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Carbon-oxygen lyases
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Enzyme Commission (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed. To navigate hierarchical structure of EC, we display all parental EC terms to the current EC term of interest ordered by their shortest distances to the current term. Also, only direct children EC terms of the current EC term are listed.
Structural Classification of Proteins (SCOP)
SCOP classifies evolutionary-related domains into Superfamily level and Family level. Accordingly, we have generated the domain-centric EC annotations for each of the three concepts at each of the two domain levels.
Structural Domain Enzyme Commission Ontology (SDEO)
As domain-centric ontology, SDEO only refers to those EC terms which are the most informative to annotate SCOP domains.
EC annotations for SCOP domains
For details, please visit Documentation: EC annotations for SCOP domains. Therein, we provide several relevant files ( Data Availability) for the download, including an annotation file (i.e., Domain2EC.txt) and the corresponding ontology (i.e., SDEO.txt).
Supra-domain Enzyme Commission Ontology (SPEO)
As an extension, SPEO includes those EC terms which are the most informative to annotate supra-domains and individual SCOP domains at the Superfamily level.
EC annotations for Supra-domains
For details, please visit Documentation: EC annotations for Supra-domains. Therein, we provide several relevant files ( Data Availability) for the download, including a annotation file (i.e., SP2EC.txt) and an ontology (i.e., SPEO.txt). For the sake of being browsable, listed below are those supra-domains (single, dual, triple, quad).
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (Not in SDEO)
Highlighted in gray are those with FDR_all>0.001
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this (Not in SDEO)
Highlighted in gray are those with FDR_all>0.001
SCOP term |
FDR (all) |
Annotation (direct or inherited) |
Rhamnogalacturonase B, RhgB, middle domain | 0 | DIRECT |
N-terminal domain of MutM-like DNA repair proteins | 0 | DIRECT |
Enolase N-terminal domain-like | 0 | DIRECT |
Dimeric chorismate mutase | 0 | DIRECT |
Crotonase-like | 0 | DIRECT |
C-terminal, Zn-finger domain of MutM-like DNA repair proteins | 0 | DIRECT |
HCDH C-domain-like | 0 | DIRECT |
Cyanase N-terminal domain | 0 | DIRECT |
MaoC-like | 0 | DIRECT |
lvD/EDD N-terminal domain-like | 0 | DIRECT |
Histidinol phosphatase-like | 0 | DIRECT |
Urocanase | 0 | DIRECT |
IlvD/EDD C-terminal domain-like | 0 | DIRECT |
Middle domain of MutM-like DNA repair proteins | 0 | DIRECT |
Type II 3-dehydroquinate dehydratase | 0 | DIRECT |
Chorismate synthase, AroC | 0 | DIRECT |
Terpenoid cyclase C-terminal domain | 0 | DIRECT |
2-methylcitrate dehydratase PrpD | 0 | DIRECT |
Bacterial muramidase, catalytic domain | 0 | DIRECT |
UxuA-like | 0 | DIRECT |
beta-Hydroxydecanol thiol ester dehydrase | 0 | DIRECT |
Endonuclease III | 0 | DIRECT |
Rhamnogalacturonase B, RhgB, N-terminal domain | 0 | DIRECT |
FumA C-terminal domain-like | 0 | DIRECT |
Dehydroquinate synthase, DHQS | 0 | DIRECT |
Methylglyoxal synthase, MgsA | 0 | DIRECT |
Enolase | 0 | DIRECT |
Rhamnogalacturonase B, RhgB, C-terminal domain | 0 | DIRECT |
Terpenoid cyclase N-terminal domain | 0 | DIRECT |
6-pyruvoyl tetrahydropterin synthase | 0 | DIRECT |
Aconitase iron-sulfur domain | 0 | DIRECT |
LeuD-like | 0 | DIRECT |
PCD-like | 0 | DIRECT |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
Pectin lyase | 0 | DIRECT |
Cyanase C-terminal domain | 0 | DIRECT |
Aristolochene/pentalenene synthase | 0 | DIRECT |
Alginate lyase A1-III | 0 | DIRECT |
mono-SIS domain | 0 | DIRECT |
beta-carbonic anhydrase, cab | 0 | DIRECT |
AgoG-like | 0 | DIRECT |
Aconitase B, N-terminal domain | 0 | DIRECT |
Trichodiene synthase | 0 | DIRECT |
Pectate lyase-like | 0 | DIRECT |
DJ-1/PfpI | 0 | DIRECT |
YjeF C-terminal domain-like | 0 | DIRECT |
