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In phosphorous-containing anhydrides
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Enzyme Commission (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed. To navigate hierarchical structure of EC, we display all parental EC terms to the current EC term of interest ordered by their shortest distances to the current term. Also, only direct children EC terms of the current EC term are listed.
Structural Classification of Proteins (SCOP)
SCOP classifies evolutionary-related domains into Superfamily level and Family level. Accordingly, we have generated the domain-centric EC annotations for each of the three concepts at each of the two domain levels.
Structural Domain Enzyme Commission Ontology (SDEO)
As domain-centric ontology, SDEO only refers to those EC terms which are the most informative to annotate SCOP domains.
EC annotations for SCOP domains
For details, please visit Documentation: EC annotations for SCOP domains. Therein, we provide several relevant files ( Data Availability) for the download, including an annotation file (i.e., Domain2EC.txt) and the corresponding ontology (i.e., SDEO.txt).
Supra-domain Enzyme Commission Ontology (SPEO)
As an extension, SPEO includes those EC terms which are the most informative to annotate supra-domains and individual SCOP domains at the Superfamily level.
EC annotations for Supra-domains
For details, please visit Documentation: EC annotations for Supra-domains. Therein, we provide several relevant files ( Data Availability) for the download, including a annotation file (i.e., SP2EC.txt) and an ontology (i.e., SPEO.txt). For the sake of being browsable, listed below are those supra-domains (single, dual, triple, quad).
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this EC term
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Plot tree as:
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Download Newick format tree:
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(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
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(show details)
Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
101386,53720 101386 - all-alpha NTP pyrophosphatases 53720 - ALDH-like | 0 | DIRECT |
56983,81296 56983 - Viral glycoprotein, central and dimerisation domains 81296 - E set domains | 0 | DIRECT |
51283,51283 51283 - dUTPase-like 51283 - dUTPase-like | 0 | DIRECT |
53067,109604 53067 - Actin-like ATPase domain 109604 - HD-domain/PDEase-like | 0 | DIRECT |
50494,56672 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases | 0 | DIRECT |
52540,47370 52540 - P-loop containing nucleoside triphosphate hydrolases 47370 - Bromodomain | 0 | DIRECT |
88633,88633 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
55811,55811 55811 - Nudix 55811 - Nudix | 0 | DIRECT |
52540,89043 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
140586,55811 140586 - Dcp2 domain-like 55811 - Nudix | 0 | DIRECT |
101386,101386 101386 - all-alpha NTP pyrophosphatases 101386 - all-alpha NTP pyrophosphatases | 0 | DIRECT |
53335,56672 53335 - S-adenosyl-L-methionine-dependent methyltransferases 56672 - DNA/RNA polymerases | 0 | DIRECT |
89043,50494 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases | 0 | DIRECT |
50494,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
88633,50494 88633 - Positive stranded ssRNA viruses 50494 - Trypsin-like serine proteases | 0 | DIRECT |
102860,54197 102860 - mRNA decapping enzyme DcpS N-terminal domain 54197 - HIT-like | 0 | DIRECT |
141734,101386 141734 - HisI-like 101386 - all-alpha NTP pyrophosphatases | 0 | DIRECT |
53649,54060 53649 - Alkaline phosphatase-like 54060 - His-Me finger endonucleases | 3.502e-16 | DIRECT |
51283,46919 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase | 0.000000000000007766 | DIRECT |
53098,51283 53098 - Ribonuclease H-like 51283 - dUTPase-like | 0.000000000000007766 | DIRECT |
90188,53649 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like | 0.000000000000007766 | DIRECT |
90188,90188 90188 - Somatomedin B domain 90188 - Somatomedin B domain | 0.000000000000007766 | DIRECT |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.000000000000436 | DIRECT |
56300,55816 56300 - Metallo-dependent phosphatases 55816 - 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.00000000002377 | DIRECT |
