SUPERFAMILY 1.75 HMM library and genome assignments server

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Thiamin diphosphate-binding fold (THDP-binding) superfamily models

A superfamily is represented by one or more models; usually there is more than one model representing the superfamily. Since each model is built to capture the whole superfamily, they are likely to be overlapping and sometimes are mostly overlapping or even redundant to each other. Also models often do not score their own seed sequence more highly than other sequences in the superfamily, so it is a mistake to think that the model represents the seed sequence.

All models are available for immediate download after obtaining a license by filling in a short online registration form. Licenses are free for academic and commercial purposes.

Plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be viewed for each model by following the model ID link.


All 45 SUPERFAMILY models representing the Thiamin diphosphate-binding fold (THDP-binding) superfamily
Model ID No. of seqs Build date Seed sequence Family of seed
0039738 1994 2005-09-08 d1jsca2 Pyruvate oxidase and decarboxylase Pyr module
0042101 1815 2005-09-08 d1ozha2 Pyruvate oxidase and decarboxylase Pyr module
0044478 1534 2005-09-08 d1upaa2 Pyruvate oxidase and decarboxylase Pyr module
0052103 2699 2008-09-10 d2c31a2 Pyruvate oxidase and decarboxylase Pyr module
0042410 1962 2005-09-08 d1poxa2 Pyruvate oxidase and decarboxylase Pyr module
0048896 6118 2008-09-10 d1q6za2 Pyruvate oxidase and decarboxylase Pyr module
0051270 3123 2008-09-10 d1ybha2 Pyruvate oxidase and decarboxylase Pyr module
0052449 3511 2008-09-10 d2djia2 Pyruvate oxidase and decarboxylase Pyr module
0042487 1395 2005-09-08 d1pvda2 Pyruvate oxidase and decarboxylase Pyr module
0042044 1752 2005-09-08 d1ovma2 Pyruvate oxidase and decarboxylase Pyr module
0045129 1505 2005-09-08 d1zpda2 Pyruvate oxidase and decarboxylase Pyr module
0049135 2714 2008-09-10 d1r9ja1 TK-like Pyr module
0040413 93 2005-09-08 d1l8aa2 TK-like Pyr module
0044102 667 2005-09-08 d1trka2 TK-like Pyr module
0039198 628 2005-09-08 d1itza2 TK-like Pyr module
0042761 675 2005-09-08 d1qgda1 TK-like Pyr module
0042965 721 2005-09-08 d1qs0b1 Branched-chain alpha-keto acid dehydrogenase Pyr module
0039059 834 2005-09-08 d1ik6a1 Branched-chain alpha-keto acid dehydrogenase Pyr module
0041403 691 2005-09-08 d1ni4b1 Branched-chain alpha-keto acid dehydrogenase Pyr module
0044440 831 2005-09-08 d1umdb1 Branched-chain alpha-keto acid dehydrogenase Pyr module
0051963 3082 2008-09-10 d2bfdb1 Branched-chain alpha-keto acid dehydrogenase Pyr module
0050395 2259 2008-09-10 d1w85b1 Branched-chain alpha-keto acid dehydrogenase Pyr module
0045857 1004 2008-09-10 d1b0pa1 PFOR Pyr module
0041167 1233 2005-09-08 d1n0ha3 Pyruvate oxidase and decarboxylase PP module
0042411 1040 2005-09-08 d1poxa3 Pyruvate oxidase and decarboxylase PP module
0048897 3474 2008-09-10 d1q6za3 Pyruvate oxidase and decarboxylase PP module
0051271 3609 2008-09-10 d1ybha3 Pyruvate oxidase and decarboxylase PP module
0052450 4131 2008-09-10 d2djia3 Pyruvate oxidase and decarboxylase PP module
0042488 1182 2005-09-08 d1pvda3 Pyruvate oxidase and decarboxylase PP module
0042045 1035 2005-09-08 d1ovma3 Pyruvate oxidase and decarboxylase PP module
0045130 1159 2005-09-08 d1zpda3 Pyruvate oxidase and decarboxylase PP module
0049968 4181 2008-09-10 d1upaa3 Pyruvate oxidase and decarboxylase PP module
0042102 1155 2005-09-08 d1ozha3 Pyruvate oxidase and decarboxylase PP module
0052104 3995 2008-09-10 d2c31a3 Pyruvate oxidase and decarboxylase PP module
0042762 1056 2005-09-08 d1qgda2 TK-like PP module
0040412 546 2005-09-08 d1l8aa1 TK-like PP module
0044101 1047 2005-09-08 d1trka1 TK-like PP module
0039197 947 2005-09-08 d1itza1 TK-like PP module
0049136 2452 2008-09-10 d1r9ja2 TK-like PP module
0044439 927 2005-09-08 d1umda_ Branched-chain alpha-keto acid dehydrogenase PP module
0050394 4239 2008-09-10 d1w85a_ Branched-chain alpha-keto acid dehydrogenase PP module
0036596 1087 2005-09-08 d1dtwa_ Branched-chain alpha-keto acid dehydrogenase PP module
0041402 1117 2005-09-08 d1ni4a_ Branched-chain alpha-keto acid dehydrogenase PP module
0049028 2807 2008-09-10 d1qs0a_ Branched-chain alpha-keto acid dehydrogenase PP module
0045858 818 2008-09-10 d1b0pa2 PFOR PP module