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Enzyme Commission (EC): Acyl groups converted into alkyl groups on transfer

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <7>
+ + 2:   Transferases [2] <10>(449|683) (448|545|278)
+ 1:   Acyltransferases [2.3] <3>(128|155) (128|116|43)
0:   Acyl groups converted into alkyl groups on transfer [2.3.3] <20>(13|14) (13|9|4)
- 1:   2-ethylmalate synthase [2.3.3.6](0|0) (0|0|0)
- 1:   2-hydroxyglutarate synthase [2.3.3.11](0|0) (0|0|0)
- 1:   2-isopropylmalate synthase [2.3.3.13](3|3) (3|2|1)
- 1:   2-methylcitrate synthase [2.3.3.5](1|1) (1|0|0)
- 1:   2-phosphinomethylmalate synthase [2.3.3.18](0|0) (0|0|0)
- 1:   2-phosphonomethylmalate synthase [2.3.3.19](0|0) (0|0|0)
- 1:   3-ethylmalate synthase [2.3.3.7](0|0) (0|0|0)
- 1:   3-propylmalate synthase [2.3.3.12](0|0) (0|0|0)
- 1:   ATP citrate synthase [2.3.3.8](4|4) (4|3|2)
- 1:   Acyl-CoA:acyl-CoA alkyltransferase [2.3.3.20](0|0) (0|0|0)
- 1:   Citrate (Re)-synthase [2.3.3.3](0|0) (0|0|0)
- 1:   Citrate (Si)-synthase [2.3.3.1](1|1) (1|0|0)
- 1:   Citrate synthase (unknown stereospecificity) [2.3.3.16](1|1) (1|0|0)
- 1:   Decylcitrate synthase [2.3.3.2](0|0) (0|0|0)
- 1:   Decylhomocitrate synthase [2.3.3.4](0|0) (0|0|0)
- 1:   Homocitrate synthase [2.3.3.14](1|1) (1|1|0)
- 1:   Hydroxymethylglutaryl-CoA synthase [2.3.3.10](1|1) (1|1|0)
- 1:   Malate synthase [2.3.3.9](2|2) (2|0|0)
- 1:   Methylthioalkylmalate synthase [2.3.3.17](0|0) (0|0|0)
- 1:   Sulfoacetaldehyde acetyltransferase [2.3.3.15](2|3) (2|2|1)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Aldolase0Direct
Citrate synthase0Direct
2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain0Direct
Malate synthase G0Direct
post-HMGL domain-like0Direct
Succinyl-CoA synthetase domains0.000000008669Direct
DHS-like NAD/FAD-binding domain0.00009916Direct
Dimeric alpha+beta barrel0.0001115Direct
Glutathione synthetase ATP-binding domain-like0.004488Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.1644Inherited
Phosphoenolpyruvate/pyruvate domain0.224Inherited
Thiolase-like1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Malate synthase G0Direct
CoA-binding domain0Direct
DmpG/LeuA communication domain-like0Direct
Lrp/AsnC-like transcriptional regulator C-terminal domain0Direct
Citrate synthase0Direct
HMGL-like0Direct
2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain0Direct
Succinyl-CoA synthetase domains0.0000000176Direct
Pyruvate oxidase and decarboxylase, middle domain0.0000007505Direct
Pyruvate oxidase and decarboxylase PP module0.0001357Direct
HpcH/HpaI aldolase0.0002282Direct
Pyruvate oxidase and decarboxylase Pyr module0.0004667Direct
Succinyl-CoA synthetase, beta-chain, N-terminal domain0.00197Inherited
Chalcone synthase-like1Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Malate synthase G0Direct
Aldolase0Direct
2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain0Direct
post-HMGL domain-like0Direct
Citrate synthase0Direct
Succinyl-CoA synthetase domains0.000000006544Direct
DHS-like NAD/FAD-binding domain0.00008008Direct
Dimeric alpha+beta barrel0.00009021Direct
Glutathione synthetase ATP-binding domain-like0.003767Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.1453Inherited
Phosphoenolpyruvate/pyruvate domain0.1995Inherited
Thiolase-like1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
51735,48256
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48256 - Citrate synthase
  • 0Direct
    89000,110921
  • 89000 - post-HMGL domain-like
  • 110921 - 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain
  • 0Direct
    51569,89000
  • 51569 - Aldolase
  • 89000 - post-HMGL domain-like
  • 0Direct
    52210,51735
  • 52210 - Succinyl-CoA synthetase domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    51569,54909
  • 51569 - Aldolase
  • 54909 - Dimeric alpha+beta barrel
  • 0Direct
    56059,52210
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52210 - Succinyl-CoA synthetase domains
  • 0.000000001623Direct
    52518,52467
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52467 - DHS-like NAD/FAD-binding domain
  • 0.00001245Direct
    52467,52518
  • 52467 - DHS-like NAD/FAD-binding domain
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0.00001245Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 1Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52210,51735,48256
  • 52210 - Succinyl-CoA synthetase domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48256 - Citrate synthase
  • 0Direct
    51569,89000,110921
  • 51569 - Aldolase
  • 89000 - post-HMGL domain-like
  • 110921 - 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain
  • 0Direct
    56059,52210,51735
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52210 - Succinyl-CoA synthetase domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    52518,52467,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52467 - DHS-like NAD/FAD-binding domain
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0.00001206Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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