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Disease Ontology (DO): skin disease

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   disease [DOID:4] <8>
+ + 2:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
+ 1:   integumentary system disease [DOID:16] <3>(30|34) (31|15|6)
0:   skin disease [DOID:37] <49>(27|31) (28|14|6)
- 1:   dermatitis [DOID:2723] <18>(13|17) (14|6|4)
- 1:   autosomal recessive congenital ichthyosis [DOID:0060655] <12>(0|0) (0|0|0)
- 1:   pigmentation disease [DOID:10123] <11>(0|0) (0|0|0)
- 1:   keratosis [DOID:161] <7>(3|1) (3|2|1)
- 1:   lipomatosis [DOID:3153] <6>(0|0) (0|0|0)
- 1:   sweat gland disease [DOID:1383] <6>(0|0) (0|0|0)
- 1:   psoriasis [DOID:8893] <3>(4|6) (4|1|0)
- 1:   chronic ulcer of skin [DOID:8549] <2>(0|0) (0|0|0)
- 1:   exanthem [DOID:0050486] <2>(0|0) (0|0|0)
- 1:   lichen disease [DOID:8574] <2>(0|0) (0|0|0)
- 1:   lipodystrophy [DOID:811] <2>(0|0) (1|0|0)
- 1:   sebaceous gland disease [DOID:9098] <2>(0|0) (0|0|0)
- 1:   urticaria [DOID:1555] <2>(0|0) (0|0|0)
- 1:   vesiculobullous skin disease [DOID:2731] <2>(3|3) (3|2|1)
- 1:   angioedema [DOID:1558] <1>(1|1) (1|0|0)
- 1:   cellulitis [DOID:3488] <1>(0|0) (0|0|0)
- 1:   ichthyosis [DOID:1697] <1>(2|2) (2|1|0)
- 1:   panniculitis [DOID:1526] <1>(0|0) (0|0|0)
- 1:   reactive cutaneous fibrous lesion [DOID:2053] <1>(0|0) (0|0|0)
- 1:   Achenbach syndrome [DOID:6687](0|0) (0|0|0)
- 1:   Kimura disease [DOID:7365](0|0) (0|0|0)
- 1:   Kindler syndrome [DOID:0060472](0|0) (0|0|0)
- 1:   Rothmund-Thomson syndrome [DOID:2732](0|0) (0|0|0)
- 1:   Stevens-Johnson syndrome [DOID:0050426](0|0) (0|0|0)
- 1:   cutis laxa [DOID:3144](0|0) (0|0|0)
- 1:   dyskeratosis congenita [DOID:2729](0|0) (0|0|0)
- 1:   epidermolytic hyperkeratosis [DOID:4603](0|0) (0|0|0)
- 1:   erythema multiforme [DOID:0050185](0|0) (0|0|0)
- 1:   erythematosquamous dermatosis [DOID:9097](0|0) (0|0|0)
- 1:   erythrokeratodermia variabilis [DOID:0050467](0|0) (0|0|0)
- 1:   facial dermatosis [DOID:3134](0|0) (0|0|0)
- 1:   hand dermatosis [DOID:3158](0|0) (0|0|0)
- 1:   hemangioma of subcutaneous tissue [DOID:13081](0|0) (0|0|0)
- 1:   hereditary mucosal leukokeratosis [DOID:0050448](0|0) (0|0|0)
- 1:   incontinentia pigmenti achromians [DOID:3156](0|0) (0|0|0)
- 1:   leg dermatosis [DOID:3142](0|0) (0|0|0)
- 1:   lethal restrictive dermopathy [DOID:0060762](0|0) (0|0|0)
- 1:   loiasis [DOID:13523](0|0) (0|0|0)
- 1:   mongolian spot [DOID:4702](0|0) (0|0|0)
- 1:   multiple symmetrical lipomatosis [DOID:3137](0|0) (0|0|0)
- 1:   necrobiosis lipoidica [DOID:3486](0|0) (0|0|0)
- 1:   peeling skin syndrome [DOID:0060283](0|0) (0|0|0)
- 1:   poikiloderma with neutropenia [DOID:0060551](0|0) (0|0|0)
- 1:   rosacea [DOID:8881](0|0) (0|0|0)
- 1:   scalp dermatosis [DOID:3136](0|0) (0|0|0)
- 1:   scleredema adultorum [DOID:3140](0|0) (0|0|0)
- 1:   skin atrophy [DOID:2733](0|0) (0|0|0)
- 1:   skin sarcoidosis [DOID:13402](0|0) (0|0|0)
- 1:   vascular skin disease [DOID:9540](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
Plakin repeat0Direct
Interleukin 8-like chemokines0.0000000000211Direct
4-helical cytokines0.000000001415Direct
Transglutaminase, two C-terminal domains0.00000341Direct
MHC antigen-recognition domain0.00002326Direct
Lipoxigenase0.0002358Direct
Anaphylotoxins (complement system)0.0004847Direct
Cytokine0.0007937Direct
Kringle-like0.001625Inherited
Integrin beta tail domain0.003951Inherited
Toll/Interleukin receptor TIR domain0.005577Inherited
Trypsin-like serine proteases0.00697Inherited
Alpha-macroglobulin receptor domain0.007247Inherited
Cysteine proteinases0.01121Inherited
Defensin-like0.01183Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.01254Inherited
Terpenoid cyclases/Protein prenyltransferases0.01744Inherited
Spectrin repeat0.02088Inherited
vWA-like0.04567Inherited
Cystine-knot cytokines0.06586Inherited
E set domains0.078Inherited
Plexin repeat0.2538Inherited
Intermediate filament protein, coiled coil region0.6968Inherited
EGF/Laminin0.6968Inherited
TNF-like0.7788Inherited
Cadherin-like0.8961Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
