SUPERFAMILY 1.75 HMM library and genome assignments server

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Disease Ontology (DO): demyelinating disease

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   disease [DOID:4] <8>
+ + + + 4:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
+ + + 3:   nervous system disease [DOID:863] <11>(51|61) (54|28|13)
+ + 2:   central nervous system disease [DOID:331] <16>(33|44) (36|21|9)
+ 1:   neurodegenerative disease [DOID:1289] <21>(24|31) (26|17|7)
0:   demyelinating disease [DOID:3213] <3>(9|14) (10|5|1)
- 1:   multiple sclerosis [DOID:2377] <4>(8|13) (9|5|1)
- 1:   Balo concentric sclerosis [DOID:0060215](0|0) (0|0|0)
- 1:   central pontine myelinolysis [DOID:636](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
MHC antigen-recognition domain0.0000000000007388Direct
Immunoglobulin0.00000000005531Direct
TNF-like0.00005572Direct
Inhibitor of apoptosis (IAP) repeat0.00006287Direct
Proton glutamate symport protein0.0006778Direct
4-helical cytokines0.0007793Direct
Fibronectin type III0.0008472Direct
Interleukin 8-like chemokines0.0009024Direct
TNF receptor-like0.004391Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
MHC antigen-recognition domain0.0000000000007347Direct
C1 set domains (antibody constant domain-like)0.0000000000007347Direct
C2 set domains0.00001003Direct
V set domains (antibody variable domain-like)0.00003374Direct
Inhibitor of apoptosis (IAP) repeat0.00004783Direct
TNF-like0.00004804Direct
Interleukin 17F, IL-17F0.00005245Direct
Proton glutamate symport protein0.0004988Direct
Interleukin 8-like chemokines0.0007677Direct
Fibronectin type III0.0008558Direct
Alpha-macroglobulin receptor domain0.000989Direct
Complement components0.000989Direct
TNF receptor-like0.003036Inherited
Long-chain cytokines0.007143Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
MHC antigen-recognition domain0.0000000000003316Direct
Immunoglobulin0.00000000002534Direct
TNF-like0.00003226Direct
Inhibitor of apoptosis (IAP) repeat0.00003667Direct
Proton glutamate symport protein0.0004166Direct
4-helical cytokines0.0004836Direct
Fibronectin type III0.0005282Direct
Interleukin 8-like chemokines0.0005643Direct
Alpha-macroglobulin receptor domain0.0008435Direct
TNF receptor-like0.002952Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.00000000000003334Direct
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.000002425Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0001847Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0009793Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.002952Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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