Hyaluronate lyase-like catalytic, N-terminal domain | 0 | DIRECT |
HemD-like | 0 | DIRECT |
Carbonic anhydrase | 0 | DIRECT |
Hyaluronate lyase-like, central domain | 0 | DIRECT |
Imidazole glycerol phosphate dehydratase | 0 | DIRECT |
D-glucarate dehydratase-like | 0 | DIRECT |
Hypothetical protein VC1974 | 0 | DIRECT |
5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) | 0 | DIRECT |
6-phosphogluconate dehydrogenase-like, N-terminal domain | 0 | DIRECT |
Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
Phosphate binding protein-like | 0.00000000000001851 | DIRECT |
Shikimate kinase (AroK) | 0.00000000000002609 | DIRECT |
AraD-like aldolase/epimerase | 0.000000000000037 | DIRECT |
DNase I-like | 0.000000000001978 | DIRECT |
Phenylalanine metabolism regulatory domain | 0.000000000002069 | DIRECT |
Nitrile hydratase beta chain | 0.000000000007147 | DIRECT |
Nitrile hydratase alpha chain | 0.000000000007147 | DIRECT |
Shikimate dehydrogenase-like | 0.00000000006722 | DIRECT |
Acyl-carrier protein (ACP) | 0.000000039 | DIRECT |
DNA repair glycosylase, N-terminal domain | 0.0000009581 | DIRECT |
Class I aldolase | 0.000001643 | DIRECT |
DNA repair glycosylase, 2 C-terminal domains | 0.000002634 | DIRECT |
Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.0000441 | DIRECT |
FabD-like | 0.0003684 | DIRECT |
Terpene synthases | 0.003186 | INHERITED FROM: Squalene--hopanol cyclase || Hydro-lyases |
CBS-domain pair | 0.009939 | INHERITED FROM: Cystathionine beta-synthase |
Tryptophan biosynthesis enzymes | 0.02023 | INHERITED FROM: Tryptophan synthase || Hydro-lyases |
FAH | 0.1648 | INHERITED FROM: 2-oxopent-4-enoate hydratase || Hydro-lyases |
Tyrosine-dependent oxidoreductases | 0.1661 | INHERITED FROM: Enoyl-CoA hydratase 2 || dTDP-glucose 4,6-dehydratase || GDP-mannose 4,6-dehydratase || 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
Enolase-phosphatase E1 | 0.2985 | INHERITED FROM: Methylthioribulose 1-phosphate dehydratase |
Enolpyruvate transferase, EPT | 0.354 | INHERITED FROM: 3-dehydroquinate dehydratase || 3-dehydroquinate synthase || Acting on phosphates |
Thiolase-related | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
Alcohol dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
Cytochrome P450 | 1 | INHERITED FROM: Hydroperoxide dehydratase |
Alcohol dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
Aminoacid dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: 3-dehydroquinate dehydratase || 3-dehydroquinate synthase |
L-aspartase/fumarase | 1 | INHERITED FROM: Fumarate hydratase || Hydro-lyases |
SCOP term |
FDR (all) |
Annotation (direct or inherited) |
Rhamnogalacturonase B, RhgB, middle domain | 0 | Direct |
N-terminal domain of MutM-like DNA repair proteins | 0 | Direct |
Enolase N-terminal domain-like | 0 | Direct |
Dimeric chorismate mutase | 0 | Direct |
Crotonase-like | 0 | Direct |
C-terminal, Zn-finger domain of MutM-like DNA repair proteins | 0 | Direct |
HCDH C-domain-like | 0 | Direct |
Cyanase N-terminal domain | 0 | Direct |
MaoC-like | 0 | Direct |
lvD/EDD N-terminal domain-like | 0 | Direct |
Histidinol phosphatase-like | 0 | Direct |
Urocanase | 0 | Direct |
IlvD/EDD C-terminal domain-like | 0 | Direct |
Middle domain of MutM-like DNA repair proteins | 0 | Direct |
Type II 3-dehydroquinate dehydratase | 0 | Direct |
Chorismate synthase, AroC | 0 | Direct |
Terpenoid cyclase C-terminal domain | 0 | Direct |
2-methylcitrate dehydratase PrpD | 0 | Direct |
Bacterial muramidase, catalytic domain | 0 | Direct |
UxuA-like | 0 | Direct |
beta-Hydroxydecanol thiol ester dehydrase | 0 | Direct |
Endonuclease III | 0 | Direct |
Rhamnogalacturonase B, RhgB, N-terminal domain | 0 | Direct |
FumA C-terminal domain-like | 0 | Direct |
Dehydroquinate synthase, DHQS | 0 | Direct |
Methylglyoxal synthase, MgsA | 0 | Direct |
Enolase | 0 | Direct |
Rhamnogalacturonase B, RhgB, C-terminal domain | 0 | Direct |
Terpenoid cyclase N-terminal domain | 0 | Direct |
6-pyruvoyl tetrahydropterin synthase | 0 | Direct |
