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Disease Ontology (DO): endocrine gland cancer

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   disease [DOID:4] <8>
+ + + 3:   disease of cellular proliferation [DOID:14566] <3>(123|191) (129|118|56)
+ + 2:   cancer [DOID:162] <2>(115|181) (120|113|54)
+ 1:   organ system cancer [DOID:0050686] <14>(66|106) (72|58|31)
0:   endocrine gland cancer [DOID:170] <7>(7|15) (8|12|3)
- 1:   adrenal gland cancer [DOID:3953] <5>(1|1) (1|0|0)
- 1:   pancreatic cancer [DOID:1793] <5>(4|7) (5|10|3)
- 1:   pineal gland cancer [DOID:5032] <5>(0|0) (0|0|0)
- 1:   neuroendocrine tumor [DOID:169] <4>(0|0) (0|0|0)
- 1:   thyroid cancer [DOID:1781] <3>(1|4) (2|2|0)
- 1:   pituitary cancer [DOID:1785] <2>(0|0) (0|0|0)
- 1:   parathyroid carcinoma [DOID:1540](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
Insulin-like0.001849Inherited
Galactose-binding domain-like0.006585Inherited
Kringle-like0.0128Inherited
TNF receptor-like0.02287Inherited
Nuclear receptor ligand-binding domain0.0751Inherited
PGBD-like0.09784Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
p53 DNA-binding domain-like0Direct
SAM (sterile alpha motif) domain0.0008107Direct
Insulin-like0.001419Inherited
Ephrin receptor ligand binding domain0.001888Inherited
Interleukin-1 (IL-1)0.003724Inherited
L domain0.01394Inherited
Platelet-derived growth factor-like0.02469Inherited
TNF receptor-like0.02862Inherited
Fibronectin type II module0.03937Inherited
Kringle modules0.05745Inherited
Nuclear receptor ligand-binding domain0.07153Inherited
MMP N-terminal domain0.08876Inherited
Nuclear receptor0.1134Inherited
Eukaryotic proteases0.217Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Insulin-like0.001193Inherited
Galactose-binding domain-like0.004519Inherited
Kringle-like0.00903Inherited
TNF receptor-like0.01668Inherited
Nuclear receptor ligand-binding domain0.0586Inherited
PGBD-like0.07768Inherited
Trypsin-like serine proteases0.22Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.0002777Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0006925Direct
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.0015Inherited
    49785,57184
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 0.001577Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.003041Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.006174Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.01223Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.01223Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0217Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.07768Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.1273Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49785,57184,49265
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.01223Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0217Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)