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Enzyme Commission (EC): Oxidoreductases

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   root [root] <7>
0:   Oxidoreductases [1] <26>(213|314) (212|187|94)
- 1:   Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate [1.14] <15>(44|52) (44|23|8)
- 1:   Acting on CH or CH(2) groups [1.17] <10>(30|24) (29|23|8)
- 1:   Acting on NADH or NADPH [1.6] <9>(23|28) (23|13|7)
- 1:   Acting on a sulfur group of donors [1.8] <9>(29|28) (29|21|9)
- 1:   Acting on the CH-CH group of donors [1.3] <9>(40|44) (40|25|12)
- 1:   Acting on the CH-NH(2) group of donors [1.4] <9>(23|27) (23|14|4)
- 1:   Acting on other nitrogenous compounds as donors [1.7] <8>(22|24) (22|13|6)
- 1:   Acting on the CH-NH group of donors [1.5] <8>(28|35) (28|14|4)
- 1:   Acting on the CH-OH group of donors [1.1] <8>(53|72) (53|47|27)
- 1:   Acting on the aldehyde or oxo group of donors [1.2] <8>(34|38) (34|27|14)
- 1:   Acting on diphenols and related substances as donors [1.10] <7>(4|4) (4|1|1)
- 1:   Acting on hydrogen as donors [1.12] <6>(8|6) (8|2|0)
- 1:   Acting on iron-sulfur proteins as donors [1.18] <6>(8|10) (8|7|3)
- 1:   Acting on phosphorus or arsenic in donors [1.20] <6>(4|5) (4|1|0)
- 1:   Oxidizing metal ions [1.16] <6>(9|9) (9|4|2)
- 1:   Catalyzing the reaction X-H + Y-H = 'X-Y' [1.21] <5>(5|4) (5|0|0)
- 1:   Acting on a heme group of donors [1.9] <4>(9|8) (9|4|1)
- 1:   Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated [1.13] <4>(19|21) (19|5|0)
- 1:   Acting on a peroxide as acceptor [1.11] <2>(18|18) (17|7|3)
- 1:   Acting on reduced flavodoxin as donor [1.19] <2>(2|2) (2|1|0)
- 1:   Other enzymes using O(2) as oxidant [1.99] <2>(0|0) (0|0|0)
- 1:   Reducing C-O-C group as acceptor [1.23] <2>(2|1) (2|0|0)
- 1:   Acting on halogen in donors [1.22] <1>(0|0) (0|0|0)
- 1:   Acting on superoxide as acceptor [1.15] <1>(5|5) (5|2|0)
- 1:   Enzymes using H(2) as reductant [1.98] <1>(0|0) (0|0|0)
- 1:   Other oxidoreductases [1.97] <1>(4|2) (3|2|1)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Di-copper centre-containing domain0Direct
L-sulfolactate dehydrogenase-like0Direct
HydB/Nqo4-like0Direct
Cytochrome c oxidase subunit III-like0Direct
Thioredoxin-like0Direct
Cytochrome c0Direct
Bacterial photosystem II reaction centre, L and M subunits0Direct
Coproporphyrinogen III oxidase0Direct
1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain0Direct
R1 subunit of ribonucleotide reductase, N-terminal domain0Direct
Nqo1C-terminal domain-like0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
DinB/YfiT-like putative metalloenzymes0Direct
CO dehydrogenase flavoprotein C-terminal domain-like0Direct
Respiratory nitrate reductase 1 gamma chain0Direct
Nitrite and sulphite reductase 4Fe-4S domain-like0Direct
FAD-linked reductases, C-terminal domain0Direct
alpha-helical ferredoxin0Direct
Nqo1 middle domain-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Dihydrofolate reductase-like0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
Nitrite/Sulfite reductase N-terminal domain-like0Direct
Tetrapyrrole methylase0Direct
FAD-linked oxidoreductase0Direct
FMN-binding split barrel0Direct
2Fe-2S ferredoxin-like0Direct
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain0Direct
Aromatic compound dioxygenase0Direct
Amine oxidase N-terminal region0Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
Amine oxidase catalytic domain0Direct
Bacterial luciferase-like0Direct
Flavoproteins0Direct
CBS-domain pair0Direct
Lipase/lipooxygenase domain (PLAT/LH2 domain)0Direct
Riboflavin synthase domain-like0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
Cytochrome c oxidase subunit II-like, transmembrane region0Direct
Superoxide reductase-like0Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
Nucleotide-binding domain0Direct
ADC-like0Direct
Tetrahydrobiopterin biosynthesis enzymes-like0Direct
CO dehydrogenase ISP C-domain like0Direct
Aldehyde ferredoxin oxidoreductase, N-terminal domain0Direct
Molybdenum cofactor-binding domain0Direct
Cytochrome P4500Direct
Siroheme synthase middle domains-like0Direct
PFL-like glycyl radical enzymes0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
Nqo5-like0Direct
Cupredoxins0Direct
N-terminal domain of bifunctional PutA protein0Direct
Lipoxigenase0Direct
Copper amine oxidase, domain N0Direct
FMN-dependent nitroreductase-like0Direct
RmlC-like cupins0Direct
Dihydropteroate synthetase-like0Direct
Cytochrome c oxidase subunit I-like0Direct
NAD(P)-binding Rossmann-fold domains0Direct
HydA/Nqo6-like0Direct
Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)0Direct
Mitochondrial cytochrome c oxidase subunit IV0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
YebC-like0Direct
Globin-like0Direct
Heme oxygenase-like0Direct
Heme-dependent catalase-like0Direct
Hemocyanin, N-terminal domain0Direct
Substrate-binding domain of HMG-CoA reductase0Direct
Glutamyl tRNA-reductase dimerization domain0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
Bet v1-like0Direct
FMN-linked oxidoreductases0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Ribbon-helix-helix0Direct
Methanol dehydrogenase subunit0Direct
Fe,Mn superoxide dismutase (SOD), C-terminal domain0Direct
4Fe-4S ferredoxins0Direct
Mss4-like0Direct
F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD)0Direct
FAD-dependent thiol oxidase0Direct
"Helical backbone" metal receptor0Direct
Clavaminate synthase-like0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
FAD/NAD(P)-binding domain0Direct
Multiheme cytochromes0Direct
Oxidoreductase molybdopterin-binding domain0Direct
Cu,Zn superoxide dismutase-like0Direct
Ferritin-like0Direct
Peptide methionine sulfoxide reductase0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
Indolic compounds 2,3-dioxygenase-like0Direct
Heme-dependent peroxidases0Direct
Dehydroquinate synthase-like0Direct
Alpha subunit of glutamate synthase, C-terminal domain0Direct
Fe-only hydrogenase0Direct
Formate dehydrogenase/DMSO reductase, domains 1-30Direct
FAD-binding/transporter-associated domain-like0Direct
Aldehyde ferredoxin oxidoreductase, C-terminal domains0Direct
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III0Direct
NAD(P)-linked oxidoreductase0Direct
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain0Direct
LDH C-terminal domain-like0Direct
Ferredoxin thioredoxin reductase (FTR), catalytic beta chain0Direct
Prismane protein-like0Direct
Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha)0Direct
Fe,Mn superoxide dismutase (SOD), N-terminal domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
ALDH-like0Direct
6-phosphogluconate dehydrogenase C-terminal domain-like0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
ISP domain0Direct
NAD-binding domain of HMG-CoA reductase0Direct
AhpD-like0Direct
Glutamyl tRNA-reductase catalytic, N-terminal domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
FAD-linked oxidases, C-terminal domain0Direct
Photosystem I subunits PsaA/PsaB0Direct
Inosine monophosphate dehydrogenase (IMPDH)0Direct
LigB-like0Direct
Methylamine dehydrogenase, L chain0Direct
GroES-like0Direct
Frataxin/Nqo15-like0Direct
Calponin-homology domain, CH-domain0.000000000000006483Direct
PHM/PNGase F0.00000000000002165Direct
Nqo1 FMN-binding domain-like0.000000000001173Direct
Serine metabolism enzymes domain0.00000000009517Direct
Phosphotyrosine protein phosphatases I0.0000000001407Direct
Quinoprotein alcohol dehydrogenase-like0.0000000008087Direct
Rubredoxin-like0.00000006069Direct
C-type lectin-like0.00000009176Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0.0000001031Direct
SRCR-like0.0000002324Direct
YVTN repeat-like/Quinoprotein amine dehydrogenase0.000001341Direct
Multidrug efflux transporter AcrB transmembrane domain0.000003321Direct
ParB/Sulfiredoxin0.00000867Direct
NTF2-like0.00003074Direct