Aconitase iron-sulfur domain | 0 | Direct |
LeuD-like | 0 | Direct |
PCD-like | 0 | Direct |
Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
Pectin lyase | 0 | Direct |
Cyanase C-terminal domain | 0 | Direct |
Aristolochene/pentalenene synthase | 0 | Direct |
Alginate lyase A1-III | 0 | Direct |
mono-SIS domain | 0 | Direct |
beta-carbonic anhydrase, cab | 0 | Direct |
AgoG-like | 0 | Direct |
Aconitase B, N-terminal domain | 0 | Direct |
Trichodiene synthase | 0 | Direct |
Pectate lyase-like | 0 | Direct |
DJ-1/PfpI | 0 | Direct |
YjeF C-terminal domain-like | 0 | Direct |
Hyaluronate lyase-like catalytic, N-terminal domain | 0 | Direct |
HemD-like | 0 | Direct |
Carbonic anhydrase | 0 | Direct |
Hyaluronate lyase-like, central domain | 0 | Direct |
Imidazole glycerol phosphate dehydratase | 0 | Direct |
D-glucarate dehydratase-like | 0 | Direct |
Hypothetical protein VC1974 | 0 | Direct |
5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) | 0 | Direct |
6-phosphogluconate dehydrogenase-like, N-terminal domain | 0 | Direct |
Hyaluronate lyase-like, C-terminal domain | 0 | Direct |
Phosphate binding protein-like | 0.00000000000001851 | Direct |
Shikimate kinase (AroK) | 0.00000000000002609 | Direct |
AraD-like aldolase/epimerase | 0.000000000000037 | Direct |
DNase I-like | 0.000000000001978 | Direct |
Phenylalanine metabolism regulatory domain | 0.000000000002069 | Direct |
Nitrile hydratase beta chain | 0.000000000007147 | Direct |
Nitrile hydratase alpha chain | 0.000000000007147 | Direct |
Shikimate dehydrogenase-like | 0.00000000006722 | Direct |
Acyl-carrier protein (ACP) | 0.000000039 | Direct |
DNA repair glycosylase, N-terminal domain | 0.0000009581 | Direct |
Class I aldolase | 0.000001643 | Direct |
DNA repair glycosylase, 2 C-terminal domains | 0.000002634 | Direct |
Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.0000441 | Direct |
FabD-like | 0.0003684 | Direct |
Terpene synthases | 0.003186 | Inherited |
CBS-domain pair | 0.009939 | Inherited |
Tryptophan biosynthesis enzymes | 0.02023 | Inherited |
FAH | 0.1648 | Inherited |
Tyrosine-dependent oxidoreductases | 0.1661 | Inherited |
Enolase-phosphatase E1 | 0.2985 | Inherited |
Enolpyruvate transferase, EPT | 0.354 | Inherited |
Thiolase-related | 1 | Inherited |
Alcohol dehydrogenase-like, N-terminal domain | 1 | Inherited |
Cytochrome P450 | 1 | Inherited |
Alcohol dehydrogenase-like, C-terminal domain | 1 | Inherited |
Aminoacid dehydrogenase-like, C-terminal domain | 1 | Inherited |
L-aspartase/fumarase | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this EC term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
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(show details)
Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55205,52540 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48230,74650 48230 - Chondroitin AC/alginate lyase 74650 - Galactose mutarotase-like | 0 | DIRECT |
53732,52016 53732 - Aconitase iron-sulfur domain 52016 - LeuD/IlvD-like | 0 | DIRECT |
51735,54637 51735 - NAD(P)-binding Rossmann-fold domains 54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
49452,49785 49452 - Starch-binding domain-like 49785 - Galactose-binding domain-like | 0 | DIRECT |
53850,53955 53850 - Periplasmic binding protein-like II 53955 - Lysozyme-like | 0 | DIRECT |
56784,54211 56784 - HAD-like 54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
54637,55718 54637 - Thioesterase/thiol ester dehydrase-isomerase 55718 - SCP-like | 0 | DIRECT |
51569,53223 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
53686,54631 53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes 54631 - CBS-domain pair | 0 | DIRECT |
48600,53850 48600 - Chorismate mutase II 53850 - Periplasmic binding protein-like II | 0 | DIRECT |
52016,53732 52016 - LeuD/IlvD-like 53732 - Aconitase iron-sulfur domain | 0 | DIRECT |
52540,51569 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase | 0 | DIRECT |
