SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Disease Ontology (DO): gastrointestinal system cancer

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   disease [DOID:4] <8>
+ + + 3:   disease of cellular proliferation [DOID:14566] <3>(123|191) (129|118|56)
+ + 2:   cancer [DOID:162] <2>(115|181) (120|113|54)
+ 1:   organ system cancer [DOID:0050686] <14>(66|106) (72|58|31)
0:   gastrointestinal system cancer [DOID:3119] <14>(12|23) (14|20|8)
- 1:   oral cavity cancer [DOID:8618] <10>(4|3) (4|1|0)
- 1:   stomach cancer [DOID:10534] <10>(1|2) (1|2|1)
- 1:   esophageal cancer [DOID:5041] <6>(0|0) (0|0|0)
- 1:   liver cancer [DOID:3571] <4>(5|7) (6|5|1)
- 1:   pharynx cancer [DOID:0060119] <4>(0|2) (1|4|1)
- 1:   intestinal cancer [DOID:10155] <3>(3|10) (3|7|4)
- 1:   biliary tract cancer [DOID:4607] <2>(2|4) (2|1|0)
- 1:   peritoneal carcinoma [DOID:1791] <1>(0|0) (0|0|0)
- 1:   gastroesophageal junction adenocarcinoma [DOID:4944](0|0) (0|0|0)
- 1:   gastrointestinal adenoma [DOID:4147](0|0) (0|0|0)
- 1:   gastrointestinal carcinoma [DOID:0050922](0|0) (0|0|0)
- 1:   gastrointestinal lymphoma [DOID:903](0|0) (0|0|0)
- 1:   gastrointestinal neuroendocrine tumor [DOID:0050626](0|0) (0|0|0)
- 1:   gastrointestinal stromal tumor [DOID:9253](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
p53 tetramerization domain0Direct
Transferrin receptor-like dimerisation domain0Direct
FAS1 domain0Direct
Notch domain0.003519Inherited
Protein kinase-like (PK-like)0.005263Inherited
Growth factor receptor domain0.009537Inherited
p53-like transcription factors0.01839Inherited
PGBD-like0.1189Inherited
Hemopexin-like domain0.1849Inherited
Bcl-2 inhibitors of programmed cell death0.2032Inherited
Metalloproteases ("zincins"), catalytic domain0.7554Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Transferrin receptor-like dimerisation domain0Direct
p53 tetramerization domain0Direct
FAS1 domain0Direct
PA domain0Direct
Bee venom hyaluronidase0Direct
FolH catalytic domain-like0Direct
p53 DNA-binding domain-like0Direct
L domain0Direct
Notch domain0.002647Inherited
Protein kinases, catalytic subunit0.004771Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.02076Inherited
Platelet-derived growth factor-like0.02076Inherited
UDPGT-like0.02076Inherited
Ephrin receptor ligand binding domain0.04092Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.04262Inherited
Growth factor receptor domain0.05413Inherited
DNA gyrase/MutL, N-terminal domain0.06549Inherited
DNA gyrase/MutL, second domain0.06549Inherited
Matrix metalloproteases, catalytic domain0.06976Inherited
MMP N-terminal domain0.1005Inherited
Hemopexin-like domain0.1609Inherited
Bcl-2 inhibitors of programmed cell death0.1766Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.2488Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Transferrin receptor-like dimerisation domain0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
FAS1 domain0Direct
Notch domain0.002353Inherited
Protein kinase-like (PK-like)0.003574Inherited
Growth factor receptor domain0.006633Inherited
p53-like transcription factors0.01324Inherited
MHC antigen-recognition domain0.03022Inherited
PGBD-like0.0951Inherited
Hemopexin-like domain0.1517Inherited
Bcl-2 inhibitors of programmed cell death0.1679Inherited
Cyclin-like0.6335Inherited
Metalloproteases ("zincins"), catalytic domain0.683Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    53187,47672
  • 53187 - Zn-dependent exopeptidases
  • 47672 - Transferrin receptor-like dimerisation domain
  • 0Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    52025,53187
  • 52025 - PA domain
  • 53187 - Zn-dependent exopeptidases
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.01969Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.02255Inherited
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.03852Inherited
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0.06305Inherited
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.06305Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.06651Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.0951Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.1121Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.2059Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.4527Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    52025,53187,47672
  • 52025 - PA domain
  • 53187 - Zn-dependent exopeptidases
  • 47672 - Transferrin receptor-like dimerisation domain
  • 0Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0006384Direct
    49785,57184,49265
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0.1121Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)