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Disease Ontology (DO): musculoskeletal system cancer

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   disease [DOID:4] <8>
+ + + 3:   disease of cellular proliferation [DOID:14566] <3>(123|191) (129|118|56)
+ + 2:   cancer [DOID:162] <2>(115|181) (120|113|54)
+ 1:   organ system cancer [DOID:0050686] <14>(66|106) (72|58|31)
0:   musculoskeletal system cancer [DOID:0060100] <2>(12|17) (12|10|6)
- 1:   connective tissue cancer [DOID:201] <17>(9|14) (9|10|6)
- 1:   muscle cancer [DOID:4045] <3>(3|4) (3|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
p53-like transcription factors0.001493Inherited
Integrin beta tail domain0.003336Inherited
Protein kinase-like (PK-like)0.004802Inherited
Kringle-like0.00514Inherited
Bcl-2 inhibitors of programmed cell death0.01127Inherited
Cystine-knot cytokines0.01988Inherited
PGBD-like0.04596Inherited
Hemopexin-like domain0.05951Inherited
Ankyrin repeat0.0964Inherited
Metalloproteases ("zincins"), catalytic domain0.5532Inherited
Immunoglobulin0.8445Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
p53 DNA-binding domain-like0Direct
Growth factor receptor domain0.001387Inherited
Paired domain0.001813Inherited
L domain0.001813Inherited
Integrin beta tail domain0.002307Inherited
Integrin beta EGF-like domains0.002307Inherited
Platelet-derived growth factor-like0.004571Inherited
Bcl-2 inhibitors of programmed cell death0.008181Inherited
Fibronectin type II module0.009045Inherited
Protein kinases, catalytic subunit0.01297Inherited
Ephrin ectodomain0.0166Inherited
MMP N-terminal domain0.0362Inherited
Hemopexin-like domain0.0475Inherited
Matrix metalloproteases, catalytic domain0.0475Inherited
Ankyrin repeat0.06937Inherited
EGF-type module0.1068Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
p53-like transcription factors0.0009561Direct
Integrin beta tail domain0.002221Inherited
Protein kinase-like (PK-like)0.003248Inherited
Kringle-like0.003484Inherited
Bcl-2 inhibitors of programmed cell death0.007916Inherited
Cystine-knot cytokines0.01439Inherited
PGBD-like0.03486Inherited
Hemopexin-like domain0.04573Inherited
Ankyrin repeat0.07644Inherited
Metalloproteases ("zincins"), catalytic domain0.4902Inherited
Immunoglobulin0.7722Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001737Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.001737Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.002221Inherited
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0.007418Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.008741Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.02872Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.03486Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.1774Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.4825Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001737Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.002221Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.002221Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.007418Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.137Inherited
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.1458Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)