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Enzyme Commission (EC): Isomerases

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   root [root] <7>
0:   Isomerases [5] <7>(128|160) (128|76|32)
- 1:   Intramolecular oxidoreductases [5.3] <5>(40|53) (40|16|6)
- 1:   Intramolecular transferases [5.4] <5>(35|42) (35|16|4)
- 1:   Racemases and epimerases [5.1] <4>(31|32) (31|15|8)
- 1:   Isomerases altering macromolecular conformation [5.6] <2>(20|21) (20|22|10)
- 1:   Cis-trans-isomerases [5.2] <1>(14|12) (14|10|5)
- 1:   Intramolecular lyases [5.5] <1>(10|11) (10|4|1)
- 1:   Other isomerases [5.99] <1>(1|0) (1|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
DeoB insert domain-like0Direct
Thioesterase/thiol ester dehydrase-isomerase0Direct
Xylose isomerase-like0Direct
RmlC-like cupins0Direct
Triosephosphate isomerase (TIM)0Direct
PLP-binding barrel0Direct
Aspartate/glutamate racemase0Direct
Cobalamin (vitamin B12)-binding domain0Direct
PLP-dependent transferases0Direct
SIS domain0Direct
Ribose/Galactose isomerase RpiB/AlsB0Direct
Chalcone isomerase0Direct
DNA breaking-rejoining enzymes0Direct
Kelch motif0Direct
Eukaryotic DNA topoisomerase I, dispensable insert domain0Direct
PTPA-like0Direct
Allene oxide cyclase-like0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
DNA topoisomerase IV, alpha subunit0Direct
Chorismate mutase II0Direct
Alanine racemase C-terminal domain-like0Direct
TPR-like0Direct
Zinc beta-ribbon0Direct
Cobalamin (vitamin B12)-dependent enzymes0Direct
NagB/RpiA/CoA transferase-like0Direct
DNA topoisomerase I domain0Direct
YjeF N-terminal domain-like0Direct
Triger factor/SurA peptide-binding domain-like0Direct
GyrA/ParC C-terminal domain-like0Direct
Precorrin-8X methylmutase CbiC/CobH0Direct
Nudix0Direct
Oxygen-evolving enhancer protein 3,0Direct
Ribulose-phoshate binding barrel0Direct
PUA domain-like0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
Dimeric alpha+beta barrel0Direct
Diaminopimelate epimerase-like0Direct
Phosphoglycerate mutase-like0Direct
FKBP-like0Direct
Type II DNA topoisomerase0Direct
RbsD-like0Direct
ERP29 C domain-like0Direct
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
D-ribose-5-phosphate isomerase (RpiA), lid domain0Direct
FMN-linked oxidoreductases0Direct
Trigger factor ribosome-binding domain0Direct
GroEL equatorial domain-like0Direct
Tautomerase/MIF0Direct
Phosphoglucomutase, first 3 domains0Direct
FucI/AraA N-terminal and middle domains0Direct
Acyl-CoA binding protein0Direct
FucI/AraA C-terminal domain-like0Direct
Prokaryotic type I DNA topoisomerase0Direct
Phosphoglucomutase, C-terminal domain0Direct
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment0Direct
Cyclophilin-like0Direct
Pseudouridine synthase0Direct
Alkaline phosphatase-like0Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)2.561e-16Direct
Alpha-L RNA-binding motif0.000000000000001511Direct
ClpP/crotonase0.00000000000009847Direct
Lipocalins0.000000000008871Direct
6-phosphogluconate dehydrogenase C-terminal domain-like0.00000000002033Direct
Thioredoxin-like0.0000000002697Direct
ABC transporter transmembrane region0.000000003034Direct
RNA-binding domain, RBD0.0000001933Direct
GroEL-intermediate domain like0.000000264Direct
GroEL apical domain-like0.000007182Direct
beta-Roll0.00009613Direct
MAPEG domain-like0.0002617Direct
AraD/HMP-PK domain-like0.000466Direct
Hedgehog/intein (Hint) domain0.0008098Direct
