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Protein-serine/threonine kinases
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Enzyme Commission (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed. To navigate hierarchical structure of EC, we display all parental EC terms to the current EC term of interest ordered by their shortest distances to the current term. Also, only direct children EC terms of the current EC term are listed.
Structural Classification of Proteins (SCOP)
SCOP classifies evolutionary-related domains into Superfamily level and Family level. Accordingly, we have generated the domain-centric EC annotations for each of the three concepts at each of the two domain levels.
Structural Domain Enzyme Commission Ontology (SDEO)
As domain-centric ontology, SDEO only refers to those EC terms which are the most informative to annotate SCOP domains.
EC annotations for SCOP domains
For details, please visit Documentation: EC annotations for SCOP domains. Therein, we provide several relevant files ( Data Availability) for the download, including an annotation file (i.e., Domain2EC.txt) and the corresponding ontology (i.e., SDEO.txt).
Supra-domain Enzyme Commission Ontology (SPEO)
As an extension, SPEO includes those EC terms which are the most informative to annotate supra-domains and individual SCOP domains at the Superfamily level.
EC annotations for Supra-domains
For details, please visit Documentation: EC annotations for Supra-domains. Therein, we provide several relevant files ( Data Availability) for the download, including a annotation file (i.e., SP2EC.txt) and an ontology (i.e., SPEO.txt). For the sake of being browsable, listed below are those supra-domains (single, dual, triple, quad).
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this (SDEO level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term |
FDR (all) |
Annotation (direct or inherited) |
Kinase associated domain 1, KA1 | 0 | DIRECT |
Spectrin repeat | 0 | DIRECT |
Legume lectins | 0 | DIRECT |
RIO1-like kinases | 0 | DIRECT |
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | DIRECT |
Protein kinases, catalytic subunit | 0 | DIRECT |
Regulator of chromosome condensation RCC1 | 0 | DIRECT |
RhoA-binding domain | 0 | DIRECT |
Doublecortin (DC) | 0 | DIRECT |
MIT domain | 0 | DIRECT |
Myosin rod fragments | 0 | DIRECT |
Regulator of G-protein signaling, RGS | 0 | DIRECT |
Extracellular domain of cell surface receptors | 0 | DIRECT |
Swapped Polo-box domain | 0 | DIRECT |
alpha-D-mannose-specific plant lectins | 0 | DIRECT |
PLC-like (P variant) | 0 | DIRECT |
Calmodulin-like | 0 | DIRECT |
MHCK/EF2 kinase | 0 | DIRECT |
DEATH domain, DD | 0 | DIRECT |
alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | DIRECT |
Pleckstrin-homology domain (PH domain) | 0 | DIRECT |
Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
Polygalacturonase inhibiting protein PGIP | 0 | DIRECT |
Polo-box duplicated region | 0 | DIRECT |
RWD domain | 0 | DIRECT |
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0 | DIRECT |
Ssp2 C-terminal domain-like | 0 | DIRECT |
alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
HR1 repeat | 0 | DIRECT |
LIM domain | 0 | DIRECT |
Synaptotagmin-like (S variant) | 0 | DIRECT |
Ankyrin repeat | 0 | DIRECT |
DBL homology domain (DH-domain) | 0 | DIRECT |
MAST3 pre-PK domain-like | 0 | DIRECT |
Ras-binding domain, RBD | 0.000000000000001037 | DIRECT |
FHA domain | 0.00000000000001563 | DIRECT |
PB1 domain | 0.0000000000001279 | DIRECT |
cAMP-binding domain | 0.000000000001257 | DIRECT |
Motor proteins | 0.00000000008303 | DIRECT |
Quinoprotein alcohol dehydrogenase-like | 0.000000001419 | DIRECT |
WD40-repeat | 0.00000009517 | DIRECT |
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) | 0.0000001075 | DIRECT |
PDZ domain | 0.0000007814 | DIRECT |
