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Disease Ontology (DO): respiratory system disease

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   disease [DOID:4] <8>
+ 1:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
0:   respiratory system disease [DOID:1579] <4>(29|38) (30|14|7)
- 1:   upper respiratory tract disease [DOID:974] <14>(10|11) (10|2|0)
- 1:   lower respiratory tract disease [DOID:0050161] <3>(25|33) (26|13|7)
- 1:   asphyxia neonatorum [DOID:11088](0|0) (0|0|0)
- 1:   croup [DOID:9395](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Chitinase insertion domain0Direct
Serine protease inhibitors0Direct
4-helical cytokines0.000000005469Direct
Toll/Interleukin receptor TIR domain0.00000001694Direct
PGBD-like0.00002016Direct
Triple coiled coil domain of C-type lectins0.0001547Direct
STAT0.000399Direct
Transcription factor STAT-4 N-domain0.000399Direct
Interleukin 8-like chemokines0.0004601Direct
Heme-dependent peroxidases0.0004635Direct
Hemopexin-like domain0.002595Inherited
Kringle-like0.002595Inherited
Riboflavin synthase domain-like0.004057Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.004057Inherited
Anaphylotoxins (complement system)0.006757Inherited
Snake toxin-like0.006883Inherited
Family A G protein-coupled receptor-like0.006901Inherited
Cystine-knot cytokines0.007108Inherited
MHC antigen-recognition domain0.01144Inherited
Flavoproteins0.01437Inherited
RNI-like0.01628Inherited
FnI-like domain0.03134Inherited
Insulin-like0.04127Inherited
SEA domain0.04324Inherited
C-type lectin-like0.04643Inherited
Immunoglobulin0.0772Inherited
Cytokine0.1796Inherited
ABC transporter transmembrane region0.4362Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Type II chitinase0Direct
Chitinase insertion domain0Direct
Neurotrophin0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Short-chain cytokines0.000000004414Direct
Toll/Interleukin receptor TIR domain0.00000001396Direct
MMP N-terminal domain0.00001894Direct
Matrix metalloproteases, catalytic domain0.0001053Direct
Triple coiled coil domain of C-type lectins0.000123Direct
Transcription factor STAT-4 N-domain0.0002953Direct
STAT DNA-binding domain0.0002953Direct
STAT0.0002953Direct
Myeloperoxidase-like0.0003498Direct
Interleukin 8-like chemokines0.0004154Direct
DEATH effector domain, DED0.0008399Direct
Hemopexin-like domain0.00209Inherited
Sir2 family of transcriptional regulators0.00296Inherited
Rhodopsin-like0.005055Inherited
Netrin-like domain (NTR/C345C module)0.005121Inherited
Cytochrome p450 reductase N-terminal domain-like0.005121Inherited
Interleukin 17F, IL-17F0.005121Inherited
Anaphylotoxins (complement system)0.005121Inherited
MHC antigen-recognition domain0.009928Inherited
Platelet-derived growth factor-like0.01151Inherited
C1 set domains (antibody constant domain-like)0.01329Inherited
Interferons/interleukin-10 (IL-10)0.01429Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.01623Inherited
NADPH-cytochrome p450 reductase-like0.01623Inherited
Pentraxin (pentaxin)0.01623Inherited
28-residue LRR0.01791Inherited
Interleukin-1 (IL-1)0.02155Inherited
Insulin-like0.03415Inherited
C-type lectin domain0.05341Inherited
Long-chain cytokines0.05558Inherited
Globins0.127Inherited
Growth factor receptor domain0.2222Inherited
ABC transporter transmembrane region0.2488Inherited
ABC transporter ATPase domain-like0.6172Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Chitinase insertion domain0Direct
Serine protease inhibitors0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
4-helical cytokines0.000000002564Direct
Toll/Interleukin receptor TIR domain0.000000008Direct
PGBD-like0.00001123Direct
Triple coiled coil domain of C-type lectins0.00009241Direct
STAT0.0002436Direct
Transcription factor STAT-4 N-domain0.0002436Direct
Interleukin 8-like chemokines0.0002813Direct
Heme-dependent peroxidases0.0002836Direct
Hemopexin-like domain0.001713Inherited
Kringle-like0.001713Inherited
Riboflavin synthase domain-like0.002731Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.002731Inherited
Anaphylotoxins (complement system)0.00464Inherited
Snake toxin-like0.004735Inherited
Family A G protein-coupled receptor-like0.004748Inherited
Cystine-knot cytokines0.004909Inherited
MHC antigen-recognition domain0.008041Inherited
Flavoproteins0.01019Inherited
RNI-like0.01161Inherited
FnI-like domain0.02333Inherited
Insulin-like0.03103Inherited
SEA domain0.03258Inherited
C-type lectin-like0.03521Inherited
Immunoglobulin0.06044Inherited
Globin-like0.1168Inherited
Cytokine0.147Inherited
ABC transporter transmembrane region0.3797Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
51445,54556
  • 51445 - (Trans)glycosidases
  • 54556 - Chitinase insertion domain
  • 0Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.00001123Direct
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.00009241Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0002436Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0002436Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0002436Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0002436Direct
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.002617Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.003149Inherited
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0.00464Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.005748Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.006624Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.01562Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3797Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0002436Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0002436Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0006947Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.001122Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.03103Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1247Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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