ADC synthase0.001001Inherited
MIT domain0.001176Inherited
Homing endonucleases0.00151Inherited
Terpenoid synthases0.005556Inherited
FumA C-terminal domain-like0.007924Inherited
Galactose mutarotase-like0.02724Inherited
WW domain0.03012Inherited
HSP20-like chaperones0.05712Inherited
Growth factor receptor domain0.08104Inherited
ACP-like0.1347Inherited
CoA-transferase family III (CaiB/BaiF)0.1816Inherited
Di-copper centre-containing domain0.2033Inherited
NTF2-like0.2503Inherited
Chondroitin AC/alginate lyase0.2813Inherited
WD40 repeat-like0.298Inherited
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0.3752Inherited
Nucleotide-binding domain0.4608Inherited
GST C-terminal domain-like0.4803Inherited
CBS-domain pair0.5472Inherited
Metallo-dependent hydrolases0.5731Inherited
FAH0.5831Inherited
Lipoxigenase0.7979Inherited
Six-hairpin glycosidases0.902Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes1Inherited
Ribosomal protein S5 domain 2-like1Inherited
Cytochrome P4501Inherited
FAD/NAD(P)-binding domain1Inherited
Nucleotide-diphospho-sugar transferases1Inherited
Periplasmic binding protein-like II1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
L-aspartase-like1Inherited
Class I glutamine amidotransferase-like1Inherited
Ribokinase-like1Inherited
FAD-linked reductases, C-terminal domain1Inherited
ACT-like1Inherited
HAD-like1Inherited
CoA-dependent acyltransferases1Inherited
Pectin lyase-like1Inherited
Glycosyl hydrolase domain1Inherited
Tetrahydrobiopterin biosynthesis enzymes-like1Inherited
Enolase C-terminal domain-like1Inherited
(Trans)glycosidases1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
Phosphoenolpyruvate/pyruvate domain1Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)1Inherited
Heme-dependent peroxidases1Inherited
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain1Inherited
Enolase N-terminal domain-like1Inherited
RuBisCo, C-terminal domain1Inherited
EF-hand1Inherited
S13-like H2TH domain1Inherited
Acetyl-CoA synthetase-like1Inherited
Radical SAM enzymes1Inherited
UDP-Glycosyltransferase/glycogen phosphorylase1Inherited
RuBisCO, large subunit, small (N-terminal) domain1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Type I phosphomannose isomerase0Direct
Helicase-like "domain" of reverse gyrase0Direct
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment0Direct
YjeF N-terminal domain-like0Direct
Prokaryotic DNA topoisomerase I, a C-terminal fragment0Direct
Alanine racemase0Direct
Aspartate/glutamate racemase0Direct
Allosteric chorismate mutase0Direct
ERP29 C domain-like0Direct
Proline racemase0Direct
Phosphoglucose isomerase, PGI0Direct
Eukaryotic DNA topoisomerase I, dispensable insert domain0Direct
GyrA/ParC C-terminal domain-like0Direct
4-oxalocrotonate tautomerase-like0Direct
GroEL-like chaperone, apical domain0Direct
Aldose 1-epimerase (mutarotase)0Direct
IolI-like0Direct
AraA C-terminal domain-like0Direct
Hypothetical protein HI13170Direct
Tryptophan biosynthesis enzymes0Direct
UDP-galactopyranose mutase, N-terminal domain0Direct
PhzC/PhzF-like0Direct
Ketosteroid isomerase-like0Direct
PA3566-like0Direct
SnoaL-like polyketide cyclase0Direct
IPP isomerase-like0Direct
Phosphoglucomutase, first 3 domains0Direct
Cobalamin (vitamin B12)-binding domain0Direct
D-ribulose-5-phosphate 3-epimerase0Direct
Porin chaperone SurA, peptide-binding domain0Direct
Phosphoglucomutase, C-terminal domain0Direct
