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Enzyme Commission (EC): Acyltransferases
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Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (Not in SDEC)
Highlighted in gray are those with FDR_all>0.001
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this EC term (SDEC level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
Galactoside acetyltransferase-like | 0 | DIRECT |
Kix domain of CBP (creb binding protein) | 0 | DIRECT |
Leucine zipper domain | 0 | DIRECT |
Trimerization domain of TRAF | 0 | DIRECT |
Glutaminyl-peptide cyclotransferase-like | 0 | DIRECT |
Transglutaminase, two C-terminal domains | 0 | DIRECT |
Acetyl-CoA synthase | 0 | DIRECT |
PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
ArgJ-like | 0 | DIRECT |
UBC-related | 0 | DIRECT |
SPRY domain | 0 | DIRECT |
Phytochelatin synthase | 0 | DIRECT |
Transcriptional factor domain | 0 | DIRECT |
Mib/herc2 domain | 0 | DIRECT |
Malate synthase G | 0 | DIRECT |
Thiolase-related | 0 | DIRECT |
PHD domain | 0 | DIRECT |
Bromodomain | 0 | DIRECT |
HLH, helix-loop-helix DNA-binding domain | 0 | DIRECT |
HMGL-like | 0 | DIRECT |
Methicillin resistance protein FemA probable tRNA-binding arm | 0 | DIRECT |
BRCT domain | 0 | DIRECT |
CCCH zinc finger | 0 | DIRECT |
Classic zinc finger, C2H2 | 0 | DIRECT |
Outer membrane enzyme PagP | 0 | DIRECT |
Transcription factor IIB (TFIIB), core domain | 0 | DIRECT |
Armadillo repeat | 0 | DIRECT |
GlmU C-terminal domain-like | 0 | DIRECT |
Phosphotransacetylase | 0 | DIRECT |
Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0 | DIRECT |
Gamma-glutamyltranspeptidase-like | 0 | DIRECT |
APC10-like | 0 | DIRECT |
CPH domain | 0 | DIRECT |
Chalcone synthase-like | 0 | DIRECT |
CAT-like | 0 | DIRECT |
Chromo barrel domain | 0 | DIRECT |
Mycobacterial antigens | 0 | DIRECT |
2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain | 0 | DIRECT |
Variant RING domain | 0 | DIRECT |
Homeodomain | 0 | DIRECT |
Zinc hairpin stack | 0 | DIRECT |
TAZ domain | 0 | DIRECT |
YeaZ-like | 0 | DIRECT |
Hect, E3 ligase catalytic domain | 0 | DIRECT |
SWIB/MDM2 domain | 0 | DIRECT |
FabD-like | 0 | DIRECT |
O-acetyltransferase | 0 | DIRECT |
Ran binding protein zinc finger-like | 0 | DIRECT |
WW domain | 0 | DIRECT |
FemXAB nonribosomal peptidyltransferases | 0 | DIRECT |
Ankyrin repeat | 0 | DIRECT |
Docking domain B of the erythromycin polyketide synthase (DEBS) | 0 | DIRECT |
Biotinyl/lipoyl-carrier proteins and domains | 0 | DIRECT |
Autoinducer synthetase | 0 | DIRECT |
Aminoglycoside 3-N-acetyltransferase-like | 0 | DIRECT |
DmpG/LeuA communication domain-like | 0 | DIRECT |
CHY zinc finger | 0 | DIRECT |
Glycerol-3-phosphate (1)-acyltransferase | 0 | DIRECT |
GABA-aminotransferase-like | 0 | DIRECT |
U-box | 0 | DIRECT |
Arylamine N-acetyltransferase | 0 | DIRECT |
NHL repeat | 0 | DIRECT |
Choline/Carnitine O-acyltransferase | 0 | DIRECT |
Hypoxia-inducible factor Hif2a, C-terminal domain | 0 | DIRECT |
N-terminal domain of cbl (N-cbl) | 0 | DIRECT |
IBR domain | 0 | DIRECT |
LFTR-like | 0 | DIRECT |
ZZ domain | 0 | DIRECT |
Citrate synthase | 0 | DIRECT |
HTS-like | 0 | DIRECT |
Serine acetyltransferase | 0 | DIRECT |
UDP N-acetylglucosamine acyltransferase | 0 | DIRECT |
SIAH, seven in absentia homolog | 0 | DIRECT |
N-acetyl transferase, NAT | 0 | DIRECT |
SRA domain-like | 0 | DIRECT |
Lrp/AsnC-like transcriptional regulator C-terminal domain | 0 | DIRECT |
B-box zinc-binding domain | 0 | DIRECT |
PlsX-like | 0 | DIRECT |
AstA-like | 0 | DIRECT |
LplA-like | 0 | DIRECT |
Formylmethanofuran:tetrahydromethanopterin formyltransferase | 0 | DIRECT |
CCHHC domain | 0 | DIRECT |
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
WWE domain | 0 | DIRECT |
Acyl-carrier protein (ACP) | 0 | DIRECT |
PABC (PABP) domain | 0 | DIRECT |
USP8 interacting domain | 0 | DIRECT |
Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
RING finger domain, C3HC4 | 0 | DIRECT |
Transglutaminase core | 0 | DIRECT |
N-myristoyl transferase, NMT | 0 | DIRECT |
Tetrahydrodipicolinate-N-succinlytransferase, THDP-succinlytransferase, DapD | 0 | DIRECT |
UDP-glucose pyrophosphorylase | 0 | DIRECT |
Sir2 family of transcriptional regulators | 0 | DIRECT |
Transglutaminase N-terminal domain | 0 | DIRECT |
Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
MATH domain | 9.189e-16 | DIRECT |
PFL-like | 0.0000000000004898 | DIRECT |
WD40-repeat | 0.000000000001047 | DIRECT |
DRTGG domain | 0.000000000001093 | DIRECT |
SAP domain | 0.00000000003969 | DIRECT |
Pentapeptide repeats | 0.000000000205 | DIRECT |
Filamin repeat (rod domain) | 0.000000002533 | DIRECT |
Ubiquitin-related | 0.000000003636 | DIRECT |
Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.000000003952 | DIRECT |
Leucine rich effector protein YopM | 0.000000009425 | DIRECT |
FHA domain | 0.00000001286 | DIRECT |
Sterol carrier protein, SCP | 0.00000005254 | DIRECT |
NRPS condensation domain (amide synthase) | 0.0000007997 | DIRECT |
CoA-binding domain | 0.000003894 | DIRECT |
FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.000005147 | DIRECT |
Tropomyosin | 0.000005246 | DIRECT |
Regulator of chromosome condensation RCC1 | 0.000005524 | DIRECT |
Hypoxia-inducible factor HIF ihhibitor (FIH1) | 0.000009474 | DIRECT |
EF-hand modules in multidomain proteins | 0.00001523 | DIRECT |
PA domain | 0.00003578 | DIRECT |
Leucine carboxy methyltransferase Ppm1 | 0.00004114 | DIRECT |
MaoC-like | 0.00005852 | DIRECT |
UBA domain | 0.0001387 | DIRECT |
PDZ domain | 0.0001387 | DIRECT |
CBS-domain pair | 0.0003103 | DIRECT |
TAF(II)230 TBP-binding fragment | 0.0003243 | DIRECT |
First domain of FERM | 0.003893 | INHERITED FROM: RING-type E3 ubiquitin transferase || Aminoacyltransferases |
Third domain of FERM | 0.003893 | INHERITED FROM: RING-type E3 ubiquitin transferase || Aminoacyltransferases |
Acetyl-CoA synthetase-like | 0.005554 | INHERITED FROM: Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase || Transferring groups other than amino-acyl groups |
