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Disease Ontology (DO): vascular disease

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   disease [DOID:4] <8>
+ + 2:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
+ 1:   cardiovascular system disease [DOID:1287] <3>(41|53) (41|24|14)
0:   vascular disease [DOID:178] <13>(37|48) (38|22|11)
- 1:   artery disease [DOID:0050828] <12>(29|34) (31|15|8)
- 1:   peripheral vascular disease [DOID:341] <8>(0|1) (0|1|0)
- 1:   vasculitis [DOID:865] <8>(3|7) (3|1|0)
- 1:   hepatic vascular disease [DOID:272] <7>(0|0) (0|0|0)
- 1:   vein disease [DOID:866] <5>(0|0) (0|0|0)
- 1:   capillary disease [DOID:1271] <3>(0|0) (0|0|0)
- 1:   ischemia [DOID:326] <3>(2|5) (2|1|1)
- 1:   cholesterol embolism [DOID:1461] <2>(0|0) (0|0|0)
- 1:   angiodysplasia [DOID:2494](0|0) (0|0|0)
- 1:   arterial calcification of infancy [DOID:0050644](0|0) (0|0|0)
- 1:   supine hypotensive syndrome [DOID:10556](0|0) (0|0|0)
- 1:   thoracic outlet syndrome [DOID:3103](0|0) (0|0|0)
- 1:   thrombosis [DOID:0060903](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Insulin-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Anaphylotoxins (complement system)0Direct
Apolipoprotein A-I0Direct
Fibrinogen coiled-coil and central regions0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.000007279Direct
GLA-domain0.000009182Direct
Leukotriene A4 hydrolase N-terminal domain0.0001921Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.0002Direct
YWTD domain0.0002548Direct
Serpins0.0002831Direct
TNF receptor-like0.0003119Direct
Kringle-like0.0003119Direct
Nuclear receptor ligand-binding domain0.0003371Direct
TNF-like0.0003837Direct
Blood coagulation inhibitor (disintegrin)0.001823Inherited
Hairpin loop containing domain-like0.004319Inherited
TSP type-3 repeat0.004319Inherited
Cytokine0.004433Inherited
Multidrug efflux transporter AcrB transmembrane domain0.008618Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.008939Inherited
Somatomedin B domain0.01354Inherited
MAPEG domain-like0.01354Inherited
Phospholipase A2, PLA20.01354Inherited
Calcium-dependent phosphotriesterase0.01354Inherited
Metalloproteases ("zincins"), catalytic domain0.1408Inherited
Snake toxin-like0.3136Inherited
Hemopexin-like domain0.3529Inherited
PGBD-like0.3939Inherited
EGF/Laminin0.4073Inherited
TIMP-like0.4445Inherited
Flavoproteins0.6271Inherited
Troponin coil-coiled subunits0.7008Inherited
MHC antigen-recognition domain0.7193Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.9779Inherited
Riboflavin synthase domain-like0.9779Inherited
RNA-binding domain, RBD1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Netrin-like domain (NTR/C345C module)0Direct
Fibrinogen coiled-coil and central regions0Direct
Apolipoprotein A-I0Direct
Anaphylotoxins (complement system)0Direct
Insulin-like0Direct
Multidomain cupredoxins0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.000006449Direct
GLA-domain0.000008621Direct
Extracellular domain of cell surface receptors0.00003393Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.00003393Direct
TNF receptor-like0.00005575Direct
Leukotriene A4 hydrolase catalytic domain0.0001629Direct
Serpins0.0001861Direct
YWTD domain0.0002432Direct
Long-chain cytokines0.0003799Direct
Nuclear receptor ligand-binding domain0.0004162Direct
TNF-like0.0004251Direct
Kringle modules0.0005149Direct
Nuclear receptor0.000706Direct
Leukotriene A4 hydrolase N-terminal domain0.0007768Direct
Blood coagulation inhibitor (disintegrin)0.001661Inherited
Platelet-derived growth factor-like0.002123Inherited
Cytochrome p450 reductase N-terminal domain-like0.003539Inherited
Interleukin 17F, IL-17F0.003539Inherited
Thrombospondin C-terminal domain0.003539Inherited
TSP type-3 repeat0.003539Inherited
Somatomedin B domain0.01153Inherited
Pentraxin (pentaxin)0.01153Inherited
Interleukin-1 (IL-1)0.01447Inherited
Pancreatic lipase, N-terminal domain0.02424Inherited
Fibronectin type II module0.0379Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.09825Inherited
C-type lectin domain0.1619Inherited
Transforming growth factor (TGF)-beta0.2447Inherited
Hemopexin-like domain0.3153Inherited
MMP N-terminal domain0.3554Inherited
Matrix metalloproteases, catalytic domain0.3554Inherited
Short-chain cytokines0.4565Inherited
EGF-type module0.5163Inherited
SPRY domain0.5835Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.6578Inherited
NADPH-cytochrome p450 reductase-like0.6578Inherited
Tissue inhibitor of metalloproteinases, TIMP0.6578Inherited
MHC antigen-recognition domain0.6797Inherited
C1 set domains (antibody constant domain-like)0.6797Inherited
Canonical RBD1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Apolipoprotein A-I0Direct
Anaphylotoxins (complement system)0Direct
Insulin-like0Direct
Fibrinogen coiled-coil and central regions0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.000003951Direct
GLA-domain0.00000506Direct
Leukotriene A4 hydrolase N-terminal domain0.0001146Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.0001197Direct
YWTD domain0.0001538Direct
Serpins0.0001714Direct
Kringle-like0.0001886Direct
TNF receptor-like0.0001886Direct
Nuclear receptor ligand-binding domain0.0002045Direct
TNF-like0.0002337Direct
Blood coagulation inhibitor (disintegrin)0.001175Inherited
TSP type-3 repeat0.002903Inherited
Hairpin loop containing domain-like0.002903Inherited
Cytokine0.002984Inherited
Multidrug efflux transporter AcrB transmembrane domain0.005922Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.006174Inherited
Somatomedin B domain0.009574Inherited
MAPEG domain-like0.009574Inherited
Phospholipase A2, PLA20.009574Inherited
Calcium-dependent phosphotriesterase0.009574Inherited
Metalloproteases ("zincins"), catalytic domain0.1138Inherited
Snake toxin-like0.2679Inherited
Hemopexin-like domain0.3034Inherited
PGBD-like0.3403Inherited
EGF/Laminin0.3528Inherited
TIMP-like0.3873Inherited
Flavoproteins0.5587Inherited
Troponin coil-coiled subunits0.6292Inherited
MHC antigen-recognition domain0.6477Inherited
FnI-like domain0.7757Inherited
Riboflavin synthase domain-like0.9101Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.9101Inherited
RNA-binding domain, RBD1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0000006635Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.00002559Direct
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.00004Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0001052Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0.0001146Direct
    63737,55486
  • 63737 - Leukotriene A4 hydrolase N-terminal domain
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.0001146Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.0001197Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.0005996Direct
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0.0005996Direct
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.001175Inherited
    103647,49899
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.002903Inherited
    103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.002903Inherited
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0.009574Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.009574Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.2881Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.3403Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.4367Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0.4442Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.6966Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0001146Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0001146Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.0001197Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.0001538Direct
    103647,103647,103647
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 0.002903Inherited
    103647,103647,49899
  • 103647 - TSP type-3 repeat
  • 103647 - TSP type-3 repeat
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.002903Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.007136Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.05639Inherited
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.4367Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.6292Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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