54001,88633 54001 - Cysteine proteinases 88633 - Positive stranded ssRNA viruses | 0.0000000008292 | DIRECT |
56672,88633 56672 - DNA/RNA polymerases 88633 - Positive stranded ssRNA viruses | 0.000000009786 | DIRECT |
53335,52949 53335 - S-adenosyl-L-methionine-dependent methyltransferases 52949 - Macro domain-like | 0.00001248 | DIRECT |
46919,53098 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0.00001547 | DIRECT |
53098,50122 53098 - Ribonuclease H-like 50122 - DNA-binding domain of retroviral integrase | 0.00001822 | DIRECT |
50630,56672 50630 - Acid proteases 56672 - DNA/RNA polymerases | 0.00003112 | DIRECT |
56672,53098 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like | 0.0001403 | DIRECT |
52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0.6708 | INHERITED FROM: Nucleoside-triphosphatase |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Nucleoside-triphosphatase |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
101386,53720 101386 - all-alpha NTP pyrophosphatases 53720 - ALDH-like | 0 | Direct |
56983,81296 56983 - Viral glycoprotein, central and dimerisation domains 81296 - E set domains | 0 | Direct |
51283,51283 51283 - dUTPase-like 51283 - dUTPase-like | 0 | Direct |
53067,109604 53067 - Actin-like ATPase domain 109604 - HD-domain/PDEase-like | 0 | Direct |
50494,56672 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases | 0 | Direct |
52540,47370 52540 - P-loop containing nucleoside triphosphate hydrolases 47370 - Bromodomain | 0 | Direct |
88633,88633 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0 | Direct |
55811,55811 55811 - Nudix 55811 - Nudix | 0 | Direct |
52540,89043 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a | 0 | Direct |
140586,55811 140586 - Dcp2 domain-like 55811 - Nudix | 0 | Direct |
101386,101386 101386 - all-alpha NTP pyrophosphatases 101386 - all-alpha NTP pyrophosphatases | 0 | Direct |
53335,56672 53335 - S-adenosyl-L-methionine-dependent methyltransferases 56672 - DNA/RNA polymerases | 0 | Direct |
89043,50494 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases | 0 | Direct |
50494,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
88633,50494 88633 - Positive stranded ssRNA viruses 50494 - Trypsin-like serine proteases | 0 | Direct |
102860,54197 102860 - mRNA decapping enzyme DcpS N-terminal domain 54197 - HIT-like | 0 | Direct |
141734,101386 141734 - HisI-like 101386 - all-alpha NTP pyrophosphatases | 0 | Direct |
53649,54060 53649 - Alkaline phosphatase-like 54060 - His-Me finger endonucleases | 3.502e-16 | Direct |
51283,46919 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase | 0.000000000000007766 | Direct |
53098,51283 53098 - Ribonuclease H-like 51283 - dUTPase-like | 0.000000000000007766 | Direct |
90188,53649 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like | 0.000000000000007766 | Direct |
90188,90188 90188 - Somatomedin B domain 90188 - Somatomedin B domain | 0.000000000000007766 | Direct |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.000000000000436 | Direct |
56300,55816 56300 - Metallo-dependent phosphatases 55816 - 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.00000000002377 | Direct |
54001,88633 54001 - Cysteine proteinases 88633 - Positive stranded ssRNA viruses | 0.0000000008292 | Direct |
56672,88633 56672 - DNA/RNA polymerases 88633 - Positive stranded ssRNA viruses | 0.000000009786 | Direct |
53335,52949 53335 - S-adenosyl-L-methionine-dependent methyltransferases 52949 - Macro domain-like | 0.00001248 | Direct |
46919,53098 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0.00001547 | Direct |
53098,50122 53098 - Ribonuclease H-like 50122 - DNA-binding domain of retroviral integrase | 0.00001822 | Direct |
50630,56672 50630 - Acid proteases 56672 - DNA/RNA polymerases | 0.00003112 | Direct |
56672,53098 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like | 0.0001403 | Direct |
52540,56672 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0.6708 | Inherited |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
89043,50494,56672 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases | 0 | DIRECT |
50494,52540,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
53067,53067,109604 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 109604 - HD-domain/PDEase-like | 0 | DIRECT |