Caspase recruitment domain, CARD | 0.03579 | INHERITED FROM: RING-type E3 ubiquitin transferase || Aminoacyltransferases |
RWD domain | 0.04771 | INHERITED FROM: RING-type E3 ubiquitin transferase || Aminoacyltransferases |
Branched-chain alpha-keto acid dehydrogenase Pyr module | 0.05275 | INHERITED FROM: Dihydrolipoyllysine-residue succinyltransferase |
Branched-chain alpha-keto acid dehydrogenase PP module | 0.05688 | INHERITED FROM: Dihydrolipoyllysine-residue succinyltransferase |
Second domain of FERM | 0.08611 | INHERITED FROM: RING-type E3 ubiquitin transferase || Aminoacyltransferases |
Glutamine synthetase, N-terminal domain | 0.1678 | INHERITED FROM: Protein S-acyltransferase |
Tetratricopeptide repeat (TPR) | 0.1846 | INHERITED FROM: RING-type E3 ubiquitin transferase || Aminoacyltransferases |
Glutamine synthetase catalytic domain | 0.2031 | INHERITED FROM: Protein S-acyltransferase |
PLC-like (P variant) | 0.2807 | INHERITED FROM: HECT-type E3 ubiquitin transferase || Aminoacyltransferases |
Cyclophilin (peptidylprolyl isomerase) | 0.3378 | INHERITED FROM: RING-type E3 ubiquitin transferase || Aminoacyltransferases |
Chromo domain | 0.4052 | INHERITED FROM: Histone acetyltransferase |
HpcH/HpaI aldolase | 0.4345 | INHERITED FROM: Acyl groups converted into alkyl groups on transfer || Malate synthase |
Pyruvate oxidase and decarboxylase, middle domain | 0.501 | INHERITED FROM: Acyl groups converted into alkyl groups on transfer || Sulfoacetaldehyde acetyltransferase |
Serine carboxypeptidase-like | 0.84 | INHERITED FROM: Sinapoylglucose--sinapoylglucose O-sinapoyltransferase |
Alcohol dehydrogenase-like, C-terminal domain | 0.8985 | INHERITED FROM: 2-methylbutanoate polyketide synthase || Beta-ketoacyl-[acyl-carrier-protein] synthase I || Fatty-acid synthase system || [Acyl-carrier-protein] S-acetyltransferase || [Acyl-carrier-protein] S-malonyltransferase |
Alcohol dehydrogenase-like, N-terminal domain | 0.9533 | INHERITED FROM: 2-methylbutanoate polyketide synthase || Beta-ketoacyl-[acyl-carrier-protein] synthase I || Fatty-acid synthase system || [Acyl-carrier-protein] S-acetyltransferase || [Acyl-carrier-protein] S-malonyltransferase |
Fibronectin type III | 0.9689 | INHERITED FROM: RING-type E3 ubiquitin transferase || Aminoacyltransferases |
SH3-domain | 0.9834 | INHERITED FROM: RING-type E3 ubiquitin transferase || Aminoacyltransferases |
SH2 domain | 1 | INHERITED FROM: RING-type E3 ubiquitin transferase || Aminoacyltransferases |
Succinyl-CoA synthetase, beta-chain, N-terminal domain | 1 | INHERITED FROM: ATP citrate synthase |
Class I aldolase | 1 | INHERITED FROM: 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase |
Pyruvate oxidase and decarboxylase PP module | 1 | INHERITED FROM: Acyl groups converted into alkyl groups on transfer || Sulfoacetaldehyde acetyltransferase |
Calmodulin-like | 1 | INHERITED FROM: 1-acylglycerol-3-phosphate O-acyltransferase || 1-alkylglycerophosphocholine O-acetyltransferase || 1-acylglycerophosphocholine O-acyltransferase |
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 1 | INHERITED FROM: Lysyltransferase |
Tyrosine-dependent oxidoreductases | 1 | INHERITED FROM: 6-deoxyerythronolide-B synthase || 10-deoxymethynolide syntase || 2-methylbutanoate polyketide synthase || Lovastatin nonaketide synthase || Beta-ketoacyl-[acyl-carrier-protein] synthase I || Fatty-acid synthase system || [Acyl-carrier-protein] S-acetyltransferase || [Acyl-carrier-protein] S-malonyltransferase || 6-methylsalicylic acid synthase || Narbonolide synthase |
Crotonase-like | 1 | INHERITED FROM: Histone acetyltransferase |
N-acetyl-l-glutamate kinase | 1 | INHERITED FROM: Amino-acid N-acetyltransferase || Transferring groups other than amino-acyl groups |
Holo-(acyl carrier protein) synthase ACPS | 1 | INHERITED FROM: Fatty-acyl-CoA synthase system || Beta-ketoacyl-[acyl-carrier-protein] synthase I |
Succinyl-CoA synthetase domains | 1 | INHERITED FROM: Acyl groups converted into alkyl groups on transfer || ATP citrate synthase |
Pyruvate oxidase and decarboxylase Pyr module | 1 | INHERITED FROM: Acyl groups converted into alkyl groups on transfer || Sulfoacetaldehyde acetyltransferase |
Anticodon-binding domain | 1 | INHERITED FROM: Lysyltransferase |
SCOP term | FDR (all) | Annotation (direct or inherited) |
Galactoside acetyltransferase-like | 0 | Direct |
Kix domain of CBP (creb binding protein) | 0 | Direct |
Leucine zipper domain | 0 | Direct |
Trimerization domain of TRAF | 0 | Direct |
Glutaminyl-peptide cyclotransferase-like | 0 | Direct |
Transglutaminase, two C-terminal domains | 0 | Direct |
Acetyl-CoA synthase | 0 | Direct |
PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
ArgJ-like | 0 | Direct |
UBC-related | 0 | Direct |
SPRY domain | 0 | Direct |
Phytochelatin synthase | 0 | Direct |
Transcriptional factor domain | 0 | Direct |
Mib/herc2 domain | 0 | Direct |
Malate synthase G | 0 | Direct |
Thiolase-related | 0 | Direct |
PHD domain | 0 | Direct |
Bromodomain | 0 | Direct |
HLH, helix-loop-helix DNA-binding domain | 0 | Direct |
HMGL-like | 0 | Direct |
Methicillin resistance protein FemA probable tRNA-binding arm | 0 | Direct |
BRCT domain | 0 | Direct |
CCCH zinc finger | 0 | Direct |
Classic zinc finger, C2H2 | 0 | Direct |
Outer membrane enzyme PagP | 0 | Direct |
Transcription factor IIB (TFIIB), core domain | 0 | Direct |
Armadillo repeat | 0 | Direct |
GlmU C-terminal domain-like | 0 | Direct |
Phosphotransacetylase | 0 | Direct |
Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0 | Direct |
Gamma-glutamyltranspeptidase-like | 0 | Direct |
APC10-like | 0 | Direct |
CPH domain | 0 | Direct |
Chalcone synthase-like | 0 | Direct |
CAT-like | 0 | Direct |
Chromo barrel domain | 0 | Direct |
Mycobacterial antigens | 0 | Direct |
2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain | 0 | Direct |
Variant RING domain | 0 | Direct |
Homeodomain | 0 | Direct |
Zinc hairpin stack | 0 | Direct |
TAZ domain | 0 | Direct |
YeaZ-like | 0 | Direct |
Hect, E3 ligase catalytic domain | 0 | Direct |
SWIB/MDM2 domain | 0 | Direct |
FabD-like | 0 | Direct |
O-acetyltransferase | 0 | Direct |
