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Disease Ontology (DO): syndrome

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   disease [DOID:4] <8>
0:   syndrome [DOID:225] <110>(16|23) (16|12|10)
- 1:   Noonan syndrome [DOID:3490] <10>(0|0) (0|0|0)
- 1:   Robinow syndrome [DOID:0060254] <4>(0|0) (0|0|0)
- 1:   lethal congenital contracture syndrome [DOID:0060558] <4>(0|0) (0|0|0)
- 1:   3MC syndrome [DOID:0060225] <3>(0|0) (0|0|0)
- 1:   Ritscher-Schinzel syndrome [DOID:0060565] <2>(0|0) (0|0|0)
- 1:   Wolfram syndrome [DOID:10632] <2>(0|0) (0|0|0)
- 1:   Ohdo syndrome [DOID:0060289] <1>(0|0) (0|0|0)
- 1:   ARC syndrome [DOID:0050763](0|0) (0|0|0)
- 1:   Aagenaes syndrome [DOID:6691](0|0) (0|0|0)
- 1:   Achard syndrome [DOID:6686](0|0) (0|0|0)
- 1:   Adams-Oliver syndrome [DOID:0060227](0|0) (0|0|0)
- 1:   Adie syndrome [DOID:11549](0|0) (0|0|0)
- 1:   Aicardi syndrome [DOID:8461](0|0) (0|0|0)
- 1:   Baraitser-Winter syndrome [DOID:0060229](0|0) (0|0|0)
- 1:   Barber-Say syndrome [DOID:0060549](0|0) (0|0|0)
- 1:   Barre-Lieou syndrome [DOID:6692](0|0) (0|0|0)
- 1:   Beckwith-Wiedemann syndrome [DOID:5572](0|0) (0|0|0)
- 1:   Beemer-Langer syndrome [DOID:9249](0|0) (0|0|0)
- 1:   Bruck syndrome [DOID:0060231](0|0) (0|0|0)
- 1:   CHARGE syndrome [DOID:0050834](0|0) (0|0|0)
- 1:   CREST syndrome [DOID:0060218](0|0) (0|0|0)
- 1:   Carey-Fineman-Ziter syndrome [DOID:0080194](0|0) (0|0|0)
- 1:   Dubowitz syndrome [DOID:14796](0|0) (0|0|0)
- 1:   EAST syndrome [DOID:0060484](0|0) (0|0|0)
- 1:   Fanconi-like syndrome [DOID:0090066](0|0) (0|0|0)
- 1:   Felty's syndrome [DOID:11042](0|0) (0|0|0)
- 1:   Fuchs' heterochromic uveitis [DOID:9375](0|0) (0|0|0)
- 1:   Gamstorp-Wohlfart syndrome [DOID:0050526](0|0) (0|0|0)
- 1:   Goldberg-Shprintzen syndrome [DOID:0060481](0|0) (0|0|0)
- 1:   Goldenhar syndrome [DOID:2907](0|0) (0|0|0)
- 1:   Gorham's disease [DOID:4837](0|0) (0|0|0)
- 1:   Hallermann-Streiff syndrome [DOID:4534](0|0) (0|0|0)
- 1:   Holzgreve-Wagner-Rehder Syndrome [DOID:0060566](0|0) (0|0|0)
- 1:   IMAGe syndrome [DOID:0050885](0|0) (0|0|0)
- 1:   Jensen syndrome [DOID:0050867](0|0) (0|0|0)
- 1:   KBG syndrome [DOID:14780](0|0) (0|0|0)
- 1:   Kabuki syndrome [DOID:0060473](0|0) (0|0|0)
- 1:   Kleefstra syndrome [DOID:0060352](0|0) (0|0|0)
- 1:   Klippel-Trenaunay syndrome [DOID:2926](0|0) (0|0|0)
- 1:   Koolen de Vries syndrome [DOID:0050880](0|0) (0|0|0)
- 1:   Lown-Ganong-Levine syndrome [DOID:13087](0|0) (0|0|0)
- 1:   MEDNIK syndrome [DOID:0060483](0|0) (0|0|0)
- 1:   Maffucci syndrome [DOID:0060221](0|0) (0|0|0)
- 1:   Marshall-Smith syndrome [DOID:0050858](0|0) (0|0|0)
- 1:   Miller-Dieker lissencephaly syndrome [DOID:0060469](0|0) (0|0|0)
- 1:   Mowat-Wilson syndrome [DOID:0060485](0|0) (0|0|0)
- 1:   N syndrome [DOID:0050769](0|0) (0|0|0)
- 1:   Ollier disease [DOID:4624](0|0) (0|0|0)
- 1:   PTEN hamartoma tumor syndrome [DOID:0080191](0|0) (0|0|0)
- 1:   Perlman syndrome [DOID:0060476](0|0) (0|0|0)
- 1:   Perry syndrome [DOID:0060486](0|0) (0|0|0)
- 1:   Peters plus syndrome [DOID:0080201](0|0) (0|0|0)
- 1:   Pitt-Hopkins syndrome [DOID:0060488](0|0) (0|0|0)
- 1:   Qazi Markouizos syndrome [DOID:0050740](0|0) (0|0|0)
- 1:   Reye syndrome [DOID:14525](0|0) (0|0|0)
- 1:   SAPHO syndrome [DOID:13677](0|0) (0|0|0)
