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Enzyme Commission (EC): Carboxylic ester hydrolases

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <7>
+ + 2:   Hydrolases [3] <13>(395|668) (394|417|206)
+ 1:   Acting on ester bonds [3.1] <23>(157|226) (157|126|55)
0:   Carboxylic ester hydrolases [3.1.1] <108>(35|49) (35|13|0)
- 1:   1,4-lactonase [3.1.1.25](0|0) (0|0|0)
- 1:   1-alkyl-2-acetylglycerophosphocholine esterase [3.1.1.47](3|3) (3|1|0)
- 1:   11-cis-retinyl-palmitate hydrolase [3.1.1.63](0|0) (0|0|0)
- 1:   2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase [3.1.1.91](0|0) (0|0|0)
- 1:   2-pyrone-4,6-dicarboxylate lactonase [3.1.1.57](0|0) (0|0|0)
- 1:   3-O-acetylpapaveroxine carboxylesterase [3.1.1.105](0|0) (0|0|0)
- 1:   3-oxoadipate enol-lactonase [3.1.1.24](0|0) (0|0|0)
- 1:   4-methyloxaloacetate esterase [3.1.1.44](0|0) (0|0|0)
- 1:   4-pyridoxolactonase [3.1.1.27](0|0) (0|0|0)
- 1:   4-sulfomuconolactone hydrolase [3.1.1.92](0|0) (0|0|0)
- 1:   5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase [3.1.1.66](0|0) (0|0|0)
- 1:   5-phospho-D-xylono-1,4-lactonase [3.1.1.104](0|0) (0|0|0)
- 1:   6-acetylglucose deacetylase [3.1.1.33](0|0) (0|0|0)
- 1:   6-deoxy-6-sulfogluconolactonase [3.1.1.99](0|0) (0|0|0)
- 1:   6-phosphogluconolactonase [3.1.1.31](4|4) (4|1|0)
- 1:   Acetoxybutynylbithiophene deacetylase [3.1.1.54](0|0) (0|0|0)
- 1:   Acetylajmaline esterase [3.1.1.80](0|0) (0|0|0)
- 1:   Acetylalkylglycerol acetylhydrolase [3.1.1.71](0|0) (0|0|0)
- 1:   Acetylcholinesterase [3.1.1.7](1|1) (1|0|0)
- 1:   Acetylesterase [3.1.1.6](2|1) (2|0|0)
- 1:   Acetylsalicylate deacetylase [3.1.1.55](0|0) (0|0|0)
- 1:   Acetylxylan esterase [3.1.1.72](3|0) (3|1|0)
- 1:   Aclacinomycin methylesterase [3.1.1.95](0|0) (0|0|0)
- 1:   Actinomycin lactonase [3.1.1.39](0|0) (0|0|0)
- 1:   Acylcarnitine hydrolase [3.1.1.28](0|0) (0|0|0)
- 1:   Acylglycerol lipase [3.1.1.23](1|1) (1|0|0)
- 1:   Acyloxyacyl hydrolase [3.1.1.77](2|0) (2|0|0)
- 1:   All-trans-retinyl ester 13-cis isomerohydrolase [3.1.1.90](0|0) (0|0|0)
- 1:   Alpha-amino-acid esterase [3.1.1.43](0|0) (0|0|0)
- 1:   Aminoacyl-tRNA hydrolase [3.1.1.29](3|3) (3|0|0)
- 1:   Arylesterase [3.1.1.2](1|1) (1|0|0)
- 1:   Bis(2-ethylhexyl)phthalate esterase [3.1.1.60](0|0) (0|0|0)
- 1:   Carboxylesterase [3.1.1.1](1|2) (1|1|0)
- 1:   Carboxymethylenebutenolidase [3.1.1.45](1|1) (1|0|0)
- 1:   Cephalosporin-C deacetylase [3.1.1.41](0|0) (0|0|0)
- 1:   Cetraxate benzylesterase [3.1.1.70](0|0) (0|0|0)
- 1:   Chlorogenate hydrolase [3.1.1.42](0|0) (0|0|0)
- 1:   Chlorophyllase [3.1.1.14](0|0) (0|0|0)
- 1:   Chlorophyllide a hydrolase [3.1.1.100](0|0) (0|0|0)
- 1:   Cholinesterase [3.1.1.8](1|1) (1|0|0)
- 1:   Cocaine esterase [3.1.1.84](0|0) (0|0|0)
- 1:   Cutinase [3.1.1.74](1|1) (1|0|0)
- 1:   D-aminoacyl-tRNA deacylase [3.1.1.96](2|2) (2|0|0)
- 1:   D-arabinonolactonase [3.1.1.30](0|0) (0|0|0)
- 1:   Deleted entry [3.1.1.21](0|0) (0|0|0)
- 1:   Deleted entry [3.1.1.9](0|0) (0|0|0)
- 1:   Deoxylimonate A-ring-lactonase [3.1.1.46](0|0) (0|0|0)
- 1:   Dihydrocoumarin hydrolase [3.1.1.35](0|0) (0|0|0)
