metal-associated domain | Calcium ATPase, transmembrane domain M | 1 | 1 | |
S-adenosylmethionine synthetase | S-adenosylmethionine synthetase | 1 | 1 | |
RuBisCO, large subunit, small (N-terminal) domain | RuBisCo, C-terminal domain | 1 | 1 | |
Cation efflux protein transmembrane domain-like | Cation efflux protein cytoplasmic domain-like | 1 | 1 | |
TATA-box binding protein-like | TATA-box binding protein-like | 1 | 1 | |
FYSH domain | EF-G C-terminal domain-like | 1 | 1 | |
TPR-like | TPR-like | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | Succinyl-CoA synthetase domains | 1 | 1 | |
Class II aaRS and biotin synthetases | GAD domain-like | 1 | 1 | |
CBS-domain pair | FAD-binding/transporter-associated domain-like | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | Siroheme synthase middle domains-like | 1 | 1 | |
MurD-like peptide ligases, catalytic domain | MurD-like peptide ligases, peptide-binding domain | 1 | 1 | |
Nucleotidylyl transferase | Ribosomal protein L25-like | 1 | 1 | |
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | ThrRS/AlaRS common domain | 1 | 1 | |
Succinyl-CoA synthetase domains | Succinyl-CoA synthetase domains | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Signal peptide-binding domain | 1 | 1 | |
PIN domain-like | 5' to 3' exonuclease, C-terminal subdomain | 1 | 1 | |
Serine metabolism enzymes domain | ACT-like | 1 | 1 | |
DNA ligase/mRNA capping enzyme, catalytic domain | Nucleic acid-binding proteins | 1 | 1 | |
PreATP-grasp domain | Methylglyoxal synthase-like | 1 | 1 | |
tRNA-binding arm | Class II aaRS and biotin synthetases | 1 | 1 | |
Chorismate mutase II | NAD(P)-binding Rossmann-fold domains | 1 | 1 | |
Insert subdomain of RNA polymerase alpha subunit | RBP11-like subunits of RNA polymerase | 1 | 1 | |
N-terminal, heterodimerisation domain of RBP7 (RpoE) | Nucleic acid-binding proteins | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | Rudiment single hybrid motif | 1 | 1 | |
Cyclin-like | Cyclin-like | 1 | 1 | |
PurM C-terminal domain-like | PurM C-terminal domain-like | 1 | 1 | |
Methionyl-tRNA synthetase (MetRS), Zn-domain | Nucleic acid-binding proteins | 1 | 1 | |
Uracil-DNA glycosylase-like | Pre-PUA domain | 1 | 1 | |
Prokaryotic type KH domain (KH-domain type II) | Prokaryotic type KH domain (KH-domain type II) | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | TrkA C-terminal domain-like | 1 | 1 | |
Methionyl-tRNA synthetase (MetRS), Zn-domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 1 | 1 | |
Hedgehog/intein (Hint) domain | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
Dom34/Pelota N-terminal domain-like | L30e-like | 1 | 1 | |
Methionyl-tRNA synthetase (MetRS), Zn-domain | Nucleotidylyl transferase | 1 | 1 | |
Carboxypeptidase regulatory domain-like | Cna protein B-type domain | 1 | 1 | |
MgtE membrane domain-like | MgtE membrane domain-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | post-AAA+ oligomerization domain-like | 1 | 1 | |
Carboxypeptidase regulatory domain-like | Carboxypeptidase regulatory domain-like | 1 | 1 | |
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | Nucleic acid-binding proteins | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | Glutamyl tRNA-reductase catalytic, N-terminal domain | 1 | 1 | |
Tetrapyrrole methylase | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 | |
