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Disease Ontology (DO): bone disease

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   disease [DOID:4] <8>
+ + + 3:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
+ + 2:   musculoskeletal system disease [DOID:17] <3>(29|42) (37|17|6)
+ 1:   connective tissue disease [DOID:65] <22>(23|31) (28|11|4)
0:   bone disease [DOID:0080001] <5>(19|22) (24|8|3)
- 1:   bone inflammation disease [DOID:3342] <8>(15|16) (18|6|1)
- 1:   bone development disease [DOID:0080006] <6>(1|2) (3|2|1)
- 1:   bone remodeling disease [DOID:0080005] <6>(3|2) (3|1|1)
- 1:   bone structure disease [DOID:0080010] <5>(0|0) (0|0|0)
- 1:   ischemic bone disease [DOID:0080008] <4>(1|1) (1|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
DEATH domain0.0001214Direct
PRTase-like0.002016Inherited
RNI-like0.003034Inherited
Annexin0.005799Inherited
TSP-1 type 1 repeat0.07657Inherited
MHC antigen-recognition domain0.09151Inherited
Cytochrome P4500.1292Inherited
Interleukin 8-like chemokines0.1299Inherited
Cystine-knot cytokines0.1493Inherited
TNF receptor-like0.1719Inherited
Hemopexin-like domain0.2529Inherited
4-helical cytokines0.2696Inherited
PGBD-like0.2982Inherited
FnI-like domain0.3724Inherited
Toll/Interleukin receptor TIR domain0.4741Inherited
TIMP-like0.8182Inherited
Nucleotide-diphospho-sugar transferases0.9179Inherited
Protein kinase-like (PK-like)1Inherited
TNF-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
C1 set domains (antibody constant domain-like)0.00000138Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0002617Direct
NADPH-cytochrome p450 reductase-like0.0002617Direct
Short-chain cytokines0.0003444Direct
Interleukin-1 (IL-1)0.0006318Direct
Exostosin0.001531Inherited
Transforming growth factor (TGF)-beta0.002516Inherited
Annexin0.004821Inherited
TSP-1 type 1 repeat0.06829Inherited
MHC antigen-recognition domain0.08129Inherited
Interleukin 8-like chemokines0.1196Inherited
TNF receptor-like0.2105Inherited
Hemopexin-like domain0.2322Inherited
MMP N-terminal domain0.2761Inherited
C2 set domains0.3892Inherited
I set domains0.4136Inherited
Toll/Interleukin receptor TIR domain0.4557Inherited
Tissue inhibitor of metalloproteinases, TIMP0.546Inherited
C-type lectin domain0.7264Inherited
Interferons/interleukin-10 (IL-10)0.9012Inherited
Protein kinases, catalytic subunit0.9949Inherited
TNF-like0.9963Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
DEATH domain0.00007177Direct
PRTase-like0.00131Inherited
RNI-like0.002012Inherited
Family A G protein-coupled receptor-like0.002962Inherited
Annexin0.003975Inherited
TSP-1 type 1 repeat0.0599Inherited
MHC antigen-recognition domain0.07229Inherited
Cytochrome P4500.104Inherited
Interleukin 8-like chemokines0.1046Inherited
Cystine-knot cytokines0.1208Inherited
TNF receptor-like0.1404Inherited
Hemopexin-like domain0.2123Inherited
HLH, helix-loop-helix DNA-binding domain0.2132Inherited
4-helical cytokines0.2274Inherited
PGBD-like0.2537Inherited
Cytokine0.2537Inherited
FnI-like domain0.3208Inherited
MFS general substrate transporter0.415Inherited
Toll/Interleukin receptor TIR domain0.4153Inherited
Immunoglobulin0.5026Inherited
TIMP-like0.7458Inherited
Nucleotide-diphospho-sugar transferases0.8476Inherited
TNF-like0.9399Inherited
Protein kinase-like (PK-like)0.9509Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.0000008832Direct
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0.0002078Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.00131Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.2147Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.2537Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.3594Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8657Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.9355Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.2537Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.3029Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9478Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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