PX domain | 0.0001282 | DIRECT |
SH3-domain | 0.0004274 | DIRECT |
I set domains | 0.002937 | INHERITED FROM: [Myosin light-chain] kinase |
Flavin-binding PAS domain | 0.006138 | INHERITED FROM: Non-specific serine/threonine protein kinase |
Histidine kinase | 0.03929 | INHERITED FROM: Non-specific serine/threonine protein kinase |
Phoshoinositide 3-kinase (PI3K) helical domain | 0.1896 | INHERITED FROM: Non-specific serine/threonine protein kinase |
Fibronectin type III | 0.2382 | INHERITED FROM: [Myosin light-chain] kinase |
SCOP term |
FDR (all) |
Annotation (direct or inherited) |
Kinase associated domain 1, KA1 | 0 | Direct |
Spectrin repeat | 0 | Direct |
Legume lectins | 0 | Direct |
RIO1-like kinases | 0 | Direct |
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | Direct |
Protein kinases, catalytic subunit | 0 | Direct |
Regulator of chromosome condensation RCC1 | 0 | Direct |
RhoA-binding domain | 0 | Direct |
Doublecortin (DC) | 0 | Direct |
MIT domain | 0 | Direct |
Myosin rod fragments | 0 | Direct |
Regulator of G-protein signaling, RGS | 0 | Direct |
Extracellular domain of cell surface receptors | 0 | Direct |
Swapped Polo-box domain | 0 | Direct |
alpha-D-mannose-specific plant lectins | 0 | Direct |
PLC-like (P variant) | 0 | Direct |
Calmodulin-like | 0 | Direct |
MHCK/EF2 kinase | 0 | Direct |
DEATH domain, DD | 0 | Direct |
alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | Direct |
Pleckstrin-homology domain (PH domain) | 0 | Direct |
Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
Polygalacturonase inhibiting protein PGIP | 0 | Direct |
Polo-box duplicated region | 0 | Direct |
RWD domain | 0 | Direct |
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0 | Direct |
Ssp2 C-terminal domain-like | 0 | Direct |
alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
HR1 repeat | 0 | Direct |
LIM domain | 0 | Direct |
Synaptotagmin-like (S variant) | 0 | Direct |
Ankyrin repeat | 0 | Direct |
DBL homology domain (DH-domain) | 0 | Direct |
MAST3 pre-PK domain-like | 0 | Direct |
Ras-binding domain, RBD | 0.000000000000001037 | Direct |
FHA domain | 0.00000000000001563 | Direct |
PB1 domain | 0.0000000000001279 | Direct |
cAMP-binding domain | 0.000000000001257 | Direct |
Motor proteins | 0.00000000008303 | Direct |
Quinoprotein alcohol dehydrogenase-like | 0.000000001419 | Direct |
WD40-repeat | 0.00000009517 | Direct |
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) | 0.0000001075 | Direct |
PDZ domain | 0.0000007814 | Direct |
PX domain | 0.0001282 | Direct |
SH3-domain | 0.0004274 | Direct |
I set domains | 0.002937 | Inherited |
Flavin-binding PAS domain | 0.006138 | Inherited |
Histidine kinase | 0.03929 | Inherited |
Phoshoinositide 3-kinase (PI3K) helical domain | 0.1896 | Inherited |
Fibronectin type III | 0.2382 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this EC term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
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Supra-domains annotated to this EC term (SPEO level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
46585,49562 46585 - HR1 repeat 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
82615,82615 82615 - Polo-box domain 82615 - Polo-box domain | 0 | DIRECT |
56112,50978 56112 - Protein kinase-like (PK-like) 50978 - WD40 repeat-like | 0 | DIRECT |
52058,52047 52058 - L domain-like 52047 - RNI-like | 0 | DIRECT |
56112,48403 56112 - Protein kinase-like (PK-like) 48403 - Ankyrin repeat | 0 | DIRECT |
49899,56112 49899 - Concanavalin A-like lectins/glucanases 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
53067,56112 53067 - Actin-like ATPase domain 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
56112,101288 56112 - Protein kinase-like (PK-like) 101288 - L27 domain | 0 | DIRECT |