Nucleic acid-binding proteins | eIF-2-alpha, C-terminal domain | 1 | 1 | |
tRNA-intron endonuclease N-terminal domain-like | tRNA-intron endonuclease N-terminal domain-like | 1 | 1 | |
DNA polymerase beta, N-terminal domain-like | Nucleotidyltransferase | 1 | 1 | |
CbiG N-terminal domain-like | CobE/GbiG C-terminal domain-like | 1 | 1 | |
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | Nucleotidylyl transferase | 1 | 1 | |
Heat shock protein 70kD (HSP70), peptide-binding domain | Heat shock protein 70kD (HSP70), C-terminal subdomain | 1 | 1 | |
L9 N-domain-like | Ribonuclease H-like | 1 | 1 | |
"Winged helix" DNA-binding domain | "Winged helix" DNA-binding domain | 1 | 1 | |
LeuD/IlvD-like | Nudix | 1 | 1 | |
Fic-like | "Winged helix" DNA-binding domain | 1 | 1 | |
N-terminal domain of MutM-like DNA repair proteins | Glucocorticoid receptor-like (DNA-binding domain) | 1 | 1 | |
4Fe-4S ferredoxins | Nitrite and sulphite reductase 4Fe-4S domain-like | 1 | 1 | |
Tropomyosin | Smc hinge domain | 1 | 1 | |
N-terminal nucleophile aminohydrolases (Ntn hydrolases) | PRTase-like | 1 | 1 | |
PPK N-terminal domain-like | Phospholipase D/nuclease | 1 | 1 | |
Prokaryotic type I DNA topoisomerase | Zinc beta-ribbon | 1 | 1 | |
Initiation factor IF2/eIF5b, domain 3 | Translation proteins | 1 | 1 | |
ATP-dependent DNA ligase DNA-binding domain | Nucleic acid-binding proteins | 1 | 1 | |
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 | L30e-like | 1 | 1 | |
4Fe-4S ferredoxins | 4Fe-4S ferredoxins | 1 | 1 | |
"Winged helix" DNA-binding domain | Sec63 N-terminal domain-like | 1 | 1 | |
Carbamoyl phosphate synthetase, large subunit connection domain | Methylglyoxal synthase-like | 1 | 1 | |
PreATP-grasp domain | Rudiment single hybrid motif | 1 | 1 | |
"Winged helix" DNA-binding domain | TPR-like | 1 | 1 | |
Class I glutamine amidotransferase-like | GMP synthetase C-terminal dimerisation domain | 1 | 1 | |
Phosphohistidine domain | Phosphoenolpyruvate/pyruvate domain | 1 | 1 | |
Zinc-binding domain of translation initiation factor 2 beta | Nucleic acid-binding proteins | 1 | 1 | |
Adenine nucleotide alpha hydrolases-like | Argininosuccinate synthetase, C-terminal domain | 1 | 1 | |
FAD/NAD(P)-binding domain | Nucleotide-binding domain | 1 | 1 | |
Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain | Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain | 1 | 1 | |
PYP-like sensor domain (PAS domain) | CheY-like | 1 | 1 | |
tRNA-guanine transglycosylase | Uracil-DNA glycosylase-like | 1 | 1 | |
Ribonuclease H-like | DNA/RNA polymerases | 1 | 1 | |
Type II DNA topoisomerase | GyrA/ParC C-terminal domain-like | 1 | 1 | |
PurM N-terminal domain-like | PurM N-terminal domain-like | 1 | 1 | |
PheT/TilS domain | Class II aaRS and biotin synthetases | 1 | 1 | |
"Winged helix" DNA-binding domain | Riboflavin kinase-like | 1 | 1 | |
Aminopeptidase/glucanase lid domain | Zn-dependent exopeptidases | 1 | 1 | |
Nucleotidyltransferase | PAP/Archaeal CCA-adding enzyme, C-terminal domain | 1 | 1 | |
IlvD/EDD N-terminal domain-like | LeuD/IlvD-like | 1 | 1 | |
Domain of the SRP/SRP receptor G-proteins | Signal peptide-binding domain | 1 | 1 | |
Ribosomal protein L6 | Ribosomal protein L6 | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | Glutathione synthetase ATP-binding domain-like | 1 | 1 | |
