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Metalloendopeptidases

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Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <6>
+ + 2:   Hydrolases [3] <13>(329|528) (368|389|207)
+ 1:   Acting on peptide bonds (peptide hydrolases) [3.4] <14>(102|148) (110|125|74)
0:   Metalloendopeptidases [3.4.24] <87>(16|26) (18|17|11)
- 1:   3.4.24.30, 3.4.24.31, 3.4.24.32, 3.4.24.39 and 3.4 [3.4.24.4](0|0) (0|0|0)
- 1:   ADAM 17 endopeptidase [3.4.24.86](0|0) (1|1|0)
- 1:   ADAM10 endopeptidase [3.4.24.81](1|2) (1|1|0)
- 1:   ADAMTS-4 endopeptidase [3.4.24.82](1|2) (1|1|0)
- 1:   ADAMTS13 endopeptidase [3.4.24.87](0|0) (0|0|0)
- 1:   Adamalysin [3.4.24.46](0|0) (0|0|0)
- 1:   Anthrax lethal factor endopeptidase [3.4.24.83](0|0) (0|0|0)
- 1:   Astacin [3.4.24.21](1|2) (1|2|1)
- 1:   Atrolysin A [3.4.24.1](0|0) (0|0|0)
- 1:   Atrolysin B [3.4.24.41](0|0) (0|0|0)
- 1:   Atrolysin C [3.4.24.42](0|0) (0|0|0)
- 1:   Atrolysin E [3.4.24.44](0|0) (0|0|0)
- 1:   Atrolysin F [3.4.24.45](0|0) (0|0|0)
- 1:   Atroxase [3.4.24.43](0|0) (0|0|0)
- 1:   Aureolysin [3.4.24.29](0|0) (0|0|0)
- 1:   Bacillolysin [3.4.24.28](0|1) (0|0|0)
- 1:   Beta-lytic metalloendopeptidase [3.4.24.32](0|0) (0|0|0)
- 1:   Bontoxilysin [3.4.24.69](3|4) (3|3|2)
- 1:   Bothrolysin [3.4.24.50](0|0) (0|0|0)
- 1:   Bothropasin [3.4.24.49](0|0) (0|0|0)
- 1:   Choriolysin H [3.4.24.67](0|0) (0|0|0)
- 1:   Choriolysin L [3.4.24.66](0|0) (0|0|0)
- 1:   Coccolysin [3.4.24.30](0|0) (0|0|0)
- 1:   Dactylysin [3.4.24.60](0|0) (0|0|0)
- 1:   Deleted entry [3.4.24.9](0|0) (0|0|0)
- 1:   Deleted entry [3.4.24.2](0|0) (0|0|0)
- 1:   Deleted entry [3.4.24.10](0|0) (0|0|0)
- 1:   Deuterolysin [3.4.24.39](0|1) (0|0|0)
- 1:   Endothelin-converting enzyme 1 [3.4.24.71](0|1) (1|0|0)
- 1:   Envelysin [3.4.24.12](0|0) (0|0|0)
- 1:   Fibrolase [3.4.24.72](0|0) (0|0|0)
- 1:   Flavastacin [3.4.24.76](0|0) (0|0|0)
- 1:   Fragilysin [3.4.24.74](0|0) (0|0|0)
- 1:   GPR endopeptidase [3.4.24.78](1|1) (1|0|0)
- 1:   Gametolysin [3.4.24.38](0|0) (0|0|0)
- 1:   Gelatinase A [3.4.24.24](3|4) (3|3|3)
- 1:   Gelatinase B [3.4.24.35](3|4) (3|3|3)
- 1:   Horrilysin [3.4.24.47](0|0) (0|0|0)
- 1:   IgA-specific metalloendopeptidase [3.4.24.13](0|0) (0|0|0)
- 1:   Insulysin [3.4.24.56](1|1) (1|1|1)
- 1:   Interstitial collagenase [3.4.24.7](2|3) (2|2|1)