51366,53686 51366 - Ribulose-phoshate binding barrel 53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
51735,48179 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
47413,55234 47413 - lambda repressor-like DNA-binding domains 55234 - Cyanase C-terminal domain | 0 | DIRECT |
74650,49863 74650 - Galactose mutarotase-like 49863 - Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
46946,57716 46946 - S13-like H2TH domain 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
53639,56784 53639 - AraD/HMP-PK domain-like 56784 - HAD-like | 0 | DIRECT |
54637,52151 54637 - Thioesterase/thiol ester dehydrase-isomerase 52151 - FabD/lysophospholipase-like | 0 | DIRECT |
48239,48239 48239 - Terpenoid cyclases/Protein prenyltransferases 48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
81624,46946 81624 - N-terminal domain of MutM-like DNA repair proteins 46946 - S13-like H2TH domain | 0 | DIRECT |
143975,52016 143975 - IlvD/EDD N-terminal domain-like 52016 - LeuD/IlvD-like | 0 | DIRECT |
52096,51735 52096 - ClpP/crotonase 51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
53697,46934 53697 - SIS domain 46934 - UBA-like | 0 | DIRECT |
74778,52016 74778 - Aconitase B, N-terminal domain 52016 - LeuD/IlvD-like | 0 | DIRECT |
53850,55021 53850 - Periplasmic binding protein-like II 55021 - ACT-like | 0 | DIRECT |
54211,54211 54211 - Ribosomal protein S5 domain 2-like 54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
48179,48179 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
48435,53955 48435 - Bacterial muramidases 53955 - Lysozyme-like | 0 | DIRECT |
74650,49452 74650 - Galactose mutarotase-like 49452 - Starch-binding domain-like | 0 | DIRECT |
56796,55205 56796 - Dehydroquinate synthase-like 55205 - EPT/RTPC-like | 0 | DIRECT |
54826,51604 54826 - Enolase N-terminal domain-like 51604 - Enolase C-terminal domain-like | 0 | DIRECT |
48239,48576 48239 - Terpenoid cyclases/Protein prenyltransferases 48576 - Terpenoid synthases | 0 | DIRECT |
54637,54637 54637 - Thioesterase/thiol ester dehydrase-isomerase 54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.0000000249 | DIRECT |
47336,53474 47336 - ACP-like 53474 - alpha/beta-Hydrolases | 0.0000001897 | DIRECT |
55945,48150 55945 - TATA-box binding protein-like 48150 - DNA-glycosylase | 0.0000007164 | DIRECT |
51735,51735 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains | 0.000007789 | DIRECT |
48179,52096 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 52096 - ClpP/crotonase | 0.000009901 | DIRECT |
51735,47336 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like | 0.0009253 | DIRECT |
52151,55048 52151 - FabD/lysophospholipase-like 55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.04164 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0.6452 | INHERITED FROM: 3-dehydroquinate dehydratase || 3-dehydroquinate synthase || Acting on phosphates |
50129,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55205,52540 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48230,74650 48230 - Chondroitin AC/alginate lyase 74650 - Galactose mutarotase-like | 0 | Direct |
53732,52016 53732 - Aconitase iron-sulfur domain 52016 - LeuD/IlvD-like | 0 | Direct |
51735,54637 51735 - NAD(P)-binding Rossmann-fold domains 54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
49452,49785 49452 - Starch-binding domain-like 49785 - Galactose-binding domain-like | 0 | Direct |
53850,53955 53850 - Periplasmic binding protein-like II 53955 - Lysozyme-like | 0 | Direct |
56784,54211 56784 - HAD-like 54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
54637,55718 54637 - Thioesterase/thiol ester dehydrase-isomerase 55718 - SCP-like | 0 | Direct |
51569,53223 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
53686,54631 53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes 54631 - CBS-domain pair | 0 | Direct |
48600,53850 48600 - Chorismate mutase II 53850 - Periplasmic binding protein-like II | 0 | Direct |
52016,53732 52016 - LeuD/IlvD-like 53732 - Aconitase iron-sulfur domain | 0 | Direct |
