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Metalloproteases ("zincins"), catalytic domain superfamily models

A superfamily is represented by one or more models; usually there is more than one model representing the superfamily. Since each model is built to capture the whole superfamily, they are likely to be overlapping and sometimes are mostly overlapping or even redundant to each other. Also models often do not score their own seed sequence more highly than other sequences in the superfamily, so it is a mistake to think that the model represents the seed sequence.

All models are available for immediate download after obtaining a license by filling in a short online registration form. Licenses are free for academic and commercial purposes.

Plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be viewed for each model by following the model ID link.


All 56 SUPERFAMILY models representing the Metalloproteases ("zincins"), catalytic domain superfamily
Model ID No. of seqs Build date Seed sequence Family of seed
0046088 839 2008-09-10 d1c7ka_ Zinc protease
0048413 334 2008-09-10 d1npca_ Thermolysin-like
0049785 315 2008-09-10 d1u4ga_ Thermolysin-like
0053382 337 2008-09-10 d8tlne_ Thermolysin-like
0035660 511 2005-09-08 d1bqba_ Thermolysin-like
0040568 55 2005-09-08 d1lmla_ Leishmanolysin
0036505 329 2005-09-08 d1dmta_ Neutral endopeptidase (neprilysin)
0039343 180 2005-09-08 d1j36a_ Neurolysin-like
0047769 1422 2008-09-10 d1k9xa_ Neurolysin-like
0049313 1131 2008-09-10 d1s4bp_ Neurolysin-like
0049097 1128 2008-09-10 d1r42a_ Neurolysin-like
0047285 1414 2008-09-10 d1i1ip_ Neurolysin-like
0048517 354 2008-09-10 d1o8aa_ Neurolysin-like
0039943 131 2005-09-08 d1k7ia2 Serralysin-like metalloprotease, catalytic (N-terminal) domain
0043540 101 2005-09-08 d1sata2 Serralysin-like metalloprotease, catalytic (N-terminal) domain
0038010 453 2005-09-08 d1g9ka2 Serralysin-like metalloprotease, catalytic (N-terminal) domain
0040001 737 2005-09-08 d1kapp2 Serralysin-like metalloprotease, catalytic (N-terminal) domain
0036710 25 2005-09-08 d1e1h.1 Clostridium neurotoxins, catalytic domain
0043847 25 2005-09-08 d1t3ca_ Clostridium neurotoxins, catalytic domain
0037125 25 2005-09-08 d1epwa3 Clostridium neurotoxins, catalytic domain
0045495 25 2005-09-08 d3btaa3 Clostridium neurotoxins, catalytic domain
0047333 750 2008-09-10 d1iaea_ Astacin
0035715 627 2005-09-08 d1buda_ Reprolysin-like
0049107 2225 2008-09-10 d1r55a_ Reprolysin-like
0045818 954 2008-09-10 d1atla_ Reprolysin-like
0050667 2227 2008-09-10 d1wnia_ Reprolysin-like
0048333 951 2008-09-10 d1nd1a_ Reprolysin-like
0053341 971 2008-09-10 d4aiga_ Reprolysin-like
0047882 1023 2008-09-10 d1kufa_ Reprolysin-like
0049043 984 2008-09-10 d1quaa_ Reprolysin-like
0035598 536 2005-09-08 d1bkca_ TNF-alpha converting enzyme, TACE, catalytic domain
0047260 1846 2008-09-10 d1hy7a_ Matrix metalloproteases, catalytic domain
0038130 503 2005-09-08 d1gkda_ Matrix metalloproteases, catalytic domain
0041006 682 2005-09-08 d1mmqa_ Matrix metalloproteases, catalytic domain
0046234 2037 2008-09-10 d1cxva_ Matrix metalloproteases, catalytic domain
0053376 1845 2008-09-10 d830ca_ Matrix metalloproteases, catalytic domain
0048880 1916 2008-09-10 d1q3aa_ Matrix metalloproteases, catalytic domain
0038739 641 2005-09-08 d1hv5a_ Matrix metalloproteases, catalytic domain
0046743 1060 2008-09-10 d1fbla2 Matrix metalloproteases, catalytic domain
0035666 707 2005-09-08 d1bqqm_ Matrix metalloproteases, catalytic domain
0046136 1901 2008-09-10 d1cgla_ Matrix metalloproteases, catalytic domain
0039592 484 2005-09-08 d1jk3a_ Matrix metalloproteases, catalytic domain
0035790 539 2005-09-08 d1bzsa_ Matrix metalloproteases, catalytic domain
0046509 1394 2008-09-10 d1eaka2 Matrix metalloproteases, catalytic domain
0049211 1054 2008-09-10 d1rm8a_ Matrix metalloproteases, catalytic domain
0036884 52 2005-09-08 d1eb6a_ Fungal zinc peptidase
0037882 50 2005-09-08 d1g12a_ Fungal zinc peptidase
0038697 589 2005-09-08 d1hs6a3 Leukotriene A4 hydrolase catalytic domain
0047530 123 2008-09-10 d1j7na2 Anthrax toxin lethal factor, N- and C-terminal domains
0047529 5 2008-09-10 d1j7na1 Anthrax toxin lethal factor, N- and C-terminal domains
0049714 927 2008-09-10 d1tvia_ Predicted metal-dependent hydrolase
0042098 248 2005-09-08 d1oz9a_ Predicted metal-dependent hydrolase
0051020 925 2008-09-10 d1xm5a_ Predicted metal-dependent hydrolase
0054898 197 2010-05-31 d3cmna1 Caur0242-like
0053887 123 2010-05-31 d2ejqa1 TTHA0227-like
0054944 270 2010-05-31 d3e11a1 TTHA0227-like