Nucleotidylyl transferase | An anticodon-binding domain of class I aminoacyl-tRNA synthetases | 1 | 1 | |
eIF2alpha middle domain-like | eIF-2-alpha, C-terminal domain | 1 | 1 | |
Periplasmic binding protein-like II | Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain | 1 | 1 | |
Diaminopimelate epimerase-like | Diaminopimelate epimerase-like | 1 | 1 | |
R1 subunit of ribonucleotide reductase, N-terminal domain | PFL-like glycyl radical enzymes | 1 | 1 | |
C-terminal effector domain of the bipartite response regulators | Ribbon-helix-helix | 1 | 1 | |
Rad51 N-terminal domain-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
Enolase N-terminal domain-like | Enolase C-terminal domain-like | 1 | 1 | |
S13-like H2TH domain | Glucocorticoid receptor-like (DNA-binding domain) | 1 | 1 | |
ATP-dependent DNA ligase DNA-binding domain | DNA ligase/mRNA capping enzyme, catalytic domain | 1 | 1 | |
Nucleotidyltransferase | PHP domain-like | 1 | 1 | |
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain | Pyrimidine nucleoside phosphorylase C-terminal domain | 1 | 1 | |
Coiled-coil domain of nucleotide exchange factor GrpE | Head domain of nucleotide exchange factor GrpE | 1 | 1 | |
DNA clamp | DNA clamp | 1 | 1 | |
tRNA-intron endonuclease N-terminal domain-like | tRNA-intron endonuclease catalytic domain-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Initiation factor IF2/eIF5b, domain 3 | 1 | 1 | |
HMA, heavy metal-associated domain | HMA, heavy metal-associated domain | 1 | 1 | |
Uracil-DNA glycosylase-like | PUA domain-like | 1 | 1 | |
LuxS/MPP-like metallohydrolase | LuxS/MPP-like metallohydrolase | 1 | 1 | |
Class II aaRS and biotin synthetases | Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) | 1 | 1 | |
ACT-like | Metallo-hydrolase/oxidoreductase | 1 | 1 | |
PKD domain | Cadherin-like | 1 | 1 | |
MFS general substrate transporter | MFS general substrate transporter | 1 | 1 | |
TATA-box binding protein-like | DNA-glycosylase | 1 | 1 | |
GatD N-terminal domain-like | Glutaminase/Asparaginase | 1 | 1 | |
PDZ domain-like | PDZ domain-like | 1 | 1 | |
Mechanosensitive channel protein MscS (YggB), transmembrane region | Mechanosensitive channel protein MscS (YggB), C-terminal domain | 1 | 1 | |
Ribulose-phoshate binding barrel | RraA-like | 1 | 1 | |
HMA, heavy metal-associated domain | HAD-like | 1 | 1 | |
Dom34/Pelota N-terminal domain-like | Translational machinery components | 1 | 1 | |
FMN-binding split barrel | 4Fe-4S ferredoxins | 1 | 1 | |
NAD(P)-linked oxidoreductase | alpha-helical ferredoxin | 1 | 1 | |
Homeodomain-like | Tetracyclin repressor-like, C-terminal domain | 1 | 1 | |
Carboxypeptidase regulatory domain-like | Hypothetical protein PA1324 | 1 | 1 | |
Metallo-hydrolase/oxidoreductase | Flavoproteins | 1 | 1 | |
HMA, heavy metal-associated domain | Calcium ATPase, transduction domain A | 1 | 1 | |
NagB/RpiA/CoA transferase-like | D-ribose-5-phosphate isomerase (RpiA), lid domain | 1 | 1 | |
FMN-binding split barrel | UbiD C-terminal domain-like | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | Glutathione synthetase ATP-binding domain-like | 1 | 1 | |
dsRNA-binding domain-like | Ribosomal protein S5 domain 2-like | 1 | 1 | |
EF-G C-terminal domain-like | EF-G C-terminal domain-like | 1 | 1 | |
