SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Disease Ontology (DO): connective tissue disease

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   disease [DOID:4] <8>
+ + 2:   disease of anatomical entity [DOID:7] <12>(143|187) (147|103|58)
+ 1:   musculoskeletal system disease [DOID:17] <3>(29|42) (37|17|6)
0:   connective tissue disease [DOID:65] <22>(23|31) (28|11|4)
- 1:   bone disease [DOID:0080001] <5>(19|22) (24|8|3)
- 1:   collagen disease [DOID:854] <5>(7|11) (8|2|1)
- 1:   fasciitis [DOID:9598] <5>(0|0) (0|0|0)
- 1:   enthesopathy [DOID:204] <4>(0|0) (0|0|0)
- 1:   periostitis [DOID:9957] <2>(0|0) (0|0|0)
- 1:   synovitis [DOID:2703] <2>(0|0) (0|0|0)
- 1:   interstitial keratitis [DOID:9857] <1>(0|0) (0|0|0)
- 1:   mediastinitis [DOID:819] <1>(0|0) (0|0|0)
- 1:   mucinoses [DOID:3141] <1>(0|0) (0|0|0)
- 1:   Marfan syndrome [DOID:14323](0|0) (0|0|0)
- 1:   Volkmann contracture [DOID:5587](0|0) (0|0|0)
- 1:   ainhum [DOID:11329](0|0) (0|0|0)
- 1:   arterial tortuosity syndrome [DOID:0050645](0|0) (0|0|0)
- 1:   chronic interstitial cystitis [DOID:1678](0|0) (0|0|0)
- 1:   fibrodysplasia ossificans progressiva [DOID:13374](0|0) (0|0|0)
- 1:   frozen shoulder [DOID:14188](0|0) (0|0|0)
- 1:   funisitis [DOID:0050698](0|0) (0|0|0)
- 1:   ochronosis [DOID:14223](0|0) (0|0|0)
- 1:   ossification of the posterior longitudinal ligament of spine [DOID:0060887](0|0) (0|0|0)
- 1:   plantar fascial fibromatosis [DOID:8936](0|0) (0|0|0)
- 1:   rheumatic fever [DOID:1586](1|2) (2|1|0)
- 1:   systemic lupus erythematosus [DOID:9074](1|1) (2|1|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
TNF receptor-like0.000000000000258Direct
TNF-like0.0000000002669Direct
MHC antigen-recognition domain0.00002566Direct
TIMP-like0.00003821Direct
TSP-1 type 1 repeat0.0001315Direct
Cupredoxins0.0008782Direct
DEATH domain0.002211Inherited
Hemopexin-like domain0.003557Inherited
PRTase-like0.004196Inherited
Cytochrome P4500.01395Inherited
Annexin0.01512Inherited
SMAD MH1 domain0.04624Inherited
4-helical cytokines0.1096Inherited
Immunoglobulin0.1232Inherited
Nucleotide-diphospho-sugar transferases0.1499Inherited
Protein kinase-like (PK-like)0.1681Inherited
FnI-like domain0.2757Inherited
Interleukin 8-like chemokines0.325Inherited
Toll/Interleukin receptor TIR domain0.3364Inherited
Cystine-knot cytokines0.3505Inherited
RNI-like0.4104Inherited
PGBD-like0.454Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Netrin-like domain (NTR/C345C module)0Direct
Anaphylotoxins (complement system)0Direct
Tissue inhibitor of metalloproteinases, TIMP0Direct
TNF receptor-like0.00000000000101Direct
TNF-like0.0000000002688Direct
MHC antigen-recognition domain0.00002395Direct
C1 set domains (antibody constant domain-like)0.00002395Direct
TSP-1 type 1 repeat0.0001237Direct
Interferons/interleukin-10 (IL-10)0.0004092Direct
C2 set domains0.000471Direct
S100 proteins0.0006975Direct
Interleukin-1 (IL-1)0.001827Inherited
Hemopexin-like domain0.003036Inherited
Exostosin0.003173Inherited
VWC domain0.003996Inherited
Pentraxin (pentaxin)0.01048Inherited
Annexin0.01247Inherited
SMAD MH1 domain0.03912Inherited
SMAD domain0.03912Inherited
Platelet-derived growth factor-like0.06102Inherited
C-type lectin domain0.1667Inherited
Protein kinases, catalytic subunit0.1881Inherited
Interleukin 8-like chemokines0.2765Inherited
Toll/Interleukin receptor TIR domain0.291Inherited
MMP N-terminal domain0.4037Inherited
Matrix metalloproteases, catalytic domain0.4037Inherited
Short-chain cytokines0.4511Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.6249Inherited
NADPH-cytochrome p450 reductase-like0.6249Inherited
Transforming growth factor (TGF)-beta0.6457Inherited
I set domains0.7992Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
TNF receptor-like0.0000000000001152Direct
TNF-like0.000000000124Direct
MHC antigen-recognition domain0.00001456Direct
TIMP-like0.00002184Direct
TSP-1 type 1 repeat0.0000781Direct
Cupredoxins0.0005488Direct
DEATH domain0.001453Inherited
Hemopexin-like domain0.00238Inherited
PRTase-like0.002822Inherited
Snake toxin-like0.00865Inherited
Cytochrome P4500.009882Inherited
Annexin0.01073Inherited
Cytokine0.02548Inherited
SMAD MH1 domain0.03504Inherited
Family A G protein-coupled receptor-like0.03818Inherited
4-helical cytokines0.08735Inherited
Immunoglobulin0.09882Inherited
Nucleotide-diphospho-sugar transferases0.1213Inherited
Protein kinase-like (PK-like)0.137Inherited
FnI-like domain0.2329Inherited
Interleukin 8-like chemokines0.2783Inherited
Toll/Interleukin receptor TIR domain0.2891Inherited
Cystine-knot cytokines0.3012Inherited
RNI-like0.3557Inherited
PGBD-like0.3958Inherited
HLH, helix-loop-helix DNA-binding domain0.5492Inherited
MFS general substrate transporter0.553Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000000000003113Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.00001556Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0003768Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.0005755Direct
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0.0005755Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.002822Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.008903Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0446Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.3958Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.4248Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000003679Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.002313Inherited
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.00433Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.7343Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)