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Disease Ontology (DO): cardiovascular system disease

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   disease [DOID:4] <8>
+ 1:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
0:   cardiovascular system disease [DOID:1287] <3>(41|53) (41|24|14)
- 1:   vascular disease [DOID:178] <13>(37|48) (38|22|11)
- 1:   heart disease [DOID:114] <8>(8|11) (9|5|4)
- 1:   pericardium disease [DOID:0050829] <2>(0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Insulin-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Anaphylotoxins (complement system)0Direct
Apolipoprotein A-I0Direct
Fibrinogen coiled-coil and central regions0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.00002301Direct
Cytochrome P4500.00003308Direct
Metalloproteases ("zincins"), catalytic domain0.0001778Direct
YWTD domain0.0008098Direct
FnI-like domain0.0009291Direct
Kringle-like0.001738Inherited
PGBD-like0.001907Inherited
GLA-domain0.002226Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain0.002906Inherited
Blood coagulation inhibitor (disintegrin)0.00514Inherited
EGF/Laminin0.006633Inherited
Leukotriene A4 hydrolase N-terminal domain0.007129Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.007359Inherited
Riboflavin synthase domain-like0.007359Inherited
Hemopexin-like domain0.007729Inherited
Snake toxin-like0.00778Inherited
Serpins0.01315Inherited
TIMP-like0.01474Inherited
Troponin coil-coiled subunits0.01716Inherited
Flavoproteins0.02433Inherited
Hairpin loop containing domain-like0.04026Inherited
MAPEG domain-like0.04026Inherited
Phospholipase A2, PLA20.04026Inherited
Calcium-dependent phosphotriesterase0.04026Inherited
TSP type-3 repeat0.04026Inherited
Nuclear receptor ligand-binding domain0.04552Inherited
Multidrug efflux transporter AcrB transmembrane domain0.05153Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.05313Inherited
TNF-like0.05604Inherited
Myosin rod fragments0.0699Inherited
TNF receptor-like0.07165Inherited
Somatomedin B domain0.1069Inherited
Cytokine0.1447Inherited
MHC antigen-recognition domain0.2702Inherited
Voltage-gated potassium channels0.515Inherited
RNA-binding domain, RBD1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Netrin-like domain (NTR/C345C module)0Direct
Fibrinogen coiled-coil and central regions0Direct
Apolipoprotein A-I0Direct
Anaphylotoxins (complement system)0Direct
Insulin-like0Direct
Tissue inhibitor of metalloproteinases, TIMP0Direct
Multidomain cupredoxins0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.00002099Direct
Cytochrome P4500.00007397Direct
YWTD domain0.000757Direct
EGF-type module0.0009047Direct
MMP N-terminal domain0.001852Inherited
Kringle modules0.001861Inherited
GLA-domain0.001861Inherited
Extracellular domain of cell surface receptors0.00235Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain0.00235Inherited
Blood coagulation inhibitor (disintegrin)0.004287Inherited
Leukotriene A4 hydrolase catalytic domain0.005749Inherited
Hemopexin-like domain0.006814Inherited
Serpins0.006912Inherited
Matrix metalloproteases, catalytic domain0.00726Inherited
Long-chain cytokines0.0118Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.01408Inherited
Leukotriene A4 hydrolase N-terminal domain0.01408Inherited
NADPH-cytochrome p450 reductase-like0.01408Inherited
Platelet-derived growth factor-like0.02076Inherited
TNF receptor-like0.02093Inherited
T-box0.0271Inherited
Cytochrome p450 reductase N-terminal domain-like0.03378Inherited
Interleukin 17F, IL-17F0.03378Inherited
Thrombospondin C-terminal domain0.03378Inherited
TSP type-3 repeat0.03378Inherited
Transforming growth factor (TGF)-beta0.04367Inherited
Nuclear receptor ligand-binding domain0.04573Inherited
Myosin rod fragments0.04765Inherited
Nuclear receptor0.05159Inherited
TNF-like0.05475Inherited
Fibronectin type II module0.06438Inherited
Short-chain cytokines0.07423Inherited
Somatomedin B domain0.09461Inherited
Pentraxin (pentaxin)0.09461Inherited
Pancreatic lipase, N-terminal domain0.09461Inherited
Interleukin-1 (IL-1)0.159Inherited
Voltage-gated potassium channels0.1667Inherited
Forkhead DNA-binding domain0.2074Inherited
SPRY domain0.2673Inherited
MHC antigen-recognition domain0.2681Inherited
C1 set domains (antibody constant domain-like)0.3181Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.3182Inherited
C-type lectin domain0.4771Inherited
Canonical RBD1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Apolipoprotein A-I0Direct
Anaphylotoxins (complement system)0Direct
Insulin-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.00001296Direct
Cytochrome P4500.00001886Direct
Metalloproteases ("zincins"), catalytic domain0.0001055Direct
YWTD domain0.0005028Direct
FnI-like domain0.0005824Direct
Kringle-like0.001116Inherited
PGBD-like0.001236Inherited
GLA-domain0.001464Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain0.001916Inherited
Blood coagulation inhibitor (disintegrin)0.003484Inherited
EGF/Laminin0.004557Inherited
Leukotriene A4 hydrolase N-terminal domain0.004921Inherited
Riboflavin synthase domain-like0.005066Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.005066Inherited
Hemopexin-like domain0.005321Inherited
Snake toxin-like0.005357Inherited
Serpins0.009306Inherited
TIMP-like0.01046Inherited
Troponin coil-coiled subunits0.01228Inherited
Flavoproteins0.01782Inherited
MAPEG domain-like0.03024Inherited
Phospholipase A2, PLA20.03024Inherited
TSP type-3 repeat0.03024Inherited
Calcium-dependent phosphotriesterase0.03024Inherited
Hairpin loop containing domain-like0.03024Inherited
Nuclear receptor ligand-binding domain0.03444Inherited
Multidrug efflux transporter AcrB transmembrane domain0.03923Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.04051Inherited
TNF-like0.04287Inherited
Myosin rod fragments0.05426Inherited
TNF receptor-like0.05577Inherited
Somatomedin B domain0.08505Inherited
Cytokine0.1171Inherited
MHC antigen-recognition domain0.2279Inherited
Voltage-gated potassium channels0.4539Inherited
RNA-binding domain, RBD1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.00006122Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.000269Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0007383Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.001236Inherited
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.001916Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.002026Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.003484Inherited
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0.004921Inherited
    63737,55486
  • 63737 - Leukotriene A4 hydrolase N-terminal domain
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.004921Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.005471Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.01228Inherited
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0.01228Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.01277Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0291Inherited
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0.03024Inherited
    103647,49899
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.03024Inherited
    103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.03024Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.03024Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.3079Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.4262Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.6469Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    49265,48726,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.001916Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.004518Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.004921Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.004921Inherited
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.005271Inherited
    103647,103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.03024Inherited
    103647,103647,49899
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.03024Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.04981Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2101Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.2147Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.3349Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)