Ran binding protein zinc finger-like | 0 | Direct |
WW domain | 0 | Direct |
FemXAB nonribosomal peptidyltransferases | 0 | Direct |
Ankyrin repeat | 0 | Direct |
Docking domain B of the erythromycin polyketide synthase (DEBS) | 0 | Direct |
Biotinyl/lipoyl-carrier proteins and domains | 0 | Direct |
Autoinducer synthetase | 0 | Direct |
Aminoglycoside 3-N-acetyltransferase-like | 0 | Direct |
DmpG/LeuA communication domain-like | 0 | Direct |
CHY zinc finger | 0 | Direct |
Glycerol-3-phosphate (1)-acyltransferase | 0 | Direct |
GABA-aminotransferase-like | 0 | Direct |
U-box | 0 | Direct |
Arylamine N-acetyltransferase | 0 | Direct |
NHL repeat | 0 | Direct |
Choline/Carnitine O-acyltransferase | 0 | Direct |
Hypoxia-inducible factor Hif2a, C-terminal domain | 0 | Direct |
N-terminal domain of cbl (N-cbl) | 0 | Direct |
IBR domain | 0 | Direct |
LFTR-like | 0 | Direct |
ZZ domain | 0 | Direct |
Citrate synthase | 0 | Direct |
HTS-like | 0 | Direct |
Serine acetyltransferase | 0 | Direct |
UDP N-acetylglucosamine acyltransferase | 0 | Direct |
SIAH, seven in absentia homolog | 0 | Direct |
N-acetyl transferase, NAT | 0 | Direct |
SRA domain-like | 0 | Direct |
Lrp/AsnC-like transcriptional regulator C-terminal domain | 0 | Direct |
B-box zinc-binding domain | 0 | Direct |
PlsX-like | 0 | Direct |
AstA-like | 0 | Direct |
LplA-like | 0 | Direct |
Formylmethanofuran:tetrahydromethanopterin formyltransferase | 0 | Direct |
CCHHC domain | 0 | Direct |
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
WWE domain | 0 | Direct |
Acyl-carrier protein (ACP) | 0 | Direct |
PABC (PABP) domain | 0 | Direct |
USP8 interacting domain | 0 | Direct |
Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
RING finger domain, C3HC4 | 0 | Direct |
Transglutaminase core | 0 | Direct |
N-myristoyl transferase, NMT | 0 | Direct |
Tetrahydrodipicolinate-N-succinlytransferase, THDP-succinlytransferase, DapD | 0 | Direct |
UDP-glucose pyrophosphorylase | 0 | Direct |
Sir2 family of transcriptional regulators | 0 | Direct |
Transglutaminase N-terminal domain | 0 | Direct |
Nuclear receptor coactivator interlocking domain | 0 | Direct |
MATH domain | 9.189e-16 | Direct |
PFL-like | 0.0000000000004898 | Direct |
WD40-repeat | 0.000000000001047 | Direct |
DRTGG domain | 0.000000000001093 | Direct |
SAP domain | 0.00000000003969 | Direct |
Pentapeptide repeats | 0.000000000205 | Direct |
Filamin repeat (rod domain) | 0.000000002533 | Direct |
Ubiquitin-related | 0.000000003636 | Direct |
Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.000000003952 | Direct |
Leucine rich effector protein YopM | 0.000000009425 | Direct |
FHA domain | 0.00000001286 | Direct |
Sterol carrier protein, SCP | 0.00000005254 | Direct |
NRPS condensation domain (amide synthase) | 0.0000007997 | Direct |
CoA-binding domain | 0.000003894 | Direct |
FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.000005147 | Direct |
Tropomyosin | 0.000005246 | Direct |
Regulator of chromosome condensation RCC1 | 0.000005524 | Direct |
Hypoxia-inducible factor HIF ihhibitor (FIH1) | 0.000009474 | Direct |
EF-hand modules in multidomain proteins | 0.00001523 | Direct |
PA domain | 0.00003578 | Direct |
Leucine carboxy methyltransferase Ppm1 | 0.00004114 | Direct |
MaoC-like | 0.00005852 | Direct |
UBA domain | 0.0001387 | Direct |
PDZ domain | 0.0001387 | Direct |
CBS-domain pair | 0.0003103 | Direct |
TAF(II)230 TBP-binding fragment | 0.0003243 | Direct |
First domain of FERM | 0.003893 | Inherited |
Third domain of FERM | 0.003893 | Inherited |
Acetyl-CoA synthetase-like | 0.005554 | Inherited |
Caspase recruitment domain, CARD | 0.03579 | Inherited |
RWD domain | 0.04771 | Inherited |
Branched-chain alpha-keto acid dehydrogenase Pyr module | 0.05275 | Inherited |
Branched-chain alpha-keto acid dehydrogenase PP module | 0.05688 | Inherited |
Second domain of FERM | 0.08611 | Inherited |
Glutamine synthetase, N-terminal domain | 0.1678 | Inherited |
Tetratricopeptide repeat (TPR) | 0.1846 | Inherited |
Glutamine synthetase catalytic domain | 0.2031 | Inherited |
PLC-like (P variant) | 0.2807 | Inherited |
Cyclophilin (peptidylprolyl isomerase) | 0.3378 | Inherited |
Chromo domain | 0.4052 | Inherited |
HpcH/HpaI aldolase | 0.4345 | Inherited |
Pyruvate oxidase and decarboxylase, middle domain | 0.501 | Inherited |
Serine carboxypeptidase-like | 0.84 | Inherited |
Alcohol dehydrogenase-like, C-terminal domain | 0.8985 | Inherited |
Alcohol dehydrogenase-like, N-terminal domain | 0.9533 | Inherited |
Fibronectin type III | 0.9689 | Inherited |
SH3-domain | 0.9834 | Inherited |
SH2 domain | 1 | Inherited |
Succinyl-CoA synthetase, beta-chain, N-terminal domain | 1 | Inherited |
Class I aldolase | 1 | Inherited |
Pyruvate oxidase and decarboxylase PP module | 1 | Inherited |
Calmodulin-like | 1 | Inherited |
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 1 | Inherited |
Tyrosine-dependent oxidoreductases | 1 | Inherited |
Crotonase-like | 1 | Inherited |
N-acetyl-l-glutamate kinase | 1 | Inherited |
Holo-(acyl carrier protein) synthase ACPS | 1 | Inherited |
Succinyl-CoA synthetase domains | 1 | Inherited |
Pyruvate oxidase and decarboxylase Pyr module | 1 | Inherited |
Anticodon-binding domain | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53448,51161 53448 - Nucleotide-diphospho-sugar transferases 51161 - Trimeric LpxA-like enzymes | 0 | DIRECT |
57850,52540 57850 - RING/U-box 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
51230,52777 51230 - Single hybrid motif 52777 - CoA-dependent acyltransferases | 0 | DIRECT |
52025,57850 52025 - PA domain 57850 - RING/U-box | 0 | DIRECT |
51045,51045 51045 - WW domain 51045 - WW domain | 0 | DIRECT |
57850,57667 57850 - RING/U-box 57667 - beta-beta-alpha zinc fingers | 0 | DIRECT |
49599,50156 49599 - TRAF domain-like 50156 - PDZ domain-like | 0 | DIRECT |
56112,57850 56112 - Protein kinase-like (PK-like) 57850 - RING/U-box | 0 | DIRECT |
161245,57850 161245 - Zinc hairpin stack 57850 - RING/U-box | 0 | DIRECT |
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases | 0 | DIRECT |
