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Cysteine endopeptidases

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Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <6>
+ + 2:   Hydrolases [3] <13>(329|528) (368|389|207)
+ 1:   Acting on peptide bonds (peptide hydrolases) [3.4] <14>(102|148) (110|125|74)
0:   Cysteine endopeptidases [3.4.22] <71>(21|26) (22|21|12)
- 1:   Actinidain [3.4.22.14](0|0) (0|0|0)
- 1:   Adenain [3.4.22.39](1|1) (1|0|0)
- 1:   Ananain [3.4.22.31](0|0) (0|0|0)
- 1:   Asclepain [3.4.22.7](0|0) (0|0|0)
- 1:   Bleomycin hydrolase [3.4.22.40](0|1) (0|0|0)
- 1:   Calicivirin [3.4.22.66](4|2) (4|3|2)
- 1:   Calpain-1 [3.4.22.52](2|3) (2|2|1)
- 1:   Calpain-2 [3.4.22.53](2|3) (2|2|1)
- 1:   Calpain-3 [3.4.22.54](2|3) (2|1|0)
- 1:   Cancer procoagulant [3.4.22.26](0|0) (0|0|0)
- 1:   Caricain [3.4.22.30](0|0) (0|0|0)
- 1:   Caspase-1 [3.4.22.36](2|2) (2|1|0)
- 1:   Caspase-10 [3.4.22.63](0|0) (0|0|0)
- 1:   Caspase-11 [3.4.22.64](0|0) (0|0|0)
- 1:   Caspase-2 [3.4.22.55](0|0) (2|1|0)
- 1:   Caspase-3 [3.4.22.56](1|1) (1|0|0)
- 1:   Caspase-4 [3.4.22.57](0|0) (0|0|0)
- 1:   Caspase-5 [3.4.22.58](0|0) (0|0|0)
- 1:   Caspase-6 [3.4.22.59](0|0) (1|0|0)
- 1:   Caspase-7 [3.4.22.60](0|0) (1|0|0)
- 1:   Caspase-8 [3.4.22.61](0|0) (1|0|0)
- 1:   Caspase-9 [3.4.22.62](0|0) (0|0|0)
- 1:   Cathepsin B [3.4.22.1](0|1) (0|0|0)
- 1:   Cathepsin F [3.4.22.41](0|0) (0|0|0)
- 1:   Cathepsin H [3.4.22.16](0|1) (0|0|0)
- 1:   Cathepsin K [3.4.22.38](0|1) (0|0|0)
- 1:   Cathepsin L [3.4.22.15](0|1) (0|0|0)
- 1:   Cathepsin O [3.4.22.42](0|0) (0|0|0)
- 1:   Cathepsin S [3.4.22.27](0|0) (0|0|0)
- 1:   Cathepsin T [3.4.22.24](0|0) (0|0|0)
- 1:   Cathepsin V [3.4.22.43](0|0) (0|0|0)
- 1:   Chymopapain [3.4.22.6](0|0) (0|0|0)
- 1:   Clostripain [3.4.22.8](0|0) (0|0|0)
- 1:   Cruzipain [3.4.22.51](0|0) (0|0|0)
- 1:   Deleted entry [3.4.22.13](0|0) (0|0|0)
- 1:   Deleted entry [3.4.22.20](0|0) (0|0|0)
- 1:   Ficain [3.4.22.3](0|0) (0|0|0)
- 1:   Fruit bromelain [3.4.22.33](0|0) (0|0|0)
- 1:   Gingipain K [3.4.22.47](0|0) (1|0|0)
- 1:   Gingipain R [3.4.22.37](0|0) (0|0|0)
- 1:   Glycyl endopeptidase [3.4.22.25](0|0) (0|0|0)
- 1:   Helper-component proteinase [3.4.22.45](4|3) (4|2|0)
- 1:   Histolysain [3.4.22.35](0|0) (0|0|0)
- 1:   L-peptidase [3.4.22.46](1|2) (1|2|1)
- 1:   Legumain [3.4.22.34](0|0) (0|0|0)
- 1:   Nuclear-inclusion-a endopeptidase [3.4.22.44](3|2) (3|2|0)
- 1:   Papain [3.4.22.2](0|0) (0|0|0)
- 1:   Peptidase 1 (mite) [3.4.22.65](0|0) (0|0|0)
- 1:   Picornain 2A [3.4.22.29](5|4) (5|5|4)
- 1:   Picornain 3C [3.4.22.28](5|4) (6|7|6)
- 1:   SARS coronavirus main proteinase [3.4.22.69](10|10) (10|6|2)
- 1:   Separase [3.4.22.49](0|0) (0|0|0)
- 1:   Sortase A [3.4.22.70](0|0) (0|0|0)
- 1:   Sortase B [3.4.22.71](0|0) (0|0|0)
- 1:   Staphopain [3.4.22.48](1|1) (1|1|0)
- 1:   Stem bromelain [3.4.22.32](0|0) (0|0|0)
- 1:   Streptopain [3.4.22.10](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.19.9 [3.4.22.12](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.21.26 [3.4.22.18](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.21.48 [3.4.22.9](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.21.61 [3.4.22.23](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.22.32 and 3.4.22.33 [3.4.22.4](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.22.33 [3.4.22.5](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.22.52 and 3.4.22.53 [3.4.22.17](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.24.15 [3.4.22.19](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.24.37 [3.4.22.22](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.24.56 [3.4.22.11](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.25.1 [3.4.22.21](0|0) (0|0|0)
- 1:   Ulp1 peptidase [3.4.22.68](1|1) (1|0|0)
- 1:   V-cath endopeptidase [3.4.22.50](0|1) (0|0|0)
- 1:   Zingipain [3.4.22.67](0|0) (0|0|0)


Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term FDR (all) Annotation (direct or inherited)
DEATH domain0Direct
EF-hand0Direct
DNA/RNA polymerases0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Coronavirus NSP8-like0Direct
Caspase-like0Direct
Cystatin/monellin0Direct
Coronavirus NSP7-like0Direct
Positive stranded ssRNA viruses0Direct
Cysteine proteinases0Direct
Soluble domain of poliovirus core protein 3a0Direct
TMV-like viral coat proteins0Direct
Replicase NSP90Direct
SARS Nsp1-like0Direct
Coronavirus NSP10-like0Direct
NSP3A-like0Direct
Calpain large subunit, middle domain (domain III)0Direct
Trypsin-like serine proteases0Direct
EndoU-like0.000000000000001867Direct
S-adenosyl-L-methionine-dependent methyltransferases0.03493Inherited
Macro domain-like0.06619Inherited


Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP term FDR (all) Annotation (direct or inherited)
Coronavirus NSP8-like0Direct
Caspase catalytic domain0Direct
Nsp15 C-terminal domain-like0Direct
TMV-like viral coat proteins0Direct
Penta-EF-hand proteins0Direct
Replicase NSP90Direct
FMDV leader protease0Direct
Papain-like0Direct
Adenain-like0Direct
Nsp15 N-terminal domain-like0Direct
Calpain large subunit, catalytic domain (domain II)0Direct
Staphopain B, prodomain0Direct
RNA-dependent RNA-polymerase0Direct
Picornaviridae-like VP (VP1, VP2, VP3 and VP4)0Direct
SARS Nsp1-like0Direct
Gingipain R (RgpB), N-terminal domain0Direct
Soluble domain of poliovirus core protein 3a0Direct
Calpain large subunit, middle domain (domain III)0Direct
NSP3A-like0Direct
Macro domain0Direct
Coronavirus NSP7-like0Direct
Caliciviridae-like VP0Direct
Caspase recruitment domain, CARD0Direct
Coronavirus NSP10-like0Direct
Viral cysteine protease of trypsin fold0Direct
Viral proteases0.000000002829Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this EC term
Plot tree as:   Download Newick format tree:
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Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Coronavirus NSP8-like0Direct
EF-hand0Direct
Soluble domain of poliovirus core protein 3a0Direct
Calpain large subunit, middle domain (domain III)0Direct
Cystatin/monellin0Direct
Trypsin-like serine proteases0Direct
Positive stranded ssRNA viruses0Direct
Replicase NSP90Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
NSP3A-like0Direct
Caspase-like0Direct
TMV-like viral coat proteins0Direct
Viral leader polypeptide zinc finger0Direct
SARS Nsp1-like0Direct
Coronavirus NSP10-like0Direct
DEATH domain0Direct
Coronavirus NSP7-like0Direct
DNA/RNA polymerases0Direct
Cysteine proteinases0Direct
EndoU-like0.000000000000001395Direct
S-adenosyl-L-methionine-dependent methyltransferases0.03917Inherited
Macro domain-like0.05851Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
159936,52949
  • 159936 - NSP3A-like
  • 52949 - Macro domain-like
  • 0Direct
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0Direct
    54001,88633
  • 54001 - Cysteine proteinases
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    50494,56672
  • 50494 - Trypsin-like serine proteases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    88633,88633
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    56672,88633
  • 56672 - DNA/RNA polymerases
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    54403,54001
  • 54403 - Cystatin/monellin
  • 54001 - Cysteine proteinases
  • 0Direct
    52540,89043
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 0Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0Direct
    140367,143076
  • 140367 - Coronavirus NSP7-like
  • 143076 - Coronavirus NSP8-like
  • 0Direct
    89043,50494
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    88633,50494
  • 88633 - Positive stranded ssRNA viruses
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    53335,142877
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 142877 - EndoU-like
  • 0Direct
    49758,47473
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0Direct
    159936,53335
  • 159936 - NSP3A-like
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0Direct
    101816,144246
  • 101816 - Replicase NSP9
  • 144246 - Coronavirus NSP10-like
  • 0Direct
    143076,101816
  • 143076 - Coronavirus NSP8-like
  • 101816 - Replicase NSP9
  • 0Direct
    50494,52540
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000000000000001395Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000000001046Direct
    52540,56672
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56672 - DNA/RNA polymerases
  • 0.00004102Direct

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    89043,50494,56672
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 50494 - Trypsin-like serine proteases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    50494,52540,89043
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 0Direct
    140367,143076,101816
  • 140367 - Coronavirus NSP7-like
  • 143076 - Coronavirus NSP8-like
  • 101816 - Replicase NSP9
  • 0Direct
    50494,56672,88633
  • 50494 - Trypsin-like serine proteases
  • 56672 - DNA/RNA polymerases
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    88633,88633,88633
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    52540,89043,50494
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 89043 - Soluble domain of poliovirus core protein 3a
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    50494,52540,56672
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56672 - DNA/RNA polymerases
  • 0Direct
    54001,88633,88633
  • 54001 - Cysteine proteinases
  • 88633 - Positive stranded ssRNA viruses
  • 88633 - Positive stranded ssRNA viruses
  • 0Direct
    143076,101816,144246
  • 143076 - Coronavirus NSP8-like
  • 101816 - Replicase NSP9
  • 144246 - Coronavirus NSP10-like
  • 0Direct
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    54001,49758,47473
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0Direct
    88633,50494,52540
  • 88633 - Positive stranded ssRNA viruses
  • 50494 - Trypsin-like serine proteases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
    Plot tree as:   Download Newick format tree:
    (show help)