EGF/Laminin0.0000589Direct
Dimeric alpha+beta barrel0.001192Inherited
Lipocalins0.001847Inherited
TK C-terminal domain-like0.002023Inherited
ACT-like0.002271Inherited
C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase0.002391Inherited
Galactose oxidase, central domain0.002736Inherited
SCOP hierarchy in SUPERFAMILY0.005279Inherited
FnI-like domain0.005846Inherited
SCP-like0.008253Inherited
ACP-like0.01037Inherited
Nitrous oxide reductase, N-terminal domain0.01666Inherited
HSP20-like chaperones0.02143Inherited
HIT/MYND zinc finger-like0.0846Inherited
Electron transport accessory proteins0.1087Inherited
NHL repeat0.3176Inherited
ARM repeat0.3866Inherited
HMA, heavy metal-associated domain0.4148Inherited
Complement control module/SCR domain0.4456Inherited
TPR-like0.489Inherited
Chorismate mutase II0.5389Inherited
SMAD/FHA domain0.5529Inherited
FYVE/PHD zinc finger0.6453Inherited
RNI-like0.7215Inherited
FabD/lysophospholipase-like0.9174Inherited
Homing endonucleases0.9439Inherited
Tudor/PWWP/MBT0.9585Inherited
Calcium-dependent phosphotriesterase0.9745Inherited
Formyltransferase1Inherited
alpha/beta-Hydrolases1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase1Inherited
EF-hand1Inherited
PLP-dependent transferases1Inherited
Thioesterase/thiol ester dehydrase-isomerase1Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
L domain-like1Inherited
Thiolase-like1Inherited
Immunoglobulin1Inherited
Aldolase1Inherited
ThiG-like1Inherited
Thymidylate synthase/dCMP hydroxymethylase1Inherited
Glucocorticoid receptor-like (DNA-binding domain)1Inherited
Radical SAM enzymes1Inherited
Aminomethyltransferase beta-barrel domain1Inherited
FMT C-terminal domain-like1Inherited
NagB/RpiA/CoA transferase-like1Inherited
Enolase C-terminal domain-like1Inherited
PDZ domain-like1Inherited
HisI-like1Inherited
Cysteine-rich domain1Inherited
Acetyl-CoA synthetase-like1Inherited
EPT/RTPC-like1Inherited
Nucleic acid-binding proteins1Inherited
Ubiquitin-like1Inherited
Cytidine deaminase-like1Inherited
E set domains1Inherited
Class I glutamine amidotransferase-like1Inherited
4'-phosphopantetheinyl transferase1Inherited
GST C-terminal domain-like1Inherited
CoA-dependent acyltransferases1Inherited
Folate-binding domain1Inherited
Probable ACP-binding domain of malonyl-CoA ACP transacylase1Inherited
Metallo-hydrolase/oxidoreductase1Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)1Inherited
HD-domain/PDEase-like1Inherited
all-alpha NTP pyrophosphatases1Inherited
Rhodanese/Cell cycle control phosphatase1Inherited
Nucleotide-diphospho-sugar transferases1Inherited
ClpP/crotonase1Inherited
Adenine nucleotide alpha hydrolases-like1Inherited
Hedgehog/intein (Hint) domain1Inherited
Carbamate kinase-like1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Nickel-iron hydrogenase, large subunit0Direct
Ferredoxin thioredoxin reductase (FTR), catalytic beta chain0Direct
PdxA-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III0Direct
Aminoacid dehydrogenase-like, C-terminal domain0Direct
Nqo5-like0Direct
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain0Direct
VWC domain0Direct
Nqo4-like0Direct
Aldehyde ferredoxin oxidoreductase, N-terminal domain0Direct
Aldo-keto reductases (NADP)0Direct
ProC C-terminal domain-like0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0Direct
ArsC-like0Direct
Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI)0Direct
Dyp-type peroxidase-like0Direct
Flavodoxin-related0Direct
PG130-like0Direct
acyl-CoA oxidase C-terminal domains0Direct
PhyH-like0Direct
Aminoacid dehydrogenases0Direct
Sulfiredoxin-like0Direct
TauD/TfdA-like0Direct
Gentisate 1,2-dioxygenase-like0Direct
Ferredoxin domains from multidomain proteins0Direct
C-terminal domain of adrenodoxin reductase-like0Direct
Monomeric isocitrate dehydrogenase0Direct
Methylamine dehydrogenase, L chain0Direct
N-terminal domain of bifunctional PutA protein0Direct
Fe-only hydrogenase0Direct
6-phosphogluconate dehydrogenase-like, N-terminal domain0Direct
Ribonucleotide reductase-like0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Di-heme cytochrome c peroxidase0Direct
Tyrosine-dependent oxidoreductases0Direct
Cu,Zn superoxide dismutase-like0Direct
RibD C-terminal domain-like0Direct
N-terminal (heme c) domain of cytochrome cd1-nitrite reductase0Direct
PNP-oxidase like0Direct
LDH N-terminal domain-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0Direct
Alcohol dehydrogenase-like, C-terminal domain0Direct
Formate/glycerate dehydrogenases, NAD-domain0Direct
Fe,Mn superoxide dismutase (SOD), C-terminal domain0Direct
YebC-like0Direct
Alpha subunit of glutamate synthase, C-terminal domain0Direct
Plant lipoxigenases0Direct
F420 dependent oxidoreductases0Direct
Hybrid cluster protein (prismane protein)0Direct
Clavaminate synthase0Direct
Molybdenum-containing oxidoreductases-like dimerisation domain0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
Nitrite and sulphite reductase 4Fe-4S domain-like0Direct
Nitrosocyanin0Direct
L-sulfolactate dehydrogenase-like0Direct
NADH:FMN oxidoreductase-like0Direct
Thioltransferase0Direct
C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase0Direct
Nickel-iron hydrogenase, small subunit0Direct
Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha)0Direct
Ferritin0Direct
Photosystem I subunits PsaA/PsaB0Direct
Multidomain cupredoxins0Direct
PAPS reductase-like0Direct
CCP-like0Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0Direct
Shikimate dehydrogenase-like0Direct
Desulforedoxin0Direct
Globins0Direct
Proline dehydrohenase domain of bifunctional PutA protein0Direct
Heme-dependent catalases0Direct
UDP-glucose/GDP-mannose dehydrogenase dimerisation domain0Direct
Ssud-like monoxygenases0Direct
Electron transfer flavoprotein-ubiquinone oxidoreductase-like0Direct
Bacterial tryptophan 2,3-dioxygenase0Direct
PFOR PP module0Direct
Homoserine dehydrogenase-like0Direct
Type II Proline 3-hydroxylase (proline oxidase)0Direct
SerA intervening domain-like0Direct
Dimeric isocitrate & isopropylmalate dehydrogenases0Direct
Myeloperoxidase-like0Direct
Malic enzyme N-domain0Direct
Mannitol 2-dehydrogenase0Direct
Formate/glycerate dehydrogenases, substrate-binding domain0Direct
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase (MurB), N-terminal domain0Direct
Bacterial photosystem II reaction centre, L and M subunits0Direct
NADPH-cytochrome p450 reductase-like0Direct
Indoleamine 2,3-dioxygenase-like0Direct
Siroheme synthase middle domains-like0Direct
Peptide methionine sulfoxide reductase0Direct
Haloperoxidase (bromoperoxidase)0Direct
Aromatic dioxygenase reductase-like0Direct
R1 subunit of ribonucleotide reductase, N-terminal domain0Direct
Nqo1C-terminal domain-like0Direct
Glycerol-3-phosphate dehydrogenase0Direct
CO dehydrogenase flavoprotein C-terminal domain-like0Direct
PBS lyase HEAT-like repeat0Direct
Cytochrome P4500Direct
Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain0Direct
Tetrapyrrole methylase0Direct
Mitochondrial cytochrome c oxidase subunit IV0Direct
HMD dimerization domain-like0Direct
Fe,Mn superoxide dismutase (SOD), N-terminal domain0Direct
Frataxin-like0Direct
Lactate & malate dehydrogenases, C-terminal domain0Direct
Inosine monophosphate dehydrogenase (IMPDH)0Direct
Flavohemoglobin, C-terminal domain0Direct
Glutamyl tRNA-reductase catalytic, N-terminal domain0Direct
Nitrogenase iron-molybdenum protein0Direct
Reductases0Direct
Hemocyanin middle domain0Direct
Glutathione peroxidase-like0Direct
Aromatic compound dioxygenase0Direct
FMN-linked oxidoreductases0Direct
Alcohol dehydrogenase-like, N-terminal domain0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0Direct
Urate oxidase (uricase)0Direct
Methylenetetrahydrofolate reductase0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain0Direct
TyrA dimerization domain-like0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
