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Enzyme Commission (EC): RING-type E3 ubiquitin transferase

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   root [root] <7>
+ + + 3:   Transferases [2] <10>(448|683) (447|545|278)
+ + 2:   Acyltransferases [2.3] <3>(128|156) (128|116|43)
+ 1:   Aminoacyltransferases [2.3.2] <32>(61|68) (61|65|22)
0:   RING-type E3 ubiquitin transferase [2.3.2.27](37|41) (37|45|14)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Trimerization domain of TRAF0Direct
N-terminal domain of cbl (N-cbl)0Direct
B-box zinc-binding domain0Direct
NRDP1 C-terminal domain-like0Direct
ClpS-like0Direct
SAP domain0Direct
PA domain0Direct
Inhibitor of apoptosis (IAP) repeat0Direct
SMAD/FHA domain0Direct
SWIB/MDM2 domain0Direct
CHY zinc finger-like0Direct
RING/U-box0Direct
Concanavalin A-like lectins/glucanases0Direct
TRAF domain-like0Direct
beta-beta-alpha zinc fingers0Direct
Zinc hairpin stack0Direct
NHL repeat0Direct
CCCH zinc finger0Direct
vWA-like0.000000000001934Direct
SH3-domain0.00000000002419Direct
L domain-like0.0000000004382Direct
Fibronectin type III0.0000000009498Direct
SH2 domain0.0000000011Direct
Cyclophilin-like0.00000001649Direct
Bromodomain0.00000004625Direct
FYVE/PHD zinc finger0.00000004946Direct
Formin homology 2 domain (FH2 domain)0.00000009839Direct
WD40 repeat-like0.0000001319Direct
EF-hand0.0000002784Direct
Second domain of FERM0.000000305Direct
DEATH domain0.00000166Direct
PDZ domain-like0.00001507Direct
ARM repeat0.00003188Direct
TPR-like0.00004757Direct
BRCT domain0.0006031Direct
RNA-binding domain, RBD0.0006699Direct
PUA domain-like0.0006789Direct


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
U-box0Direct
FHA domain0Direct
Classic zinc finger, C2H20Direct
CCCH zinc finger0Direct
MATH domain0Direct
FYVE, a phosphatidylinositol-3-phosphate binding domain0Direct
RING finger domain, C3HC40Direct
Trimerization domain of TRAF0Direct
SRA domain-like0Direct
SWIB/MDM2 domain0Direct
Inhibitor of apoptosis (IAP) repeat0Direct
SIAH, seven in absentia homolog0Direct
N-terminal domain of cbl (N-cbl)0Direct
B-box zinc-binding domain0Direct
Filamin repeat (rod domain)0Direct
USP8 interacting domain0Direct
Zinc hairpin stack0Direct
ZZ domain0Direct
SAP domain0Direct
SPRY domain0Direct
Variant RING domain0Direct
CHY zinc finger0Direct
BRCT domain0Direct
NHL repeat0Direct
Leucine rich effector protein YopM5.536e-16Direct
EF-hand modules in multidomain proteins0.000000000000001101Direct
PA domain0.000000000000657Direct
SH3-domain0.000000000001092Direct
PDZ domain0.0000000000455Direct
Fibronectin type III0.00000000004668Direct
SH2 domain0.00000000006001Direct
Cyclophilin (peptidylprolyl isomerase)0.0000000005232Direct
First domain of FERM0.00000000332Direct
Third domain of FERM0.000000005727Direct
Bromodomain0.000000008437Direct
Second domain of FERM0.00000005843Direct
RWD domain0.0000003714Direct
Tetratricopeptide repeat (TPR)0.0000004506Direct
WD40-repeat0.000004813Direct
Caspase recruitment domain, CARD0.00001747Direct
PHD domain0.00004555Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Trimerization domain of TRAF0Direct
Concanavalin A-like lectins/glucanases0Direct
TRAF domain-like0Direct
N-terminal domain of cbl (N-cbl)0Direct
Inhibitor of apoptosis (IAP) repeat0Direct
PA domain0Direct
ClpS-like0Direct
SAP domain0Direct
beta-beta-alpha zinc fingers0Direct
NRDP1 C-terminal domain-like0Direct
RING/U-box0Direct
NHL repeat0Direct
B-box zinc-binding domain0Direct
Zinc hairpin stack0Direct
SMAD/FHA domain0Direct
CHY zinc finger-like0Direct
CCCH zinc finger0Direct
SWIB/MDM2 domain0Direct
vWA-like0.000000000001394Direct
SH3-domain0.00000000001763Direct
L domain-like0.0000000003251Direct
Fibronectin type III0.0000000007079Direct
SH2 domain0.0000000008206Direct
Cyclophilin-like0.00000001249Direct
Bromodomain0.00000003524Direct
FYVE/PHD zinc finger0.00000003772Direct
Formin homology 2 domain (FH2 domain)0.00000007529Direct
WD40 repeat-like0.0000001012Direct
EF-hand0.0000002149Direct
Second domain of FERM0.0000002356Direct
DEATH domain0.000001301Direct
PDZ domain-like0.00001199Direct
ARM repeat0.00002547Direct
TPR-like0.00003814Direct
BRCT domain0.0004953Direct
RNA-binding domain, RBD0.0005507Direct
PUA domain-like0.0005583Direct