Plakin repeat0Direct
Interleukin 8-like chemokines0.00000000002912Direct
Interleukin-1 (IL-1)0.0000000378Direct
Transglutaminase N-terminal domain0.000002782Direct
Transglutaminase, two C-terminal domains0.000002782Direct
Transglutaminase core0.00001032Direct
Short-chain cytokines0.00002225Direct
MHC antigen-recognition domain0.00002353Direct
C1 set domains (antibody constant domain-like)0.00002353Direct
Interferons/interleukin-10 (IL-10)0.00004436Direct
Animal lipoxigenases0.0001861Direct
Netrin-like domain (NTR/C345C module)0.0003666Direct
Interleukin 17F, IL-17F0.0003666Direct
Anaphylotoxins (complement system)0.0003666Direct
Lipoxigenase N-terminal domain0.001356Inherited
Integrin A (or I) domain0.00209Inherited
Integrin beta tail domain0.003148Inherited
Integrin beta EGF-like domains0.003148Inherited
Toll/Interleukin receptor TIR domain0.003747Inherited
Eukaryotic proteases0.004207Inherited
Alpha-macroglobulin receptor domain0.005862Inherited
Complement components0.005862Inherited
Defensin0.00982Inherited
Interferon regulatory factor0.01466Inherited
Laminin-type module0.01858Inherited
Spectrin repeat0.01874Inherited
Plexin repeat0.2425Inherited
Intermediate filament protein, coiled coil region0.6479Inherited
TNF-like0.7337Inherited
Cadherin0.8595Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
Plakin repeat0Direct
Interleukin 8-like chemokines0.000000000009573Direct
4-helical cytokines0.0000000006595Direct
Transglutaminase, two C-terminal domains0.000001817Direct
MHC antigen-recognition domain0.00001312Direct
Lipoxigenase0.0001416Direct
Anaphylotoxins (complement system)0.0002964Direct
Cytokine0.0004924Direct
Kringle-like0.001039Inherited
Integrin beta tail domain0.002652Inherited
Toll/Interleukin receptor TIR domain0.003801Inherited
Trypsin-like serine proteases0.004803Inherited
Alpha-macroglobulin receptor domain0.00498Inherited
Cysteine proteinases0.007869Inherited
Defensin-like0.008322Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.008837Inherited
Terpenoid cyclases/Protein prenyltransferases0.01251Inherited
Spectrin repeat0.01513Inherited
vWA-like0.0346Inherited
Cystine-knot cytokines0.05093Inherited
E set domains0.06112Inherited
Plexin repeat0.2132Inherited
MFS general substrate transporter0.45Inherited
Intermediate filament protein, coiled coil region0.6254Inherited
EGF/Laminin0.6254Inherited
TNF-like0.707Inherited
Cadherin-like0.8244Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    54001,49309
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.000001817Direct
    49309,49309
  • 49309 - Transglutaminase, two C-terminal domains
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.000001817Direct
    81296,54001
  • 81296 - E set domains
  • 54001 - Cysteine proteinases
  • 0.000001817Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000002705Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.000003713Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0001342Direct
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.0001416Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0.0002964Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0004015Direct
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.0004015Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.002652Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.7522Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.8244Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    81296,54001,49309
  • 81296 - E set domains
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.000001817Direct
    54001,49309,49309
  • 54001 - Cysteine proteinases
  • 49309 - Transglutaminase, two C-terminal domains
  • 49309 - Transglutaminase, two C-terminal domains
  • 0.000001817Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.000003055Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.002652Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.8244Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.8491Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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