47986,56112 47986 - DEATH domain 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
52047,56112 52047 - RNI-like 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
52058,56112 52058 - L domain-like 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0 | DIRECT |
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
116846,116846 116846 - MIT domain 116846 - MIT domain | 0 | DIRECT |
50998,56112 50998 - Quinoprotein alcohol dehydrogenase-like 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49562,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
89837,89837 89837 - Doublecortin (DC) 89837 - Doublecortin (DC) | 0 | DIRECT |
49562,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain | 0 | DIRECT |
52058,52058 52058 - L domain-like 52058 - L domain-like | 0 | DIRECT |
48097,56112 48097 - Regulator of G-protein signaling, RGS 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
56112,103243 56112 - Protein kinase-like (PK-like) 103243 - KA1-like | 0 | DIRECT |
50156,50044 50156 - PDZ domain-like 50044 - SH3-domain | 0 | DIRECT |
48726,56112 48726 - Immunoglobulin 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
56112,48371 56112 - Protein kinase-like (PK-like) 48371 - ARM repeat | 0 | DIRECT |
57850,48371 57850 - RING/U-box 48371 - ARM repeat | 0 | DIRECT |
69012,55874 69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
52087,46966 52087 - CRAL/TRIO domain 46966 - Spectrin repeat | 0 | DIRECT |
52058,52540 52058 - L domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
56112,55681 56112 - Protein kinase-like (PK-like) 55681 - Class II aaRS and biotin synthetases | 0 | DIRECT |
47370,47370 47370 - Bromodomain 47370 - Bromodomain | 0 | DIRECT |
55073,56112 55073 - Nucleotide cyclase 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
52047,52058 52047 - RNI-like 52058 - L domain-like | 0 | DIRECT |
57716,50156 57716 - Glucocorticoid receptor-like (DNA-binding domain) 50156 - PDZ domain-like | 0 | DIRECT |
56112,50998 56112 - Protein kinase-like (PK-like) 50998 - Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
101288,50156 101288 - L27 domain 50156 - PDZ domain-like | 0 | DIRECT |
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0 | DIRECT |
64268,56112 64268 - PX domain 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
56112,116846 56112 - Protein kinase-like (PK-like) 116846 - MIT domain | 0 | DIRECT |
56112,90257 56112 - Protein kinase-like (PK-like) 90257 - Myosin rod fragments | 0 | DIRECT |
48403,56112 48403 - Ankyrin repeat 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
56112,54928 56112 - Protein kinase-like (PK-like) 54928 - RNA-binding domain, RBD | 0 | DIRECT |
101288,101288 101288 - L27 domain 101288 - L27 domain | 0 | DIRECT |
46785,56112 46785 - "Winged helix" DNA-binding domain 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
54277,57889 54277 - CAD & PB1 domains 57889 - Cysteine-rich domain | 0 | DIRECT |
56112,54427 56112 - Protein kinase-like (PK-like) 54427 - NTF2-like | 0 | DIRECT |
52047,52047 52047 - RNI-like 52047 - RNI-like | 0 | DIRECT |
56112,50985 56112 - Protein kinase-like (PK-like) 50985 - RCC1/BLIP-II | 0 | DIRECT |
50729,69322 50729 - PH domain-like 69322 - Tricorn protease domain 2 | 0 | DIRECT |
56112,50729 56112 - Protein kinase-like (PK-like) 50729 - PH domain-like | 0 | DIRECT |
46585,46585 46585 - HR1 repeat 46585 - HR1 repeat | 0 | DIRECT |
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat | 0 | DIRECT |
56112,48452 56112 - Protein kinase-like (PK-like) 48452 - TPR-like | 0 | DIRECT |
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49879,56112 49879 - SMAD/FHA domain 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
50044,52540 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50156,56112 50156 - PDZ domain-like 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
56112,47473 56112 - Protein kinase-like (PK-like) 47473 - EF-hand | 0 | DIRECT |
