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Disease Ontology (DO): inherited metabolic disorder

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   disease [DOID:4] <8>
+ 1:   disease of metabolism [DOID:0014667] <2>(22|34) (27|12|5)
0:   inherited metabolic disorder [DOID:655] <18>(12|15) (16|5|0)
- 1:   mitochondrial metabolism disease [DOID:700] <41>(0|0) (0|0|0)
- 1:   amino acid metabolic disorder [DOID:9252] <30>(1|1) (1|0|0)
- 1:   carbohydrate metabolic disorder [DOID:2978] <14>(0|0) (0|0|0)
- 1:   lipid metabolism disorder [DOID:3146] <13>(3|8) (7|3|0)
- 1:   lysosomal storage disease [DOID:3211] <12>(6|5) (6|2|0)
- 1:   metal metabolism disorder [DOID:896] <8>(2|2) (2|1|0)
- 1:   peroxisomal disease [DOID:906] <7>(0|0) (0|0|0)
- 1:   plasma protein metabolism disease [DOID:2345] <4>(1|1) (1|0|0)
- 1:   bilirubin metabolic disorder [DOID:2741] <3>(1|1) (1|0|0)
- 1:   purine-pyrimidine metabolic disorder [DOID:653] <3>(0|0) (0|0|0)
- 1:   vitamin metabolic disorder [DOID:0050718] <3>(0|0) (0|0|0)
- 1:   porphyria [DOID:13268] <2>(0|0) (0|0|0)
- 1:   pyrimidine metabolic disorder [DOID:0050832] <1>(0|0) (0|0|0)
- 1:   aromatic L-amino acid decarboxylase deficiency [DOID:0090123](0|0) (0|0|0)
- 1:   dopamine beta-hydroxylase deficiency [DOID:0090145](0|0) (0|0|0)
- 1:   glycerol kinase deficiency [DOID:0060363](0|0) (0|0|0)
- 1:   multiple acyl-CoA dehydrogenase deficiency [DOID:0060358](0|0) (0|0|0)
- 1:   thiopurine S-methyltransferase deficiency [DOID:0080172](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Homocysteine S-methyltransferase0Direct
Apolipoprotein A-I0Direct
(Trans)glycosidases0.0001584Direct
Glycosyl hydrolase domain0.007041Inherited
Alkaline phosphatase-like0.01765Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.03761Inherited
TNF-like0.09361Inherited
PGBD-like0.1544Inherited
Nuclear receptor ligand-binding domain0.2551Inherited
FabD/lysophospholipase-like0.3239Inherited
Voltage-gated potassium channels0.6525Inherited
MHC antigen-recognition domain0.7952Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Homocysteine S-methyltransferase0Direct
Apolipoprotein A-I0Direct
Arylsulfatase0.000004262Direct
beta-glycanases0.00007986Direct
UDPGT-like0.02104Inherited
Fatty acid binding protein-like0.0618Inherited
TNF-like0.06811Inherited
Matrix metalloproteases, catalytic domain0.1195Inherited
MMP N-terminal domain0.1195Inherited
Hemopexin-like domain0.1195Inherited
Nuclear receptor0.1638Inherited
Long-chain cytokines0.1918Inherited
Nuclear receptor ligand-binding domain0.2003Inherited
C1 set domains (antibody constant domain-like)0.5951Inherited
MHC antigen-recognition domain0.7335Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Apolipoprotein A-I0Direct
Homocysteine S-methyltransferase0Direct
(Trans)glycosidases0.00009494Direct
Glycosyl hydrolase domain0.004858Inherited
Alkaline phosphatase-like0.01269Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.02814Inherited
TNF-like0.07408Inherited
Kringle-like0.106Inherited
Hemopexin-like domain0.1251Inherited
PGBD-like0.1251Inherited
Lipocalins0.1612Inherited
Nuclear receptor ligand-binding domain0.2144Inherited
FabD/lysophospholipase-like0.2774Inherited
Voltage-gated potassium channels0.5826Inherited
MHC antigen-recognition domain0.7232Inherited
4-helical cytokines0.7232Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.004858Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.06052Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.1251Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.1958Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.7232Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)