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Acid--D-amino-acid ligases (peptide synthases)

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <6>
+ + 2:   Ligases [6] <6>(80|99) (88|104|66)
+ 1:   Forming carbon-nitrogen bonds [6.3] <5>(45|56) (51|54|37)
0:   Acid--D-amino-acid ligases (peptide synthases) [6.3.2] <42>(18|23) (19|18|11)
- 1:   4-phosphopantoate--beta-alanine ligase [6.3.2.36](0|0) (0|0|0)
- 1:   Aerobactin synthase [6.3.2.27](0|0) (0|0|0)
- 1:   Alpha-aminoadipate--LysW ligase [6.3.2.n4](0|0) (0|0|0)
- 1:   Carnosine synthase [6.3.2.11](0|0) (0|0|0)
- 1:   Coenzyme F420-0:L-glutamate ligase [6.3.2.31](0|0) (0|0|0)
- 1:   Coenzyme F420-1:gamma-L-glutamate ligase [6.3.2.34](0|0) (0|0|0)
- 1:   Coenzyme gamma-F420-2:alpha-L-glutamate ligase [6.3.2.32](0|0) (0|0|0)
- 1:   Cyanophycin synthase (L-arginine-adding) [6.3.2.30](1|0) (1|1|1)
- 1:   Cyanophycin synthase (L-aspartate-adding) [6.3.2.29](1|0) (1|1|1)
- 1:   D-alanine--D-alanine ligase [6.3.2.4](2|2) (2|2|2)
- 1:   D-alanine--D-serine ligase [6.3.2.35](0|0) (0|0|0)
- 1:   D-alanine--alanyl-poly(glycerolphosphate) ligase [6.3.2.16](0|0) (0|0|0)
- 1:   Dihydrofolate synthase [6.3.2.12](0|0) (0|0|0)
- 1:   Enterobactin synthase [6.3.2.14](0|0) (0|0|0)
- 1:   Gamma-glutamylhistamine synthase [6.3.2.18](0|0) (0|0|0)
- 1:   Glutamate--cysteine ligase [6.3.2.2](1|1) (1|1|0)
- 1:   Glutathione synthase [6.3.2.3](3|5) (3|3|0)
- 1:   Homoglutathione synthase [6.3.2.23](0|0) (0|0|0)
- 1:   ISG15--protein ligase [6.3.2.n3](0|0) (0|0|0)
- 1:   Indoleacetate--lysine synthetase [6.3.2.20](0|0) (0|0|0)
- 1:   L-amino-acid alpha-ligase [6.3.2.28](0|0) (0|0|0)
- 1:   N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin [6.3.2.26](4|3) (4|5|5)
- 1:   Pantoate--beta-alanine ligase [6.3.2.1](1|2) (1|1|0)
- 1:   Pantoate--beta-alanine ligase (ADP-forming) [6.3.2.n5](0|0) (0|0|0)
- 1:   Phosphopantothenate--cysteine ligase [6.3.2.5](2|2) (2|1|0)
- 1:   Phosphoribosylaminoimidazolesuccinocarboxamide syn [6.3.2.6](2|2) (2|1|0)
- 1:   Pup--protein ligase [6.3.2.n2](0|0) (0|0|0)
- 1:   Tetrahydrofolate synthase [6.3.2.17](2|2) (2|1|0)
- 1:   Tetrahydrosarcinapterin synthase [6.3.2.33](0|0) (0|0|0)
- 1:   Transferred entry: 6.3.1.14 [6.3.2.22](0|0) (0|0|0)
- 1:   Transferred entry: 6.3.2.10 [6.3.2.15](0|0) (0|0|0)
- 1:   Transferred entry: 6.3.2.37 [6.3.2.n1](0|0) (0|0|0)
- 1:   Tubulin--tyrosine ligase [6.3.2.25](1|0) (1|0|0)
- 1:   Tyrosine--arginine ligase [6.3.2.24](0|0) (0|0|0)
- 1:   UDP-N-acetylmuramate--L-alanine ligase [6.3.2.8](3|3) (3|3|3)
- 1:   UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase [6.3.2.9](3|3) (3|3|2)
- 1:   UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-dia [6.3.2.13](3|3) (3|2|1)
- 1:   UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysin [6.3.2.37](0|0) (0|0|0)
- 1:   UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysin [6.3.2.7](3|3) (3|2|1)
- 1:   UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanin [6.3.2.10](3|2) (3|2|1)
- 1:   Ubiquitin--calmodulin ligase [6.3.2.21](0|0) (0|0|0)
- 1:   Ubiquitin--protein ligase [6.3.2.19](2|1) (3|1|0)