54236,57889 54236 - Ubiquitin-like 57889 - Cysteine-rich domain | 0 | DIRECT |
56112,82615 56112 - Protein kinase-like (PK-like) 82615 - Polo-box domain | 0 | DIRECT |
57889,49562 57889 - Cysteine-rich domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
56112,48726 56112 - Protein kinase-like (PK-like) 48726 - Immunoglobulin | 0 | DIRECT |
50044,56112 50044 - SH3-domain 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
53850,56112 53850 - Periplasmic binding protein-like II 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
56112,52799 56112 - Protein kinase-like (PK-like) 52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
51206,56112 51206 - cAMP-binding domain-like 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
81995,56112 81995 - beta-sandwich domain of Sec23/24 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57889,50729 57889 - Cysteine-rich domain 50729 - PH domain-like | 0 | DIRECT |
48371,48371 48371 - ARM repeat 48371 - ARM repeat | 0.0000000000002965 | DIRECT |
56112,56112 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like) | 0.0000000000008136 | DIRECT |
49265,56112 49265 - Fibronectin type III 56112 - Protein kinase-like (PK-like) | 0.000000000002305 | DIRECT |
51206,51206 51206 - cAMP-binding domain-like 51206 - cAMP-binding domain-like | 0.00000000002209 | DIRECT |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.00000004661 | DIRECT |
47212,56112 47212 - FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) 56112 - Protein kinase-like (PK-like) | 0.00000005897 | DIRECT |
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin | 0.0000004572 | DIRECT |
48403,52540 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0000008195 | DIRECT |
54768,54768 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like | 0.0000008195 | DIRECT |
48403,47769 48403 - Ankyrin repeat 47769 - SAM/Pointed domain | 0.000005453 | DIRECT |
50729,57889 50729 - PH domain-like 57889 - Cysteine-rich domain | 0.00001762 | DIRECT |
50729,50044 50729 - PH domain-like 50044 - SH3-domain | 0.00009172 | DIRECT |
52799,49562 52799 - (Phosphotyrosine protein) phosphatases II 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.00009833 | DIRECT |
56112,52540 56112 - Protein kinase-like (PK-like) 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0002518 | DIRECT |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0.0004991 | DIRECT |
56112,50044 56112 - Protein kinase-like (PK-like) 50044 - SH3-domain | 0.0005061 | DIRECT |
53850,53850 53850 - Periplasmic binding protein-like II 53850 - Periplasmic binding protein-like II | 0.01129 | INHERITED FROM: Non-specific serine/threonine protein kinase |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0.1042 | INHERITED FROM: Non-specific serine/threonine protein kinase |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.5101 | INHERITED FROM: [Myosin light-chain] kinase |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
46585,49562 46585 - HR1 repeat 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
82615,82615 82615 - Polo-box domain 82615 - Polo-box domain | 0 | Direct |
56112,50978 56112 - Protein kinase-like (PK-like) 50978 - WD40 repeat-like | 0 | Direct |
52058,52047 52058 - L domain-like 52047 - RNI-like | 0 | Direct |
56112,48403 56112 - Protein kinase-like (PK-like) 48403 - Ankyrin repeat | 0 | Direct |
49899,56112 49899 - Concanavalin A-like lectins/glucanases 56112 - Protein kinase-like (PK-like) | 0 | Direct |
53067,56112 53067 - Actin-like ATPase domain 56112 - Protein kinase-like (PK-like) | 0 | Direct |
56112,101288 56112 - Protein kinase-like (PK-like) 101288 - L27 domain | 0 | Direct |
47986,56112 47986 - DEATH domain 56112 - Protein kinase-like (PK-like) | 0 | Direct |
52047,56112 52047 - RNI-like 56112 - Protein kinase-like (PK-like) | 0 | Direct |
