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Disease Ontology (DO): hematologic cancer

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   disease [DOID:4] <8>
+ + + + 4:   disease of cellular proliferation [DOID:14566] <3>(123|191) (129|118|56)
+ + + 3:   cancer [DOID:162] <2>(115|181) (120|113|54)
+ + 2:   organ system cancer [DOID:0050686] <14>(66|106) (72|58|31)
+ 1:   immune system cancer [DOID:0060083] <3>(31|42) (33|27|13)
0:   hematologic cancer [DOID:2531] <7>(30|42) (32|25|13)
- 1:   leukemia [DOID:1240] <11>(14|23) (16|19|11)
- 1:   lymphoma [DOID:0060058] <7>(8|7) (9|1|1)
- 1:   histiocytic and dendritic cell cancer [DOID:5621] <3>(0|0) (0|0|0)
- 1:   mast cell neoplasm [DOID:3664] <3>(0|0) (0|0|0)
- 1:   refractory hematologic cancer [DOID:712] <3>(0|0) (0|0|0)
- 1:   bone marrow cancer [DOID:4960] <2>(10|13) (10|8|6)
- 1:   myeloid sarcoma [DOID:8683](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
TAFH domain-like0Direct
4-helical cytokines0.00000007246Direct
TNF receptor-like0.0000001167Direct
Inhibitor of apoptosis (IAP) repeat0.0001254Direct
A DNA-binding domain in eukaryotic transcription factors0.000165Direct
Leucine zipper domain0.0002538Direct
p53-like transcription factors0.001442Inherited
Bcl-2 inhibitors of programmed cell death0.002943Inherited
MHC antigen-recognition domain0.003338Inherited
Defensin-like0.005877Inherited
TNF-like0.007035Inherited
Frizzled cysteine-rich domain0.009234Inherited
Integrin domains0.01292Inherited
STAT0.01722Inherited
Transcription factor STAT-4 N-domain0.01722Inherited
Notch domain0.02348Inherited
Interleukin 8-like chemokines0.02757Inherited
PGBD-like0.02919Inherited
ABC transporter transmembrane region0.03079Inherited
Kringle-like0.0459Inherited
TIMP-like0.06054Inherited
SOCS box-like0.07582Inherited
HD-domain/PDEase-like0.1187Inherited
DPP6 N-terminal domain-like0.1632Inherited
Hemopexin-like domain0.181Inherited
Toll/Interleukin receptor TIR domain0.181Inherited
Cystine-knot cytokines0.2149Inherited
Arginase/deacetylase0.4181Inherited
SH2 domain0.8738Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
BAFF receptor-like0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
DNA ligase0Direct
TAFH domain-like0Direct
p53 DNA-binding domain-like0Direct
Short-chain cytokines0.000000008689Direct
TNF receptor-like0.000005252Direct
Inhibitor of apoptosis (IAP) repeat0.0000953Direct
A DNA-binding domain in eukaryotic transcription factors0.0001274Direct
C2 set domains0.0001274Direct
Leucine zipper domain0.0002352Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0007943Direct
Bcl-2 inhibitors of programmed cell death0.002353Inherited
MHC antigen-recognition domain0.00292Inherited
C1 set domains (antibody constant domain-like)0.00292Inherited
Defensin0.004647Inherited
L domain0.005838Inherited
DEATH effector domain, DED0.006024Inherited
Nucleoside diphosphate kinase, NDK0.006024Inherited
TNF-like0.006097Inherited
ABC transporter transmembrane region0.007585Inherited
Frizzled cysteine-rich domain0.007722Inherited
Integrin domains0.01108Inherited
STAT DNA-binding domain0.0139Inherited
STAT0.0139Inherited
Transcription factor STAT-4 N-domain0.0139Inherited
Fibronectin type II module0.01722Inherited
Notch domain0.019Inherited
MMP N-terminal domain0.02527Inherited
Interleukin 8-like chemokines0.02564Inherited
Interleukin-1 (IL-1)0.02601Inherited
DPP6 N-terminal domain-like0.03983Inherited
PDEase0.06012Inherited
Matrix metalloproteases, catalytic domain0.06104Inherited
SOCS box-like0.06586Inherited
ABC transporter ATPase domain-like0.1263Inherited
Toll/Interleukin receptor TIR domain0.1382Inherited
Hemopexin-like domain0.1667Inherited
Histone deacetylase, HDAC0.2399Inherited
SH2 domain0.8423Inherited
I set domains0.853Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
TAFH domain-like0Direct
4-helical cytokines0.00000003541Direct
TNF receptor-like0.0000000576Direct
Inhibitor of apoptosis (IAP) repeat0.00007431Direct
A DNA-binding domain in eukaryotic transcription factors0.00009852Direct
Leucine zipper domain0.0001531Direct
p53-like transcription factors0.0009203Direct
Bcl-2 inhibitors of programmed cell death0.001941Inherited
MHC antigen-recognition domain0.002223Inherited
Defensin-like0.004027Inherited
TNF-like0.004853Inherited
Frizzled cysteine-rich domain0.006408Inherited
Integrin domains0.009118Inherited
STAT0.01231Inherited
Transcription factor STAT-4 N-domain0.01231Inherited
Nucleoside diphosphate kinase, NDK0.01717Inherited
Notch domain0.01717Inherited
Interleukin 8-like chemokines0.02031Inherited
PGBD-like0.02161Inherited
ABC transporter transmembrane region0.02289Inherited
Kringle-like0.0348Inherited
TIMP-like0.04654Inherited
SOCS box-like0.05927Inherited
HD-domain/PDEase-like0.09496Inherited
DPP6 N-terminal domain-like0.1328Inherited
Cytokine0.1454Inherited
Toll/Interleukin receptor TIR domain0.1483Inherited
Hemopexin-like domain0.1483Inherited
Cystine-knot cytokines0.1784Inherited
Arginase/deacetylase0.3627Inherited
SH2 domain0.8018Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0Direct
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000001155Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.00007431Direct
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.00009852Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.0003228Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.000389Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.0008614Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.002407Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00518Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.00518Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.00518Inherited
    82199,57667
  • 82199 - SET domain
  • 57667 - beta-beta-alpha zinc fingers
  • 0.005437Inherited
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0.005437Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.008434Inherited
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.01231Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01231Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.01231Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01231Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.02161Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02289Inherited
    82171,53474
  • 82171 - DPP6 N-terminal domain-like
  • 53474 - alpha/beta-Hydrolases
  • 0.03599Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.03599Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000389Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00518Inherited
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.005437Inherited
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0.005437Inherited
    82199,57667,57667
  • 82199 - SET domain
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.005437Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01231Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01231Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.03599Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)