81296,54001 81296 - E set domains 54001 - Cysteine proteinases | 0 | DIRECT |
68906,57850 68906 - SAP domain 57850 - RING/U-box | 0 | DIRECT |
90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger | 0 | DIRECT |
53300,57850 53300 - vWA-like 57850 - RING/U-box | 0 | DIRECT |
117839,117839 117839 - WWE domain 117839 - WWE domain | 0 | DIRECT |
52151,51412 52151 - FabD/lysophospholipase-like 51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
51230,51230 51230 - Single hybrid motif 51230 - Single hybrid motif | 0 | DIRECT |
53474,54631 53474 - alpha/beta-Hydrolases 54631 - CBS-domain pair | 0 | DIRECT |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0 | DIRECT |
54001,49309 54001 - Cysteine proteinases 49309 - Transglutaminase, two C-terminal domains | 0 | DIRECT |
57850,57850 57850 - RING/U-box 57850 - RING/U-box | 0 | DIRECT |
69593,56801 69593 - Glycerol-3-phosphate (1)-acyltransferase 56801 - Acetyl-CoA synthetase-like | 0 | DIRECT |
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like | 0 | DIRECT |
57850,101898 57850 - RING/U-box 101898 - NHL repeat | 0 | DIRECT |
57850,50978 57850 - RING/U-box 50978 - WD40 repeat-like | 0 | DIRECT |
57953,49599 57953 - Trimerization domain of TRAF 49599 - TRAF domain-like | 0 | DIRECT |
90209,57850 90209 - Ran binding protein zinc finger-like 57850 - RING/U-box | 0 | DIRECT |
55550,57850 55550 - SH2 domain 57850 - RING/U-box | 0 | DIRECT |
55729,47370 55729 - Acyl-CoA N-acyltransferases (Nat) 47370 - Bromodomain | 0 | DIRECT |
57850,57845 57850 - RING/U-box 57845 - B-box zinc-binding domain | 0 | DIRECT |
50044,50044 50044 - SH3-domain 50044 - SH3-domain | 0 | DIRECT |
57850,117839 57850 - RING/U-box 117839 - WWE domain | 0 | DIRECT |
51735,51735 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
57783,47954 57783 - Zinc beta-ribbon 47954 - Cyclin-like | 0 | DIRECT |
47005,52777 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases | 0 | DIRECT |
69593,47473 69593 - Glycerol-3-phosphate (1)-acyltransferase 47473 - EF-hand | 0 | DIRECT |
54495,46934 54495 - UBC-like 46934 - UBA-like | 0 | DIRECT |
49879,57850 49879 - SMAD/FHA domain 57850 - RING/U-box | 0 | DIRECT |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0 | DIRECT |
57903,57850 57903 - FYVE/PHD zinc finger 57850 - RING/U-box | 0 | DIRECT |
63570,56204 63570 - PABC (PABP) domain 56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
52210,51735 52210 - Succinyl-CoA synthetase domains 51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
48452,57850 48452 - TPR-like 57850 - RING/U-box | 0 | DIRECT |
54637,52151 54637 - Thioesterase/thiol ester dehydrase-isomerase 52151 - FabD/lysophospholipase-like | 0 | DIRECT |
49599,57953 49599 - TRAF domain-like 57953 - Trimerization domain of TRAF | 0 | DIRECT |
57850,49599 57850 - RING/U-box 49599 - TRAF domain-like | 0 | DIRECT |
53067,56112 53067 - Actin-like ATPase domain 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
54236,90209 54236 - Ubiquitin-like 90209 - Ran binding protein zinc finger-like | 0 | DIRECT |
51735,48256 51735 - NAD(P)-binding Rossmann-fold domains 48256 - Citrate synthase | 0 | DIRECT |
55729,55729 55729 - Acyl-CoA N-acyltransferases (Nat) 55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
81296,101898 81296 - E set domains 101898 - NHL repeat | 0 | DIRECT |
48403,57850 48403 - Ankyrin repeat 57850 - RING/U-box | 0 | DIRECT |
49599,49599 49599 - TRAF domain-like 49599 - TRAF domain-like | 0 | DIRECT |
52540,75138 52540 - P-loop containing nucleoside triphosphate hydrolases 75138 - HprK N-terminal domain-like | 0 | DIRECT |
46785,57903 46785 - "Winged helix" DNA-binding domain 57903 - FYVE/PHD zinc finger | 0 | DIRECT |
53901,55718 53901 - Thiolase-like 55718 - SCP-like | 0 | DIRECT |
57850,48371 57850 - RING/U-box 48371 - ARM repeat | 0 | DIRECT |
48371,117839 48371 - ARM repeat 117839 - WWE domain | 0 | DIRECT |
49785,50985 49785 - Galactose-binding domain-like 50985 - RCC1/BLIP-II | 0 | DIRECT |
52151,55048 52151 - FabD/lysophospholipase-like 55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0 | DIRECT |
55112,55112 55112 - Formylmethanofuran:tetrahydromethanopterin formyltransferase 55112 - Formylmethanofuran:tetrahydromethanopterin formyltransferase | 0 | DIRECT |
57850,57933 57850 - RING/U-box 57933 - TAZ domain | 0 | DIRECT |
49785,159034 49785 - Galactose-binding domain-like 159034 - Mib/herc2 domain-like | 0 | DIRECT |
57850,159034 57850 - RING/U-box 159034 - Mib/herc2 domain-like | 0 | DIRECT |
49309,49309 49309 - Transglutaminase, two C-terminal domains 49309 - Transglutaminase, two C-terminal domains | 0 | DIRECT |
51569,54909 51569 - Aldolase 54909 - Dimeric alpha+beta barrel | 0 | DIRECT |
54495,57850 54495 - UBC-like 57850 - RING/U-box | 0 | DIRECT |
161219,161245 161219 - CHY zinc finger-like 161245 - Zinc hairpin stack | 0 | DIRECT |
159034,57850 159034 - Mib/herc2 domain-like 57850 - RING/U-box | 0 | DIRECT |
46589,55729 46589 - tRNA-binding arm 55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
53901,53901 53901 - Thiolase-like 53901 - Thiolase-like | 0 | DIRECT |
53335,50965 53335 - S-adenosyl-L-methionine-dependent methyltransferases 50965 - Galactose oxidase, central domain | 0 | DIRECT |
75138,53659 75138 - HprK N-terminal domain-like 53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
48403,52113 48403 - Ankyrin repeat 52113 - BRCT domain | 0 | DIRECT |
53633,55729 53633 - Carbamate kinase-like 55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
55729,46589 55729 - Acyl-CoA N-acyltransferases (Nat) 46589 - tRNA-binding arm | 0 | DIRECT |
51230,47005 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
50965,51197 50965 - Galactose oxidase, central domain 51197 - Clavaminate synthase-like | 0 | DIRECT |
49265,49899 49265 - Fibronectin type III 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
52540,55729 52540 - P-loop containing nucleoside triphosphate hydrolases 55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
90229,57850 90229 - CCCH zinc finger 57850 - RING/U-box | 0 | DIRECT |
47473,55550 47473 - EF-hand 55550 - SH2 domain | 0 | DIRECT |