50494,52540,89043 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
50494,56672,88633 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases 88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
88633,88633,88633 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
52540,89043,50494 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases | 0 | DIRECT |
52540,52540,47370 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 47370 - Bromodomain | 0 | DIRECT |
50494,52540,56672 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | DIRECT |
141734,101386,53720 141734 - HisI-like 101386 - all-alpha NTP pyrophosphatases 53720 - ALDH-like | 0 | DIRECT |
88633,50494,52540 88633 - Positive stranded ssRNA viruses 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
90188,53649,54060 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like 54060 - His-Me finger endonucleases | 3.502e-16 | DIRECT |
53098,51283,46919 53098 - Ribonuclease H-like 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase | 0.000000000000007766 | DIRECT |
56672,53098,51283 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like 51283 - dUTPase-like | 0.000000000000007766 | DIRECT |
90188,90188,53649 90188 - Somatomedin B domain 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like | 0.000000000000007766 | DIRECT |
51283,46919,53098 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0.000000000000007766 | DIRECT |
54001,88633,88633 54001 - Cysteine proteinases 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0.0000000008292 | DIRECT |
46919,53098,50122 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like 50122 - DNA-binding domain of retroviral integrase | 0.00001309 | DIRECT |
50630,56672,53098 50630 - Acid proteases 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like | 0.00002484 | DIRECT |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
89043,50494,56672 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases | 0 | Direct |
50494,52540,52540 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
53067,53067,109604 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 109604 - HD-domain/PDEase-like | 0 | Direct |
50494,52540,89043 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a | 0 | Direct |
50494,56672,88633 50494 - Trypsin-like serine proteases 56672 - DNA/RNA polymerases 88633 - Positive stranded ssRNA viruses | 0 | Direct |
88633,88633,88633 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0 | Direct |
52540,89043,50494 52540 - P-loop containing nucleoside triphosphate hydrolases 89043 - Soluble domain of poliovirus core protein 3a 50494 - Trypsin-like serine proteases | 0 | Direct |
52540,52540,47370 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 47370 - Bromodomain | 0 | Direct |
50494,52540,56672 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases 56672 - DNA/RNA polymerases | 0 | Direct |
141734,101386,53720 141734 - HisI-like 101386 - all-alpha NTP pyrophosphatases 53720 - ALDH-like | 0 | Direct |
88633,50494,52540 88633 - Positive stranded ssRNA viruses 50494 - Trypsin-like serine proteases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
90188,53649,54060 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like 54060 - His-Me finger endonucleases | 3.502e-16 | Direct |
53098,51283,46919 53098 - Ribonuclease H-like 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase | 0.000000000000007766 | Direct |
56672,53098,51283 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like 51283 - dUTPase-like | 0.000000000000007766 | Direct |
90188,90188,53649 90188 - Somatomedin B domain 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like | 0.000000000000007766 | Direct |
51283,46919,53098 51283 - dUTPase-like 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like | 0.000000000000007766 | Direct |
54001,88633,88633 54001 - Cysteine proteinases 88633 - Positive stranded ssRNA viruses 88633 - Positive stranded ssRNA viruses | 0.0000000008292 | Direct |
46919,53098,50122 46919 - N-terminal Zn binding domain of HIV integrase 53098 - Ribonuclease H-like 50122 - DNA-binding domain of retroviral integrase | 0.00001309 | Direct |
50630,56672,53098 50630 - Acid proteases 56672 - DNA/RNA polymerases 53098 - Ribonuclease H-like | 0.00002484 | Direct |
Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
|
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|