- 1:   Saldino-Noonan syndrome [DOID:0050549](0|0) (0|0|0)
- 1:   Shwachman-Diamond syndrome [DOID:0060479](0|0) (0|0|0)
- 1:   Takayasu's arteritis [DOID:2508](0|0) (0|0|0)
- 1:   VACTERL association [DOID:14679](0|0) (0|0|0)
- 1:   Van Maldergem syndrome [DOID:0060238](0|0) (0|0|0)
- 1:   Van der Woude syndrome [DOID:0060239](0|0) (0|0|0)
- 1:   Warsaw breakage syndrome [DOID:0060535](0|0) (0|0|0)
- 1:   Wissler's syndrome [DOID:3047](0|0) (0|0|0)
- 1:   XFE progeroid syndrome [DOID:0060590](0|0) (0|0|0)
- 1:   Yunis-Varon syndrome [DOID:0060589](0|0) (0|0|0)
- 1:   Zika virus congenital syndrome [DOID:0080180](0|0) (0|0|0)
- 1:   Zollinger-Ellison syndrome [DOID:0050782](0|0) (0|0|0)
- 1:   ablepharon macrostomia syndrome [DOID:0060550](0|0) (0|0|0)
- 1:   acrocallosal syndrome [DOID:9250](0|0) (0|0|0)
- 1:   acrorenal syndrome [DOID:0060347](0|0) (0|0|0)
- 1:   branchiootic syndrome [DOID:0060232](0|0) (0|0|0)
- 1:   cardiofaciocutaneous syndrome [DOID:0060233](0|0) (0|0|0)
- 1:   chondrodysplasia-pseudohermaphroditism syndrome [DOID:0060644](0|0) (0|0|0)
- 1:   chronic atrial and intestinal dysrhythmia [DOID:0060339](0|0) (0|0|0)
- 1:   chronic fatigue syndrome [DOID:8544](0|0) (0|0|0)
- 1:   cocoon syndrome [DOID:0060647](0|0) (0|0|0)
- 1:   diffuse infiltrative lymphocytosis syndrome [DOID:6677](0|0) (0|0|0)
- 1:   endocrine-cerebro-osteodysplasia syndrome [DOID:0060641](0|0) (0|0|0)
- 1:   fetal valproate syndrome [DOID:0060471](0|0) (0|0|0)
- 1:   fibrogenesis imperfecta ossium [DOID:0080040](0|0) (0|0|0)
- 1:   hypotonia-cystinuria syndrome [DOID:0060858](0|0) (0|0|0)
- 1:   inclusion body myopathy with Paget disease of bone and frontotemporal dementia [DOID:0050881](0|0) (0|0|0)
- 1:   irritable bowel syndrome [DOID:9778](3|2) (3|0|0)
- 1:   mandibulofacial dysostosis with alopecia [DOID:0060365](0|0) (0|0|0)
- 1:   megacystis-microcolon-intestinal hypoperistalsis syndrome [DOID:0060610](0|0) (0|0|0)
- 1:   microcephaly and chorioretinopathy 1 [DOID:0080105](0|0) (0|0|0)
- 1:   microcephaly and chorioretinopathy 2 [DOID:0080106](0|0) (0|0|0)
- 1:   microcephaly and chorioretinopathy 3 [DOID:0080107](0|0) (0|0|0)
- 1:   microcephaly with or without chorioretinopathy, lymphedema, or mental retardation [DOID:0060349](0|0) (0|0|0)
- 1:   mosaic variegated aneuploidy syndrome 1 [DOID:0080141](0|0) (0|0|0)
- 1:   mosaic variegated aneuploidy syndrome 2 [DOID:0080142](0|0) (0|0|0)
- 1:   multicentric reticulohistiocytosis [DOID:11824](0|0) (0|0|0)
- 1:   multiple chemical sensitivity [DOID:4661](0|0) (0|0|0)
- 1:   multiple congenital anomalies-hypotonia-seizures syndrome 1 [DOID:0080138](0|0) (0|0|0)
- 1:   multiple congenital anomalies-hypotonia-seizures syndrome 2 [DOID:0080139](0|0) (0|0|0)
- 1:   multiple congenital anomalies-hypotonia-seizures syndrome 3 [DOID:0080140](0|0) (0|0|0)
- 1:   oculoauricular syndrome [DOID:0060482](0|0) (0|0|0)
- 1:   oculodentodigital dysplasia [DOID:0060291](0|0) (0|0|0)
- 1:   palindromic rheumatism [DOID:1166](0|0) (0|0|0)
- 1:   persian gulf syndrome [DOID:4491](0|0) (0|0|0)
- 1:   polycystic ovary syndrome [DOID:11612](1|5) (1|0|0)
- 1:   primary hypertrophic osteoarthropathy [DOID:14283](0|0) (0|0|0)
- 1:   prune belly syndrome [DOID:0060889](0|0) (0|0|0)
- 1:   psoriatic arthritis [DOID:9008](1|3) (1|1|0)
