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Acting on NADH or NADPH

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   root [root] <6>
+ 1:   Oxidoreductases [1] <23>(183|263) (202|169|83)
0:   Acting on NADH or NADPH [1.6] <6>(26|27) (27|16|7)
- 1:   With a nitrogenous group as acceptor [1.6.6] <13>(0|0) (0|0|0)
- 1:   With other acceptors [1.6.99] <13>(15|13) (15|8|4)
- 1:   With a quinone or similar compound as acceptor [1.6.5] <10>(15|14) (15|7|2)
- 1:   With a heme protein as acceptor [1.6.2] <6>(5|6) (6|5|3)
- 1:   With NAD(+) or NADP(+) as acceptor [1.6.1] <2>(5|5) (5|2|0)
- 1:   With a oxygen as acceptor [1.6.3] <1>(4|3) (4|1|0)


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Superfamily

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SCOP term FDR (all) Annotation (direct or inherited)
HydB/Nqo4-like0Direct
HydA/Nqo6-like0Direct
2Fe-2S ferredoxin-like0Direct
4Fe-4S ferredoxins0Direct
Nqo1C-terminal domain-like0Direct
Nqo5-like0Direct
Nqo1 FMN-binding domain-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
Riboflavin synthase domain-like0Direct
Nqo1 middle domain-like0Direct
Flavoproteins0.0000000000002025Direct
Formate dehydrogenase/DMSO reductase, domains 1-30.00000000001207Direct
HSP20-like chaperones0.00000000003112Direct
EF-hand0.0001396Direct
DHS-like NAD/FAD-binding domain0.02009Inherited
Cytochrome b5-like heme/steroid binding domain0.0902Inherited
ADC-like0.2132Inherited
alpha-helical ferredoxin0.3724Inherited
Thioredoxin-like0.7939Inherited
GroES-like1Inherited
Heme-dependent peroxidases1Inherited
Formate/glycerate dehydrogenase catalytic domain-like1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
FAD/NAD(P)-binding domain1Inherited
FMN-linked oxidoreductases1Inherited


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Family

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SCOP term FDR (all) Annotation (direct or inherited)
Nqo1 FMN-binding domain-like0Direct
Nqo5-like0Direct
Nqo1 middle domain-like0Direct
Nqo4-like0Direct
Reductases0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
Ferredoxin domains from multidomain proteins0Direct
NQO2-like0Direct
Nqo1C-terminal domain-like0Direct
Nq06-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Transhydrogenase domain III (dIII)0Direct
FAD/NAD-linked reductases, N-terminal and central domains0.00000000000005659Direct
Formate dehydrogenase/DMSO reductase, domains 1-30.0000000001386Direct
NADPH-cytochrome p450 reductase-like0.00000000138Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.000000002159Direct
Calmodulin-like0.0000000155Direct
Cytochrome p450 reductase N-terminal domain-like0.00000008027Direct
Quinone reductase0.00001572Direct
Myeloperoxidase-like0.007541Inherited
L-alanine dehydrogenase-like0.0139Inherited
Cytochrome b50.0974Inherited
2Fe-2S ferredoxin domains from multidomain proteins0.1332Inherited
Alcohol dehydrogenase-like, N-terminal domain1Inherited
Alcohol dehydrogenase-like, C-terminal domain1Inherited
FMN-linked oxidoreductases1Inherited
Formate/glycerate dehydrogenases, NAD-domain1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this EC term
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Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
Nqo1C-terminal domain-like0Direct
HydB/Nqo4-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Nqo5-like0Direct
Nqo1 FMN-binding domain-like0Direct
Nqo1 middle domain-like0Direct
4Fe-4S ferredoxins0Direct
HydA/Nqo6-like0Direct
Riboflavin synthase domain-like0Direct
2Fe-2S ferredoxin-like1.756e-16Direct
Flavoproteins0.0000000000001401Direct
Formate dehydrogenase/DMSO reductase, domains 1-30.000000000008438Direct
HSP20-like chaperones0.00000000002356Direct
EF-hand0.0001146Direct
DHS-like NAD/FAD-binding domain0.0174Inherited
Cytochrome b5-like heme/steroid binding domain0.08004Inherited
ADC-like0.1914Inherited
alpha-helical ferredoxin0.3413Inherited
Thioredoxin-like0.7397Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
FAD/NAD(P)-binding domain1Inherited
GroES-like1Inherited
Cytochrome P4501Inherited
FMN-linked oxidoreductases1Inherited
Formate/glycerate dehydrogenase catalytic domain-like1Inherited
Heme-dependent peroxidases1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
142984,140490
  • 142984 - Nqo1 middle domain-like
  • 140490 - Nqo1C-terminal domain-like
  • 0Direct
    143243,56762
  • 143243 - Nqo5-like
  • 56762 - HydB/Nqo4-like
  • 0Direct
    48264,52218
  • 48264 - Cytochrome P450
  • 52218 - Flavoproteins
  • 0Direct
    54862,53706
  • 54862 - 4Fe-4S ferredoxins
  • 53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    55856,49764
  • 55856 - Cytochrome b5-like heme/steroid binding domain
  • 49764 - HSP20-like chaperones
  • 0Direct
    142019,142984
  • 142019 - Nqo1 FMN-binding domain-like
  • 142984 - Nqo1 middle domain-like
  • 0Direct
    54292,54862
  • 54292 - 2Fe-2S ferredoxin-like
  • 54862 - 4Fe-4S ferredoxins
  • 0Direct
    49764,63380
  • 49764 - HSP20-like chaperones
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    56770,143243
  • 56770 - HydA/Nqo6-like
  • 143243 - Nqo5-like
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    52218,63380
  • 52218 - Flavoproteins
  • 63380 - Riboflavin synthase domain-like
  • 0.00000000001165Direct
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0.1334Inherited
    53706,50692
  • 53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
  • 50692 - ADC-like
  • 0.1503Inherited
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 1Inherited
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 1Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    56770,143243,56762
  • 56770 - HydA/Nqo6-like
  • 143243 - Nqo5-like
  • 56762 - HydB/Nqo4-like
  • 0Direct
    55856,49764,63380
  • 55856 - Cytochrome b5-like heme/steroid binding domain
  • 49764 - HSP20-like chaperones
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    54292,54862,53706
  • 54292 - 2Fe-2S ferredoxin-like
  • 54862 - 4Fe-4S ferredoxins
  • 53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
  • 0Direct
    142019,142984,140490
  • 142019 - Nqo1 FMN-binding domain-like
  • 142984 - Nqo1 middle domain-like
  • 140490 - Nqo1C-terminal domain-like
  • 0Direct
    48264,52218,63380
  • 48264 - Cytochrome P450
  • 52218 - Flavoproteins
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    49764,63380,52343
  • 49764 - HSP20-like chaperones
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    54862,53706,50692
  • 54862 - 4Fe-4S ferredoxins
  • 53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
  • 50692 - ADC-like
  • 0.0000000000001028Direct


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
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