51735,47336 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like | 0 | DIRECT |
47592,90209 47592 - SWIB/MDM2 domain 90209 - Ran binding protein zinc finger-like | 0 | DIRECT |
89000,110921 89000 - post-HMGL domain-like 110921 - 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain | 0 | DIRECT |
117281,51197 117281 - Kelch motif 51197 - Clavaminate synthase-like | 0 | DIRECT |
51569,89000 51569 - Aldolase 89000 - post-HMGL domain-like | 0 | DIRECT |
49599,160088 49599 - TRAF domain-like 160088 - NRDP1 C-terminal domain-like | 0 | DIRECT |
54160,55729 54160 - Chromo domain-like 55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
47668,47473 47668 - N-terminal domain of cbl (N-cbl) 47473 - EF-hand | 0 | DIRECT |
57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
49562,51045 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 51045 - WW domain | 0 | DIRECT |
51045,56204 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
47336,53474 47336 - ACP-like 53474 - alpha/beta-Hydrolases | 0.0000000000001132 | DIRECT |
52113,52113 52113 - BRCT domain 52113 - BRCT domain | 0.0000000000001387 | DIRECT |
49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0.000000001925 | DIRECT |
53335,51735 53335 - S-adenosyl-L-methionine-dependent methyltransferases 51735 - NAD(P)-binding Rossmann-fold domains | 0.0000003649 | DIRECT |
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain | 0.000005741 | DIRECT |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.000006231 | DIRECT |
48371,48403 48371 - ARM repeat 48403 - Ankyrin repeat | 0.00004673 | DIRECT |
47336,52777 47336 - ACP-like 52777 - CoA-dependent acyltransferases | 0.0001281 | DIRECT |
47370,47370 47370 - Bromodomain 47370 - Bromodomain | 0.0003502 | DIRECT |
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM | 0.004313 | INHERITED FROM: Aminoacyltransferases || RING-type E3 ubiquitin transferase |
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like | 0.0333 | INHERITED FROM: Aminoacyltransferases || RING-type E3 ubiquitin transferase |
48371,48371 48371 - ARM repeat 48371 - ARM repeat | 0.04995 | INHERITED FROM: Aminoacyltransferases || RING-type E3 ubiquitin transferase |
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger | 0.05059 | INHERITED FROM: Transferring groups other than amino-acyl groups || Histone acetyltransferase |
55785,55785 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0.07117 | INHERITED FROM: Transferring groups other than amino-acyl groups || Histone acetyltransferase |
51735,50129 51735 - NAD(P)-binding Rossmann-fold domains 50129 - GroES-like | 0.21 | INHERITED FROM: Beta-ketoacyl-[acyl-carrier-protein] synthase I |
54368,55931 54368 - Glutamine synthetase, N-terminal domain 55931 - Glutamine synthetase/guanido kinase | 0.2475 | INHERITED FROM: Protein S-acyltransferase |
48452,48452 48452 - TPR-like 48452 - TPR-like | 0.2681 | INHERITED FROM: Aminoacyltransferases || RING-type E3 ubiquitin transferase |
50129,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains | 0.97 | INHERITED FROM: Beta-ketoacyl-[acyl-carrier-protein] synthase I || [Acyl-carrier-protein] S-malonyltransferase || [Acyl-carrier-protein] S-acetyltransferase || 2-methylbutanoate polyketide synthase || Fatty-acid synthase system |
52518,52518 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52518 - Thiamin diphosphate-binding fold (THDP-binding) | 1 | INHERITED FROM: Dihydrolipoyllysine-residue succinyltransferase |
50249,55681 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases | 1 | INHERITED FROM: Lysyltransferase |
56059,52210 56059 - Glutathione synthetase ATP-binding domain-like 52210 - Succinyl-CoA synthetase domains | 1 | INHERITED FROM: ATP citrate synthase || Acyl groups converted into alkyl groups on transfer |
52518,52467 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52467 - DHS-like NAD/FAD-binding domain | 1 | INHERITED FROM: Sulfoacetaldehyde acetyltransferase || Acyl groups converted into alkyl groups on transfer |
52467,52518 52467 - DHS-like NAD/FAD-binding domain 52518 - Thiamin diphosphate-binding fold (THDP-binding) | 1 | INHERITED FROM: Sulfoacetaldehyde acetyltransferase || Acyl groups converted into alkyl groups on transfer |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53448,51161 53448 - Nucleotide-diphospho-sugar transferases 51161 - Trimeric LpxA-like enzymes | 0 | Direct |
57850,52540 57850 - RING/U-box 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
51230,52777 51230 - Single hybrid motif 52777 - CoA-dependent acyltransferases | 0 | Direct |
52025,57850 52025 - PA domain 57850 - RING/U-box | 0 | Direct |
51045,51045 51045 - WW domain 51045 - WW domain | 0 | Direct |
57850,57667 57850 - RING/U-box 57667 - beta-beta-alpha zinc fingers | 0 | Direct |
49599,50156 49599 - TRAF domain-like 50156 - PDZ domain-like | 0 | Direct |
56112,57850 56112 - Protein kinase-like (PK-like) 57850 - RING/U-box | 0 | Direct |
161245,57850 161245 - Zinc hairpin stack 57850 - RING/U-box | 0 | Direct |
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases | 0 | Direct |
81296,54001 81296 - E set domains 54001 - Cysteine proteinases | 0 | Direct |
68906,57850 68906 - SAP domain 57850 - RING/U-box | 0 | Direct |
90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger | 0 | Direct |
53300,57850 53300 - vWA-like 57850 - RING/U-box | 0 | Direct |
117839,117839 117839 - WWE domain 117839 - WWE domain | 0 | Direct |
52151,51412 52151 - FabD/lysophospholipase-like 51412 - Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
51230,51230 51230 - Single hybrid motif 51230 - Single hybrid motif | 0 | Direct |
53474,54631 53474 - alpha/beta-Hydrolases 54631 - CBS-domain pair | 0 | Direct |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0 | Direct |
54001,49309 54001 - Cysteine proteinases 49309 - Transglutaminase, two C-terminal domains | 0 | Direct |
57850,57850 57850 - RING/U-box 57850 - RING/U-box | 0 | Direct |
69593,56801 69593 - Glycerol-3-phosphate (1)-acyltransferase 56801 - Acetyl-CoA synthetase-like | 0 | Direct |
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like | 0 | Direct |
