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Enzyme Commission (EC): Thiolester hydrolases

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <7>
+ + 2:   Hydrolases [3] <13>(395|668) (394|417|206)
+ 1:   Acting on ester bonds [3.1] <23>(157|226) (157|126|55)
0:   Thiolester hydrolases [3.1.2] <34>(16|19) (16|11|4)
- 1:   (3S)-malyl-CoA thioesterase [3.1.2.30](1|1) (1|0|0)
- 1:   (S)-methylmalonyl-CoA hydrolase [3.1.2.17](0|0) (0|0|0)
- 1:   1,4-dihydroxy-2-naphthoyl-CoA hydrolase [3.1.2.28](1|1) (1|0|0)
- 1:   2-aminobenzoylacetyl-CoA thioesterase [3.1.2.32](0|0) (0|0|0)
- 1:   3-hydroxyisobutyryl-CoA hydrolase [3.1.2.4](1|1) (1|0|0)
- 1:   4-hydroxybenzoyl-CoA thioesterase [3.1.2.23](0|0) (0|0|0)
- 1:   ADP-dependent medium-chain-acyl-CoA hydrolase [3.1.2.19](0|0) (0|0|0)
- 1:   ADP-dependent short-chain-acyl-CoA hydrolase [3.1.2.18](0|0) (0|0|0)
- 1:   Acetoacetyl-CoA hydrolase [3.1.2.11](0|1) (0|1|0)
- 1:   Acetyl-CoA hydrolase [3.1.2.1](3|3) (3|4|1)
- 1:   Acyl-CoA hydrolase [3.1.2.20](0|0) (0|0|0)
- 1:   Choloyl-CoA hydrolase [3.1.2.27](0|1) (0|1|0)
- 1:   Citrate-lyase deacetylase [3.1.2.16](0|0) (0|0|0)
- 1:   Deleted entry [3.1.2.9](0|0) (0|0|0)
- 1:   Deleted entry [3.1.2.15](0|0) (0|0|0)
- 1:   Dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase [3.1.2.31](0|0) (0|0|0)
- 1:   Dodecanoyl-[acyl-carrier-protein] hydrolase [3.1.2.21](0|0) (0|0|0)
- 1:   Fluoroacetyl-CoA thioesterase [3.1.2.29](0|0) (0|0|0)
- 1:   Formyl-CoA hydrolase [3.1.2.10](0|0) (0|0|0)
- 1:   Glutathione thiolesterase [3.1.2.7](0|0) (0|0|0)
- 1:   Hydroxyacylglutathione hydrolase [3.1.2.6](1|1) (1|0|0)
- 1:   Hydroxymethylglutaryl-CoA hydrolase [3.1.2.5](0|1) (0|1|0)
- 1:   Oleoyl-[acyl-carrier-protein] hydrolase [3.1.2.14](9|10) (9|7|3)
- 1:   Palmitoyl-CoA hydrolase [3.1.2.2](3|2) (3|2|0)
- 1:   Palmitoyl-protein hydrolase [3.1.2.22](1|1) (1|0|0)
- 1:   Phenylacetyl-CoA hydrolase [3.1.2.25](0|0) (0|0|0)
- 1:   S-formylglutathione hydrolase [3.1.2.12](1|1) (1|0|0)
- 1:   S-succinylglutathione hydrolase [3.1.2.13](0|0) (0|0|0)
- 1:   Succinyl-CoA hydrolase [3.1.2.3](0|1) (0|1|0)
- 1:   Transferred entry: 2.8.3.25 [3.1.2.26](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.2.28 [3.1.2.n1](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.2.30 [3.1.2.n2](0|0) (0|0|0)
- 1:   Transferred entry: 3.1.2.6 [3.1.2.8](0|0) (0|0|0)
- 1:   Transferred entry: 3.13.1.3 [3.1.2.24](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
alpha/beta-Hydrolases0Direct
Thioesterase/thiol ester dehydrase-isomerase0Direct
Metallo-hydrolase/oxidoreductase0Direct
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.00000002345Direct
Bet v1-like0.00000002821Direct
ACP-like0.00000005589Direct
Thiolase-like0.00002314Direct
ClpP/crotonase0.00004117Direct
NagB/RpiA/CoA transferase-like0.00004929Direct
FabD/lysophospholipase-like0.0005461Direct
Phosphoenolpyruvate/pyruvate domain0.001704Inherited
GroES-like0.002455Inherited
Inosine monophosphate dehydrogenase (IMPDH)0.003972Inherited
SGNH hydrolase0.553Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
CoA transferase alpha subunit-like0Direct
Thioesterases0Direct
4HBT-like0Direct
Acyl-ACP thioesterase-like0Direct
Acyl-CoA thioesterase0Direct
FabD-like0Direct
Hypothetical esterase YJL068C0Direct
Glyoxalase II (hydroxyacylglutathione hydrolase)0Direct
Acyl-carrier protein (ACP)0.000000000000001646Direct
Crotonase-like0.000000000000001646Direct
Thioesterase domain of polypeptide, polyketide and fatty acid synthases0.000000000000003457Direct
MaoC-like0.00000000000008857Direct
PaaI/YdiI-like0.0000000000001016Direct
HpcH/HpaI aldolase0.0000000000001831Direct
Thiolase-related0.0000000006144Direct
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.0000002519Direct
Alcohol dehydrogenase-like, C-terminal domain0.001256Inherited
Alcohol dehydrogenase-like, N-terminal domain0.001615Inherited
Tyrosine-dependent oxidoreductases0.04325Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Metallo-hydrolase/oxidoreductase0Direct
Thioesterase/thiol ester dehydrase-isomerase0Direct
alpha/beta-Hydrolases0Direct
Probable ACP-binding domain of malonyl-CoA ACP transacylase0.0000000178Direct
Bet v1-like0.00000002145Direct
ACP-like0.00000004266Direct
Thiolase-like0.00001846Direct
ClpP/crotonase0.00003296Direct
NagB/RpiA/CoA transferase-like0.00003954Direct
FabD/lysophospholipase-like0.0004479Direct
Phosphoenolpyruvate/pyruvate domain0.001415Inherited
GroES-like0.002048Inherited
Inosine monophosphate dehydrogenase (IMPDH)0.003328Inherited
SGNH hydrolase0.5069Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
100950,100950
  • 100950 - NagB/RpiA/CoA transferase-like
  • 100950 - NagB/RpiA/CoA transferase-like
  • 0Direct
    54637,55961
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 55961 - Bet v1-like
  • 0Direct
    52151,51412
  • 52151 - FabD/lysophospholipase-like
  • 51412 - Inosine monophosphate dehydrogenase (IMPDH)
  • 0Direct
    54637,52151
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 52151 - FabD/lysophospholipase-like
  • 0Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    47336,53474
  • 47336 - ACP-like
  • 53474 - alpha/beta-Hydrolases
  • 0.00000000000006195Direct
    51735,47336
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 0.0000000005077Direct
    51735,51735
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.000000006411Direct
    52151,55048
  • 52151 - FabD/lysophospholipase-like
  • 55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase
  • 0.0000000178Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0.001633Inherited
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.00199Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    54637,54637,55961
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 55961 - Bet v1-like
  • 0Direct
    51735,47336,53474
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 53474 - alpha/beta-Hydrolases
  • 3.545e-16Direct
    50129,51735,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.000000000003503Direct
    51735,51735,47336
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 47336 - ACP-like
  • 0.0000000002919Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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