- 1:   Fatty-acyl-ethyl-ester synthase [3.1.1.67](0|0) (0|0|0)
- 1:   Feruloyl esterase [3.1.1.73](1|1) (1|1|0)
- 1:   Fumonisin B1 esterase [3.1.1.87](0|0) (0|0|0)
- 1:   Fusarinine-C ornithinesterase [3.1.1.48](0|0) (0|0|0)
- 1:   Galactolipase [3.1.1.26](2|3) (2|1|0)
- 1:   Gluconolactonase [3.1.1.17](1|1) (1|0|0)
- 1:   Hormone-sensitive lipase [3.1.1.79](1|1) (1|0|0)
- 1:   Hydroxybutyrate-dimer hydrolase [3.1.1.22](1|0) (1|0|0)
- 1:   Juvenile-hormone esterase [3.1.1.59](0|0) (0|0|0)
- 1:   L-arabinonolactonase [3.1.1.15](0|0) (0|0|0)
- 1:   L-rhamnono-1,4-lactonase [3.1.1.65](0|0) (0|0|0)
- 1:   Limonin-D-ring-lactonase [3.1.1.36](0|0) (0|0|0)
- 1:   Lipoprotein lipase [3.1.1.34](2|1) (2|1|0)
- 1:   Lysophospholipase [3.1.1.5](5|6) (5|4|0)
- 1:   Methylated diphthine methylhydrolase [3.1.1.97](1|0) (1|0|0)
- 1:   Methylumbelliferyl-acetate deacetylase [3.1.1.56](0|0) (0|0|0)
- 1:   Mono(ethylene terephthalate) hydrolase [3.1.1.102](0|0) (0|0|0)
- 1:   Monoterpene epsilon-lactone hydrolase [3.1.1.83](0|0) (0|0|0)
- 1:   Mycophenolic acid acyl-glucuronide esterase [3.1.1.93](0|0) (0|0|0)
- 1:   N-acetylgalactosaminoglycan deacetylase [3.1.1.58](0|0) (0|0|0)
- 1:   O-acetyl-ADP-ribose deacetylase [3.1.1.106](1|1) (1|0|0)
- 1:   Orsellinate-depside hydrolase [3.1.1.40](0|0) (0|0|0)
- 1:   Pectinesterase [3.1.1.11](2|2) (2|1|0)
- 1:   Pheophorbidase [3.1.1.82](0|0) (0|0|0)
- 1:   Phorbol-diester hydrolase [3.1.1.51](0|0) (0|0|0)
- 1:   Phosphatidylinositol deacylase [3.1.1.52](0|0) (0|0|0)
- 1:   Phospholipase A(1) [3.1.1.32](2|3) (2|0|0)
- 1:   Phospholipase A(2) [3.1.1.4](5|7) (5|2|0)
- 1:   Pimeloyl-[acyl-carrier protein] methyl ester esterase [3.1.1.85](1|1) (1|0|0)
- 1:   Poly(3-hydroxybutyrate) depolymerase [3.1.1.75](0|0) (0|0|0)
- 1:   Poly(3-hydroxyoctanoate) depolymerase [3.1.1.76](0|0) (0|0|0)
- 1:   Poly(ethylene terephthalate) hydrolase [3.1.1.101](0|0) (0|0|0)
- 1:   Polyneuridine-aldehyde esterase [3.1.1.78](0|0) (0|0|0)
- 1:   Protein phosphatase methylesterase-1 [3.1.1.89](1|0) (1|0|0)
- 1:   Protein-S-isoprenylcysteine alpha-carbonyl methylesterase [3.1.1.n2](1|0) (1|0|0)
- 1:   Protein-glutamate methylesterase [3.1.1.61](2|2) (2|1|0)
- 1:   Pyrethroid hydrolase [3.1.1.88](0|0) (0|0|0)
- 1:   Quorum-quenching N-acyl-homoserine lactonase [3.1.1.81](2|1) (2|0|0)
- 1:   Retinoid isomerohydrolase [3.1.1.64](0|0) (0|0|0)
- 1:   Rhamnogalacturonan acetylesterase [3.1.1.86](0|0) (0|0|0)
- 1:   Sialate O-acetylesterase [3.1.1.53](3|3) (3|1|0)
- 1:   Sinapine esterase [3.1.1.49](0|0) (0|0|0)
- 1:   Steroid-lactonase [3.1.1.37](0|0) (0|0|0)
- 1:   Sterol esterase [3.1.1.13](1|2) (1|0|0)
- 1:   Tannase [3.1.1.20](0|0) (0|0|0)
- 1:   Teichoic acid D-alanine hydrolase [3.1.1.103](1|1) (1|0|0)
- 1:   Transferred entry: 3.1.1.1 [3.1.1.12](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.1.17 [3.1.1.18](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.1.24 and 5.3.3.4 [3.1.1.16](0|0) (0|0|0)
- 1:   Transferred entry: 3.5.1.103 [3.1.1.n1](0|0) (0|0|0)
- 1:   Transferred entry: 3.5.1.47 [3.1.1.62](0|0) (0|0|0)