Mechanosensitive channel protein MscS (YggB), transmembrane region | Sm-like ribonucleoproteins | 1 | 1 | |
CBS-domain pair | ParB/Sulfiredoxin | 1 | 1 | |
Nucleotidylyl transferase | ITPase-like | 1 | 1 | |
Actin-like ATPase domain | Heat shock protein 70kD (HSP70), C-terminal subdomain | 1 | 1 | |
cAMP-binding domain-like | "Winged helix" DNA-binding domain | 1 | 1 | |
Ribosomal L11/L12e N-terminal domain | Ribosomal protein L11, C-terminal domain | 1 | 1 | |
PRTase-like | PRTase-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Sec63 N-terminal domain-like | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | Phosphohistidine domain | 1 | 1 | |
Carbamate kinase-like | PUA domain-like | 1 | 1 | |
Translation proteins | EF-G C-terminal domain-like | 1 | 1 | |
N-terminal domain of MutM-like DNA repair proteins | S13-like H2TH domain | 1 | 1 | |
GAD domain-like | GatB/YqeY motif | 1 | 1 | |
PYP-like sensor domain (PAS domain) | PYP-like sensor domain (PAS domain) | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Tropomyosin | 1 | 1 | |
Actin-like ATPase domain | HD-domain/PDEase-like | 1 | 1 | |
Translation initiation factor 2 beta, aIF2beta, N-terminal domain | Nucleic acid-binding proteins | 1 | 1 | |
Nucleic acid-binding proteins | eIF2alpha middle domain-like | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | Serine metabolism enzymes domain | 1 | 1 | |
FAD/NAD(P)-binding domain | 4Fe-4S ferredoxins | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | EF-G C-terminal domain-like | 1 | 1 | |
Carbamate kinase-like | ACT-like | 1 | 1 | |
PreATP-grasp domain | Carbamoyl phosphate synthetase, large subunit connection domain | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | Glutamyl tRNA-reductase dimerization domain | 1 | 1 | |
Radical SAM enzymes | Acyl-CoA N-acyltransferases (Nat) | 1 | 1 | |
Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | Pyrimidine nucleoside phosphorylase C-terminal domain | 1 | 1 | |
Rubredoxin-like | Superoxide reductase-like | 1 | 1 | |
Ribosomal L27 protein-like | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 | |
ACT-like | 4Fe-4S ferredoxins | 1 | 1 | |
PreATP-grasp domain | PreATP-grasp domain | 1 | 1 | |
Creatinase/prolidase N-terminal domain | Creatinase/aminopeptidase | 1 | 1 | |
Thiamin diphosphate-binding fold (THDP-binding) | DHS-like NAD/FAD-binding domain | 1 | 1 | |
HisI-like | all-alpha NTP pyrophosphatases | 1 | 1 | |
Glutamine synthetase, N-terminal domain | Glutamine synthetase/guanido kinase | 1 | 1 | |
TPR-like | HCP-like | 1 | 1 | |
FGAM synthase PurL, linker domain | PurM N-terminal domain-like | 1 | 1 | |
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 1 | 1 | |
GroES-like | NAD(P)-binding Rossmann-fold domains | 1 | 1 | |
Glutamyl tRNA-reductase catalytic, N-terminal domain | Glutamyl tRNA-reductase dimerization domain | 1 | 1 | |
Translation proteins | Ribosomal protein S5 domain 2-like | 1 | 1 | |
Radical SAM enzymes | Nitrogenase accessory factor-like | 1 | 1 | |
Cobalamin (vitamin B12)-binding domain | Radical SAM enzymes | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | Methylglyoxal synthase-like | 1 | 1 | |
Translation proteins | ThrRS/AlaRS common domain | 1 | 1 | |
Formate/glycerate dehydrogenase catalytic domain-like | ACT-like | 1 | 1 | |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | S13-like H2TH domain | 1 | 1 | |
