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Disease Ontology (DO): lower respiratory tract disease

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   disease [DOID:4] <8>
+ + 2:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
+ 1:   respiratory system disease [DOID:1579] <4>(29|38) (30|14|7)
0:   lower respiratory tract disease [DOID:0050161] <3>(25|33) (26|13|7)
- 1:   lung disease [DOID:850] <16>(14|18) (15|6|3)
- 1:   pleural disease [DOID:1532] <4>(0|0) (0|0|0)
- 1:   bronchial disease [DOID:1176] <3>(17|24) (17|8|2)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Interleukin 8-like chemokines0.0000003874Direct
PGBD-like0.00001319Direct
Cystine-knot cytokines0.00007406Direct
STAT0.0000818Direct
Transcription factor STAT-4 N-domain0.0000818Direct
Triple coiled coil domain of C-type lectins0.0001253Direct
Family A G protein-coupled receptor-like0.0001812Direct
Hemopexin-like domain0.0007287Direct
Anaphylotoxins (complement system)0.0009253Direct
Kringle-like0.001046Inherited
Flavoproteins0.001426Inherited
FnI-like domain0.003425Inherited
Insulin-like0.007041Inherited
Cytokine0.02945Inherited
ABC transporter transmembrane region0.1667Inherited
4-helical cytokines0.4705Inherited
Toll/Interleukin receptor TIR domain0.6509Inherited
C-type lectin-like0.6968Inherited
Snake toxin-like0.8283Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.8563Inherited
Riboflavin synthase domain-like0.8563Inherited
RNI-like0.8563Inherited
Serine protease inhibitors0.9457Inherited
Chitinase insertion domain0.9457Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Neurotrophin0Direct
Short-chain cytokines0.00000000000209Direct
Interleukin 8-like chemokines0.0000005399Direct
MMP N-terminal domain0.00001315Direct
STAT DNA-binding domain0.00006965Direct
STAT0.00006965Direct
Transcription factor STAT-4 N-domain0.00006965Direct
Matrix metalloproteases, catalytic domain0.00007594Direct
Triple coiled coil domain of C-type lectins0.0001019Direct
Rhodopsin-like0.000181Direct
Hemopexin-like domain0.0006939Direct
Cytochrome p450 reductase N-terminal domain-like0.0007261Direct
Netrin-like domain (NTR/C345C module)0.0007261Direct
Interleukin 17F, IL-17F0.0007261Direct
Anaphylotoxins (complement system)0.0007261Direct
DEATH effector domain, DED0.0007261Direct
Interferons/interleukin-10 (IL-10)0.001198Inherited
Interleukin-1 (IL-1)0.002453Inherited
Platelet-derived growth factor-like0.002453Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.00258Inherited
NADPH-cytochrome p450 reductase-like0.00258Inherited
Pentraxin (pentaxin)0.00258Inherited
Sir2 family of transcriptional regulators0.00258Inherited
Insulin-like0.005833Inherited
Globins0.04893Inherited
Growth factor receptor domain0.09088Inherited
ABC transporter transmembrane region0.09494Inherited
ABC transporter ATPase domain-like0.2447Inherited
Toll/Interleukin receptor TIR domain0.6578Inherited
C-type lectin domain0.7755Inherited
Chitinase insertion domain0.9383Inherited
Type II chitinase0.9383Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Interleukin 8-like chemokines0.0000001972Direct
PGBD-like0.000007252Direct
Cystine-knot cytokines0.00004334Direct
STAT0.00004775Direct
Transcription factor STAT-4 N-domain0.00004775Direct
Triple coiled coil domain of C-type lectins0.00007422Direct
Family A G protein-coupled receptor-like0.0001076Direct
Hemopexin-like domain0.0004489Direct
Anaphylotoxins (complement system)0.0005798Direct
Kringle-like0.0006593Direct
Flavoproteins0.0009079Direct
FnI-like domain0.002282Inherited
Insulin-like0.004858Inherited
Cytokine0.02182Inherited
Globin-like0.04099Inherited
ABC transporter transmembrane region0.1357Inherited
4-helical cytokines0.4119Inherited
Toll/Interleukin receptor TIR domain0.5811Inherited
C-type lectin-like0.6254Inherited
Snake toxin-like0.7559Inherited
RNI-like0.7843Inherited
Riboflavin synthase domain-like0.7843Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.7843Inherited
Chitinase insertion domain0.8769Inherited
Serine protease inhibitors0.8769Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.000007252Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.00004775Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00004775Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.00004775Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00004775Direct
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.00007422Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0003589Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0003589Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0.0005798Direct
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.002012Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.01274Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1357Inherited
    51445,54556
  • 51445 - (Trans)glycosidases
  • 54556 - Chitinase insertion domain
  • 0.8769Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.00004775Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.00004775Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0005798Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.0008519Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.004858Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.04588Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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