Bacterial luciferase (alkanal monooxygenase)0Direct
ALDH-like0Direct
Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain0Direct
CO dehydrogenase ISP C-domain like0Direct
Substrate-binding domain of HMG-CoA reductase0Direct
GAPDH-like0Direct
L-histidinol dehydrogenase HisD0Direct
Amine oxidase N-terminal region0Direct
1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain0Direct
D-lactate dehydrogenase0Direct
MioX-like0Direct
acyl-CoA oxidase N-terminal domains0Direct
DsrA/DsrB N-terminal-domain-like0Direct
Cytokinin dehydrogenase 10Direct
Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)0Direct
Eukaryotic type heme oxygenase0Direct
Formate dehydrogenase/DMSO reductase, C-terminal domain0Direct
CBS-domain pair0Direct
NirD-like0Direct
Oxidoreductase molybdopterin-binding domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
FAD-dependent thiol oxidase0Direct
PHBH-like0Direct
LigB-like0Direct
Acireductone dioxygenase0Direct
FAD-linked reductases, N-terminal domain0Direct
Ketopantoate reductase PanE0Direct
Lipoxigenase N-terminal domain0Direct
Class III anaerobic ribonucleotide reductase NRDD subunit0Direct
ETF-QO domain-like0Direct
Ring hydroxylating alpha subunit ISP domain0Direct
R1 subunit of ribonucleotide reductase, C-terminal domain0Direct
L-alanine dehydrogenase-like0Direct
GMC oxidoreductases0Direct
HCDH C-domain-like0Direct
Pirin-like0Direct
L-aminoacid/polyamine oxidase0Direct
Aldehyde ferredoxin oxidoreductase, C-terminal domains0Direct
Glutamyl tRNA-reductase dimerization domain0Direct
Cytochrome c oxidase subunit III-like0Direct
Dihydropyrimidine dehydrogenase, N-terminal domain0Direct
NQO2-like0Direct
Formate dehydrogenase/DMSO reductase, domains 1-30Direct
Catalase-peroxidase KatG0Direct
Biliverdin reductase0Direct
Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain0Direct
Respiratory nitrate reductase 1 gamma chain0Direct
3-hydroxyanthranilic acid dioxygenase-like0Direct
Catechol oxidase0Direct
C1-like domain0Direct
Methanol dehydrogenase subunit0Direct
FAD/NAD-linked reductases, N-terminal and central domains0Direct
Copper amine oxidase, domain N0Direct
Molybdenum cofactor-binding domain0Direct
CO dehydrogenase flavoprotein N-terminal domain-like0Direct
PqqC-like0Direct
Arthropod hemocyanin, C-terminal domain0Direct
Coproporphyrinogen III oxidase0Direct
Penicillin synthase-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
FAD-linked oxidases, N-terminal domain0Direct
Cytochrome c oxidase subunit I-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain0Direct
Dihydrofolate reductases0Direct
Ring hydroxylating alpha subunit catalytic domain0Direct
N-terminal domain of adrenodoxin reductase-like0Direct
Periplasmic domain of cytochrome c oxidase subunit II0Direct
7-Fe ferredoxin0Direct
Glycine dehydrogenase subunits (GDC-P)0Direct
NAD-binding domain of HMG-CoA reductase0Direct
Manganese catalase (T-catalase)0Direct
Cytochrome c oxidase subunit II-like, transmembrane region0Direct
WrbA-like0Direct
PFOR Pyr module0Direct
Animal lipoxigenases0Direct
Crotonase-like0Direct
Methylamine dehydrogenase, H-chain0Direct
Ring hydroxylating beta subunit0Direct
Nqo1 middle domain-like0Direct
D-aminoacid oxidase-like0Direct
Quinone reductase0Direct
Tetrahydrofolate dehydrogenase/cyclohydrolase0Direct
Pyruvate-ferredoxin oxidoreductase, PFOR, domain II0Direct
Peptidylglycine alpha-hydroxylating monooxygenase, PHM0Direct
SelR domain0Direct
Extradiol dioxygenases0Direct
F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD)0Direct
B12-dependent (class II) ribonucleotide reductase0Direct
AhpD0Direct
Iron-containing alcohol dehydrogenase0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
R67 dihydrofolate reductase0Direct
Rubredoxin0Direct
Hemocyanin, N-terminal domain0Direct
Siroheme synthase N-terminal domain-like0Direct
Galactose oxidase, central domain0Direct
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain0Direct
Quinoprotein alcohol dehydrogenase, C-terminal domain0Direct
Homogentisate dioxygenase0Direct
PutA pre-N-terminal region-like0Direct
NADH oxidase/flavin reductase0Direct
Superoxide reductase-like0Direct
Cytochrome b50Direct
2Fe-2S ferredoxin domains from multidomain proteins0Direct
Cysteine dioxygenase type I0Direct
D-aminoacid oxidase, N-terminal domain0Direct
N-(1-D-carboxylethyl)-L-norvaline dehydrogenase0Direct
Amine oxidase catalytic domain0Direct
Duplicated SiR/NiR-like domains 1 and 30Direct
Dihydrodipicolinate reductase-like0Direct
NADPH-dependent FMN reductase0Direct
Carbon monoxide dehydrogenase0Direct
Di-heme elbow motif0Direct
Glucose 6-phosphate dehydrogenase-like0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Catalase, C-terminal domain0Direct
Asparaginyl hydroxylase-like0Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0Direct
Quinoprotein alcohol dehydrogenase-like1.856e-16Direct
Calponin-homology domain, CH-domain0.000000000000004898Direct
Nq06-like0.000000000000239Direct
Phenylalanine metabolism regulatory domain0.0000000000005291Direct
Nqo1 FMN-binding domain-like0.0000000000008919Direct
Ornithine cyclodeaminase-like0.00000000001651Direct
Low-molecular-weight phosphotyrosine protein phosphatases0.00000000002731Direct
Scavenger receptor cysteine-rich (SRCR) domain0.0000000002558Direct
Sulfatase-modifying factor-like0.000000002334Direct
AlkB-like0.000000004459Direct
MaoC-like0.000000007292Direct
Oxygen-independent coproporphyrinogen III oxidase HemN0.00000002001Direct
Hypoxia-inducible factor HIF ihhibitor (FIH1)0.00000002667Direct
Acyl-carrier protein (ACP)0.00004497Direct
Germin/Seed storage 7S protein0.00007953Direct
Haloperoxidase0.0001568Direct
EGF-type module0.0003175Direct
FabD-like0.001285Inherited
Nitrous oxide reductase, N-terminal domain0.001834Inherited
Aspartokinase allosteric domain-like0.004534Inherited
Sterol carrier protein, SCP0.007109Inherited
Ngr ectodomain-like0.009085Inherited
Thioesterase domain of polypeptide, polyketide and fatty acid synthases0.01142Inherited
Deoxycytidylate deaminase-like0.02406Inherited
LIM domain0.04654Inherited
Shikimate kinase (AroK)0.04771Inherited
Peptidyl carrier domain0.0602Inherited
PDZ domain0.08784Inherited
Tudor domain0.1619Inherited
Dihydropteroate synthetase0.2446Inherited
NHL repeat0.2642Inherited
Transketolase C-terminal domain-like0.2964Inherited
HMA, heavy metal-associated domain0.3852Inherited
Complement control module/SCR domain0.4141Inherited
Phosphotransacetylase0.5843Inherited
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain0.5857Inherited
FHA domain0.615Inherited
Tetratricopeptide repeat (TPR)0.6969Inherited
TK-like Pyr module0.7792Inherited
4HBT-like0.8039Inherited
PHD domain0.9303Inherited
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.9384Inherited
Dehydroquinate synthase, DHQS0.9397Inherited
MoCo biosynthesis proteins0.9463Inherited
Calmodulin-like0.9716Inherited
Cell cycle control phosphatase, catalytic domain0.9829Inherited
PyrH-like1Inherited
I set domains1Inherited
E-set domains of sugar-utilizing enzymes1Inherited
HisI-like1Inherited
Thymidylate synthase/dCMP hydroxymethylase1Inherited
ThiG-like1Inherited
NagB-like1Inherited
Thiolase-related1Inherited
GTP cyclohydrolase I1Inherited
Glutathione S-transferase (GST), C-terminal domain1Inherited
Nitrogenase iron protein-like1Inherited
Enolpyruvate transferase, EPT1Inherited
TK-like PP module1Inherited
Acetyl-CoA synthetase-like1Inherited
D-glucarate dehydratase-like1Inherited
Class II glutamine amidotransferases1Inherited
Aminomethyltransferase beta-barrel domain1Inherited
Cold shock DNA-binding domain-like1Inherited
Holo-(acyl carrier protein) synthase ACPS1Inherited
Glutathione S-transferase (GST), N-terminal domain1Inherited
HisE-like (PRA-PH)1Inherited
CAT-like1Inherited
Glyoxalase II (hydroxyacylglutathione hydrolase)1Inherited
Formyltransferase1Inherited
Aminomethyltransferase folate-binding domain1Inherited
