SUPERFAMILY 1.75 HMM library and genome assignments server

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Disease Ontology (DO): bone marrow cancer

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   disease [DOID:4] <8>
+ + + + + 5:   disease of cellular proliferation [DOID:14566] <3>(123|191) (129|118|56)
+ + + + 4:   cancer [DOID:162] <2>(115|181) (120|113|54)
+ + + 3:   organ system cancer [DOID:0050686] <14>(66|106) (72|58|31)
+ + 2:   immune system cancer [DOID:0060083] <3>(31|42) (33|27|13)
+ 1:   hematologic cancer [DOID:2531] <7>(30|42) (32|25|13)
0:   bone marrow cancer [DOID:4960] <2>(10|13) (10|8|6)
- 1:   myeloid neoplasm [DOID:0070004] <5>(10|13) (10|7|4)
- 1:   myelodysplastic syndrome [DOID:0050908](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
TIMP-like0.0001553Direct
Hemopexin-like domain0.0009057Direct
TNF-like0.00163Inherited
PGBD-like0.001808Inherited
Cystine-knot cytokines0.004049Inherited
Frizzled cysteine-rich domain0.007268Inherited
SH2 domain0.01367Inherited
TNF receptor-like0.02552Inherited
Integrin domains0.07055Inherited
4-helical cytokines0.1516Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
BAFF receptor-like0Direct
DEATH effector domain, DED0.0001013Direct
Hemopexin-like domain0.0007253Direct
TNF-like0.001161Inherited
MMP N-terminal domain0.001259Inherited
Matrix metalloproteases, catalytic domain0.001259Inherited
Frizzled cysteine-rich domain0.005374Inherited
Fibronectin type II module0.009205Inherited
SH2 domain0.01105Inherited
Interleukin-1 (IL-1)0.0239Inherited
Integrin domains0.05824Inherited
TNF receptor-like0.1179Inherited
Short-chain cytokines0.1975Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
TIMP-like0.00009288Direct
Hemopexin-like domain0.0005671Direct
TNF-like0.001043Inherited
PGBD-like0.001164Inherited
Cystine-knot cytokines0.002724Inherited
Frizzled cysteine-rich domain0.004994Inherited
SH2 domain0.009679Inherited
TNF receptor-like0.01873Inherited
Integrin domains0.05484Inherited
4-helical cytokines0.1228Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.0000291Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0.00008259Direct
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.0008092Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.001164Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.008721Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.02869Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.04096Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0.00008259Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.00008259Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0008092Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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