52058,56112 52058 - L domain-like 56112 - Protein kinase-like (PK-like) | 0 | Direct |
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0 | Direct |
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
116846,116846 116846 - MIT domain 116846 - MIT domain | 0 | Direct |
50998,56112 50998 - Quinoprotein alcohol dehydrogenase-like 56112 - Protein kinase-like (PK-like) | 0 | Direct |
49562,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 56112 - Protein kinase-like (PK-like) | 0 | Direct |
89837,89837 89837 - Doublecortin (DC) 89837 - Doublecortin (DC) | 0 | Direct |
49562,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain | 0 | Direct |
52058,52058 52058 - L domain-like 52058 - L domain-like | 0 | Direct |
48097,56112 48097 - Regulator of G-protein signaling, RGS 56112 - Protein kinase-like (PK-like) | 0 | Direct |
56112,103243 56112 - Protein kinase-like (PK-like) 103243 - KA1-like | 0 | Direct |
50156,50044 50156 - PDZ domain-like 50044 - SH3-domain | 0 | Direct |
48726,56112 48726 - Immunoglobulin 56112 - Protein kinase-like (PK-like) | 0 | Direct |
56112,48371 56112 - Protein kinase-like (PK-like) 48371 - ARM repeat | 0 | Direct |
57850,48371 57850 - RING/U-box 48371 - ARM repeat | 0 | Direct |
69012,55874 69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
52087,46966 52087 - CRAL/TRIO domain 46966 - Spectrin repeat | 0 | Direct |
52058,52540 52058 - L domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
56112,55681 56112 - Protein kinase-like (PK-like) 55681 - Class II aaRS and biotin synthetases | 0 | Direct |
47370,47370 47370 - Bromodomain 47370 - Bromodomain | 0 | Direct |
55073,56112 55073 - Nucleotide cyclase 56112 - Protein kinase-like (PK-like) | 0 | Direct |
52047,52058 52047 - RNI-like 52058 - L domain-like | 0 | Direct |
57716,50156 57716 - Glucocorticoid receptor-like (DNA-binding domain) 50156 - PDZ domain-like | 0 | Direct |
56112,50998 56112 - Protein kinase-like (PK-like) 50998 - Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
101288,50156 101288 - L27 domain 50156 - PDZ domain-like | 0 | Direct |
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like | 0 | Direct |
64268,56112 64268 - PX domain 56112 - Protein kinase-like (PK-like) | 0 | Direct |
56112,116846 56112 - Protein kinase-like (PK-like) 116846 - MIT domain | 0 | Direct |
56112,90257 56112 - Protein kinase-like (PK-like) 90257 - Myosin rod fragments | 0 | Direct |
48403,56112 48403 - Ankyrin repeat 56112 - Protein kinase-like (PK-like) | 0 | Direct |
56112,54928 56112 - Protein kinase-like (PK-like) 54928 - RNA-binding domain, RBD | 0 | Direct |
101288,101288 101288 - L27 domain 101288 - L27 domain | 0 | Direct |
46785,56112 46785 - "Winged helix" DNA-binding domain 56112 - Protein kinase-like (PK-like) | 0 | Direct |
54277,57889 54277 - CAD & PB1 domains 57889 - Cysteine-rich domain | 0 | Direct |
56112,54427 56112 - Protein kinase-like (PK-like) 54427 - NTF2-like | 0 | Direct |
52047,52047 52047 - RNI-like 52047 - RNI-like | 0 | Direct |
56112,50985 56112 - Protein kinase-like (PK-like) 50985 - RCC1/BLIP-II | 0 | Direct |
50729,69322 50729 - PH domain-like 69322 - Tricorn protease domain 2 | 0 | Direct |
56112,50729 56112 - Protein kinase-like (PK-like) 50729 - PH domain-like | 0 | Direct |
46585,46585 46585 - HR1 repeat 46585 - HR1 repeat | 0 | Direct |
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat | 0 | Direct |
56112,48452 56112 - Protein kinase-like (PK-like) 48452 - TPR-like | 0 | Direct |
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like) | 0 | Direct |
49879,56112 49879 - SMAD/FHA domain 56112 - Protein kinase-like (PK-like) | 0 | Direct |
50044,52540 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50156,56112 50156 - PDZ domain-like 56112 - Protein kinase-like (PK-like) | 0 | Direct |
