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Disease Ontology (DO): immune system disease

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   disease [DOID:4] <8>
+ 1:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
0:   immune system disease [DOID:2914] <4>(39|47) (42|27|16)
- 1:   lymphatic system disease [DOID:75] <9>(4|7) (5|3|1)
- 1:   primary immunodeficiency disease [DOID:612] <8>(6|3) (6|3|0)
- 1:   hypersensitivity reaction disease [DOID:0060056] <5>(35|46) (37|23|14)
- 1:   otulipenia [DOID:0080163](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Di-copper centre-containing domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Anaphylotoxins (complement system)0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Immunoglobulin0.000000000001216Direct
4-helical cytokines0.00000139Direct
MHC antigen-recognition domain0.00002223Direct
TNF-like0.0002339Direct
TNF receptor-like0.0003369Direct
Notch domain0.000695Direct
PGBD-like0.007887Inherited
Toll/Interleukin receptor TIR domain0.01302Inherited
Integrin domains0.01302Inherited
Interleukin 8-like chemokines0.0171Inherited
DEATH domain0.01758Inherited
ABC transporter transmembrane region0.01936Inherited
Calcium-dependent phosphotriesterase0.01949Inherited
Hemopexin-like domain0.02034Inherited
Complement control module/SCR domain0.02076Inherited
STAT0.02212Inherited
Transcription factor STAT-4 N-domain0.02212Inherited
Integrin beta tail domain0.02212Inherited
Single hybrid motif0.03865Inherited
Bcl-2 inhibitors of programmed cell death0.03941Inherited
Transglutaminase, two C-terminal domains0.04749Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.07615Inherited
Riboflavin synthase domain-like0.07615Inherited
RNI-like0.08276Inherited
CoA-dependent acyltransferases0.1057Inherited
SMAD MH1 domain0.1057Inherited
Plexin repeat0.1353Inherited
Growth factor receptor domain0.2234Inherited
Cytokine0.3033Inherited
Cysteine proteinases0.3489Inherited
vWA-like0.4428Inherited
Metalloproteases ("zincins"), catalytic domain0.4705Inherited
E set domains0.5939Inherited
EGF/Laminin0.5941Inherited
SET domain0.7409Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Netrin-like domain (NTR/C345C module)0Direct
Anaphylotoxins (complement system)0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
C1 set domains (antibody constant domain-like)0.00000608Direct
MHC antigen-recognition domain0.00001613Direct
Short-chain cytokines0.0001218Direct
Interferons/interleukin-10 (IL-10)0.0001218Direct
TNF-like0.0001726Direct
I set domains0.0002352Direct
Notch domain0.0005121Direct
TNF receptor-like0.0006865Direct
V set domains (antibody variable domain-like)0.001235Inherited
ABC transporter transmembrane region0.001882Inherited
Matrix metalloproteases, catalytic domain0.005121Inherited
C2 set domains0.006409Inherited
MMP N-terminal domain0.006428Inherited
Toll/Interleukin receptor TIR domain0.01015Inherited
Integrin domains0.01015Inherited
Interleukin 8-like chemokines0.01381Inherited
Cytochrome p450 reductase N-terminal domain-like0.01485Inherited
Interleukin-1 (IL-1)0.01596Inherited
Hemopexin-like domain0.01604Inherited
Complement control module/SCR domain0.01686Inherited
STAT DNA-binding domain0.01705Inherited
STAT0.01705Inherited
Integrin beta tail domain0.01705Inherited
Integrin beta EGF-like domains0.01705Inherited
Transcription factor STAT-4 N-domain0.01705Inherited
S100 proteins0.03138Inherited
Bcl-2 inhibitors of programmed cell death0.03138Inherited
Biotinyl/lipoyl-carrier proteins and domains0.03234Inherited
Transglutaminase N-terminal domain0.03823Inherited
Transglutaminase, two C-terminal domains0.03823Inherited
Platelet-derived growth factor-like0.03823Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.04421Inherited
NADPH-cytochrome p450 reductase-like0.04421Inherited
Pentraxin (pentaxin)0.04421Inherited
Long-chain cytokines0.05371Inherited
Transglutaminase core0.0688Inherited
SMAD MH1 domain0.08817Inherited
SMAD domain0.08817Inherited
Growth factor receptor domain0.1104Inherited
Plexin repeat0.1247Inherited
Ankyrin repeat0.1777Inherited
Integrin A (or I) domain0.3022Inherited
EGF-type module0.3582Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Anaphylotoxins (complement system)0Direct
Di-copper centre-containing domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Immunoglobulin0.0000000000005474Direct
4-helical cytokines0.0000007224Direct
MHC antigen-recognition domain0.00001249Direct
TNF-like0.0001404Direct
TNF receptor-like0.0002043Direct
Notch domain0.0004273Direct
Kringle-like0.0007947Direct
PGBD-like0.005433Inherited
Integrin domains0.009207Inherited
Toll/Interleukin receptor TIR domain0.009207Inherited
Interleukin 8-like chemokines0.01223Inherited
DEATH domain0.01261Inherited
ABC transporter transmembrane region0.014Inherited
Calcium-dependent phosphotriesterase0.01409Inherited
Hemopexin-like domain0.01473Inherited
Complement control module/SCR domain0.01504Inherited
STAT0.01608Inherited
Integrin beta tail domain0.01608Inherited
Transcription factor STAT-4 N-domain0.01608Inherited
Single hybrid motif0.02897Inherited
Bcl-2 inhibitors of programmed cell death0.0296Inherited
Snake toxin-like0.03485Inherited
Transglutaminase, two C-terminal domains0.03599Inherited
Riboflavin synthase domain-like0.0595Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0595Inherited
RNI-like0.06502Inherited
SMAD MH1 domain0.08417Inherited
CoA-dependent acyltransferases0.08417Inherited
Plexin repeat0.1091Inherited
Ankyrin repeat0.1778Inherited
Growth factor receptor domain0.1859Inherited
Cytokine0.2584Inherited
Cysteine proteinases0.2998Inherited
vWA-like0.3856Inherited
Metalloproteases ("zincins"), catalytic domain0.4119Inherited
E set domains0.5276Inherited
EGF/Laminin0.5278Inherited
SET domain0.6691Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.000003914Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.00001338Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.000033Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.00004094Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0002729Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.002167Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.005433Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.014Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.01403Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01608Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01608Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.01608Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01608Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.032Inherited
    54001,49309
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.03599Inherited
    49309,49309
  • 49309 - Transglutaminase, two C-terminal domains
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.03599Inherited
    81296,54001
  • 81296 - E set domains
  • 54001 - Cysteine proteinases
  • 0.03599Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.04953Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1504Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.1516Inherited
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.1987Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3813Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.001503Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.001503Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.004717Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.01493Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01608Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01608Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01608Inherited
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.02603Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.02934Inherited
    81296,54001,49309
  • 81296 - E set domains
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.03599Inherited
    54001,49309,49309
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.03599Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.07811Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2078Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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