SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

S-adenosyl-L-methionine-dependent methyltransferases superfamily models

A superfamily is represented by one or more models; usually there is more than one model representing the superfamily. Since each model is built to capture the whole superfamily, they are likely to be overlapping and sometimes are mostly overlapping or even redundant to each other. Also models often do not score their own seed sequence more highly than other sequences in the superfamily, so it is a mistake to think that the model represents the seed sequence.

All models are available for immediate download after obtaining a license by filling in a short online registration form. Licenses are free for academic and commercial purposes.

Plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be viewed for each model by following the model ID link.


All 127 SUPERFAMILY models representing the S-adenosyl-L-methionine-dependent methyltransferases superfamily
Model ID No. of seqs Build date Seed sequence Family of seed
0051840 56 2008-09-10 d2avda1 COMT-like
0052182 3642 2008-09-10 d2cl5a1 COMT-like
0049474 19752 2008-09-10 d1suia1 COMT-like
0046568 4749 2008-09-10 d1ej0a_ RNA methyltransferase FtsJ
0048438 19330 2008-09-10 d1nt2a_ Fibrillarin homologue
0037982 845 2005-09-08 d1g8aa_ Fibrillarin homologue
0048805 2202 2008-09-10 d1prya_ Fibrillarin homologue
0046744 20589 2008-09-10 d1fbna_ Fibrillarin homologue
0036610 2141 2005-09-08 d1dusa_ Hypothetical protein MJ0882
0045060 3085 2005-09-08 d1xvaa_ Glycine N-methyltransferase
0049122 18911 2008-09-10 d1r74a_ Glycine N-methyltransferase
0046696 19477 2008-09-10 d1f3la_ Arginine methyltransferase
0048629 7181 2008-09-10 d1oria_ Arginine methyltransferase
0046931 20013 2008-09-10 d1g6q1_ Arginine methyltransferase
0052807 19217 2008-09-10 d2fyta1 Arginine methyltransferase
0044689 2917 2005-09-08 d1vbfa_ Protein-L-isoaspartyl O-methyltransferase
0047862 32 2008-09-10 d1kr5a_ Protein-L-isoaspartyl O-methyltransferase
0047580 5673 2008-09-10 d1jg1a_ Protein-L-isoaspartyl O-methyltransferase
0043085 2193 2005-09-08 d1r18a_ Protein-L-isoaspartyl O-methyltransferase
0046354 5737 2008-09-10 d1dl5a1 Protein-L-isoaspartyl O-methyltransferase
0035026 738 2005-09-08 d1af7a2 Chemotaxis receptor methyltransferase CheR, C-terminal domain
0036976 850 2005-09-08 d1eg2a_ Type II DNA methylase
0045988 1243 2008-09-10 d1booa_ Type II DNA methylase
0037952 928 2005-09-08 d1g60a_ Type II DNA methylase
0040327 1226 2005-09-08 d1kywa2 Plant O-methyltransferase, C-terminal domain
0049074 17345 2008-09-10 d1qzza2 Plant O-methyltransferase, C-terminal domain
0049719 21326 2008-09-10 d1tw3a2 Plant O-methyltransferase, C-terminal domain
0046838 15843 2008-09-10 d1fp1d2 Plant O-methyltransferase, C-terminal domain
0046840 14655 2008-09-10 d1fp2a2 Plant O-methyltransferase, C-terminal domain