56112,47473 56112 - Protein kinase-like (PK-like) 47473 - EF-hand | 0 | Direct |
54236,57889 54236 - Ubiquitin-like 57889 - Cysteine-rich domain | 0 | Direct |
56112,82615 56112 - Protein kinase-like (PK-like) 82615 - Polo-box domain | 0 | Direct |
57889,49562 57889 - Cysteine-rich domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
56112,48726 56112 - Protein kinase-like (PK-like) 48726 - Immunoglobulin | 0 | Direct |
50044,56112 50044 - SH3-domain 56112 - Protein kinase-like (PK-like) | 0 | Direct |
53850,56112 53850 - Periplasmic binding protein-like II 56112 - Protein kinase-like (PK-like) | 0 | Direct |
56112,52799 56112 - Protein kinase-like (PK-like) 52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
51206,56112 51206 - cAMP-binding domain-like 56112 - Protein kinase-like (PK-like) | 0 | Direct |
81995,56112 81995 - beta-sandwich domain of Sec23/24 56112 - Protein kinase-like (PK-like) | 0 | Direct |
57889,50729 57889 - Cysteine-rich domain 50729 - PH domain-like | 0 | Direct |
48371,48371 48371 - ARM repeat 48371 - ARM repeat | 0.0000000000002965 | Direct |
56112,56112 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like) | 0.0000000000008136 | Direct |
49265,56112 49265 - Fibronectin type III 56112 - Protein kinase-like (PK-like) | 0.000000000002305 | Direct |
51206,51206 51206 - cAMP-binding domain-like 51206 - cAMP-binding domain-like | 0.00000000002209 | Direct |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.00000004661 | Direct |
47212,56112 47212 - FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) 56112 - Protein kinase-like (PK-like) | 0.00000005897 | Direct |
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin | 0.0000004572 | Direct |
48403,52540 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0000008195 | Direct |
54768,54768 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like | 0.0000008195 | Direct |
48403,47769 48403 - Ankyrin repeat 47769 - SAM/Pointed domain | 0.000005453 | Direct |
50729,57889 50729 - PH domain-like 57889 - Cysteine-rich domain | 0.00001762 | Direct |
50729,50044 50729 - PH domain-like 50044 - SH3-domain | 0.00009172 | Direct |
52799,49562 52799 - (Phosphotyrosine protein) phosphatases II 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.00009833 | Direct |
56112,52540 56112 - Protein kinase-like (PK-like) 52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0002518 | Direct |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0.0004991 | Direct |
56112,50044 56112 - Protein kinase-like (PK-like) 50044 - SH3-domain | 0.0005061 | Direct |
53850,53850 53850 - Periplasmic binding protein-like II 53850 - Periplasmic binding protein-like II | 0.01129 | Inherited |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0.1042 | Inherited |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.5101 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEO level: Least Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56112,101288,101288 56112 - Protein kinase-like (PK-like) 101288 - L27 domain 101288 - L27 domain | 0 | DIRECT |
52087,46966,46966 52087 - CRAL/TRIO domain 46966 - Spectrin repeat 46966 - Spectrin repeat | 0 | DIRECT |
48726,49265,48726 48726 - Immunoglobulin 49265 - Fibronectin type III 48726 - Immunoglobulin | 0 | DIRECT |
48726,49265,56112 48726 - Immunoglobulin 49265 - Fibronectin type III 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
52058,52058,56112 52058 - L domain-like 52058 - L domain-like 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
52047,52047,52058 52047 - RNI-like 52047 - RNI-like 52058 - L domain-like | 0 | DIRECT |
49562,57889,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0 | DIRECT |
51206,51206,56112 51206 - cAMP-binding domain-like 51206 - cAMP-binding domain-like 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