- 1:   Jararhagin [3.4.24.73](0|0) (0|0|0)
- 1:   Leishmanolysin [3.4.24.36](0|1) (0|0|0)
- 1:   Leucolysin [3.4.24.6](0|0) (0|0|0)
- 1:   Lysostaphin [3.4.24.75](1|1) (1|0|0)
- 1:   Macrophage elastase [3.4.24.65](0|0) (2|2|1)
- 1:   Magnolysin [3.4.24.62](0|0) (0|0|0)
- 1:   Matrilysin [3.4.24.23](0|0) (1|1|0)
- 1:   Membrane-type matrix metalloproteinase-1 [3.4.24.80](2|3) (2|2|1)
- 1:   Meprin A [3.4.24.18](0|0) (3|2|1)
- 1:   Meprin B [3.4.24.63](0|0) (2|2|1)
- 1:   Microbial collagenase [3.4.24.3](0|0) (0|0|0)
- 1:   Mitochondrial intermediate peptidase [3.4.24.59](0|1) (0|0|0)
- 1:   Mitochondrial processing peptidase [3.4.24.64](1|1) (1|1|0)
- 1:   Mucrolysin [3.4.24.54](0|0) (0|0|0)
- 1:   Mycolysin [3.4.24.31](0|0) (0|0|0)
- 1:   Nardilysin [3.4.24.61](0|0) (1|1|1)
- 1:   Neprilysin [3.4.24.11](0|1) (0|0|0)
- 1:   Neurolysin [3.4.24.16](0|1) (0|0|0)
- 1:   Neutrophil collagenase [3.4.24.34](0|0) (2|2|1)
- 1:   O-sialoglycoprotein endopeptidase [3.4.24.57](0|0) (0|0|0)
- 1:   Oligopeptidase A [3.4.24.70](0|0) (0|0|0)
- 1:   Ophiolysin [3.4.24.51](0|0) (0|0|0)
- 1:   Pappalysin-1 [3.4.24.79](0|0) (0|0|0)
- 1:   Peptidyl-Asp metalloendopeptidase [3.4.24.33](0|0) (0|0|0)
- 1:   Peptidyl-Lys metalloendopeptidase [3.4.24.20](0|0) (0|0|0)
- 1:   Pitrilysin [3.4.24.55](1|1) (1|1|1)
- 1:   Procollagen C-endopeptidase [3.4.24.19](0|0) (0|0|0)
- 1:   Procollagen N-endopeptidase [3.4.24.14](0|0) (1|2|1)
- 1:   Pseudolysin [3.4.24.26](0|0) (0|0|0)
- 1:   Ruberlysin [3.4.24.48](0|0) (0|0|0)
- 1:   Russellysin [3.4.24.58](0|0) (0|0|0)
- 1:   S2P endopeptidase [3.4.24.85](1|0) (1|0|0)
- 1:   Saccharolysin [3.4.24.37](0|0) (0|0|0)
- 1:   Serralysin [3.4.24.40](1|2) (1|1|0)
- 1:   Snapalysin [3.4.24.77](0|0) (0|0|0)
- 1:   Ste24 endopeptidase [3.4.24.84](0|0) (0|0|0)
- 1:   Stromelysin 1 [3.4.24.17](2|3) (2|2|1)
- 1:   Stromelysin 2 [3.4.24.22](0|0) (2|2|1)
- 1:   Tentoxilysin [3.4.24.68](0|0) (0|0|0)
- 1:   Thermolysin [3.4.24.27](0|0) (0|0|0)
- 1:   Thimet oligopeptidase [3.4.24.15](0|1) (0|0|0)
- 1:   Transferred entry: 3.4.22.52, 3.4.22.53 and 3.4.25 [3.4.24.5](0|0) (0|0|0)
- 1:   Transferred entry: 3.4.24.3 [3.4.24.8](0|0) (0|0|0)
- 1:   Trimerelysin I [3.4.24.52](0|0) (0|0|0)
- 1:   Trimerelysin II [3.4.24.53](0|0) (0|0|0)
- 1:   Vibriolysin [3.4.24.25](0|0) (0|0|0)


Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP term FDR (all) Annotation (direct or inherited)
STI-like0Direct
Clostridium neurotoxins, "coiled-coil" domain0Direct
beta-Roll0Direct
HybD-like0Direct
PGBD-like0Direct
Metalloproteases ("zincins"), catalytic domain0Direct
LuxS/MPP-like metallohydrolase0Direct
Hemopexin-like domain0Direct
TSP-1 type 1 repeat0Direct
Duplicated hybrid motif0Direct
Concanavalin A-like lectins/glucanases0Direct
Blood coagulation inhibitor (disintegrin)0Direct
Spermadhesin, CUB domain0.000000000008539Direct
TRAF domain-like0.0002316Direct
Kringle-like0.0002463Direct
PDZ domain-like0.3199Inherited


Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP term FDR (all) Annotation (direct or inherited)
Serralysin-like metalloprotease, C-terminal domain0Direct
Serralysin-like metalloprotease, catalytic (N-terminal) domain0Direct
Clostridium neurotoxins, the second last domain0Direct
TNF-alpha converting enzyme, TACE, catalytic domain0Direct
Hemopexin-like domain0Direct
Germination protease0Direct
Peptidoglycan hydrolase LytM0Direct
Clostridium neurotoxins, C-terminal domain0Direct
MPP-like0Direct
MMP N-terminal domain0Direct
Matrix metalloproteases, catalytic domain0Direct
Reprolysin-like0Direct
Thermolysin-like0Direct
Clostridium neurotoxins, "coiled-coil" domain0Direct
Astacin0Direct
TSP-1 type 1 repeat0Direct
Fungal zinc peptidase0Direct
Blood coagulation inhibitor (disintegrin)0Direct
Neurolysin-like0Direct
Neutral endopeptidase (neprilysin)0Direct
Clostridium neurotoxins, catalytic domain0Direct
Leishmanolysin0Direct
Fibronectin type II module0.0000000000116Direct
Spermadhesin, CUB domain0.0000000002308Direct
MAM domain0.000001251Direct
MATH domain0.0001226Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this EC term
Plot tree as:   Download Newick format tree:
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Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
TSP-1 type 1 repeat0Direct
PGBD-like0Direct
Duplicated hybrid motif0Direct
Metalloproteases ("zincins"), catalytic domain0Direct
HybD-like0Direct
Concanavalin A-like lectins/glucanases0Direct
STI-like0Direct
LuxS/MPP-like metallohydrolase0Direct
Blood coagulation inhibitor (disintegrin)0Direct
beta-Roll0Direct
Hemopexin-like domain0Direct
Clostridium neurotoxins, "coiled-coil" domain0Direct
Spermadhesin, CUB domain0.000000000006468Direct
TRAF domain-like0.0001945Direct
Kringle-like0.0002064Direct
EGF/Laminin0.1581Inherited
PDZ domain-like0.2948Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0Direct
    58091,49899
  • 58091 - Clostridium neurotoxins, "coiled-coil" domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    49899,50386
  • 49899 - Concanavalin A-like lectins/glucanases
  • 50386 - STI-like
  • 0Direct
    55486,82895
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    55486,49899
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    55486,51120
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 51120 - beta-Roll
  • 0Direct
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0Direct
    49854,82895
  • 49854 - Spermadhesin, CUB domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    55486,58091
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 58091 - Clostridium neurotoxins, "coiled-coil" domain
  • 0Direct
    55486,49854
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    55486,57440
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57440 - Kringle-like
  • 0Direct
    49899,49599
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49599 - TRAF domain-like
  • 0Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0000004023Direct
    49854,49854
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0.00005913Direct

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47090,55486,57440
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57440 - Kringle-like
  • 0Direct
    55486,58091,49899
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 58091 - Clostridium neurotoxins, "coiled-coil" domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    55486,49899,49599
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49599 - TRAF domain-like
  • 0Direct
    63411,63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0Direct
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    58091,49899,50386
  • 58091 - Clostridium neurotoxins, "coiled-coil" domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 50386 - STI-like
  • 0Direct
    55486,49854,49854
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    55486,57440,57440
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    55486,49854,82895
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 49854 - Spermadhesin, CUB domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0000000005229Direct


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
    Plot tree as:   Download Newick format tree:
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