Methylmalonyl-CoA epimerase0Direct
Eukaryotic DNA topoisomerase I, catalytic core0Direct
FKBP immunophilin/proline isomerase0Direct
Methylmalonyl-CoA mutase, N-terminal (CoA-binding) domain0Direct
dTDP-sugar isomerase0Direct
IF2B-like0Direct
Tetratricopeptide repeat (TPR)0Direct
L-fucose isomerase, N-terminal and second domains0Direct
L-rhamnose isomerase0Direct
UDP-galactopyranose mutase0Direct
Precorrin-8X methylmutase CbiC/CobH0Direct
D-lysine 5,6-aminomutase alpha subunit, KamD0Direct
PUA domain0Direct
DeoB catalytic domain-like0Direct
L-fucose isomerase, C-terminal domain0Direct
Uronate isomerase-like0Direct
Glutamate mutase, large subunit0Direct
Tyrosine-dependent oxidoreductases0Direct
DNA topoisomerase IV, alpha subunit0Direct
Muconalactone isomerase, MLI0Direct
AraA N-terminal and middle domain-like0Direct
mono-SIS domain0Direct
Crotonase-like0Direct
beta-Hydroxydecanol thiol ester dehydrase0Direct
Topoisomerase VI-B subunit middle domain0Direct
Secreted chorismate mutase-like0Direct
Glucose-6-phosphate isomerase, GPI0Direct
D-ribose-5-phosphate isomerase (RpiA), lid domain0Direct
tRNA pseudouridine synthase TruD0Direct
Pseudouridine synthase I TruA0Direct
PDI-like0Direct
Ribose/Galactose isomerase RpiB/AlsB0Direct
TF C-terminus0Direct
Histidine biosynthesis enzymes0Direct
GroEL-like chaperone, intermediate domain0Direct
RbsD-like0Direct
Cyclophilin (peptidylprolyl isomerase)0Direct
YiiL-like0Direct
Xylose isomerase0Direct
Hypothetical protein YgbM (EC1530)0Direct
DNA gyrase/MutL, second domain0Direct
FMN-linked oxidoreductases0Direct
KduI-like0Direct
Type II DNA topoisomerase0Direct
Acyl-CoA binding protein0Direct
Pseudouridine synthase II TruB0Direct
Pseudouridine synthase RsuA N-terminal domain0Direct
Triosephosphate isomerase (TIM)0Direct
NanE-like0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
Chalcone isomerase0Direct
Vaccinia DNA topoisomerase I, 9 kDa N-terminal fragment0Direct
Diaminopimelate epimerase0Direct
Allene oxide cyclase-like0Direct
Cofactor-dependent phosphoglycerate mutase0Direct
Kelch motif0Direct
DeoB insert domain-like0Direct
GABA-aminotransferase-like0Direct
Prokaryotic type I DNA topoisomerase0Direct
GroEL chaperone, ATPase domain0Direct
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, catalytic domain0Direct
HCDH C-domain-like0Direct
N-acylglucosamine (NAG) epimerase0Direct
Alanine racemase-like, N-terminal domain0Direct
Trigger factor ribosome-binding domain0Direct
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain0Direct
DNA gyrase/MutL, N-terminal domain0Direct
PTPA-like0Direct
Terpene synthases0Direct
D-ribose-5-phosphate isomerase (RpiA), catalytic domain0Direct
Pseudouridine synthase RsuA/RluD0Direct
Retinol binding protein-like0.000000000000001282Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0.000000000000001462Direct
UDP-N-acetylglucosamine 2-epimerase0.00000000000002047Direct
YjeF C-terminal domain-like0.00000000000003379Direct
6-phosphogluconate dehydrogenase-like, N-terminal domain0.000000000001368Direct
MIF-related0.000000000006049Direct
Dimeric chorismate mutase0.00000000005233Direct
Canonical RBD0.0000000001316Direct
ABC transporter transmembrane region0.00000006631Direct
Predicted hydrolases Cof0.000001361Direct
Peptidyl carrier domain0.000005192Direct
DHN aldolase/epimerase0.00004716Direct
Serralysin-like metalloprotease, C-terminal domain0.0001221Direct
mannose-1-phosphate guanylyl transferase0.0001493Direct
