SUPERFAMILY 1.75 HMM library and genome assignments server

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Disease Ontology (DO): scleroderma

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   disease [DOID:4] <8>
+ + + + 4:   immune system disease [DOID:2914] <4>(39|47) (42|27|16)
+ + + + 4:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
+ + + 3:   hypersensitivity reaction disease [DOID:0060056] <5>(35|46) (37|23|14)
+ + + 3:   musculoskeletal system disease [DOID:17] <3>(29|42) (37|17|6)
+ + 2:   connective tissue disease [DOID:65] <22>(23|31) (28|11|4)
+ + 2:   hypersensitivity reaction type II disease [DOID:417] <26>(33|43) (35|23|14)
+ 1:   collagen disease [DOID:854] <5>(7|11) (8|2|1)
+ 1:   rheumatic disease [DOID:1575] <1>(6|10) (7|2|1)
0:   scleroderma [DOID:419] <2>(6|10) (7|2|1)
- 1:   systemic scleroderma [DOID:418] <3>(0|0) (0|0|0)
- 1:   localized scleroderma [DOID:8472](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
PGBD-like0.00004129Direct
Hemopexin-like domain0.0001368Direct
SMAD MH1 domain0.0001831Direct
4-helical cytokines0.0006886Direct
TNF-like0.0007514Direct
Interleukin 8-like chemokines0.0007835Direct


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Pentraxin (pentaxin)0.00002544Direct
MMP N-terminal domain0.00003155Direct
Matrix metalloproteases, catalytic domain0.00008096Direct
Hemopexin-like domain0.0001053Direct
SMAD MH1 domain0.0001326Direct
SMAD domain0.0001326Direct
Interleukin-1 (IL-1)0.0002352Direct
Platelet-derived growth factor-like0.0002352Direct
TNF-like0.0005815Direct
Interleukin 8-like chemokines0.0006249Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
PGBD-like0.00002367Direct
Hemopexin-like domain0.00008149Direct
SMAD MH1 domain0.0001089Direct
4-helical cytokines0.0004228Direct
TNF-like0.0004643Direct
Interleukin 8-like chemokines0.0004865Direct
Snake toxin-like0.0008692Direct

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.00002367Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0003238Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.00005379Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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