Tandem AAA-ATPase domain1Inherited
Class I aldolase1Inherited
Post formyltransferase domain1Inherited


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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Tetrahydrobiopterin biosynthesis enzymes-like0Direct
Bet v1-like0Direct
YebC-like0Direct
Nitrite/Sulfite reductase N-terminal domain-like0Direct
Oxidoreductase molybdopterin-binding domain0Direct
Nqo1C-terminal domain-like0Direct
6-phosphogluconate dehydrogenase C-terminal domain-like0Direct
F420-dependent methylenetetrahydromethanopterin dehydrogenase (MTD)0Direct
Inosine monophosphate dehydrogenase (IMPDH)0Direct
HydA/Nqo6-like0Direct
Aromatic compound dioxygenase0Direct
Amine oxidase catalytic domain0Direct
Aldehyde ferredoxin oxidoreductase, N-terminal domain0Direct
ALDH-like0Direct
Siroheme synthase middle domains-like0Direct
Heme-dependent peroxidases0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain0Direct
Clavaminate synthase-like0Direct
FMN-binding split barrel0Direct
Isocitrate/Isopropylmalate dehydrogenase-like0Direct
Nucleotide-binding domain0Direct
Superoxide reductase-like0Direct
Cupredoxins0Direct
LDH C-terminal domain-like0Direct
Heme oxygenase-like0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Substrate-binding domain of HMG-CoA reductase0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
Thioredoxin-like0Direct
Di-copper centre-containing domain0Direct
Cu,Zn superoxide dismutase-like0Direct
2Fe-2S ferredoxin-like0Direct
FAD/NAD(P)-binding domain0Direct
"Helical backbone" metal receptor0Direct
N-terminal domain of bifunctional PutA protein0Direct
ISP domain0Direct
Ribbon-helix-helix0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
Bacterial photosystem II reaction centre, L and M subunits0Direct
1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain0Direct
Fe-only hydrogenase0Direct
FAD-linked reductases, C-terminal domain0Direct
CO dehydrogenase ISP C-domain like0Direct
CBS-domain pair0Direct
Ferredoxin thioredoxin reductase (FTR), catalytic beta chain0Direct
LigB-like0Direct
FAD-linked oxidases, C-terminal domain0Direct
Bacterial luciferase-like0Direct
Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain0Direct
Indolic compounds 2,3-dioxygenase-like0Direct
Cytochrome c oxidase subunit III-like0Direct
Ferritin-like0Direct
Hemocyanin, N-terminal domain0Direct
Flavoproteins0Direct
Mitochondrial cytochrome c oxidase subunit IV0Direct
FAD-dependent thiol oxidase0Direct
Coproporphyrinogen III oxidase0Direct
Cytochrome c0Direct
AhpD-like0Direct
Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha)0Direct
Globin-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Cytochrome P4500Direct
CO dehydrogenase flavoprotein C-terminal domain-like0Direct
Dihydrofolate reductase-like0Direct
Multiheme cytochromes0Direct
RmlC-like cupins0Direct
Riboflavin synthase domain-like0Direct
Dehydroquinate synthase-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
GroES-like0Direct
Aldehyde ferredoxin oxidoreductase, C-terminal domains0Direct
NAD-binding domain of HMG-CoA reductase0Direct
FAD-linked oxidoreductase0Direct
Fe,Mn superoxide dismutase (SOD), N-terminal domain0Direct
Cytochrome b5-like heme/steroid binding domain0Direct
FMN-linked oxidoreductases0Direct
Lipase/lipooxygenase domain (PLAT/LH2 domain)0Direct
Glutamyl tRNA-reductase dimerization domain0Direct
Lipoxigenase0Direct
alpha-helical ferredoxin0Direct
NAD(P)-linked oxidoreductase0Direct
Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)0Direct
4Fe-4S ferredoxins0Direct
Cytochrome c oxidase subunit I-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Respiratory nitrate reductase 1 gamma chain0Direct
Methanol dehydrogenase subunit0Direct
ADC-like0Direct
Photosystem I subunits PsaA/PsaB0Direct
NAD(P)-binding Rossmann-fold domains0Direct
Prismane protein-like0Direct
Heme-dependent catalase-like0Direct
Glutamyl tRNA-reductase catalytic, N-terminal domain0Direct
Nqo1 middle domain-like0Direct
Amine oxidase N-terminal region0Direct
Molybdenum cofactor-binding domain0Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0Direct
Tetrapyrrole methylase0Direct
Fe,Mn superoxide dismutase (SOD), C-terminal domain0Direct
Frataxin/Nqo15-like0Direct
UDP-glucose/GDP-mannose dehydrogenase C-terminal domain0Direct
Nqo5-like0Direct
DinB/YfiT-like putative metalloenzymes0Direct
Formate dehydrogenase/DMSO reductase, domains 1-30Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
Aminoacid dehydrogenase-like, N-terminal domain0Direct
PFL-like glycyl radical enzymes0Direct
L-sulfolactate dehydrogenase-like0Direct
FMN-dependent nitroreductase-like0Direct
Cytochrome c oxidase subunit II-like, transmembrane region0Direct
Formate/glycerate dehydrogenase catalytic domain-like0Direct
Peptide methionine sulfoxide reductase0Direct
CO dehydrogenase molybdoprotein N-domain-like0Direct
Alpha subunit of glutamate synthase, C-terminal domain0Direct
FAD-binding/transporter-associated domain-like0Direct
Dihydropteroate synthetase-like0Direct
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III0Direct
Copper amine oxidase, domain N0Direct
Mss4-like0Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
Methylamine dehydrogenase, L chain0Direct
R1 subunit of ribonucleotide reductase, N-terminal domain0Direct
Nitrite and sulphite reductase 4Fe-4S domain-like0Direct
HydB/Nqo4-like0Direct
Calponin-homology domain, CH-domain0.000000000000004549Direct
PHM/PNGase F0.00000000000001529Direct
Nqo1 FMN-binding domain-like0.0000000000008432Direct
Serine metabolism enzymes domain0.00000000006996Direct
Phosphotyrosine protein phosphatases I0.0000000001037Direct
Quinoprotein alcohol dehydrogenase-like0.0000000006021Direct
Rubredoxin-like0.00000004634Direct
C-type lectin-like0.00000007014Direct
3-carboxy-cis,cis-mucoante lactonizing enzyme0.000000079Direct
SRCR-like0.0000001792Direct
YVTN repeat-like/Quinoprotein amine dehydrogenase0.000001048Direct
Multidrug efflux transporter AcrB transmembrane domain0.000002612Direct
ParB/Sulfiredoxin0.000006857Direct
NTF2-like0.00002456Direct
EGF/Laminin0.00004729Direct
Dimeric alpha+beta barrel0.0009859Direct
Lipocalins0.001536Inherited
TK C-terminal domain-like0.001684Inherited
ACT-like0.001893Inherited
C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase0.001994Inherited
Galactose oxidase, central domain0.002286Inherited
FnI-like domain0.004923Inherited
SCP-like0.006978Inherited
ACP-like0.008795Inherited
Nitrous oxide reductase, N-terminal domain0.0142Inherited
HSP20-like chaperones0.01833Inherited
HIT/MYND zinc finger-like0.07367Inherited
Electron transport accessory proteins0.09503Inherited
NHL repeat0.2871Inherited
ARM repeat0.3505Inherited
HMA, heavy metal-associated domain0.3765Inherited
Complement control module/SCR domain0.4057Inherited
TPR-like0.4466Inherited
Chorismate mutase II0.4935Inherited
SMAD/FHA domain0.5067Inherited
FYVE/PHD zinc finger0.5929Inherited
RNI-like0.6639Inherited
FabD/lysophospholipase-like0.8476Inherited
Homing endonucleases0.873Inherited
Tudor/PWWP/MBT0.8871Inherited
Calcium-dependent phosphotriesterase0.9022Inherited
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.9306Inherited
Hedgehog/intein (Hint) domain0.989Inherited
Nucleic acid-binding proteins1Inherited
Metallo-hydrolase/oxidoreductase1Inherited
L domain-like1Inherited
Thioesterase/thiol ester dehydrase-isomerase1Inherited
HD-domain/PDEase-like1Inherited
Adenine nucleotide alpha hydrolases-like1Inherited
PLP-dependent transferases1Inherited
Cytidine deaminase-like1Inherited
Aminomethyltransferase beta-barrel domain1Inherited
4'-phosphopantetheinyl transferase1Inherited
Immunoglobulin1Inherited
Glucocorticoid receptor-like (DNA-binding domain)1Inherited
CoA-dependent acyltransferases1Inherited
Aldolase1Inherited
PDZ domain-like1Inherited
ThiG-like1Inherited
ClpP/crotonase1Inherited
Nucleotide-diphospho-sugar transferases1Inherited