Periplasmic binding protein-like II | ACT-like | 1 | 1 | |
"Winged helix" DNA-binding domain | Periplasmic binding protein-like II | 1 | 1 | |
Nucleotidylyl transferase | Nucleic acid-binding proteins | 1 | 1 | |
EPT/RTPC-like | RNA 3'-terminal phosphate cyclase, RPTC, insert domain | 1 | 1 | |
Peptide methionine sulfoxide reductase | Mss4-like | 1 | 1 | |
Glutamine synthetase/guanido kinase | GAD domain-like | 1 | 1 | |
Ribosomal protein S5 domain 2-like | Type II DNA topoisomerase | 1 | 1 | |
Chaperone J-domain | HSP40/DnaJ peptide-binding domain | 1 | 1 | |
PHP14-like | Phospholipase D/nuclease | 1 | 1 | |
NAD(P)-binding Rossmann-fold domains | ACT-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | MOP-like | 1 | 1 | |
4Fe-4S ferredoxins | FMN-linked oxidoreductases | 1 | 1 | |
PLP-binding barrel | Alanine racemase C-terminal domain-like | 1 | 1 | |
Siroheme synthase middle domains-like | Glutamyl tRNA-reductase dimerization domain | 1 | 1 | |
Putative DNA-binding domain | Class II aaRS and biotin synthetases | 1 | 1 | |
Multidrug resistance efflux transporter EmrE | Multidrug resistance efflux transporter EmrE | 1 | 1 | |
DNA polymerase beta, N-terminal domain-like | PHP domain-like | 1 | 1 | |
Class II aaRS and biotin synthetases | C-terminal domain of ProRS | 1 | 1 | |
S13-like H2TH domain | Ribosomal protein S5 domain 2-like | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | Phosphoenolpyruvate/pyruvate domain | 1 | 1 | |
beta-lactamase/transpeptidase-like | TT1751-like | 1 | 1 | |
Aldolase | Aminoacid dehydrogenase-like, N-terminal domain | 1 | 1 | |
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD | CoaB-like | 1 | 1 | |
PAP/OAS1 substrate-binding domain | PAP/Archaeal CCA-adding enzyme, C-terminal domain | 1 | 1 | |
Hypothetical protein AF0491, middle domain | EF-G C-terminal domain-like | 1 | 1 | |
Zinc beta-ribbon | Cyclin-like | 1 | 1 | |
FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain | 1 | 1 | |
Metallo-dependent phosphatases | HD-domain/PDEase-like | 1 | 1 | |
tRNA-intron endonuclease catalytic domain-like | tRNA-intron endonuclease catalytic domain-like | 1 | 1 | |
PUA domain-like | 4Fe-4S ferredoxins | 1 | 1 | |
DnaJ/Hsp40 cysteine-rich domain | HSP40/DnaJ peptide-binding domain | 1 | 1 | |
Siroheme synthase middle domains-like | Glutamyl tRNA-reductase catalytic, N-terminal domain | 1 | 1 | |
PPK N-terminal domain-like | PHP14-like | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | Smc hinge domain | 1 | 1 | |
Succinyl-CoA synthetase domains | Glutathione synthetase ATP-binding domain-like | 1 | 1 | |
Creatinase/aminopeptidase | "Winged helix" DNA-binding domain | 1 | 1 | |
Formate/glycerate dehydrogenase catalytic domain-like | Serine metabolism enzymes domain | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | HSP20-like chaperones | 1 | 1 | |
Nucleic acid-binding proteins | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 | |
PP2C-like | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 1 | 1 | |
EF-G C-terminal domain-like | Ribosomal protein S5 domain 2-like | 1 | 1 | |
FAD/NAD(P)-binding domain | FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 1 | 1 | |
Prokaryotic type KH domain (KH-domain type II) | Ribosomal protein S3 C-terminal domain | 1 | 1 | |