101288,101288,50156 101288 - L27 domain 101288 - L27 domain 50156 - PDZ domain-like | 0 | DIRECT |
46585,46585,46585 46585 - HR1 repeat 46585 - HR1 repeat 46585 - HR1 repeat | 0 | DIRECT |
57716,57716,50156 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 50156 - PDZ domain-like | 0 | DIRECT |
56112,52799,49562 56112 - Protein kinase-like (PK-like) 52799 - (Phosphotyrosine protein) phosphatases II 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
50156,50044,52540 50156 - PDZ domain-like 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
49265,48726,49265 49265 - Fibronectin type III 48726 - Immunoglobulin 49265 - Fibronectin type III | 0 | DIRECT |
57889,49562,56112 57889 - Cysteine-rich domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
52047,52047,56112 52047 - RNI-like 52047 - RNI-like 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49265,56112,48726 49265 - Fibronectin type III 56112 - Protein kinase-like (PK-like) 48726 - Immunoglobulin | 0 | DIRECT |
57889,50729,69322 57889 - Cysteine-rich domain 50729 - PH domain-like 69322 - Tricorn protease domain 2 | 0 | DIRECT |
56112,48726,48726 56112 - Protein kinase-like (PK-like) 48726 - Immunoglobulin 48726 - Immunoglobulin | 0 | DIRECT |
57889,57889,49562 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
52058,52047,56112 52058 - L domain-like 52047 - RNI-like 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
48065,50729,50044 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like 50044 - SH3-domain | 0 | DIRECT |
56112,48403,52540 56112 - Protein kinase-like (PK-like) 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
101288,50156,50044 101288 - L27 domain 50156 - PDZ domain-like 50044 - SH3-domain | 0 | DIRECT |
48726,48726,56112 48726 - Immunoglobulin 48726 - Immunoglobulin 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
52058,52047,52058 52058 - L domain-like 52047 - RNI-like 52058 - L domain-like | 0 | DIRECT |
52047,52058,56112 52047 - RNI-like 52058 - L domain-like 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
48097,56112,50729 48097 - Regulator of G-protein signaling, RGS 56112 - Protein kinase-like (PK-like) 50729 - PH domain-like | 0 | DIRECT |
53850,53850,56112 53850 - Periplasmic binding protein-like II 53850 - Periplasmic binding protein-like II 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
56112,82615,82615 56112 - Protein kinase-like (PK-like) 82615 - Polo-box domain 82615 - Polo-box domain | 0 | DIRECT |
56112,116846,116846 56112 - Protein kinase-like (PK-like) 116846 - MIT domain 116846 - MIT domain | 0 | DIRECT |
57716,50156,56112 57716 - Glucocorticoid receptor-like (DNA-binding domain) 50156 - PDZ domain-like 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
52058,52058,52058 52058 - L domain-like 52058 - L domain-like 52058 - L domain-like | 0.0000000000639 | DIRECT |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.000001123 | DIRECT |
49265,48726,48726 49265 - Fibronectin type III 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.00003077 | DIRECT |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0.1042 | INHERITED FROM: Non-specific serine/threonine protein kinase |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.2368 | INHERITED FROM: [Myosin light-chain] kinase |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56112,101288,101288 56112 - Protein kinase-like (PK-like) 101288 - L27 domain 101288 - L27 domain | 0 | Direct |
52087,46966,46966 52087 - CRAL/TRIO domain 46966 - Spectrin repeat 46966 - Spectrin repeat | 0 | Direct |
48726,49265,48726 48726 - Immunoglobulin 49265 - Fibronectin type III 48726 - Immunoglobulin | 0 | Direct |
48726,49265,56112 48726 - Immunoglobulin 49265 - Fibronectin type III 56112 - Protein kinase-like (PK-like) | 0 | Direct |
52058,52058,56112 52058 - L domain-like 52058 - L domain-like 56112 - Protein kinase-like (PK-like) | 0 | Direct |
