SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Disease Ontology (DO): reproductive system disease

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   disease [DOID:4] <8>
+ 1:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
0:   reproductive system disease [DOID:15] <4>(11|13) (11|7|6)
- 1:   female reproductive system disease [DOID:229] <18>(7|11) (7|5|4)
- 1:   male reproductive system disease [DOID:48] <13>(0|0) (0|0|0)
- 1:   aromatase excess syndrome [DOID:0090122](0|0) (0|0|0)
- 1:   infertility [DOID:5223](2|2) (2|2|2)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
PGBD-like0.000001154Direct
Cystine-knot cytokines0.000003403Direct
Hemopexin-like domain0.0002766Direct
4-helical cytokines0.0005092Direct
Serum albumin-like0.007652Inherited
Kringle-like0.008384Inherited
Integrin domains0.008539Inherited
Aquaporin-like0.01435Inherited
Integrin alpha N-terminal domain0.02279Inherited
Metalloproteases ("zincins"), catalytic domain0.0501Inherited
Cytokine0.0538Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
MMP N-terminal domain0.000001259Direct
Matrix metalloproteases, catalytic domain0.000008305Direct
Hemopexin-like domain0.0002498Direct
Long-chain cytokines0.0004596Direct
Transforming growth factor (TGF)-beta0.0004808Direct
C5 cytosine-specific DNA methylase, DCM0.00185Inherited
Serum albumin-like0.006187Inherited
Interleukin-1 (IL-1)0.006989Inherited
Integrin domains0.007683Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.008321Inherited
Aquaporin-like0.01229Inherited
Integrin alpha N-terminal domain0.0205Inherited
Forkhead DNA-binding domain0.1071Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
PGBD-like0.0000005971Direct
Cystine-knot cytokines0.000001817Direct
Hemopexin-like domain0.0001673Direct
4-helical cytokines0.0003117Direct
Serum albumin-like0.005271Inherited
Kringle-like0.005761Inherited
Integrin domains0.00586Inherited
Aquaporin-like0.01017Inherited
Integrin alpha N-terminal domain0.01662Inherited
Metalloproteases ("zincins"), catalytic domain0.03805Inherited
Cytokine0.0411Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.0000005971Direct
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.0004435Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.001473Inherited
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.005271Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.00577Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.01662Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.01662Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.0001724Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.001121Inherited
    48552,48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.001547Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.007868Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.01172Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.01662Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)