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Disease Ontology (DO): musculoskeletal system disease

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   disease [DOID:4] <8>
+ 1:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
0:   musculoskeletal system disease [DOID:17] <3>(29|42) (37|17|6)
- 1:   connective tissue disease [DOID:65] <22>(23|31) (28|11|4)
- 1:   muscular disease [DOID:0080000] <2>(9|13) (12|7|3)
- 1:   spinal disease [DOID:0060564](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Anaphylotoxins (complement system)0Direct
TNF receptor-like0.0000002159Direct
Immunoglobulin0.0000003762Direct
TNF-like0.000005339Direct
FnI-like domain0.000107Direct
TIMP-like0.0002895Direct
4-helical cytokines0.0008329Direct
Interleukin 8-like chemokines0.0008329Direct
PGBD-like0.001539Inherited
Cupredoxins0.004234Inherited
TSP-1 type 1 repeat0.004394Inherited
MHC antigen-recognition domain0.004817Inherited
Toll/Interleukin receptor TIR domain0.005924Inherited
PRTase-like0.006536Inherited
RNI-like0.0118Inherited
Cystine-knot cytokines0.01772Inherited
Hemopexin-like domain0.02164Inherited
Annexin0.02577Inherited
DEATH domain0.06112Inherited
Kringle-like0.06152Inherited
Calpain large subunit, middle domain (domain III)0.09814Inherited
Protein kinase-like (PK-like)0.1448Inherited
SMAD MH1 domain0.1807Inherited
Cytochrome P4500.2248Inherited
Nucleotide-diphospho-sugar transferases0.2504Inherited
Spectrin repeat0.348Inherited
RNA-binding domain, RBD0.6685Inherited
PH domain-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Tissue inhibitor of metalloproteinases, TIMP0Direct
Netrin-like domain (NTR/C345C module)0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0Direct
IP3 receptor type 1 binding core, domain 20Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
NADPH-cytochrome p450 reductase-like0Direct
Anaphylotoxins (complement system)0Direct
TNF receptor-like0.000000184Direct
TNF-like0.000003887Direct
Interleukin 8-like chemokines0.000652Direct
MMP N-terminal domain0.001292Inherited
C2 set domains0.00175Inherited
S100 proteins0.003121Inherited
TSP-1 type 1 repeat0.003427Inherited
MHC antigen-recognition domain0.003747Inherited
MIR domain0.004568Inherited
Toll/Interleukin receptor TIR domain0.004579Inherited
Exostosin0.005047Inherited
Matrix metalloproteases, catalytic domain0.005269Inherited
C1 set domains (antibody constant domain-like)0.006076Inherited
VWC domain0.007462Inherited
C-type lectin domain0.01119Inherited
I set domains0.0172Inherited
Hemopexin-like domain0.01725Inherited
Short-chain cytokines0.01836Inherited
Interferons/interleukin-10 (IL-10)0.01836Inherited
Annexin0.02204Inherited
Transforming growth factor (TGF)-beta0.03059Inherited
Interleukin-1 (IL-1)0.03901Inherited
Calpain large subunit, catalytic domain (domain II)0.08148Inherited
Calpain large subunit, middle domain (domain III)0.08148Inherited
Penta-EF-hand proteins0.08148Inherited
Pentraxin (pentaxin)0.08148Inherited
FAD-linked reductases, N-terminal domain0.0893Inherited
SMAD domain0.1553Inherited
SMAD MH1 domain0.1553Inherited
Protein kinases, catalytic subunit0.1919Inherited
Platelet-derived growth factor-like0.2412Inherited
EF-hand modules in multidomain proteins0.2412Inherited
Spectrin repeat0.3202Inherited
Canonical RBD0.6733Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
TNF receptor-like0.0000001077Direct
Immunoglobulin0.000000191Direct
TNF-like0.000002859Direct
FnI-like domain0.00006305Direct
TIMP-like0.0001753Direct
Interleukin 8-like chemokines0.0005185Direct
4-helical cytokines0.0005185Direct
PGBD-like0.0009848Direct
Cupredoxins0.002852Inherited
TSP-1 type 1 repeat0.002954Inherited
MHC antigen-recognition domain0.003258Inherited
Toll/Interleukin receptor TIR domain0.00406Inherited
MIR domain0.004261Inherited
PRTase-like0.004479Inherited
RNI-like0.008298Inherited
Cystine-knot cytokines0.01273Inherited
Hemopexin-like domain0.01573Inherited
Annexin0.01895Inherited
DEATH domain0.04704Inherited
Kringle-like0.04738Inherited
Calpain large subunit, middle domain (domain III)0.07782Inherited
EF-hand0.08549Inherited
Snake toxin-like0.1009Inherited
Protein kinase-like (PK-like)0.1172Inherited
SMAD MH1 domain0.1481Inherited
Calponin-homology domain, CH-domain0.1607Inherited
Cytochrome P4500.1871Inherited
Nucleotide-diphospho-sugar transferases0.2098Inherited
Spectrin repeat0.299Inherited
Cytokine0.3155Inherited
HLH, helix-loop-helix DNA-binding domain0.3299Inherited
Family A G protein-coupled receptor-like0.4579Inherited
RNA-binding domain, RBD0.5975Inherited
MFS general substrate transporter0.6335Inherited
PH domain-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0Direct
    49758,47473
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0Direct
    57196,57535
  • 57196 - EGF/Laminin
  • 57535 - Complement control module/SCR domain
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0000003914Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.00005193Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.0009848Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.005907Inherited
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0.01088Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.01088Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.01724Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.02743Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.03504Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.1382Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1869Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.2076Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.2632Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0005902Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.002669Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.03504Inherited
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.04738Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.09588Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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