- 1:   subclavian steal syndrome [DOID:13002](0|0) (0|0|0)
- 1:   sudden infant death syndrome [DOID:9007](1|1) (1|0|0)
- 1:   tooth and nail syndrome [DOID:6678](0|0) (0|0|0)
- 1:   ulnar-mammary syndrome [DOID:0060614](0|0) (0|0|0)
- 1:   yellow nail syndrome [DOID:0050468](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Composite domain of metallo-dependent hydrolases0Direct
Apolipoprotein A-I0Direct
2Fe-2S ferredoxin-like0Direct
GTF2I-like repeat0Direct
HRDC-like0Direct
4-helical cytokines0.0001276Direct
GLA-domain0.0002617Direct
Complement control module/SCR domain0.0006361Direct
Kringle-like0.000865Direct
Insulin-like0.01813Inherited
Toll/Interleukin receptor TIR domain0.01977Inherited
Voltage-gated potassium channels0.02291Inherited
DEATH domain0.05173Inherited
RNI-like0.2369Inherited
MHC antigen-recognition domain0.2878Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Noncollagenous (NC1) domain of collagen IV0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Apolipoprotein A-I0Direct
NADPH-cytochrome p450 reductase-like0Direct
Hydantoinase (dihydropyrimidinase)0Direct
Hydantoinase (dihydropyrimidinase), catalytic domain0Direct
GTF2I-like repeat0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
GLA-domain0.0002034Direct
Complement control module/SCR domain0.0005945Direct
Long-chain cytokines0.0007126Direct
Cytoplasmic domain of inward rectifier potassium channel0.0007126Direct
Toll/Interleukin receptor TIR domain0.01185Inherited
Insulin-like0.01467Inherited
Transforming growth factor (TGF)-beta0.01516Inherited
Retinol binding protein-like0.03313Inherited
Interleukin-1 (IL-1)0.06032Inherited
C1 set domains (antibody constant domain-like)0.1674Inherited
S100 proteins0.2423Inherited
MHC antigen-recognition domain0.2779Inherited
Tyrosine-dependent oxidoreductases0.3364Inherited
Caspase recruitment domain, CARD0.4755Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
2Fe-2S ferredoxin-like0Direct
GTF2I-like repeat0Direct
Apolipoprotein A-I0Direct
Composite domain of metallo-dependent hydrolases0Direct
HRDC-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
4-helical cytokines0.00007573Direct
GLA-domain0.0001582Direct
Complement control module/SCR domain0.0003909Direct
Kringle-like0.0005403Direct
Insulin-like0.01303Inherited
Toll/Interleukin receptor TIR domain0.01431Inherited
Voltage-gated potassium channels0.01672Inherited
DEATH domain0.0394Inherited
RNI-like0.1978Inherited
MHC antigen-recognition domain0.2441Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57581,57581
  • 57581 - TB module/8-cys domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    57196,50494
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.00002591Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0005124Direct
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.0005711Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0008449Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.2655Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    51338,51556,51338
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    57581,57184,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57581,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57630,57196,50494
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)