52540,51569 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase | 0 | Direct |
51366,53686 51366 - Ribulose-phoshate binding barrel 53686 - Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
51735,48179 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
47413,55234 47413 - lambda repressor-like DNA-binding domains 55234 - Cyanase C-terminal domain | 0 | Direct |
74650,49863 74650 - Galactose mutarotase-like 49863 - Hyaluronate lyase-like, C-terminal domain | 0 | Direct |
46946,57716 46946 - S13-like H2TH domain 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
53639,56784 53639 - AraD/HMP-PK domain-like 56784 - HAD-like | 0 | Direct |
54637,52151 54637 - Thioesterase/thiol ester dehydrase-isomerase 52151 - FabD/lysophospholipase-like | 0 | Direct |
48239,48239 48239 - Terpenoid cyclases/Protein prenyltransferases 48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
81624,46946 81624 - N-terminal domain of MutM-like DNA repair proteins 46946 - S13-like H2TH domain | 0 | Direct |
143975,52016 143975 - IlvD/EDD N-terminal domain-like 52016 - LeuD/IlvD-like | 0 | Direct |
52096,51735 52096 - ClpP/crotonase 51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
53697,46934 53697 - SIS domain 46934 - UBA-like | 0 | Direct |
74778,52016 74778 - Aconitase B, N-terminal domain 52016 - LeuD/IlvD-like | 0 | Direct |
53850,55021 53850 - Periplasmic binding protein-like II 55021 - ACT-like | 0 | Direct |
54211,54211 54211 - Ribosomal protein S5 domain 2-like 54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
48179,48179 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
48435,53955 48435 - Bacterial muramidases 53955 - Lysozyme-like | 0 | Direct |
74650,49452 74650 - Galactose mutarotase-like 49452 - Starch-binding domain-like | 0 | Direct |
56796,55205 56796 - Dehydroquinate synthase-like 55205 - EPT/RTPC-like | 0 | Direct |
54826,51604 54826 - Enolase N-terminal domain-like 51604 - Enolase C-terminal domain-like | 0 | Direct |
48239,48576 48239 - Terpenoid cyclases/Protein prenyltransferases 48576 - Terpenoid synthases | 0 | Direct |
54637,54637 54637 - Thioesterase/thiol ester dehydrase-isomerase 54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.0000000249 | Direct |
47336,53474 47336 - ACP-like 53474 - alpha/beta-Hydrolases | 0.0000001897 | Direct |
55945,48150 55945 - TATA-box binding protein-like 48150 - DNA-glycosylase | 0.0000007164 | Direct |
51735,51735 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains | 0.000007789 | Direct |
48179,52096 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 52096 - ClpP/crotonase | 0.000009901 | Direct |
51735,47336 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like | 0.0009253 | Direct |
52151,55048 52151 - FabD/lysophospholipase-like 55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.04164 | Inherited |
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0.6452 | Inherited |
50129,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56796,55205,52540 56796 - Dehydroquinate synthase-like 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51735,54637,54637 51735 - NAD(P)-binding Rossmann-fold domains 54637 - Thioesterase/thiol ester dehydrase-isomerase 54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
51735,48179,48179 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
51735,51735,54637 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains 54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
48239,48239,48576 48239 - Terpenoid cyclases/Protein prenyltransferases 48239 - Terpenoid cyclases/Protein prenyltransferases 48576 - Terpenoid synthases | 0 | DIRECT |
54637,54637,55718 54637 - Thioesterase/thiol ester dehydrase-isomerase 54637 - Thioesterase/thiol ester dehydrase-isomerase 55718 - SCP-like | 0 | DIRECT |
74650,49452,49785 74650 - Galactose mutarotase-like 49452 - Starch-binding domain-like 49785 - Galactose-binding domain-like | 0 | DIRECT |
51569,53223,51735 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
