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Disease Ontology (DO): leukemia

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   disease [DOID:4] <8>
+ + + + + 5:   disease of cellular proliferation [DOID:14566] <3>(123|191) (129|118|56)
+ + + + 4:   cancer [DOID:162] <2>(115|181) (120|113|54)
+ + + 3:   organ system cancer [DOID:0050686] <14>(66|106) (72|58|31)
+ + 2:   immune system cancer [DOID:0060083] <3>(31|42) (33|27|13)
+ 1:   hematologic cancer [DOID:2531] <7>(30|42) (32|25|13)
0:   leukemia [DOID:1240] <11>(14|23) (16|19|11)
- 1:   lymphoblastic leukemia [DOID:1037] <6>(5|7) (5|4|4)
- 1:   myeloid leukemia [DOID:8692] <4>(6|11) (8|11|5)
- 1:   chronic leukemia [DOID:1036] <2>(3|4) (3|3|2)
- 1:   aleukemic leukemia [DOID:6004] <1>(0|0) (0|0|0)
- 1:   childhood leukemia [DOID:7757] <1>(0|0) (0|0|0)
- 1:   acute leukemia [DOID:12603](0|0) (0|0|0)
- 1:   chronic erythremia [DOID:11868](0|0) (0|0|0)
- 1:   mast-cell leukemia [DOID:9254](0|0) (0|0|0)
- 1:   megakaryocytic leukemia [DOID:8761](0|0) (0|0|0)
- 1:   subacute leukemia [DOID:3264](0|0) (0|0|0)
- 1:   subleukemic leukemia [DOID:12965](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
TAFH domain-like0Direct
Inhibitor of apoptosis (IAP) repeat0.00004519Direct
MHC antigen-recognition domain0.0007482Direct
Bcl-2 inhibitors of programmed cell death0.001101Inherited
STAT0.009415Inherited
Transcription factor STAT-4 N-domain0.009415Inherited
ABC transporter transmembrane region0.01206Inherited
Notch domain0.01466Inherited
SOCS box-like0.04484Inherited
HD-domain/PDEase-like0.06729Inherited
DPP6 N-terminal domain-like0.1089Inherited
SH2 domain0.1629Inherited
p53-like transcription factors0.1858Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
DNA ligase0Direct
TAFH domain-like0Direct
p53 DNA-binding domain-like0Direct
Inhibitor of apoptosis (IAP) repeat0.00003542Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0002547Direct
MHC antigen-recognition domain0.0006784Direct
C1 set domains (antibody constant domain-like)0.0006784Direct
Bcl-2 inhibitors of programmed cell death0.0008889Direct
ABC transporter transmembrane region0.002642Inherited
Nucleoside diphosphate kinase, NDK0.003621Inherited
STAT DNA-binding domain0.00759Inherited
STAT0.00759Inherited
Transcription factor STAT-4 N-domain0.00759Inherited
Notch domain0.01177Inherited
DPP6 N-terminal domain-like0.02473Inherited
PDEase0.03258Inherited
SOCS box-like0.0388Inherited
ABC transporter ATPase domain-like0.05037Inherited
SH2 domain0.1546Inherited
L domain0.6578Inherited
Frizzled cysteine-rich domain0.784Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
TAFH domain-like0Direct
Inhibitor of apoptosis (IAP) repeat0.00002598Direct
MHC antigen-recognition domain0.0004619Direct
Bcl-2 inhibitors of programmed cell death0.0006952Direct
STAT0.006542Inherited
Transcription factor STAT-4 N-domain0.006542Inherited
ABC transporter transmembrane region0.008479Inherited
Nucleoside diphosphate kinase, NDK0.0104Inherited
Notch domain0.0104Inherited
SOCS box-like0.03388Inherited
HD-domain/PDEase-like0.05212Inherited
DPP6 N-terminal domain-like0.08668Inherited
SH2 domain0.1326Inherited
p53-like transcription factors0.1524Inherited
Frizzled cysteine-rich domain0.7343Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.00002598Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.0001314Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0001406Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.0005496Direct
    82199,57667
  • 82199 - SET domain
  • 57667 - beta-beta-alpha zinc fingers
  • 0.003179Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.004029Inherited
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.006542Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.006542Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.006542Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.006542Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.008479Inherited
    82171,53474
  • 82171 - DPP6 N-terminal domain-like
  • 53474 - alpha/beta-Hydrolases
  • 0.02202Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.6179Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.6179Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.6179Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.8841Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0001406Direct
    82199,57667,57667
  • 82199 - SET domain
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.003179Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.006542Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.006542Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.02202Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.6179Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.6179Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.6179Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)