SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Disease Ontology (DO): acquired metabolic disease

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   disease [DOID:4] <8>
+ 1:   disease of metabolism [DOID:0014667] <2>(22|34) (27|12|5)
0:   acquired metabolic disease [DOID:0060158] <8>(14|21) (16|10|5)
- 1:   amyloidosis [DOID:9120] <6>(0|0) (0|0|0)
- 1:   mineral metabolism disease [DOID:0050032] <4>(0|0) (0|0|0)
- 1:   nutrition disease [DOID:374] <2>(6|9) (7|1|0)
- 1:   carbohydrate metabolism disease [DOID:0050013] <1>(7|9) (8|5|4)
- 1:   lactic acidosis [DOID:3650] <1>(0|0) (0|0|0)
- 1:   carotenemia [DOID:9969](0|0) (0|0|0)
- 1:   hyperprolactinemia [DOID:12700](0|0) (0|0|0)
- 1:   hyperuricemia [DOID:1920](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Rudiment single hybrid motif0Direct
Apolipoprotein A-I0Direct
Calpain large subunit, middle domain (domain III)0Direct
Fibrinogen coiled-coil and central regions0Direct
FabD/lysophospholipase-like0.000008888Direct
Insulin-like0.0001886Direct
Flavoproteins0.0008765Direct
Family A G protein-coupled receptor-like0.002716Inherited
MHC antigen-recognition domain0.1281Inherited
4-helical cytokines0.1281Inherited
Nuclear receptor ligand-binding domain0.4249Inherited
TNF-like0.6061Inherited
MFS general substrate transporter0.7569Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Fibrinogen coiled-coil and central regions0Direct
Apolipoprotein A-I0Direct
Multidomain cupredoxins0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
BC C-terminal domain-like0Direct
Calpain large subunit, middle domain (domain III)0Direct
Calpain large subunit, catalytic domain (domain II)0Direct
Insulin-like0.0001426Direct
L domain0.0001426Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0006975Direct
BC N-terminal domain-like0.0006975Direct
NADPH-cytochrome p450 reductase-like0.0006975Direct
BC ATP-binding domain-like0.0006975Direct
Rhodopsin-like0.002264Inherited
Interleukin-1 (IL-1)0.01321Inherited
C1 set domains (antibody constant domain-like)0.0983Inherited
MHC antigen-recognition domain0.112Inherited
Nuclear receptor ligand-binding domain0.4037Inherited
Nuclear receptor0.4349Inherited
Long-chain cytokines0.4516Inherited
TNF-like0.578Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Apolipoprotein A-I0Direct
Rudiment single hybrid motif0Direct
Calpain large subunit, middle domain (domain III)0Direct
Fibrinogen coiled-coil and central regions0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
FabD/lysophospholipase-like0.000004881Direct
Insulin-like0.0001125Direct
Flavoproteins0.0005475Direct
Family A G protein-coupled receptor-like0.001784Inherited
Cytokine0.02612Inherited
MHC antigen-recognition domain0.103Inherited
4-helical cytokines0.103Inherited
Nuclear receptor ligand-binding domain0.3693Inherited
Complement control module/SCR domain0.4128Inherited
TNF-like0.5396Inherited
MFS general substrate transporter0.6846Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0Direct
    49758,47473
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0001125Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0001125Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.103Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.4141Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.4227Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.4227Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0001125Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.002364Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.002364Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.5461Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)