0047329 6890 2008-09-10 d1i9ga_ tRNA(1-methyladenosine) methyltransferase-like
0051261 6305 2008-09-10 d1yb2a1 tRNA(1-methyladenosine) methyltransferase-like
0051884 1764 2008-09-10 d2b25a1 tRNA(1-methyladenosine) methyltransferase-like
0048490 24375 2008-09-10 d1o54a_ tRNA(1-methyladenosine) methyltransferase-like
0047386 18131 2008-09-10 d1im8a_ Hypothetical protein HI0319 (YecO)
0051679 693 2008-09-10 d2a14a1 Arylamine N-methyltransferase
0047211 935 2008-09-10 d1hnna_ Arylamine N-methyltransferase
0050919 979 2008-09-10 d1xcla_ Guanidinoacetate methyltransferase
0051657 1045 2008-09-10 d1zx0a1 Guanidinoacetate methyltransferase
0049915 18310 2008-09-10 d1uira_ Spermidine synthase
0040964 826 2005-09-08 d1mjfa_ Spermidine synthase
0050988 18746 2008-09-10 d1xj5a_ Spermidine synthase
0039093 638 2005-09-08 d1inla_ Spermidine synthase
0047471 18390 2008-09-10 d1iy9a_ Spermidine synthase
0051885 20018 2008-09-10 d2b2ca1 Spermidine synthase
0053229 2152 2008-09-10 d2o07a1 Spermidine synthase
0054332 7946 2010-05-31 d2o57a1 Mycolic acid cyclopropane synthase
0047851 8505 2008-09-10 d1kpia_ Mycolic acid cyclopropane synthase
0052709 4807 2008-09-10 d2fk8a1 Mycolic acid cyclopropane synthase
0040196 2051 2005-09-08 d1kpga_ Mycolic acid cyclopropane synthase
0049671 19779 2008-09-10 d1tpya_ Mycolic acid cyclopropane synthase
0047919 19364 2008-09-10 d1l1ea_ Mycolic acid cyclopropane synthase
0047656 810 2008-09-10 d1jqea_ Histamine methyltransferase
0047676 12359 2008-09-10 d1jsxa_ Glucose-inhibited division protein B (GidB)
0050935 10067 2008-09-10 d1xdza_ Glucose-inhibited division protein B (GidB)
0041444 2849 2005-09-08 d1nkva_ Hypothetical Protein YjhP
0047923 24076 2008-09-10 d1l3ia_ Precorrin-6Y methyltransferase (CbiT)
0050519 1441 2008-09-10 d1wg8a2 MraW-like putative methyltransferases
0040829 2327 2005-09-08 d1m6ya2 MraW-like putative methyltransferases
0042682 1174 2005-09-08 d1qama_ rRNA adenine dimethylase-like
0045109 2078 2005-09-08 d1yuba_ rRNA adenine dimethylase-like
0047303 2306 2008-09-10 d1i4wa_ rRNA adenine dimethylase-like
0049069 2189 2008-09-10 d1qyra_ rRNA adenine dimethylase-like
0051617 6693 2008-09-10 d1zq9a1 rRNA adenine dimethylase-like
0050038 83 2008-09-10 d1v39a_ mRNA cap methylase
0047945 8628 2008-09-10 d1l9ka_ mRNA cap methylase
0046303 1768 2008-09-10 d1dcta_ C5 cytosine-specific DNA methylase, DCM
0046923 1675 2008-09-10 d1g55a_ C5 cytosine-specific DNA methylase, DCM
0045633 602 2005-09-08 d6mhta_ C5 cytosine-specific DNA methylase, DCM
0053087 4529 2008-09-10 d2ibta1 DNA methylase TaqI, N-terminal domain
0052484 593 2008-09-10 d2dpma_ N6 adenine-specific DNA methylase, DAM
0048856 595 2008-09-10 d1q0sa_ N6 adenine-specific DNA methylase, DAM
0048524 1346 2008-09-10 d1o9ga_ rRNA methyltransferase AviRa
0041580 3390 2005-09-08 d1nv8a_ N5-glutamine methyltransferase, HemK