all-alpha NTP pyrophosphatases1Inherited
Enolase C-terminal domain-like1Inherited
FMT C-terminal domain-like1Inherited
alpha/beta-Hydrolases1Inherited
Thymidylate synthase/dCMP hydroxymethylase1Inherited
Acetyl-CoA synthetase-like1Inherited
Thiolase-like1Inherited
GST C-terminal domain-like1Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)1Inherited
E set domains1Inherited
Rhodanese/Cell cycle control phosphatase1Inherited
Carbamate kinase-like1Inherited
NagB/RpiA/CoA transferase-like1Inherited
Folate-binding domain1Inherited
Formyltransferase1Inherited
Class I glutamine amidotransferase-like1Inherited
Cysteine-rich domain1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
EPT/RTPC-like1Inherited
EF-hand1Inherited
HisI-like1Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase1Inherited
Ubiquitin-like1Inherited
Radical SAM enzymes1Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
51730,53720
  • 51730 - FAD-linked oxidoreductase
  • 53720 - ALDH-like
  • 0Direct
    55205,52540
  • 55205 - EPT/RTPC-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51735,50129
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    51395,54862
  • 51395 - FMN-linked oxidoreductases
  • 54862 - 4Fe-4S ferredoxins
  • 0Direct
    50998,46626
  • 50998 - Quinoprotein alcohol dehydrogenase-like
  • 46626 - Cytochrome c
  • 0Direct
    47336,53720
  • 47336 - ACP-like
  • 53720 - ALDH-like
  • 0Direct
    51735,56327
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 56327 - LDH C-terminal domain-like
  • 0Direct
    81935,51730
  • 81935 - N-terminal domain of bifunctional PutA protein
  • 51730 - FAD-linked oxidoreductase
  • 0Direct
    56425,46977
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 46977 - Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
  • 0Direct
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0Direct
    55856,51395
  • 55856 - Cytochrome b5-like heme/steroid binding domain
  • 51395 - FMN-linked oxidoreductases
  • 0Direct
    53323,52518
  • 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    81464,49503
  • 81464 - Cytochrome c oxidase subunit II-like, transmembrane region
  • 49503 - Cupredoxins
  • 0Direct
    53633,53720
  • 53633 - Carbamate kinase-like
  • 53720 - ALDH-like
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    51735,54637
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    81296,55856
  • 81296 - E set domains
  • 55856 - Cytochrome b5-like heme/steroid binding domain
  • 0Direct
    54862,52518
  • 54862 - 4Fe-4S ferredoxins
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    54862,48371
  • 54862 - 4Fe-4S ferredoxins
  • 48371 - ARM repeat
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    81442,81464
  • 81442 - Cytochrome c oxidase subunit I-like
  • 81464 - Cytochrome c oxidase subunit II-like, transmembrane region
  • 0Direct
    51604,56014
  • 51604 - Enolase C-terminal domain-like
  • 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
  • 0Direct
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    47203,47203
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    55035,56542
  • 55035 - NAD-binding domain of HMG-CoA reductase
  • 56542 - Substrate-binding domain of HMG-CoA reductase
  • 0Direct
    47240,-9
  • 47240 - Ferritin-like
  • -9 - PDB
  • 0Direct
    55008,51905
  • 55008 - HMA, heavy metal-associated domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    52833,55068
  • 52833 - Thioredoxin-like
  • 55068 - Peptide methionine sulfoxide reductase
  • 0Direct
    52833,51905
  • 52833 - Thioredoxin-like
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    55856,49764
  • 55856 - Cytochrome b5-like heme/steroid binding domain
  • 49764 - HSP20-like chaperones
  • 0Direct
    48179,52413
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 52413 - UDP-glucose/GDP-mannose dehydrogenase C-terminal domain
  • 0Direct
    53597,55831
  • 53597 - Dihydrofolate reductase-like
  • 55831 - Thymidylate synthase/dCMP hydroxymethylase
  • 0Direct
    57196,48113
  • 57196 - EGF/Laminin
  • 48113 - Heme-dependent peroxidases
  • 0Direct
    56796,55205
  • 56796 - Dehydroquinate synthase-like
  • 55205 - EPT/RTPC-like
  • 0Direct
    54862,53920
  • 54862 - 4Fe-4S ferredoxins
  • 53920 - Fe-only hydrogenase
  • 0Direct
    51735,53659
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 53659 - Isocitrate/Isopropylmalate dehydrogenase-like
  • 0Direct
    55124,54862
  • 55124 - Nitrite/Sulfite reductase N-terminal domain-like
  • 54862 - 4Fe-4S ferredoxins
  • 0Direct
    51905,47576
  • 51905 - FAD/NAD(P)-binding domain
  • 47576 - Calponin-homology domain, CH-domain
  • 0Direct
    51735,75615
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 75615 - Siroheme synthase middle domains-like
  • 0Direct
    55608,51998
  • 55608 - Homing endonucleases
  • 51998 - PFL-like glycyl radical enzymes
  • 0Direct
    49503,-7
  • 49503 - Cupredoxins
  • -7 - CATH
  • 0Direct
    51735,69075
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 69075 - Glutamyl tRNA-reductase dimerization domain
  • 0Direct
    54292,54862
  • 54292 - 2Fe-2S ferredoxin-like
  • 54862 - 4Fe-4S ferredoxins
  • 0Direct
    52151,51412
  • 52151 - FabD/lysophospholipase-like
  • 51412 - Inosine monophosphate dehydrogenase (IMPDH)
  • 0Direct
    52922,52518
  • 52922 - TK C-terminal domain-like
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    48264,52218
  • 48264 - Cytochrome P450
  • 52218 - Flavoproteins
  • 0Direct
    52922,53323
  • 52922 - TK C-terminal domain-like
  • 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
  • 0Direct
    51735,143548
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 143548 - Serine metabolism enzymes domain
  • 0Direct
    53383,53383
  • 53383 - PLP-dependent transferases
  • 53383 - PLP-dependent transferases
  • 0Direct
    54637,52151
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    75615,53790
  • 75615 - Siroheme synthase middle domains-like
  • 53790 - Tetrapyrrole methylase
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    51717,56014
  • 51717 - Dihydropteroate synthetase-like
  • 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
  • 0Direct
    46609,54719
  • 46609 - Fe,Mn superoxide dismutase (SOD), N-terminal domain
  • 54719 - Fe,Mn superoxide dismutase (SOD), C-terminal domain
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    55383,54416
  • 55383 - Copper amine oxidase, domain N
  • 54416 - Amine oxidase N-terminal region
  • 0Direct
    48179,52096
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 52096 - ClpP/crotonase
  • 0Direct
    55021,51735
  • 55021 - ACT-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    48179,55021
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 55021 - ACT-like
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    51182,52833
  • 51182 - RmlC-like cupins
  • 52833 - Thioredoxin-like
  • 0Direct
    54416,54416
  • 54416 - Amine oxidase N-terminal region
  • 54416 - Amine oxidase N-terminal region
  • 0Direct
    48452,51197
  • 48452 - TPR-like
  • 51197 - Clavaminate synthase-like
  • 0Direct
    50486,47336
  • 50486 - FMT C-terminal domain-like
  • 47336 - ACP-like
  • 0Direct
    54292,47741
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 0Direct
    55347,55021
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 55021 - ACT-like
  • 0Direct
    47598,81935
  • 47598 - Ribbon-helix-helix
  • 81935 - N-terminal domain of bifunctional PutA protein
  • 0Direct
    54862,56014
  • 54862 - 4Fe-4S ferredoxins
  • 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
  • 0Direct
    51971,51395
  • 51971 - Nucleotide-binding domain
  • 51395 - FMN-linked oxidoreductases
  • 0Direct
    56634,52317
  • 56634 - Heme-dependent catalase-like
  • 52317 - Class I glutamine amidotransferase-like