52047,52047,52058 52047 - RNI-like 52047 - RNI-like 52058 - L domain-like | 0 | Direct |
49562,57889,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0 | Direct |
51206,51206,56112 51206 - cAMP-binding domain-like 51206 - cAMP-binding domain-like 56112 - Protein kinase-like (PK-like) | 0 | Direct |
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
101288,101288,50156 101288 - L27 domain 101288 - L27 domain 50156 - PDZ domain-like | 0 | Direct |
46585,46585,46585 46585 - HR1 repeat 46585 - HR1 repeat 46585 - HR1 repeat | 0 | Direct |
57716,57716,50156 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 50156 - PDZ domain-like | 0 | Direct |
56112,52799,49562 56112 - Protein kinase-like (PK-like) 52799 - (Phosphotyrosine protein) phosphatases II 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
50156,50044,52540 50156 - PDZ domain-like 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
49265,48726,49265 49265 - Fibronectin type III 48726 - Immunoglobulin 49265 - Fibronectin type III | 0 | Direct |
57889,49562,56112 57889 - Cysteine-rich domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 56112 - Protein kinase-like (PK-like) | 0 | Direct |
52047,52047,56112 52047 - RNI-like 52047 - RNI-like 56112 - Protein kinase-like (PK-like) | 0 | Direct |
49265,56112,48726 49265 - Fibronectin type III 56112 - Protein kinase-like (PK-like) 48726 - Immunoglobulin | 0 | Direct |
57889,50729,69322 57889 - Cysteine-rich domain 50729 - PH domain-like 69322 - Tricorn protease domain 2 | 0 | Direct |
56112,48726,48726 56112 - Protein kinase-like (PK-like) 48726 - Immunoglobulin 48726 - Immunoglobulin | 0 | Direct |
57889,57889,49562 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
52058,52047,56112 52058 - L domain-like 52047 - RNI-like 56112 - Protein kinase-like (PK-like) | 0 | Direct |
48065,50729,50044 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like 50044 - SH3-domain | 0 | Direct |
56112,48403,52540 56112 - Protein kinase-like (PK-like) 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
101288,50156,50044 101288 - L27 domain 50156 - PDZ domain-like 50044 - SH3-domain | 0 | Direct |
48726,48726,56112 48726 - Immunoglobulin 48726 - Immunoglobulin 56112 - Protein kinase-like (PK-like) | 0 | Direct |
52058,52047,52058 52058 - L domain-like 52047 - RNI-like 52058 - L domain-like | 0 | Direct |
52047,52058,56112 52047 - RNI-like 52058 - L domain-like 56112 - Protein kinase-like (PK-like) | 0 | Direct |
48097,56112,50729 48097 - Regulator of G-protein signaling, RGS 56112 - Protein kinase-like (PK-like) 50729 - PH domain-like | 0 | Direct |
53850,53850,56112 53850 - Periplasmic binding protein-like II 53850 - Periplasmic binding protein-like II 56112 - Protein kinase-like (PK-like) | 0 | Direct |
56112,82615,82615 56112 - Protein kinase-like (PK-like) 82615 - Polo-box domain 82615 - Polo-box domain | 0 | Direct |
56112,116846,116846 56112 - Protein kinase-like (PK-like) 116846 - MIT domain 116846 - MIT domain | 0 | Direct |
57716,50156,56112 57716 - Glucocorticoid receptor-like (DNA-binding domain) 50156 - PDZ domain-like 56112 - Protein kinase-like (PK-like) | 0 | Direct |
52058,52058,52058 52058 - L domain-like 52058 - L domain-like 52058 - L domain-like | 0.0000000000639 | Direct |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.000001123 | Direct |
49265,48726,48726 49265 - Fibronectin type III 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.00003077 | Direct |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0.1042 | Inherited |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.2368 | Inherited |
Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
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A presence/absence matrix is generated using protein domains and supradomains
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