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Disease Ontology (DO): central nervous system disease

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   disease [DOID:4] <8>
+ + 2:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
+ 1:   nervous system disease [DOID:863] <11>(51|61) (54|28|13)
0:   central nervous system disease [DOID:331] <16>(33|44) (36|21|9)
- 1:   brain disease [DOID:936] <30>(14|18) (15|6|1)
- 1:   neurodegenerative disease [DOID:1289] <21>(24|31) (26|17|7)
- 1:   meningitis [DOID:9471] <6>(3|2) (3|1|1)
- 1:   spinal cord disease [DOID:319] <5>(0|0) (0|0|0)
- 1:   paraplegia [DOID:607] <2>(0|0) (0|0|0)
- 1:   encephalomyelitis [DOID:640] <1>(0|0) (0|0|0)
- 1:   hemiplegia [DOID:10969] <1>(0|0) (0|0|0)
- 1:   epidural abscess [DOID:11387](0|0) (0|0|0)
- 1:   high pressure neurological syndrome [DOID:3230](0|0) (0|0|0)
- 1:   intracranial abscess [DOID:10095](0|0) (0|0|0)
- 1:   meningoencephalitis [DOID:10554](0|0) (0|0|0)
- 1:   neuromyelitis optica [DOID:8869](1|2) (1|1|0)
- 1:   neuronitis [DOID:8117](0|0) (0|0|0)
- 1:   quadriplegia [DOID:12835](0|0) (0|0|0)
- 1:   restless legs syndrome [DOID:0050425](0|0) (0|0|0)
- 1:   subdural empyema [DOID:11389](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Synuclein0Direct
Flavoproteins0.00008287Direct
4-helical cytokines0.004748Inherited
Cation efflux protein transmembrane domain-like0.006414Inherited
ACT-like0.006414Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.006414Inherited
MHC antigen-recognition domain0.01722Inherited
Calcium-dependent phosphotriesterase0.01921Inherited
Immunoglobulin0.03579Inherited
Insulin-like0.03932Inherited
Proton glutamate symport protein0.03932Inherited
Periplasmic binding protein-like II0.04691Inherited
YWTD domain0.05339Inherited
Nudix0.06625Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.07195Inherited
Riboflavin synthase domain-like0.07195Inherited
Kringle-like0.0776Inherited
Family A G protein-coupled receptor-like0.1141Inherited
Interleukin 8-like chemokines0.1257Inherited
Nicotinic receptor ligand binding domain-like0.1257Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1257Inherited
Toll/Interleukin receptor TIR domain0.143Inherited
TNF receptor-like0.1644Inherited
Periplasmic binding protein-like I0.1796Inherited
Voltage-gated potassium channels0.1843Inherited
ABC transporter transmembrane region0.2204Inherited
Inhibitor of apoptosis (IAP) repeat0.3373Inherited
Protein kinase-like (PK-like)0.5024Inherited
Fibronectin type III0.6389Inherited
TNF-like0.7367Inherited
SCOP hierarchy in SUPERFAMILY0.796Inherited
Thioredoxin-like0.8336Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Pentraxin (pentaxin)0Direct
Synuclein0Direct
Transferrin0Direct
2'-5'-oligoadenylate synthetase 1, OAS1, second domain0Direct
Multidomain cupredoxins0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
C2 set domains0.00008415Direct
Long-chain cytokines0.0007402Direct
Kringle modules0.001056Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001214Inherited
NADPH-cytochrome p450 reductase-like0.001214Inherited
Cytochrome p450 reductase N-terminal domain-like0.004958Inherited
Interleukin 17F, IL-17F0.004958Inherited
Phenylalanine metabolism regulatory domain0.004958Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.004958Inherited
Cation efflux protein transmembrane domain-like0.004958Inherited
Tetramerization domain of potassium channels0.01335Inherited
MHC antigen-recognition domain0.01379Inherited
Interleukin-1 (IL-1)0.02081Inherited
Proton glutamate symport protein0.03317Inherited
Insulin-like0.03317Inherited
YWTD domain0.04742Inherited
C1 set domains (antibody constant domain-like)0.05487Inherited
Rhodopsin-like0.07589Inherited
Phosphate binding protein-like0.0846Inherited
Toll/Interleukin receptor TIR domain0.1104Inherited
Nicotinic receptor ligand binding domain-like0.1104Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1104Inherited
Interleukin 8-like chemokines0.1223Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.1331Inherited
TNF receptor-like0.1419Inherited
V set domains (antibody variable domain-like)0.199Inherited
L-arabinose binding protein-like0.2274Inherited
Inhibitor of apoptosis (IAP) repeat0.3079Inherited
Glutathione peroxidase-like0.3536Inherited
Alpha-macroglobulin receptor domain0.3955Inherited
Complement components0.3955Inherited
ABC transporter transmembrane region0.4258Inherited
Calmodulin-like0.5061Inherited
ABC transporter ATPase domain-like0.5348Inherited
Fibronectin type III0.6215Inherited
TNF-like0.7112Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Synuclein0Direct
Flavoproteins0.0000484Direct
4-helical cytokines0.00321Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.004388Inherited
ACT-like0.004388Inherited
Cation efflux protein transmembrane domain-like0.004388Inherited
MHC antigen-recognition domain0.01232Inherited
Calcium-dependent phosphotriesterase0.01389Inherited
Immunoglobulin0.02671Inherited
Lipoxigenase0.02953Inherited
Proton glutamate symport protein0.02953Inherited
Insulin-like0.02953Inherited
Periplasmic binding protein-like II0.0356Inherited
YWTD domain0.04072Inherited
Nudix0.05125Inherited
Riboflavin synthase domain-like0.05604Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.05604Inherited
Kringle-like0.06077Inherited
Family A G protein-coupled receptor-like0.09106Inherited
Nicotinic receptor ligand binding domain-like0.1008Inherited
Interleukin 8-like chemokines0.1008Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1008Inherited
Toll/Interleukin receptor TIR domain0.1156Inherited
TNF receptor-like0.1338Inherited
Periplasmic binding protein-like I0.1471Inherited
Voltage-gated potassium channels0.1512Inherited
ABC transporter transmembrane region0.1832Inherited
Inhibitor of apoptosis (IAP) repeat0.2894Inherited
Alpha-macroglobulin receptor domain0.3735Inherited
Protein kinase-like (PK-like)0.4419Inherited
Fibronectin type III0.5703Inherited
TNF-like0.6648Inherited
L domain-like0.7546Inherited
Thioredoxin-like0.7611Inherited
ARM repeat0.812Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    53850,53850
  • 53850 - Periplasmic binding protein-like II
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    57414,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 0Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.00006133Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0.001029Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.01232Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.01389Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.01389Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.02124Inherited
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.02953Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.1008Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.1034Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.1741Inherited
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.1819Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1832Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.2894Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.4143Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.7611Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57414,57440,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.004388Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.004388Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.01136Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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