  • 0Direct
    55620,55620
  • 55620 - Tetrahydrobiopterin biosynthesis enzymes-like
  • 55620 - Tetrahydrobiopterin biosynthesis enzymes-like
  • 0Direct
    51569,53223
  • 51569 - Aldolase
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 0Direct
    48600,51735
  • 48600 - Chorismate mutase II
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    52518,54862
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 54862 - 4Fe-4S ferredoxins
  • 0Direct
    46458,63380
  • 46458 - Globin-like
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    55347,69055
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 69055 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
  • 0Direct
    54292,46548
  • 54292 - 2Fe-2S ferredoxin-like
  • 46548 - alpha-helical ferredoxin
  • 0Direct
    101386,53720
  • 101386 - all-alpha NTP pyrophosphatases
  • 53720 - ALDH-like
  • 0Direct
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    49764,63380
  • 49764 - HSP20-like chaperones
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    142019,142984
  • 142019 - Nqo1 FMN-binding domain-like
  • 142984 - Nqo1 middle domain-like
  • 0Direct
    56512,52218
  • 56512 - Nitric oxide (NO) synthase oxygenase domain
  • 52218 - Flavoproteins
  • 0Direct
    54637,55718
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 55718 - SCP-like
  • 0Direct
    51905,51971
  • 51905 - FAD/NAD(P)-binding domain
  • 51971 - Nucleotide-binding domain
  • 0Direct
    52402,52833
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 52833 - Thioredoxin-like
  • 0Direct
    51412,51412
  • 51412 - Inosine monophosphate dehydrogenase (IMPDH)
  • 51412 - Inosine monophosphate dehydrogenase (IMPDH)
  • 0Direct
    46548,51971
  • 46548 - alpha-helical ferredoxin
  • 51971 - Nucleotide-binding domain
  • 0Direct
    51395,51971
  • 51395 - FMN-linked oxidoreductases
  • 51971 - Nucleotide-binding domain
  • 0Direct
    55856,56524
  • 55856 - Cytochrome b5-like heme/steroid binding domain
  • 56524 - Oxidoreductase molybdopterin-binding domain
  • 0Direct
    57802,49367
  • 57802 - Rubredoxin-like
  • 49367 - Superoxide reductase-like
  • 0Direct
    57535,57196
  • 57535 - Complement control module/SCR domain
  • 57196 - EGF/Laminin
  • 0Direct
    51182,51182
  • 51182 - RmlC-like cupins
  • 51182 - RmlC-like cupins
  • 0Direct
    51905,56425
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    52540,51569
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51569 - Aldolase
  • 0Direct
    48113,48113
  • 48113 - Heme-dependent peroxidases
  • 48113 - Heme-dependent peroxidases
  • 0Direct
    56524,81296
  • 56524 - Oxidoreductase molybdopterin-binding domain
  • 81296 - E set domains
  • 0Direct
    69742,51735
  • 69742 - Glutamyl tRNA-reductase catalytic, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    81558,-9
  • 81558 - Photosystem I subunits PsaA/PsaB
  • -9 - PDB
  • 0Direct
    51971,51905
  • 51971 - Nucleotide-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    46626,51004
  • 46626 - Cytochrome c
  • 51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
  • 0Direct
    51735,55021
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55021 - ACT-like
  • 0Direct
    51905,54373
  • 51905 - FAD/NAD(P)-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0Direct
    48695,51905
  • 48695 - Multiheme cytochromes
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    51905,47473
  • 51905 - FAD/NAD(P)-binding domain
  • 47473 - EF-hand
  • 0Direct
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    50022,56281
  • 50022 - ISP domain
  • 56281 - Metallo-hydrolase/oxidoreductase
  • 0Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    56821,46548
  • 56821 - Prismane protein-like
  • 46548 - alpha-helical ferredoxin
  • 0Direct
    50965,81296
  • 50965 - Galactose oxidase, central domain
  • 81296 - E set domains
  • 0Direct
    75625,51998
  • 75625 - YebC-like
  • 51998 - PFL-like glycyl radical enzymes
  • 0Direct
    55068,51316
  • 55068 - Peptide methionine sulfoxide reductase
  • 51316 - Mss4-like
  • 0Direct
    52518,52218
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52218 - Flavoproteins
  • 0Direct
    54631,51412
  • 54631 - CBS-domain pair
  • 51412 - Inosine monophosphate dehydrogenase (IMPDH)
  • 0Direct
    53223,51735
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    50974,49503
  • 50974 - Nitrous oxide reductase, N-terminal domain
  • 49503 - Cupredoxins
  • 0Direct
    55856,63380
  • 55856 - Cytochrome b5-like heme/steroid binding domain
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    51395,56014
  • 51395 - FMN-linked oxidoreductases
  • 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
  • 0Direct
    47741,56176
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    53720,56796
  • 53720 - ALDH-like
  • 56796 - Dehydroquinate synthase-like
  • 0Direct
    56014,50022
  • 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
  • 50022 - ISP domain
  • 0Direct
    56487,56487
  • 56487 - SRCR-like
  • 56487 - SRCR-like
  • 0Direct
    81558,81558
  • 81558 - Photosystem I subunits PsaA/PsaB
  • 81558 - Photosystem I subunits PsaA/PsaB
  • 0Direct
    50022,55961
  • 50022 - ISP domain
  • 55961 - Bet v1-like
  • 0Direct
    55124,56014
  • 55124 - Nitrite/Sulfite reductase N-terminal domain-like
  • 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
  • 0Direct
    52096,51735
  • 52096 - ClpP/crotonase
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    55447,54665
  • 55447 - CO dehydrogenase flavoprotein C-terminal domain-like
  • 54665 - CO dehydrogenase molybdoprotein N-domain-like
  • 0Direct
    54665,56003
  • 54665 - CO dehydrogenase molybdoprotein N-domain-like
  • 56003 - Molybdenum cofactor-binding domain
  • 0Direct
    48113,-9
  • 48113 - Heme-dependent peroxidases
  • -9 - PDB
  • 0Direct
    51366,56014
  • 51366 - Ribulose-phoshate binding barrel
  • 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
  • 0Direct
    52833,57889
  • 52833 - Thioredoxin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    52343,54292
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 54292 - 2Fe-2S ferredoxin-like
  • 0Direct
    142984,140490
  • 142984 - Nqo1 middle domain-like
  • 140490 - Nqo1C-terminal domain-like
  • 0Direct
    48168,51998
  • 48168 - R1 subunit of ribonucleotide reductase, N-terminal domain
  • 51998 - PFL-like glycyl radical enzymes
  • 0Direct
    53323,54862
  • 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
  • 54862 - 4Fe-4S ferredoxins
  • 0Direct
    51412,56014
  • 51412 - Inosine monophosphate dehydrogenase (IMPDH)
  • 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
  • 0Direct
    54862,53706
  • 54862 - 4Fe-4S ferredoxins
  • 53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
  • 0Direct
    56014,55124
  • 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
  • 55124 - Nitrite/Sulfite reductase N-terminal domain-like
  • 0Direct
    49503,46626
  • 49503 - Cupredoxins
  • 46626 - Cytochrome c
  • 0Direct
    48050,48056
  • 48050 - Hemocyanin, N-terminal domain
  • 48056 - Di-copper centre-containing domain
  • 0Direct
    51905,52833
  • 51905 - FAD/NAD(P)-binding domain
  • 52833 - Thioredoxin-like
  • 0Direct
    69336,50692
  • 69336 - Alpha subunit of glutamate synthase, C-terminal domain
  • 50692 - ADC-like
  • 0Direct
    54862,51395
  • 54862 - 4Fe-4S ferredoxins
  • 51395 - FMN-linked oxidoreductases
  • 0Direct
    56176,56194
  • 56176 - FAD-binding/transporter-associated domain-like
  • 56194 - Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
  • 0Direct
    52218,63380
  • 52218 - Flavoproteins
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    48056,81296
  • 48056 - Di-copper centre-containing domain
  • 81296 - E set domains