- 1:   Transferred entry: 3.5.1.89 [3.1.1.69](0|0) (0|0|0)
- 1:   Triacetate-lactonase [3.1.1.38](0|0) (0|0|0)
- 1:   Triacylglycerol lipase [3.1.1.3](3|7) (3|1|0)
- 1:   Tropinesterase [3.1.1.10](0|0) (0|0|0)
- 1:   Uronolactonase [3.1.1.19](0|0) (0|0|0)
- 1:   Versiconal hemiacetal acetate esterase [3.1.1.94](0|0) (0|0|0)
- 1:   Wax-ester hydrolase [3.1.1.50](0|0) (0|0|0)
- 1:   Xylono-1,4-lactonase [3.1.1.68](0|0) (0|0|0)
- 1:   [Wnt protein] O-palmitoleoyl-L-serine hydrolase [3.1.1.98](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Viral protein domain0Direct
alpha/beta-Hydrolases0Direct
Calcium-dependent phosphotriesterase0Direct
Outer membrane phospholipase A (OMPLA)0Direct
SGNH hydrolase0Direct
Peptidyl-tRNA hydrolase domain-like0Direct
Pectin lyase-like0Direct
Methylesterase CheB, C-terminal domain0Direct
Phospholipase A2, PLA20Direct
CheY-like0Direct
Peptidyl-tRNA hydrolase-like0Direct
Nitrous oxide reductase, N-terminal domain0Direct
Plant invertase/pectin methylesterase inhibitor0Direct
FabD/lysophospholipase-like0Direct
DTD-like0Direct
Peptidyl-tRNA hydrolase II0Direct
Influenza hemagglutinin (stalk)0Direct
AF0625-like0Direct
cAMP-binding domain-like0Direct
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.000000000000001513Direct
ssDNA viruses0.000000000000008704Direct
NagB/RpiA/CoA transferase-like0.000000000006673Direct
Autotransporter0.00001207Direct
Glutaminase/Asparaginase0.001385Inherited
C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase0.00725Inherited
Ankyrin repeat0.01613Inherited
Putative isomerase YbhE0.04875Inherited
Macro domain-like0.1628Inherited
Saposin0.2506Inherited
Glycoside hydrolase/deacetylase0.9095Inherited
beta-lactamase/transpeptidase-like0.9479Inherited
WD40 repeat-like0.9862Inherited
Thioredoxin-like1Inherited
Metallo-hydrolase/oxidoreductase1Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Methylesterase CheB, C-terminal domain0Direct
Peptidyl-tRNA hydrolase II0Direct
Pancreatic lipase, N-terminal domain0Direct
Insect phospholipase A20Direct
Influenza hemagglutinin (stalk)0Direct
Putative isomerase YbhE0Direct
Peptidyl-tRNA hydrolase domain0Direct
Pectin methylesterase0Direct
Nitrous oxide reductase, N-terminal domain0Direct
Putative acetylxylan esterase-like0Direct
Cutinase-like0Direct
NagB-like0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Dienelactone hydrolase0Direct
Fungal lipases0Direct
Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein HEF10Direct
Colipase-binding domain0Direct
Acetylhydrolase0Direct
Outer membrane phospholipase A (OMPLA)0Direct
Bacterial lipase0Direct
Patatin0Direct
Esterase domain of haemagglutinin-esterase-fusion glycoprotein HEF10Direct
Plant invertase/pectin methylesterase inhibitor0Direct
Biotin biosynthesis protein BioH0Direct
DTD-like0Direct
Acetylcholinesterase-like0Direct
AF0625-like0Direct
TAP-like0Direct
Parvoviridae-like VP0Direct
Esterase0Direct
Gastric lipase0Direct
Vertebrate phospholipase A20Direct
Lysophospholipase0Direct
CheY-related0Direct
Peptidyl-tRNA hydrolase-like0Direct
Carboxylesterase0Direct
cAMP-binding domain0Direct