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Superfamily

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SCOP term FDR (all) Annotation (direct or inherited)
UBC-like0Direct
MurD-like peptide ligases, peptide-binding domain0Direct
SAICAR synthase-like0Direct
Glutathione synthetase ATP-binding domain-like0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0Direct
MurD-like peptide ligases, catalytic domain0Direct
Nucleotidylyl transferase0Direct
MurE/MurF N-terminal domain0Direct
CoaB-like0Direct
MurCD N-terminal domain0Direct
PreATP-grasp domain0Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0.00000009136Direct
UBA-like0.0001583Direct
ACP-like0.01316Inherited
Glutamine synthetase/guanido kinase0.03504Inherited
CoA-dependent acyltransferases0.08881Inherited
Acetyl-CoA synthetase-like0.7567Inherited
alpha/beta-Hydrolases1Inherited


Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP term FDR (all) Annotation (direct or inherited)
Glutamate-cysteine ligase0Direct
D-Alanine ligase N-terminal domain0Direct
MurE/MurF N-terminal domain0Direct
Folylpolyglutamate synthetase, C-terminal domain0Direct
Folylpolyglutamate synthetase0Direct
Eukaryotic glutathione synthetase, substrate-binding domain0Direct
ATP-binding domain of peptide synthetases0Direct
UBC-related0Direct
Lysine biosynthesis enzyme LysX ATP-binding domain0Direct
MurCDEF C-terminal domain0Direct
Eukaryotic glutathione synthetase ATP-binding domain0Direct
CoaB-like0Direct
SAICAR synthase0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0Direct
MurCDEF0Direct
Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC)0Direct
MurCD N-terminal domain0Direct
Prokaryotic glutathione synthetase, N-terminal domain0Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0.0000001143Direct
Thioesterase domain of polypeptide, polyketide and fatty acid synthases0.0000001163Direct
Peptidyl carrier domain0.0000005075Direct
Acetyl-CoA synthetase-like0.8841Inherited
Nucleotide and nucleoside kinases1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this EC term
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Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
MurCD N-terminal domain0Direct
MurD-like peptide ligases, peptide-binding domain0Direct
Nucleotidylyl transferase0Direct
Glutathione synthetase ATP-binding domain-like0Direct
MurE/MurF N-terminal domain0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0Direct
MurD-like peptide ligases, catalytic domain0Direct
PreATP-grasp domain0Direct
SAICAR synthase-like0Direct
UBC-like0Direct
CoaB-like0Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0.00000007163Direct
UBA-like0.0002211Direct
ACP-like0.01134Inherited
Glutamine synthetase/guanido kinase0.03079Inherited
CoA-dependent acyltransferases0.07871Inherited
RING/U-box0.193Inherited
Acetyl-CoA synthetase-like0.707Inherited
alpha/beta-Hydrolases1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
51984,53623
  • 51984 - MurCD N-terminal domain
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 0Direct
    51735,53623
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 0Direct
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    52374,52540
  • 52374 - Nucleotidylyl transferase
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    56104,52255
  • 56104 - SAICAR synthase-like
  • 52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
  • 0Direct
    52777,53474
  • 52777 - CoA-dependent acyltransferases
  • 53474 - alpha/beta-Hydrolases
  • 0Direct
    55931,56059
  • 55931 - Glutamine synthetase/guanido kinase
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    53244,52440
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 52440 - PreATP-grasp domain
  • 0Direct
    53623,53244
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 0Direct
    52507,102645
  • 52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
  • 102645 - CoaB-like
  • 0Direct
    63418,53623
  • 63418 - MurE/MurF N-terminal domain
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 0Direct
    56059,53623
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 0Direct
    52777,56801
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 0.000000005895Direct
    56801,47336
  • 56801 - Acetyl-CoA synthetase-like
  • 47336 - ACP-like
  • 0.0000001447Direct
    47336,52777
  • 47336 - ACP-like
  • 52777 - CoA-dependent acyltransferases
  • 0.0000003703Direct
    56059,52440
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52440 - PreATP-grasp domain
  • 0.0004858Direct
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.0007298Direct

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53244,52440,56059
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    51984,53623,53244
  • 51984 - MurCD N-terminal domain
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 0Direct
    52777,52777,53474
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 53474 - alpha/beta-Hydrolases
  • 0Direct
    56059,53623,53244
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 0Direct
    53623,53244,52440
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 52440 - PreATP-grasp domain
  • 0Direct
    63418,53623,53244
  • 63418 - MurE/MurF N-terminal domain
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 0Direct
    51735,53623,53244
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 0Direct
    52777,52777,56801
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 0.000000004523Direct
    52777,56801,47336
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 47336 - ACP-like
  • 0.00000001105Direct
    56801,47336,52777
  • 56801 - Acetyl-CoA synthetase-like
  • 47336 - ACP-like
  • 52777 - CoA-dependent acyltransferases
  • 0.00000004644Direct
    47336,52777,52777
  • 47336 - ACP-like
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.0000003703Direct


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
    Plot tree as:   Download Newick format tree:
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