0049532 16057 2008-09-10 d1t43a_ N5-glutamine methyltransferase, HemK
0049778 685 2008-09-10 d1u2za_ Catalytic, N-terminal domain of histone methyltransferase Dot1l
0041593 569 2005-09-08 d1nw3a_ Catalytic, N-terminal domain of histone methyltransferase Dot1l
0041326 2548 2005-09-08 d1ne2a_ Ta1320-like
0050749 9294 2008-09-10 d1wy7a1 Ta1320-like
0042197 3517 2005-09-08 d1p91a_ rRNA methyltransferase RlmA
0049171 9566 2008-09-10 d1ri5a_ mRNA cap (Guanine N-7) methyltransferase
0048106 349 2008-09-10 d1m6ex_ Salicylic acid carboxyl methyltransferase (SAMT)
0052084 587 2008-09-10 d2bzga1 Thiopurine S-methyltransferase
0048774 585 2008-09-10 d1pjza_ Thiopurine S-methyltransferase
0049186 816 2008-09-10 d1rjda_ Leucine carboxy methyltransferase Ppm1
0051944 4826 2008-09-10 d2b9ea1 NOL1/NOP2/sun
0047465 7214 2008-09-10 d1ixka_ NOL1/NOP2/sun
0049442 5549 2008-09-10 d1sqga2 NOL1/NOP2/sun
0049885 18171 2008-09-10 d1ufka_ Ribosomal protein L11 methyltransferase PrmA
0044550 3047 2005-09-08 d1uwva2 (Uracil-5-)-methyltransferase
0050242 15940 2008-09-10 d1vlma_ UbiE/COQ5-like
0051842 15247 2008-09-10 d2avna1 UbiE/COQ5-like
0054473 4881 2010-05-31 d2p7ia1 UbiE/COQ5-like
0051143 18621 2008-09-10 d1xxla_ UbiE/COQ5-like
0050234 18259 2008-09-10 d1vl5a_ UbiE/COQ5-like
0051103 24097 2008-09-10 d1xtpa_ AD-003 protein-like
0052536 4457 2008-09-10 d2ex4a1 AD-003 protein-like
0050154 18248 2008-09-10 d1ve3a1 CAC2371-like
0051239 8201 2008-09-10 d1y8ca_ CAC2371-like
0050762 19746 2008-09-10 d1wzna1 CAC2371-like
0053077 11844 2008-09-10 d2i6ga1 TehB-like
0052618 9340 2008-09-10 d2f8la1 N-6 DNA Methylase-like
0051816 1629 2008-09-10 d2ar0a1 N-6 DNA Methylase-like
0054378 3866 2010-05-31 d2okca1 N-6 DNA Methylase-like
0052739 3082 2008-09-10 d2fpoa1 YhhF-like
0052510 17 2008-09-10 d2esra1 YhhF-like
0053107 10757 2008-09-10 d2ifta1 YhhF-like
0050693 1787 2008-09-10 d1ws6a1 YhhF-like
0052693 2778 2008-09-10 d2fhpa1 YhhF-like
0052749 1059 2008-09-10 d2frna1 Met-10+ protein-like
0052949 193 2008-09-10 d2gtia1 Nsp15 N-terminal domain-like
0052992 185 2008-09-10 d2h85a1 Nsp15 N-terminal domain-like
0052894 42 2008-09-10 d2gh1a1 BC2162-like
0052001 673 2008-09-10 d2bm8a1 CmcI-like
0053110 4115 2008-09-10 d2igta1 hypothetical RNA methyltransferase
0050745 21325 2008-09-10 d1wxxa2 hypothetical RNA methyltransferase
0051823 19441 2008-09-10 d2as0a2 hypothetical RNA methyltransferase
0051930 21145 2008-09-10 d2b78a2 hypothetical RNA methyltransferase
0051588 615 2008-09-10 d1zkda1 RPA4359-like
0052649 20602 2008-09-10 d2fcaa1 TrmB-like
0051449 20726 2008-09-10 d1yzha1 TrmB-like
0052982 23 2008-09-10 d2h00a1 Methyltransferase 10 domain
0054432 870 2010-05-31 d2oyra1 YhiQ-like
0054520 733 2010-05-31 d2pkwa1 YhiQ-like
0054557 718 2010-05-31 d2py6a1 FkbM-like
0054686 714 2010-05-31 d2uyoa1 ML2640-like
0053855 1243 2010-05-31 d2dula1 TRM1-like
0054391 341 2010-05-31 d2oo3a1 LPG1296-like