SGL-like0.00000001087Direct
Hydroxynitrile lyase-like0.0000003847Direct
PP1699/LP2961-like0.000001373Direct
Carbon-carbon bond hydrolase0.000002322Direct
Haloperoxidase0.000005016Direct
Glutaminase/Asparaginase0.001061Inherited
Ankyrin repeat0.01157Inherited
Glucose 6-phosphate dehydrogenase-like0.03103Inherited
Macro domain0.04058Inherited
Glutathione peroxidase-like0.04058Inherited
beta-Lactamase/D-ala carboxypeptidase0.3921Inherited
PLC-like (P variant)1Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SGNH hydrolase0Direct
AF0625-like0Direct
Outer membrane phospholipase A (OMPLA)0Direct
DTD-like0Direct
alpha/beta-Hydrolases0Direct
cAMP-binding domain-like0Direct
Calcium-dependent phosphotriesterase0Direct
Influenza hemagglutinin (stalk)0Direct
Peptidyl-tRNA hydrolase II0Direct
Peptidyl-tRNA hydrolase-like0Direct
CheY-like0Direct
Plant invertase/pectin methylesterase inhibitor0Direct
FabD/lysophospholipase-like0Direct
Phospholipase A2, PLA20Direct
Nitrous oxide reductase, N-terminal domain0Direct
Viral protein domain0Direct
Pectin lyase-like0Direct
Methylesterase CheB, C-terminal domain0Direct
Peptidyl-tRNA hydrolase domain-like0Direct
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.000000000000001058Direct
ssDNA viruses0.000000000000006115Direct
NagB/RpiA/CoA transferase-like0.000000000004827Direct
Autotransporter0.000009581Direct
Glutaminase/Asparaginase0.001147Inherited
C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase0.006117Inherited
Ankyrin repeat0.01376Inherited
Putative isomerase YbhE0.04211Inherited
Macro domain-like0.1437Inherited
Saposin0.2239Inherited
Glycoside hydrolase/deacetylase0.84Inherited
beta-lactamase/transpeptidase-like0.877Inherited
WD40 repeat-like0.9135Inherited
Thioredoxin-like0.9602Inherited
Metallo-hydrolase/oxidoreductase1Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0Direct
    101148,51126
  • 101148 - Plant invertase/pectin methylesterase inhibitor
  • 51126 - Pectin lyase-like
  • 0Direct
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0Direct
    52266,103515
  • 52266 - SGNH hydrolase
  • 103515 - Autotransporter
  • 0Direct
    48403,52151
  • 48403 - Ankyrin repeat
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    53474,53474
  • 53474 - alpha/beta-Hydrolases
  • 53474 - alpha/beta-Hydrolases
  • 0Direct
    52266,49818
  • 52266 - SGNH hydrolase
  • 49818 - Viral protein domain
  • 0Direct
    49562,52151
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    52151,52151
  • 52151 - FabD/lysophospholipase-like
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    50974,50974
  • 50974 - Nitrous oxide reductase, N-terminal domain
  • 50974 - Nitrous oxide reductase, N-terminal domain
  • 0Direct
    52172,52738
  • 52172 - CheY-like
  • 52738 - Methylesterase CheB, C-terminal domain
  • 0Direct
    53774,48403
  • 53774 - Glutaminase/Asparaginase
  • 48403 - Ankyrin repeat
  • 0.00000008536Direct
    53474,53335
  • 53474 - alpha/beta-Hydrolases
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 0.000001215Direct


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