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
53300,57850
  • 53300 - vWA-like
  • 57850 - RING/U-box
  • 0Direct
    49599,49599
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0Direct
    57850,48371
  • 57850 - RING/U-box
  • 48371 - ARM repeat
  • 0Direct
    57850,50978
  • 57850 - RING/U-box
  • 50978 - WD40 repeat-like
  • 0Direct
    90229,57850
  • 90229 - CCCH zinc finger
  • 57850 - RING/U-box
  • 0Direct
    47473,55550
  • 47473 - EF-hand
  • 55550 - SH2 domain
  • 0Direct
    48452,57850
  • 48452 - TPR-like
  • 57850 - RING/U-box
  • 0Direct
    56112,57850
  • 56112 - Protein kinase-like (PK-like)
  • 57850 - RING/U-box
  • 0Direct
    57953,49599
  • 57953 - Trimerization domain of TRAF
  • 49599 - TRAF domain-like
  • 0Direct
    81296,101898
  • 81296 - E set domains
  • 101898 - NHL repeat
  • 0Direct
    161245,57850
  • 161245 - Zinc hairpin stack
  • 57850 - RING/U-box
  • 0Direct
    117839,117839
  • 117839 - WWE domain
  • 117839 - WWE domain
  • 0Direct
    47668,47473
  • 47668 - N-terminal domain of cbl (N-cbl)
  • 47473 - EF-hand
  • 0Direct
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57850,117839
  • 57850 - RING/U-box
  • 117839 - WWE domain
  • 0Direct
    49879,57850
  • 49879 - SMAD/FHA domain
  • 57850 - RING/U-box
  • 0Direct
    57850,52540
  • 57850 - RING/U-box
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0Direct
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0Direct
    57903,57850
  • 57903 - FYVE/PHD zinc finger
  • 57850 - RING/U-box
  • 0Direct
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    49599,57953
  • 49599 - TRAF domain-like
  • 57953 - Trimerization domain of TRAF
  • 0Direct
    48403,57850
  • 48403 - Ankyrin repeat
  • 57850 - RING/U-box
  • 0Direct
    57850,101898
  • 57850 - RING/U-box
  • 101898 - NHL repeat
  • 0Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0Direct
    49599,50156
  • 49599 - TRAF domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    48403,52113
  • 48403 - Ankyrin repeat
  • 52113 - BRCT domain
  • 0Direct
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    161219,161245
  • 161219 - CHY zinc finger-like
  • 161245 - Zinc hairpin stack
  • 0Direct
    159034,57850
  • 159034 - Mib/herc2 domain-like
  • 57850 - RING/U-box
  • 0Direct
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0Direct
    52025,57850
  • 52025 - PA domain
  • 57850 - RING/U-box
  • 0Direct
    57850,159034
  • 57850 - RING/U-box
  • 159034 - Mib/herc2 domain-like
  • 0Direct
    49599,160088
  • 49599 - TRAF domain-like
  • 160088 - NRDP1 C-terminal domain-like
  • 0Direct
    68906,57850
  • 68906 - SAP domain
  • 57850 - RING/U-box
  • 0Direct
    55550,57850
  • 55550 - SH2 domain
  • 57850 - RING/U-box
  • 0Direct
    47592,90209
  • 47592 - SWIB/MDM2 domain
  • 90209 - Ran binding protein zinc finger-like
  • 0Direct
    49265,49899
  • 49265 - Fibronectin type III
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57850,57667
  • 57850 - RING/U-box
  • 57667 - beta-beta-alpha zinc fingers
  • 0Direct
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.00000000000003315Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.0000000008998Direct
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.000000001485Direct
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.00000001978Direct
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.00000007816Direct
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.00002888Direct

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47473,55550,57850
  • 47473 - EF-hand
  • 55550 - SH2 domain
  • 57850 - RING/U-box
  • 0Direct
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0Direct
    159034,57850,159034
  • 159034 - Mib/herc2 domain-like
  • 57850 - RING/U-box
  • 159034 - Mib/herc2 domain-like
  • 0Direct
    57850,48371,48371
  • 57850 - RING/U-box
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    57850,49599,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0Direct
    48403,52113,52113
  • 48403 - Ankyrin repeat
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0Direct
    47668,47473,55550
  • 47668 - N-terminal domain of cbl (N-cbl)
  • 47473 - EF-hand
  • 55550 - SH2 domain
  • 0Direct
    57850,49599,50156
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    49599,49599,49599
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0Direct
    57850,49599,160088
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 160088 - NRDP1 C-terminal domain-like
  • 0Direct
    49599,57953,49599
  • 49599 - TRAF domain-like
  • 57953 - Trimerization domain of TRAF
  • 49599 - TRAF domain-like
  • 0Direct
    161219,161245,57850
  • 161219 - CHY zinc finger-like
  • 161245 - Zinc hairpin stack
  • 57850 - RING/U-box
  • 0Direct
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.0000000002147Direct
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.00000001978Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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