  • 0Direct
    51971,51971
  • 51971 - Nucleotide-binding domain
  • 51971 - Nucleotide-binding domain
  • 0Direct
    56228,48310
  • 56228 - Aldehyde ferredoxin oxidoreductase, N-terminal domain
  • 48310 - Aldehyde ferredoxin oxidoreductase, C-terminal domains
  • 0Direct
    53706,50692
  • 53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
  • 50692 - ADC-like
  • 0Direct
    56176,55103
  • 56176 - FAD-binding/transporter-associated domain-like
  • 55103 - FAD-linked oxidases, C-terminal domain
  • 0Direct
    47576,57716
  • 47576 - Calponin-homology domain, CH-domain
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0Direct
    56176,55447
  • 56176 - FAD-binding/transporter-associated domain-like
  • 55447 - CO dehydrogenase flavoprotein C-terminal domain-like
  • 0Direct
    54416,49998
  • 54416 - Amine oxidase N-terminal region
  • 49998 - Amine oxidase catalytic domain
  • 0Direct
    51905,54862
  • 51905 - FAD/NAD(P)-binding domain
  • 54862 - 4Fe-4S ferredoxins
  • 0Direct
    50486,51735
  • 50486 - FMT C-terminal domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    48179,54637
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    51971,54373
  • 51971 - Nucleotide-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0.000000000000003154Direct
    49742,49742
  • 49742 - PHM/PNGase F
  • 49742 - PHM/PNGase F
  • 0.00000000000001529Direct
    53927,53597
  • 53927 - Cytidine deaminase-like
  • 53597 - Dihydrofolate reductase-like
  • 0.0000000000002245Direct
    143548,55021
  • 143548 - Serine metabolism enzymes domain
  • 55021 - ACT-like
  • 0.00000000349Direct
    46626,46626
  • 46626 - Cytochrome c
  • 46626 - Cytochrome c
  • 0.00001705Direct
    54593,54593
  • 54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
  • 54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
  • 0.00001797Direct
    53659,53659
  • 53659 - Isocitrate/Isopropylmalate dehydrogenase-like
  • 53659 - Isocitrate/Isopropylmalate dehydrogenase-like
  • 0.0000532Direct
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.00008441Direct
    47336,53474
  • 47336 - ACP-like
  • 53474 - alpha/beta-Hydrolases
  • 0.0008828Direct
    54292,63380
  • 54292 - 2Fe-2S ferredoxin-like
  • 63380 - Riboflavin synthase domain-like
  • 0.0009094Direct
    51735,51735
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.002288Inherited
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0.002956Inherited
    53633,55021
  • 53633 - Carbamate kinase-like
  • 55021 - ACT-like
  • 0.005541Inherited
    52777,56801
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 0.01119Inherited
    52058,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 0.03022Inherited
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0.03682Inherited
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0.07527Inherited
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.1903Inherited
    51735,47336
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 0.379Inherited
    141734,101386
  • 141734 - HisI-like
  • 101386 - all-alpha NTP pyrophosphatases
  • 0.7585Inherited
    52151,55048
  • 52151 - FabD/lysophospholipase-like
  • 55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase
  • 0.9306Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 1Inherited
    103025,101790
  • 103025 - Folate-binding domain
  • 101790 - Aminomethyltransferase beta-barrel domain
  • 1Inherited
    53328,50486
  • 53328 - Formyltransferase
  • 50486 - FMT C-terminal domain-like
  • 1Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 1Inherited
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 1Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 1Inherited
    55021,55021
  • 55021 - ACT-like
  • 55021 - ACT-like
  • 1Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52283,51735,55021
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55021 - ACT-like
  • 0Direct
    56487,56487,56487
  • 56487 - SRCR-like
  • 56487 - SRCR-like
  • 56487 - SRCR-like
  • 0Direct
    81464,49503,46626
  • 81464 - Cytochrome c oxidase subunit II-like, transmembrane region
  • 49503 - Cupredoxins
  • 46626 - Cytochrome c
  • 0Direct
    52518,52922,53323
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
  • 0Direct
    54292,54862,53706
  • 54292 - 2Fe-2S ferredoxin-like
  • 54862 - 4Fe-4S ferredoxins
  • 53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
  • 0Direct
    51971,51905,55424
  • 51971 - Nucleotide-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    81558,81558,-9
  • 81558 - Photosystem I subunits PsaA/PsaB
  • 81558 - Photosystem I subunits PsaA/PsaB
  • -9 - PDB
  • 0Direct
    48113,48113,-9
  • 48113 - Heme-dependent peroxidases
  • 48113 - Heme-dependent peroxidases
  • -9 - PDB
  • 0Direct
    55856,63380,52343
  • 55856 - Cytochrome b5-like heme/steroid binding domain
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    51395,51971,51905
  • 51395 - FMN-linked oxidoreductases
  • 51971 - Nucleotide-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    51971,51971,51395
  • 51971 - Nucleotide-binding domain
  • 51971 - Nucleotide-binding domain
  • 51395 - FMN-linked oxidoreductases
  • 0Direct
    55008,51905,55424
  • 55008 - HMA, heavy metal-associated domain
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    55856,49764,63380
  • 55856 - Cytochrome b5-like heme/steroid binding domain
  • 49764 - HSP20-like chaperones
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    52540,51569,53223
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51569 - Aldolase
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 0Direct
    51735,55347,69055
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 69055 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain
  • 0Direct
    55447,54665,56003
  • 55447 - CO dehydrogenase flavoprotein C-terminal domain-like
  • 54665 - CO dehydrogenase molybdoprotein N-domain-like
  • 56003 - Molybdenum cofactor-binding domain
  • 0Direct
    81935,51730,53720
  • 81935 - N-terminal domain of bifunctional PutA protein
  • 51730 - FAD-linked oxidoreductase
  • 53720 - ALDH-like
  • 0Direct
    51569,53223,51735
  • 51569 - Aldolase
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    48264,52218,63380
  • 48264 - Cytochrome P450
  • 52218 - Flavoproteins
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    49764,63380,52343
  • 49764 - HSP20-like chaperones
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    51905,56425,46977
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 46977 - Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
  • 0Direct
    55124,54862,56014
  • 55124 - Nitrite/Sulfite reductase N-terminal domain-like
  • 54862 - 4Fe-4S ferredoxins
  • 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
  • 0Direct
    54292,47741,56176
  • 54292 - 2Fe-2S ferredoxin-like
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 0Direct
    48600,51735,48179
  • 48600 - Chorismate mutase II
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    53328,50486,47336
  • 53328 - Formyltransferase
  • 50486 - FMT C-terminal domain-like
  • 47336 - ACP-like
  • 0Direct
    56176,55447,54665
  • 56176 - FAD-binding/transporter-associated domain-like
  • 55447 - CO dehydrogenase flavoprotein C-terminal domain-like
  • 54665 - CO dehydrogenase molybdoprotein N-domain-like
  • 0Direct
    46548,51971,51971
  • 46548 - alpha-helical ferredoxin
  • 51971 - Nucleotide-binding domain
  • 51971 - Nucleotide-binding domain
  • 0Direct
    51735,48179,52413
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 52413 - UDP-glucose/GDP-mannose dehydrogenase C-terminal domain
  • 0Direct
    48695,51905,56425
  • 48695 - Multiheme cytochromes
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    55856,56524,81296
  • 55856 - Cytochrome b5-like heme/steroid binding domain
