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Enzyme Commission (EC): Protein-tyrosine kinases

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <7>
+ + 2:   Transferases [2] <10>(448|683) (447|545|278)
+ 1:   Transferring phosphorus-containing groups [2.7] <15>(256|338) (255|318|190)
0:   Protein-tyrosine kinases [2.7.10] <2>(26|29) (26|32|22)
- 1:   Non-specific protein-tyrosine kinase [2.7.10.2](12|14) (12|13|8)
- 1:   Receptor protein-tyrosine kinase [2.7.10.1](13|14) (13|19|14)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Cadherin-like0Direct
L domain-like0Direct
Growth factor receptor domain0Direct
Immunoglobulin0Direct
SAM/Pointed domain0Direct
SH2 domain0Direct
Sema domain0Direct
BAR/IMD domain-like0Direct
Galactose-binding domain-like0Direct
E set domains0Direct
PH domain-like0Direct
Plexin repeat0Direct
Protein kinase-like (PK-like)0Direct
Second domain of FERM0Direct
Fibronectin type III0Direct
YWTD domain0Direct
SH3-domain0Direct
FAT domain of focal adhesion kinase0Direct
Kringle-like0.000000001908Direct
Bromodomain0.0000005053Direct
Ubiquitin-like0.000008768Direct
FYVE/PHD zinc finger0.0001549Direct
DEATH domain0.000591Direct
RNI-like0.000722Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.2215Inherited
Cysteine-rich domain0.4477Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain)0Direct
SH3-domain0Direct
I set domains0Direct
Ngr ectodomain-like0Direct
Protein kinases, catalytic subunit0Direct
Plexin repeat0Direct
YWTD domain0Direct
L domain0Direct
Sema domain0Direct
Growth factor receptor domain0Direct
V set domains (antibody variable domain-like)0Direct
First domain of FERM0Direct
Second domain of FERM0Direct
SH2 domain0Direct
SAM (sterile alpha motif) domain0Direct
Ephrin receptor ligand binding domain0Direct
FAT domain of focal adhesion kinase0Direct
Fibronectin type III0Direct
Third domain of FERM0Direct
FCH domain0Direct
Kringle modules0.0000000005597Direct
Bromodomain0.0000005943Direct
Caspase recruitment domain, CARD0.000002431Direct
Pleckstrin-homology domain (PH domain)0.00000849Direct
PHD domain0.00001531Direct
Polygalacturonase inhibiting protein PGIP0.0002877Direct
PLC-like (P variant)0.01115Inherited
Nitrogenase iron protein-like0.1392Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.3611Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SH2 domain0Direct
L domain-like0Direct
PH domain-like0Direct
Immunoglobulin0Direct
FAT domain of focal adhesion kinase0Direct
Sema domain0Direct
Galactose-binding domain-like0Direct
Growth factor receptor domain0Direct
Fibronectin type III0Direct
Second domain of FERM0Direct
Protein kinase-like (PK-like)0Direct
SH3-domain0Direct
E set domains0Direct
SAM/Pointed domain0Direct
BAR/IMD domain-like0Direct
YWTD domain0Direct
Cadherin-like0Direct
Plexin repeat0Direct
Kringle-like0.000000001426Direct
Bromodomain0.0000003922Direct
Ubiquitin-like0.000006938Direct
FYVE/PHD zinc finger0.0001257Direct
DEATH domain0.0004851Direct
RNI-like0.0005942Direct
C2 domain (Calcium/lipid-binding domain, CaLB)0.1971Inherited
Cysteine-rich domain0.4079Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    103575,81296
  • 103575 - Plexin repeat
  • 81296 - E set domains
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0Direct
    49785,57184
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0Direct
    52058,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 0Direct
    56112,50044
  • 56112 - Protein kinase-like (PK-like)
  • 50044 - SH3-domain
  • 0Direct
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    63825,49265
  • 63825 - YWTD domain
  • 49265 - Fibronectin type III
  • 0Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    57184,49265
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0Direct
    49265,63825
  • 49265 - Fibronectin type III
  • 63825 - YWTD domain
  • 0Direct
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0Direct
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0Direct
    57440,56112
  • 57440 - Kringle-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.000000000000006981Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0000000001157Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.000000007689Direct
    50729,50044
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.00000007409Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0000006406Direct
    52058,56112
  • 52058 - L domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.00003866Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.0004851Direct
    52058,52047
  • 52058 - L domain-like
  • 52047 - RNI-like
  • 0.0008971Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.08818Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0Direct
    101912,103575,81296
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 81296 - E set domains
  • 0Direct
    47031,50729,55550
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0Direct
    52058,57184,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0Direct
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0Direct
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    63825,49265,63825
  • 63825 - YWTD domain
  • 49265 - Fibronectin type III
  • 63825 - YWTD domain
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    49785,57184,49265
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 49265 - Fibronectin type III
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    103575,81296,81296
  • 103575 - Plexin repeat
  • 81296 - E set domains
  • 81296 - E set domains
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47031,50729,56112
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.0000000000003489Direct
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0000000000003534Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.0004851Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)