57850,101898 57850 - RING/U-box 101898 - NHL repeat | 0 | Direct |
57850,50978 57850 - RING/U-box 50978 - WD40 repeat-like | 0 | Direct |
57953,49599 57953 - Trimerization domain of TRAF 49599 - TRAF domain-like | 0 | Direct |
90209,57850 90209 - Ran binding protein zinc finger-like 57850 - RING/U-box | 0 | Direct |
55550,57850 55550 - SH2 domain 57850 - RING/U-box | 0 | Direct |
55729,47370 55729 - Acyl-CoA N-acyltransferases (Nat) 47370 - Bromodomain | 0 | Direct |
57850,57845 57850 - RING/U-box 57845 - B-box zinc-binding domain | 0 | Direct |
50044,50044 50044 - SH3-domain 50044 - SH3-domain | 0 | Direct |
57850,117839 57850 - RING/U-box 117839 - WWE domain | 0 | Direct |
51735,51735 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
57783,47954 57783 - Zinc beta-ribbon 47954 - Cyclin-like | 0 | Direct |
47005,52777 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases | 0 | Direct |
69593,47473 69593 - Glycerol-3-phosphate (1)-acyltransferase 47473 - EF-hand | 0 | Direct |
54495,46934 54495 - UBC-like 46934 - UBA-like | 0 | Direct |
49879,57850 49879 - SMAD/FHA domain 57850 - RING/U-box | 0 | Direct |
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) | 0 | Direct |
57903,57850 57903 - FYVE/PHD zinc finger 57850 - RING/U-box | 0 | Direct |
63570,56204 63570 - PABC (PABP) domain 56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
52210,51735 52210 - Succinyl-CoA synthetase domains 51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
48452,57850 48452 - TPR-like 57850 - RING/U-box | 0 | Direct |
54637,52151 54637 - Thioesterase/thiol ester dehydrase-isomerase 52151 - FabD/lysophospholipase-like | 0 | Direct |
49599,57953 49599 - TRAF domain-like 57953 - Trimerization domain of TRAF | 0 | Direct |
57850,49599 57850 - RING/U-box 49599 - TRAF domain-like | 0 | Direct |
53067,56112 53067 - Actin-like ATPase domain 56112 - Protein kinase-like (PK-like) | 0 | Direct |
54236,90209 54236 - Ubiquitin-like 90209 - Ran binding protein zinc finger-like | 0 | Direct |
51735,48256 51735 - NAD(P)-binding Rossmann-fold domains 48256 - Citrate synthase | 0 | Direct |
55729,55729 55729 - Acyl-CoA N-acyltransferases (Nat) 55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
81296,101898 81296 - E set domains 101898 - NHL repeat | 0 | Direct |
48403,57850 48403 - Ankyrin repeat 57850 - RING/U-box | 0 | Direct |
49599,49599 49599 - TRAF domain-like 49599 - TRAF domain-like | 0 | Direct |
52540,75138 52540 - P-loop containing nucleoside triphosphate hydrolases 75138 - HprK N-terminal domain-like | 0 | Direct |
46785,57903 46785 - "Winged helix" DNA-binding domain 57903 - FYVE/PHD zinc finger | 0 | Direct |
53901,55718 53901 - Thiolase-like 55718 - SCP-like | 0 | Direct |
57850,48371 57850 - RING/U-box 48371 - ARM repeat | 0 | Direct |
48371,117839 48371 - ARM repeat 117839 - WWE domain | 0 | Direct |
49785,50985 49785 - Galactose-binding domain-like 50985 - RCC1/BLIP-II | 0 | Direct |
52151,55048 52151 - FabD/lysophospholipase-like 55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0 | Direct |
55112,55112 55112 - Formylmethanofuran:tetrahydromethanopterin formyltransferase 55112 - Formylmethanofuran:tetrahydromethanopterin formyltransferase | 0 | Direct |
57850,57933 57850 - RING/U-box 57933 - TAZ domain | 0 | Direct |
49785,159034 49785 - Galactose-binding domain-like 159034 - Mib/herc2 domain-like | 0 | Direct |
57850,159034 57850 - RING/U-box 159034 - Mib/herc2 domain-like | 0 | Direct |
49309,49309 49309 - Transglutaminase, two C-terminal domains 49309 - Transglutaminase, two C-terminal domains | 0 | Direct |
51569,54909 51569 - Aldolase 54909 - Dimeric alpha+beta barrel | 0 | Direct |
54495,57850 54495 - UBC-like 57850 - RING/U-box | 0 | Direct |
161219,161245 161219 - CHY zinc finger-like 161245 - Zinc hairpin stack | 0 | Direct |
159034,57850 159034 - Mib/herc2 domain-like 57850 - RING/U-box | 0 | Direct |
46589,55729 46589 - tRNA-binding arm 55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
53901,53901 53901 - Thiolase-like 53901 - Thiolase-like | 0 | Direct |
53335,50965 53335 - S-adenosyl-L-methionine-dependent methyltransferases 50965 - Galactose oxidase, central domain | 0 | Direct |
75138,53659 75138 - HprK N-terminal domain-like 53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
48403,52113 48403 - Ankyrin repeat 52113 - BRCT domain | 0 | Direct |
53633,55729 53633 - Carbamate kinase-like 55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
55729,46589 55729 - Acyl-CoA N-acyltransferases (Nat) 46589 - tRNA-binding arm | 0 | Direct |
51230,47005 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
50965,51197 50965 - Galactose oxidase, central domain 51197 - Clavaminate synthase-like | 0 | Direct |
49265,49899 49265 - Fibronectin type III 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
52540,55729 52540 - P-loop containing nucleoside triphosphate hydrolases 55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
90229,57850 90229 - CCCH zinc finger 57850 - RING/U-box | 0 | Direct |
47473,55550 47473 - EF-hand 55550 - SH2 domain | 0 | Direct |
51735,47336 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like | 0 | Direct |
47592,90209 47592 - SWIB/MDM2 domain 90209 - Ran binding protein zinc finger-like | 0 | Direct |
89000,110921 89000 - post-HMGL domain-like 110921 - 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain | 0 | Direct |
117281,51197 117281 - Kelch motif 51197 - Clavaminate synthase-like | 0 | Direct |
51569,89000 51569 - Aldolase 89000 - post-HMGL domain-like | 0 | Direct |
49599,160088 49599 - TRAF domain-like 160088 - NRDP1 C-terminal domain-like | 0 | Direct |
54160,55729 54160 - Chromo domain-like 55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
47668,47473 47668 - N-terminal domain of cbl (N-cbl) 47473 - EF-hand | 0 | Direct |
57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
49562,51045 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 51045 - WW domain | 0 | Direct |
51045,56204 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
47336,53474 47336 - ACP-like 53474 - alpha/beta-Hydrolases | 0.0000000000001132 | Direct |