81624,46946,57716 81624 - N-terminal domain of MutM-like DNA repair proteins 46946 - S13-like H2TH domain 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
74778,52016,53732 74778 - Aconitase B, N-terminal domain 52016 - LeuD/IlvD-like 53732 - Aconitase iron-sulfur domain | 0 | DIRECT |
55205,52540,51569 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase | 0 | DIRECT |
48600,53850,55021 48600 - Chorismate mutase II 53850 - Periplasmic binding protein-like II 55021 - ACT-like | 0 | DIRECT |
52096,51735,48179 52096 - ClpP/crotonase 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | DIRECT |
56784,54211,54211 56784 - HAD-like 54211 - Ribosomal protein S5 domain 2-like 54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
52540,51569,53223 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
48230,74650,49863 48230 - Chondroitin AC/alginate lyase 74650 - Galactose mutarotase-like 49863 - Hyaluronate lyase-like, C-terminal domain | 0 | DIRECT |
51735,47336,53474 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like 53474 - alpha/beta-Hydrolases | 0.00000002889 | DIRECT |
48179,48179,52096 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 52096 - ClpP/crotonase | 0.000009901 | DIRECT |
50129,51735,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains | 0.000019 | DIRECT |
51735,51735,47336 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like | 0.0005297 | DIRECT |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56796,55205,52540 56796 - Dehydroquinate synthase-like 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51735,54637,54637 51735 - NAD(P)-binding Rossmann-fold domains 54637 - Thioesterase/thiol ester dehydrase-isomerase 54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
51735,48179,48179 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
51735,51735,54637 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains 54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
48239,48239,48576 48239 - Terpenoid cyclases/Protein prenyltransferases 48239 - Terpenoid cyclases/Protein prenyltransferases 48576 - Terpenoid synthases | 0 | Direct |
54637,54637,55718 54637 - Thioesterase/thiol ester dehydrase-isomerase 54637 - Thioesterase/thiol ester dehydrase-isomerase 55718 - SCP-like | 0 | Direct |
74650,49452,49785 74650 - Galactose mutarotase-like 49452 - Starch-binding domain-like 49785 - Galactose-binding domain-like | 0 | Direct |
51569,53223,51735 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
81624,46946,57716 81624 - N-terminal domain of MutM-like DNA repair proteins 46946 - S13-like H2TH domain 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
74778,52016,53732 74778 - Aconitase B, N-terminal domain 52016 - LeuD/IlvD-like 53732 - Aconitase iron-sulfur domain | 0 | Direct |
55205,52540,51569 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase | 0 | Direct |
48600,53850,55021 48600 - Chorismate mutase II 53850 - Periplasmic binding protein-like II 55021 - ACT-like | 0 | Direct |
52096,51735,48179 52096 - ClpP/crotonase 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like | 0 | Direct |
56784,54211,54211 56784 - HAD-like 54211 - Ribosomal protein S5 domain 2-like 54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
52540,51569,53223 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
48230,74650,49863 48230 - Chondroitin AC/alginate lyase 74650 - Galactose mutarotase-like 49863 - Hyaluronate lyase-like, C-terminal domain | 0 | Direct |
51735,47336,53474 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like 53474 - alpha/beta-Hydrolases | 0.00000002889 | Direct |
48179,48179,52096 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 52096 - ClpP/crotonase | 0.000009901 | Direct |
50129,51735,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains | 0.000019 | Direct |
51735,51735,47336 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like | 0.0005297 | Direct |
Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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