Radical SAM enzymes | Thioredoxin-like | 1 | 1 | |
S-adenosyl-L-methionine-dependent methyltransferases | "Winged helix" DNA-binding domain | 1 | 1 | |
YjeF N-terminal domain-like | Ribokinase-like | 1 | 1 | |
PUA domain-like | Adenine nucleotide alpha hydrolases-like | 1 | 1 | |
Chaperone J-domain | DnaJ/Hsp40 cysteine-rich domain | 1 | 1 | |
Carbamoyl phosphate synthetase, small subunit N-terminal domain | Class I glutamine amidotransferase-like | 1 | 1 | |
NAD-binding domain of HMG-CoA reductase | Substrate-binding domain of HMG-CoA reductase | 1 | 1 | |
Ribosomal protein S5 domain 2-like | Ribosomal protein S5 domain 2-like | 1 | 1 | |
N-terminal domain of alpha and beta subunits of F1 ATP synthase | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
SIS domain | HAD-like | 1 | 1 | |
Nitrite/Sulfite reductase N-terminal domain-like | Nitrite and sulphite reductase 4Fe-4S domain-like | 1 | 1 | |
TrkA C-terminal domain-like | TrkA C-terminal domain-like | 1 | 1 | |
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | Type II DNA topoisomerase | 1 | 1 | |
Methylated DNA-protein cysteine methyltransferase domain | Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 1 | 1 | |
Glutathione synthetase ATP-binding domain-like | Carbamoyl phosphate synthetase, large subunit connection domain | 1 | 1 | |
THUMP domain-like | S-adenosyl-L-methionine-dependent methyltransferases | 1 | 1 | |
P-loop containing nucleoside triphosphate hydrolases | HprK N-terminal domain-like | 1 | 1 | |
Class II aaRS and biotin synthetases | ThrRS/AlaRS common domain | 1 | 1 | |
TPR-like | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
Hedgehog/intein (Hint) domain | Hedgehog/intein (Hint) domain | 1 | 1 | |
Nucleic acid-binding proteins | Hedgehog/intein (Hint) domain | 1 | 1 | |
Methylglyoxal synthase-like | Cytidine deaminase-like | 1 | 1 | |
Nucleotidyltransferase | PAP/OAS1 substrate-binding domain | 1 | 1 | |
Nucleic acid-binding proteins | GAD domain-like | 1 | 1 | |
Putative DNA-binding domain | PheT/TilS domain | 1 | 1 | |
Periplasmic binding protein-like II | GlnB-like | 1 | 1 | |
Nitrite/Sulfite reductase N-terminal domain-like | 4Fe-4S ferredoxins | 1 | 1 | |
Nucleic acid-binding proteins | Nucleic acid-binding proteins | 1 | 1 | |
ALDH-like | Acetyl-CoA synthetase-like | 1 | 1 | |
Putative DNA-binding domain | Putative DNA-binding domain | 1 | 1 | |
Riboflavin synthase domain-like | Ferredoxin reductase-like, C-terminal NADP-linked domain | 1 | 1 | |
Eukaryotic type KH-domain (KH-domain type I) | Eukaryotic type KH-domain (KH-domain type I) | 1 | 1 | |
FGAM synthase PurL, linker domain | PurM C-terminal domain-like | 1 | 1 | |
Class II aaRS ABD-related | C-terminal domain of ProRS | 1 | 1 | |
4Fe-4S ferredoxins | P-loop containing nucleoside triphosphate hydrolases | 1 | 1 | |
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 | Translational machinery components | 1 | 1 | |
Radical SAM enzymes | RuvA domain 2-like | 1 | 1 | |
Hypothetical protein PA1324 | Cna protein B-type domain | 1 | 1 | |
FYSH domain | Hypothetical protein AF0491, middle domain | 1 | 1 | |
Nucleotide-binding domain | 4Fe-4S ferredoxins | 1 | 1 | |
Chorismate mutase II | 6-phosphogluconate dehydrogenase C-terminal domain-like | 1 | 1 | |
Aconitase iron-sulfur domain | LeuD/IlvD-like | 1 | 1 | |