  • 56524 - Oxidoreductase molybdopterin-binding domain
  • 81296 - E set domains
  • 0Direct
    54637,54637,55718
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 55718 - SCP-like
  • 0Direct
    51735,51735,54637
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    47598,81935,51730
  • 47598 - Ribbon-helix-helix
  • 81935 - N-terminal domain of bifunctional PutA protein
  • 51730 - FAD-linked oxidoreductase
  • 0Direct
    51905,51905,47473
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 47473 - EF-hand
  • 0Direct
    141734,101386,53720
  • 141734 - HisI-like
  • 101386 - all-alpha NTP pyrophosphatases
  • 53720 - ALDH-like
  • 0Direct
    48179,48179,52096
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 52096 - ClpP/crotonase
  • 0Direct
    52283,51735,143548
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 143548 - Serine metabolism enzymes domain
  • 0Direct
    51735,54637,54637
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    50486,47336,53720
  • 50486 - FMT C-terminal domain-like
  • 47336 - ACP-like
  • 53720 - ALDH-like
  • 0Direct
    52518,52922,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    53323,52518,52922
  • 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    56645,47203,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    63380,52343,54292
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 54292 - 2Fe-2S ferredoxin-like
  • 0Direct
    51735,143548,55021
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 143548 - Serine metabolism enzymes domain
  • 55021 - ACT-like
  • 0Direct
    55021,55021,51735
  • 55021 - ACT-like
  • 55021 - ACT-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    53323,54862,52518
  • 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
  • 54862 - 4Fe-4S ferredoxins
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    51735,48179,54637
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    55124,56014,55124
  • 55124 - Nitrite/Sulfite reductase N-terminal domain-like
  • 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
  • 55124 - Nitrite/Sulfite reductase N-terminal domain-like
  • 0Direct
    81296,55856,63380
  • 81296 - E set domains
  • 55856 - Cytochrome b5-like heme/steroid binding domain
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    51905,51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    52218,63380,52343
  • 52218 - Flavoproteins
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    51735,48179,55021
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 55021 - ACT-like
  • 0Direct
    56512,52218,63380
  • 56512 - Nitric oxide (NO) synthase oxygenase domain
  • 52218 - Flavoproteins
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    51735,75615,53790
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 75615 - Siroheme synthase middle domains-like
  • 53790 - Tetrapyrrole methylase
  • 0Direct
    51905,47576,57716
  • 51905 - FAD/NAD(P)-binding domain
  • 47576 - Calponin-homology domain, CH-domain
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0Direct
    54416,54416,49998
  • 54416 - Amine oxidase N-terminal region
  • 54416 - Amine oxidase N-terminal region
  • 49998 - Amine oxidase catalytic domain
  • 0Direct
    52833,55068,51316
  • 52833 - Thioredoxin-like
  • 55068 - Peptide methionine sulfoxide reductase
  • 51316 - Mss4-like
  • 0Direct
    56524,81296,55856
  • 56524 - Oxidoreductase molybdopterin-binding domain
  • 81296 - E set domains
  • 55856 - Cytochrome b5-like heme/steroid binding domain
  • 0Direct
    50129,51735,50129
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0Direct
    52096,51735,48179
  • 52096 - ClpP/crotonase
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    55021,51735,55347
  • 55021 - ACT-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    53223,51735,53659
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 53659 - Isocitrate/Isopropylmalate dehydrogenase-like
  • 0Direct
    52833,52833,57889
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    53328,50486,51735
  • 53328 - Formyltransferase
  • 50486 - FMT C-terminal domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    69742,51735,69075
  • 69742 - Glutamyl tRNA-reductase catalytic, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 69075 - Glutamyl tRNA-reductase dimerization domain
  • 0Direct
    52922,53323,54862
  • 52922 - TK C-terminal domain-like
  • 53323 - Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
  • 54862 - 4Fe-4S ferredoxins
  • 0Direct
    56014,55124,56014
  • 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
  • 55124 - Nitrite/Sulfite reductase N-terminal domain-like
  • 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
  • 0Direct
    46626,46626,46626
  • 46626 - Cytochrome c
  • 46626 - Cytochrome c
  • 46626 - Cytochrome c
  • 0Direct
    142019,142984,140490
  • 142019 - Nqo1 FMN-binding domain-like
  • 142984 - Nqo1 middle domain-like
  • 140490 - Nqo1C-terminal domain-like
  • 0Direct
    56796,55205,52540
  • 56796 - Dehydroquinate synthase-like
  • 55205 - EPT/RTPC-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51735,55347,55021
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 55021 - ACT-like
  • 0Direct
    47741,56176,55447
  • 47741 - CO dehydrogenase ISP C-domain like
  • 56176 - FAD-binding/transporter-associated domain-like
  • 55447 - CO dehydrogenase flavoprotein C-terminal domain-like
  • 0Direct
    54862,53706,50692
  • 54862 - 4Fe-4S ferredoxins
  • 53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
  • 50692 - ADC-like
  • 0Direct
    55383,54416,54416
  • 55383 - Copper amine oxidase, domain N
  • 54416 - Amine oxidase N-terminal region
  • 54416 - Amine oxidase N-terminal region
  • 0Direct
    48050,48056,81296
  • 48050 - Hemocyanin, N-terminal domain
  • 48056 - Di-copper centre-containing domain
  • 81296 - E set domains
  • 0Direct
    46458,63380,52343
  • 46458 - Globin-like
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    55124,56014,50022
  • 55124 - Nitrite/Sulfite reductase N-terminal domain-like
  • 56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
  • 50022 - ISP domain
  • 0Direct
    55205,52540,51569
  • 55205 - EPT/RTPC-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 51569 - Aldolase
  • 0Direct
    51971,51395,54862
  • 51971 - Nucleotide-binding domain
  • 51395 - FMN-linked oxidoreductases
  • 54862 - 4Fe-4S ferredoxins
  • 0Direct
    52922,52518,54862
  • 52922 - TK C-terminal domain-like
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 54862 - 4Fe-4S ferredoxins
  • 0Direct
    47576,57716,57716
  • 47576 - Calponin-homology domain, CH-domain
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0Direct
    51971,51905,51971
  • 51971 - Nucleotide-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 51971 - Nucleotide-binding domain
  • 0Direct
    51735,47336,53474
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 53474 - alpha/beta-Hydrolases
  • 0.000007275Direct
    50249,50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.0003882Direct
    54292,63380,52343
  • 54292 - 2Fe-2S ferredoxin-like
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0.0009094Direct
    53633,55021,55021
  • 53633 - Carbamate kinase-like
  • 55021 - ACT-like
  • 55021 - ACT-like
  • 0.005541Inherited
    50129,51735,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.02167Inherited
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.02376Inherited
    51735,51735,47336
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 0.2996Inherited
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.7833Inherited
    52518,52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 1Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 1Inherited


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