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Disease Ontology (DO): heart disease

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   disease [DOID:4] <8>
+ + 2:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
+ 1:   cardiovascular system disease [DOID:1287] <3>(41|53) (41|24|14)
0:   heart disease [DOID:114] <8>(8|11) (9|5|4)
- 1:   heart conduction disease [DOID:10273] <10>(0|0) (0|0|0)
- 1:   congenital heart disease [DOID:1682] <7>(0|1) (0|0|0)
- 1:   congestive heart failure [DOID:6000] <5>(0|1) (0|0|0)
- 1:   heart valve disease [DOID:4079] <5>(0|0) (0|0|0)
- 1:   cardiomyopathy [DOID:0050700] <2>(7|6) (7|4|4)
- 1:   endocardium disease [DOID:0050825] <2>(0|0) (0|0|0)
- 1:   heart aneurysm [DOID:9768] <1>(0|0) (0|0|0)
- 1:   hypertensive heart disease [DOID:11516](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Apolipoprotein A-I0Direct
Troponin coil-coiled subunits0.00003556Direct
PGBD-like0.0176Inherited
Hemopexin-like domain0.04254Inherited
TNF-like0.08703Inherited
Myosin rod fragments0.1071Inherited
Voltage-gated potassium channels0.1841Inherited
Metalloproteases ("zincins"), catalytic domain0.5119Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Apolipoprotein A-I0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Interleukin-1 (IL-1)0.0007959Direct
MMP N-terminal domain0.01375Inherited
Matrix metalloproteases, catalytic domain0.01375Inherited
T-box0.0302Inherited
Hemopexin-like domain0.0346Inherited
Forkhead DNA-binding domain0.04882Inherited
TNF-like0.07383Inherited
Myosin rod fragments0.09028Inherited
Voltage-gated potassium channels0.1178Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Apolipoprotein A-I0Direct
Troponin coil-coiled subunits0.0000203Direct
Calcium-dependent phosphotriesterase0.0008144Direct
PGBD-like0.01263Inherited
Hemopexin-like domain0.03202Inherited
TNF-like0.06859Inherited
Myosin rod fragments0.08529Inherited
Voltage-gated potassium channels0.151Inherited
Metalloproteases ("zincins"), catalytic domain0.4509Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.0000001391Direct
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0.0008144Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.01263Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.04576Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.4866Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    49265,48726,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.04576Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.1705Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)