SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Disease Ontology (DO): integumentary system disease

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   disease [DOID:4] <8>
+ 1:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
0:   integumentary system disease [DOID:16] <3>(30|34) (31|15|6)
- 1:   skin disease [DOID:37] <49>(27|31) (28|14|6)
- 1:   nail disease [DOID:4123] <12>(0|0) (0|0|0)
- 1:   hair disease [DOID:421] <4>(5|7) (5|2|1)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
Plakin repeat0Direct
Interleukin 8-like chemokines0.0000002714Direct
Intermediate filament protein, coiled coil region0.000004162Direct
4-helical cytokines0.000008479Direct
Transglutaminase, two C-terminal domains0.00002639Direct
TNF-like0.0002576Direct
Lipoxigenase0.0007506Direct
MHC antigen-recognition domain0.0007602Direct
TNF receptor-like0.0009267Direct
Anaphylotoxins (complement system)0.003565Inherited
Kringle-like0.003692Inherited
Alpha-macroglobulin receptor domain0.01136Inherited
Cytokine0.01261Inherited
Defensin-like0.01325Inherited
Cysteine proteinases0.01439Inherited
Terpenoid cyclases/Protein prenyltransferases0.02343Inherited
Integrin beta tail domain0.02343Inherited
Cadherin-like0.02641Inherited
Nuclear receptor ligand-binding domain0.03283Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.03397Inherited
Trypsin-like serine proteases0.04672Inherited
Toll/Interleukin receptor TIR domain0.04755Inherited
Spectrin repeat0.06426Inherited
E set domains0.09405Inherited
vWA-like0.1562Inherited
EGF/Laminin0.2337Inherited
Plexin repeat0.2749Inherited
Immunoglobulin0.2866Inherited
Cystine-knot cytokines0.3386Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
Plakin repeat0Direct
Interleukin 8-like chemokines0.0000002529Direct
Interleukin-1 (IL-1)0.000003431Direct
Intermediate filament protein, coiled coil region0.000003652Direct
Transglutaminase N-terminal domain0.00001973Direct
Transglutaminase, two C-terminal domains0.00001973Direct
Transglutaminase core0.0001079Direct
TNF receptor-like0.000161Direct
TNF-like0.0002163Direct
Animal lipoxigenases0.0005439Direct
MHC antigen-recognition domain0.0006289Direct
C1 set domains (antibody constant domain-like)0.0009343Direct
Short-chain cytokines0.000989Direct
Interferons/interleukin-10 (IL-10)0.000989Direct
Netrin-like domain (NTR/C345C module)0.002663Inherited
Interleukin 17F, IL-17F0.002663Inherited
Anaphylotoxins (complement system)0.002663Inherited
Lipoxigenase N-terminal domain0.002663Inherited
Alpha-macroglobulin receptor domain0.008837Inherited
Complement components0.008837Inherited
Defensin0.01109Inherited
Cadherin0.01604Inherited
Integrin beta tail domain0.01891Inherited
Integrin beta EGF-like domains0.01891Inherited
Eukaryotic proteases0.02534Inherited
Integrin A (or I) domain0.02889Inherited
Nuclear receptor ligand-binding domain0.02937Inherited
Toll/Interleukin receptor TIR domain0.04135Inherited
Nuclear receptor0.04678Inherited
Spectrin repeat0.05599Inherited
Laminin-type module0.05711Inherited
Interferon regulatory factor0.07576Inherited
Plexin repeat0.2637Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
Plakin repeat0Direct
Interleukin 8-like chemokines0.0000001358Direct
Intermediate filament protein, coiled coil region0.00000223Direct
4-helical cytokines0.000004646Direct
Transglutaminase, two C-terminal domains0.00001497Direct
TNF-like0.0001556Direct
Lipoxigenase0.0004636Direct
MHC antigen-recognition domain0.0004713Direct
TNF receptor-like0.0005809Direct
Anaphylotoxins (complement system)0.002384Inherited
Kringle-like0.002474Inherited
Alpha-macroglobulin receptor domain0.007977Inherited
Cytokine0.008879Inherited
Defensin-like0.009374Inherited
Cysteine proteinases0.0102Inherited
Terpenoid cyclases/Protein prenyltransferases0.01713Inherited
Integrin beta tail domain0.01713Inherited
Cadherin-like0.01942Inherited
Nuclear receptor ligand-binding domain0.02451Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.02537Inherited
Trypsin-like serine proteases0.03543Inherited
Toll/Interleukin receptor TIR domain0.03604Inherited
Spectrin repeat0.04959Inherited
E set domains0.07447Inherited
vWA-like0.1266Inherited
EGF/Laminin0.195Inherited
Plexin repeat0.2321Inherited
Immunoglobulin0.2429Inherited
Cystine-knot cytokines0.2907Inherited
MFS general substrate transporter0.5027Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    54001,49309
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.00001497Direct
    49309,49309
  • 49309 - Transglutaminase, two C-terminal domains
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.00001497Direct
    81296,54001
  • 81296 - E set domains
  • 54001 - Cysteine proteinases
  • 0.00001497Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.000301Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0004069Direct
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.0004135Direct
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.0004636Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.001892Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.001892Inherited
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0.002384Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.002714Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.01231Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01713Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1292Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    81296,54001,49309
  • 81296 - E set domains
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.00001497Direct
    54001,49309,49309
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.00001497Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.00008512Direct
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.01231Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01713Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.09971Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)