52113,52113 52113 - BRCT domain 52113 - BRCT domain | 0.0000000000001387 | Direct |
49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0.000000001925 | Direct |
53335,51735 53335 - S-adenosyl-L-methionine-dependent methyltransferases 51735 - NAD(P)-binding Rossmann-fold domains | 0.0000003649 | Direct |
57903,47370 57903 - FYVE/PHD zinc finger 47370 - Bromodomain | 0.000005741 | Direct |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.000006231 | Direct |
48371,48403 48371 - ARM repeat 48403 - Ankyrin repeat | 0.00004673 | Direct |
47336,52777 47336 - ACP-like 52777 - CoA-dependent acyltransferases | 0.0001281 | Direct |
47370,47370 47370 - Bromodomain 47370 - Bromodomain | 0.0003502 | Direct |
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM | 0.004313 | Inherited |
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like | 0.0333 | Inherited |
48371,48371 48371 - ARM repeat 48371 - ARM repeat | 0.04995 | Inherited |
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger | 0.05059 | Inherited |
55785,55785 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0.07117 | Inherited |
51735,50129 51735 - NAD(P)-binding Rossmann-fold domains 50129 - GroES-like | 0.21 | Inherited |
54368,55931 54368 - Glutamine synthetase, N-terminal domain 55931 - Glutamine synthetase/guanido kinase | 0.2475 | Inherited |
48452,48452 48452 - TPR-like 48452 - TPR-like | 0.2681 | Inherited |
50129,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains | 0.97 | Inherited |
52518,52518 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52518 - Thiamin diphosphate-binding fold (THDP-binding) | 1 | Inherited |
50249,55681 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases | 1 | Inherited |
56059,52210 56059 - Glutathione synthetase ATP-binding domain-like 52210 - Succinyl-CoA synthetase domains | 1 | Inherited |
52518,52467 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52467 - DHS-like NAD/FAD-binding domain | 1 | Inherited |
52467,52518 52467 - DHS-like NAD/FAD-binding domain 52518 - Thiamin diphosphate-binding fold (THDP-binding) | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEC level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
81296,54001,49309 81296 - E set domains 54001 - Cysteine proteinases 49309 - Transglutaminase, two C-terminal domains | 0 | DIRECT |
53901,53901,55718 53901 - Thiolase-like 53901 - Thiolase-like 55718 - SCP-like | 0 | DIRECT |
57850,57850,57933 57850 - RING/U-box 57850 - RING/U-box 57933 - TAZ domain | 0 | DIRECT |
57924,57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
51569,89000,110921 51569 - Aldolase 89000 - post-HMGL domain-like 110921 - 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain | 0 | DIRECT |
51230,51230,47005 51230 - Single hybrid motif 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
55729,46589,55729 55729 - Acyl-CoA N-acyltransferases (Nat) 46589 - tRNA-binding arm 55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | DIRECT |
161219,161245,57850 161219 - CHY zinc finger-like 161245 - Zinc hairpin stack 57850 - RING/U-box | 0 | DIRECT |
51735,50129,51735 51735 - NAD(P)-binding Rossmann-fold domains 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
49599,49599,49599 49599 - TRAF domain-like 49599 - TRAF domain-like 49599 - TRAF domain-like | 0 | DIRECT |
54001,49309,49309 54001 - Cysteine proteinases 49309 - Transglutaminase, two C-terminal domains 49309 - Transglutaminase, two C-terminal domains | 0 | DIRECT |
57850,49599,160088 57850 - RING/U-box 49599 - TRAF domain-like 160088 - NRDP1 C-terminal domain-like | 0 | DIRECT |
52540,75138,53659 52540 - P-loop containing nucleoside triphosphate hydrolases 75138 - HprK N-terminal domain-like 53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0 | DIRECT |
56059,52210,51735 56059 - Glutathione synthetase ATP-binding domain-like 52210 - Succinyl-CoA synthetase domains 51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
51735,47336,53474 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like 53474 - alpha/beta-Hydrolases | 0 | DIRECT |
49599,57953,49599 49599 - TRAF domain-like 57953 - Trimerization domain of TRAF 49599 - TRAF domain-like | 0 | DIRECT |
53335,50965,51197 53335 - S-adenosyl-L-methionine-dependent methyltransferases 50965 - Galactose oxidase, central domain 51197 - Clavaminate synthase-like | 0 | DIRECT |
57850,49599,49599 57850 - RING/U-box 49599 - TRAF domain-like 49599 - TRAF domain-like | 0 | DIRECT |
51045,51045,51045 51045 - WW domain 51045 - WW domain 51045 - WW domain | 0 | DIRECT |
48403,52113,52113 48403 - Ankyrin repeat 52113 - BRCT domain 52113 - BRCT domain | 0 | DIRECT |
90209,57850,57850 90209 - Ran binding protein zinc finger-like 57850 - RING/U-box 57850 - RING/U-box | 0 | DIRECT |
57850,49599,50156 57850 - RING/U-box 49599 - TRAF domain-like 50156 - PDZ domain-like | 0 | DIRECT |
51045,51045,56204 51045 - WW domain 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
46785,57903,57903 46785 - "Winged helix" DNA-binding domain 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger | 0 | DIRECT |
47668,47473,55550 47668 - N-terminal domain of cbl (N-cbl) 47473 - EF-hand 55550 - SH2 domain | 0 | DIRECT |
54236,90209,57850 54236 - Ubiquitin-like 90209 - Ran binding protein zinc finger-like 57850 - RING/U-box | 0 | DIRECT |
57850,48371,48371 57850 - RING/U-box 48371 - ARM repeat 48371 - ARM repeat | 0 | DIRECT |
51230,51230,51230 51230 - Single hybrid motif 51230 - Single hybrid motif 51230 - Single hybrid motif | 0 | DIRECT |
52210,51735,48256 52210 - Succinyl-CoA synthetase domains 51735 - NAD(P)-binding Rossmann-fold domains 48256 - Citrate synthase | 0 | DIRECT |
51735,47336,52777 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like 52777 - CoA-dependent acyltransferases | 0 | DIRECT |
51230,47005,52777 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases | 0 | DIRECT |
57783,47954,47954 57783 - Zinc beta-ribbon 47954 - Cyclin-like 47954 - Cyclin-like | 0 | DIRECT |
57850,57850,57850 57850 - RING/U-box 57850 - RING/U-box 57850 - RING/U-box | 0 | DIRECT |
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0 | DIRECT |
