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Enzyme Commission (EC): Acting on NADH or NADPH

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   root [root] <7>
+ 1:   Oxidoreductases [1] <26>(213|314) (212|187|94)
0:   Acting on NADH or NADPH [1.6] <9>(23|28) (23|13|7)
- 1:   With other acceptors [1.6.99] <14>(13|13) (13|5|2)
- 1:   With a nitrogenous group as acceptor [1.6.6] <13>(0|0) (0|0|0)
- 1:   With a quinone or similar compound as acceptor [1.6.5] <12>(6|7) (6|4|2)
- 1:   With a disulfide as acceptor [1.6.4] <10>(0|0) (0|0|0)
- 1:   With a heme protein as acceptor [1.6.2] <6>(6|8) (6|5|3)
- 1:   With NAD(+) or NADP(+) as acceptor [1.6.1] <5>(2|2) (2|1|0)
- 1:   With oxygen as acceptor [1.6.3] <5>(5|3) (5|1|0)
- 1:   With a flavin as acceptor [1.6.8] <2>(0|0) (0|0|0)
- 1:   With a iron-sulfur protein as acceptor [1.6.7] <2>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
FAD/NAD(P)-binding domain0Direct
Nqo1C-terminal domain-like0Direct
Nqo1 middle domain-like0Direct
Riboflavin synthase domain-like0Direct
Flavoproteins0Direct
Nqo1 FMN-binding domain-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
HydB/Nqo4-like0Direct
Nqo5-like0Direct
EF-hand0.000000000000008929Direct
4Fe-4S ferredoxins0.00000000000004094Direct
HSP20-like chaperones0.0000000000006603Direct
HydA/Nqo6-like0.000000000003528Direct
2Fe-2S ferredoxin-like0.00000008768Direct
Formate dehydrogenase/DMSO reductase, domains 1-30.00000009643Direct
FMN-linked oxidoreductases0.000001887Direct
Cytochrome b5-like heme/steroid binding domain0.007766Inherited
GroES-like0.164Inherited
Thioredoxin-like0.496Inherited
Heme-dependent peroxidases0.9114Inherited
Cytochrome P4501Inherited
NAD(P)-binding Rossmann-fold domains1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
WrbA-like0Direct
Nqo1C-terminal domain-like0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
Nq06-like0Direct
NQO2-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
FAD/NAD-linked reductases, N-terminal and central domains0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Nqo1 middle domain-like0Direct
Quinone reductase0Direct
Reductases0Direct
Nqo4-like0Direct
Ferredoxin domains from multidomain proteins0Direct
NADPH-cytochrome p450 reductase-like0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0Direct
Nqo1 FMN-binding domain-like0Direct
Nqo5-like0Direct
Flavodoxin-related0.0000000000002234Direct
Calmodulin-like0.00000000000983Direct
NADPH-dependent FMN reductase0.00000000001937Direct
Formate dehydrogenase/DMSO reductase, domains 1-30.0000007832Direct
Myeloperoxidase-like0.000002392Direct
FMN-linked oxidoreductases0.000008452Direct
Cytochrome b50.007089Inherited
Alcohol dehydrogenase-like, C-terminal domain0.1512Inherited
Alcohol dehydrogenase-like, N-terminal domain0.2011Inherited
2Fe-2S ferredoxin domains from multidomain proteins0.3859Inherited
Cytochrome P4501Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
FAD/NAD(P)-binding domain0Direct
Nqo5-like0Direct
HydB/Nqo4-like0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Flavoproteins0Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
Riboflavin synthase domain-like0Direct
Nqo1 middle domain-like0Direct
Nqo1 FMN-binding domain-like0Direct
Nqo1C-terminal domain-like0Direct
EF-hand0.000000000000006279Direct
4Fe-4S ferredoxins0.00000000000002897Direct
HSP20-like chaperones0.0000000000004738Direct
HydA/Nqo6-like0.000000000002548Direct
2Fe-2S ferredoxin-like0.000000067Direct
Formate dehydrogenase/DMSO reductase, domains 1-30.00000007381Direct
FMN-linked oxidoreductases0.00000148Direct
Cytochrome b5-like heme/steroid binding domain0.006561Inherited
GroES-like0.1449Inherited
Thioredoxin-like0.4532Inherited
Heme-dependent peroxidases0.8419Inherited
Cytochrome P4501Inherited
NAD(P)-binding Rossmann-fold domains1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48264,52218
  • 48264 - Cytochrome P450
  • 52218 - Flavoproteins
  • 0Direct
    49764,63380
  • 49764 - HSP20-like chaperones
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    142984,140490
  • 142984 - Nqo1 middle domain-like
  • 140490 - Nqo1C-terminal domain-like
  • 0Direct
    51905,47473
  • 51905 - FAD/NAD(P)-binding domain
  • 47473 - EF-hand
  • 0Direct
    55856,49764
  • 55856 - Cytochrome b5-like heme/steroid binding domain
  • 49764 - HSP20-like chaperones
  • 0Direct
    54862,53706
  • 54862 - 4Fe-4S ferredoxins
  • 53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
  • 0Direct
    54292,54862
  • 54292 - 2Fe-2S ferredoxin-like
  • 54862 - 4Fe-4S ferredoxins
  • 0Direct
    142019,142984
  • 142019 - Nqo1 FMN-binding domain-like
  • 142984 - Nqo1 middle domain-like
  • 0Direct
    52218,63380
  • 52218 - Flavoproteins
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0.00000000000002387Direct
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.1398Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    54292,54862,53706
  • 54292 - 2Fe-2S ferredoxin-like
  • 54862 - 4Fe-4S ferredoxins
  • 53706 - Formate dehydrogenase/DMSO reductase, domains 1-3
  • 0Direct
    48264,52218,63380
  • 48264 - Cytochrome P450
  • 52218 - Flavoproteins
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    49764,63380,52343
  • 49764 - HSP20-like chaperones
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    142019,142984,140490
  • 142019 - Nqo1 FMN-binding domain-like
  • 142984 - Nqo1 middle domain-like
  • 140490 - Nqo1C-terminal domain-like
  • 0Direct
    51905,51905,47473
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 47473 - EF-hand
  • 0Direct
    55856,49764,63380
  • 55856 - Cytochrome b5-like heme/steroid binding domain
  • 49764 - HSP20-like chaperones
  • 63380 - Riboflavin synthase domain-like
  • 0Direct
    51905,51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.00001498Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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