51735,51735,47336 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like | 0 | DIRECT |
47459,55785,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0 | DIRECT |
159034,57850,159034 159034 - Mib/herc2 domain-like 57850 - RING/U-box 159034 - Mib/herc2 domain-like | 0 | DIRECT |
47473,55550,57850 47473 - EF-hand 55550 - SH2 domain 57850 - RING/U-box | 0 | DIRECT |
50129,51735,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
47336,52777,52777 47336 - ACP-like 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases | 0.0001281 | DIRECT |
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like | 0.004313 | INHERITED FROM: Aminoacyltransferases || RING-type E3 ubiquitin transferase |
53067,53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.2832 | INHERITED FROM: N(6)-L-threonylcarbamoyladenine synthase |
52518,52467,52518 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52467 - DHS-like NAD/FAD-binding domain 52518 - Thiamin diphosphate-binding fold (THDP-binding) | 1 | INHERITED FROM: Sulfoacetaldehyde acetyltransferase || Acyl groups converted into alkyl groups on transfer |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
81296,54001,49309 81296 - E set domains 54001 - Cysteine proteinases 49309 - Transglutaminase, two C-terminal domains | 0 | Direct |
53901,53901,55718 53901 - Thiolase-like 53901 - Thiolase-like 55718 - SCP-like | 0 | Direct |
57850,57850,57933 57850 - RING/U-box 57850 - RING/U-box 57933 - TAZ domain | 0 | Direct |
57924,57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
51569,89000,110921 51569 - Aldolase 89000 - post-HMGL domain-like 110921 - 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain | 0 | Direct |
51230,51230,47005 51230 - Single hybrid motif 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
55729,46589,55729 55729 - Acyl-CoA N-acyltransferases (Nat) 46589 - tRNA-binding arm 55729 - Acyl-CoA N-acyltransferases (Nat) | 0 | Direct |
161219,161245,57850 161219 - CHY zinc finger-like 161245 - Zinc hairpin stack 57850 - RING/U-box | 0 | Direct |
51735,50129,51735 51735 - NAD(P)-binding Rossmann-fold domains 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
49599,49599,49599 49599 - TRAF domain-like 49599 - TRAF domain-like 49599 - TRAF domain-like | 0 | Direct |
54001,49309,49309 54001 - Cysteine proteinases 49309 - Transglutaminase, two C-terminal domains 49309 - Transglutaminase, two C-terminal domains | 0 | Direct |
57850,49599,160088 57850 - RING/U-box 49599 - TRAF domain-like 160088 - NRDP1 C-terminal domain-like | 0 | Direct |
52540,75138,53659 52540 - P-loop containing nucleoside triphosphate hydrolases 75138 - HprK N-terminal domain-like 53659 - Isocitrate/Isopropylmalate dehydrogenase-like | 0 | Direct |
56059,52210,51735 56059 - Glutathione synthetase ATP-binding domain-like 52210 - Succinyl-CoA synthetase domains 51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
51735,47336,53474 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like 53474 - alpha/beta-Hydrolases | 0 | Direct |
49599,57953,49599 49599 - TRAF domain-like 57953 - Trimerization domain of TRAF 49599 - TRAF domain-like | 0 | Direct |
53335,50965,51197 53335 - S-adenosyl-L-methionine-dependent methyltransferases 50965 - Galactose oxidase, central domain 51197 - Clavaminate synthase-like | 0 | Direct |
57850,49599,49599 57850 - RING/U-box 49599 - TRAF domain-like 49599 - TRAF domain-like | 0 | Direct |
51045,51045,51045 51045 - WW domain 51045 - WW domain 51045 - WW domain | 0 | Direct |
48403,52113,52113 48403 - Ankyrin repeat 52113 - BRCT domain 52113 - BRCT domain | 0 | Direct |
90209,57850,57850 90209 - Ran binding protein zinc finger-like 57850 - RING/U-box 57850 - RING/U-box | 0 | Direct |
57850,49599,50156 57850 - RING/U-box 49599 - TRAF domain-like 50156 - PDZ domain-like | 0 | Direct |
51045,51045,56204 51045 - WW domain 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
46785,57903,57903 46785 - "Winged helix" DNA-binding domain 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger | 0 | Direct |
47668,47473,55550 47668 - N-terminal domain of cbl (N-cbl) 47473 - EF-hand 55550 - SH2 domain | 0 | Direct |
54236,90209,57850 54236 - Ubiquitin-like 90209 - Ran binding protein zinc finger-like 57850 - RING/U-box | 0 | Direct |
57850,48371,48371 57850 - RING/U-box 48371 - ARM repeat 48371 - ARM repeat | 0 | Direct |
51230,51230,51230 51230 - Single hybrid motif 51230 - Single hybrid motif 51230 - Single hybrid motif | 0 | Direct |
52210,51735,48256 52210 - Succinyl-CoA synthetase domains 51735 - NAD(P)-binding Rossmann-fold domains 48256 - Citrate synthase | 0 | Direct |
51735,47336,52777 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like 52777 - CoA-dependent acyltransferases | 0 | Direct |
51230,47005,52777 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases | 0 | Direct |
57783,47954,47954 57783 - Zinc beta-ribbon 47954 - Cyclin-like 47954 - Cyclin-like | 0 | Direct |
57850,57850,57850 57850 - RING/U-box 57850 - RING/U-box 57850 - RING/U-box | 0 | Direct |
57667,57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0 | Direct |
51735,51735,47336 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like | 0 | Direct |
47459,55785,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain) | 0 | Direct |
159034,57850,159034 159034 - Mib/herc2 domain-like 57850 - RING/U-box 159034 - Mib/herc2 domain-like | 0 | Direct |
47473,55550,57850 47473 - EF-hand 55550 - SH2 domain 57850 - RING/U-box | 0 | Direct |
50129,51735,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
47336,52777,52777 47336 - ACP-like 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases | 0.0001281 | Direct |
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like | 0.004313 | Inherited |
53067,53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.2832 | Inherited |
52518,52467,52518 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52467 - DHS-like NAD/FAD-binding domain 52518 - Thiamin diphosphate-binding fold (THDP-binding) | 1 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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