NRPS condensation domain (amide synthase)0.0001938Direct
Terpenoid cyclase N-terminal domain0.0005545Direct
AraD-like aldolase/epimerase0.0008743Direct
MAPEG domain0.001611Inherited
ADC synthase0.001616Inherited
Terpenoid cyclase C-terminal domain0.002523Inherited
Co-chaperone p23-like0.002588Inherited
Intein (protein splicing domain)0.00289Inherited
TyrA dimerization domain-like0.005687Inherited
FumA C-terminal domain-like0.008458Inherited
MIT domain0.02154Inherited
WD40-repeat0.02442Inherited
D-glucarate dehydratase-like0.03417Inherited
WW domain0.03809Inherited
Animal lipoxigenases0.0802Inherited
Growth factor receptor domain0.1255Inherited
CoA-transferase family III (CaiB/BaiF)0.1993Inherited
Glutathione S-transferase (GST), N-terminal domain0.3202Inherited
Phenylalanine metabolism regulatory domain0.366Inherited
Squalene synthase0.3832Inherited
Glutathione S-transferase (GST), C-terminal domain0.3837Inherited
Myeloperoxidase-like0.4265Inherited
CBS-domain pair0.5383Inherited
FAH0.5839Inherited
Lipoxigenase N-terminal domain0.6149Inherited
double-SIS domain0.7949Inherited
Phosphoenolpyruvate mutase/Isocitrate lyase-like0.8791Inherited
beta-Phosphoglucomutase-like0.9605Inherited
Class I glutamine amidotransferases (GAT)1Inherited
RuBisCo, large subunit, C-terminal domain1Inherited
Extended AAA-ATPase domain1Inherited
Phosphate binding protein-like1Inherited
ABC transporter ATPase domain-like1Inherited
Dihydrodipicolinate reductase-like1Inherited
L-aspartase/fumarase1Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes1Inherited
Cytochrome P4501Inherited
Acetyl-CoA synthetase-like1Inherited
Amylase, catalytic domain1Inherited
Enolase N-terminal domain-like1Inherited
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain1Inherited
HAL/PAL-like1Inherited
Nitrogenase iron protein-like1Inherited
Ribulose 1,5-bisphosphate carboxylase-oxygenase1Inherited


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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Diaminopimelate epimerase-like0Direct
Chorismate mutase II0Direct
Triosephosphate isomerase (TIM)0Direct
Oxygen-evolving enhancer protein 3,0Direct
Eukaryotic DNA topoisomerase I, dispensable insert domain0Direct
Trigger factor ribosome-binding domain0Direct
PUA domain-like0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
GroEL equatorial domain-like0Direct
D-ribose-5-phosphate isomerase (RpiA), lid domain0Direct
Zinc beta-ribbon0Direct
DeoB insert domain-like0Direct
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain0Direct
FucI/AraA N-terminal and middle domains0Direct
Tautomerase/MIF0Direct
NagB/RpiA/CoA transferase-like0Direct
FKBP-like0Direct
SIS domain0Direct
Phosphoglucomutase, C-terminal domain0Direct
Allene oxide cyclase-like0Direct
Type II DNA topoisomerase0Direct
Phosphoglycerate mutase-like0Direct
Acyl-CoA binding protein0Direct
FucI/AraA C-terminal domain-like0Direct
RmlC-like cupins0Direct
Pseudouridine synthase0Direct
PLP-dependent transferases0Direct
Xylose isomerase-like0Direct
Dimeric alpha+beta barrel0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
RbsD-like0Direct
DNA topoisomerase IV, alpha subunit0Direct
Chalcone isomerase0Direct
PTPA-like0Direct
PLP-binding barrel0Direct
FMN-linked oxidoreductases0Direct
Triger factor/SurA peptide-binding domain-like0Direct
ERP29 C domain-like0Direct
Precorrin-8X methylmutase CbiC/CobH0Direct
Alkaline phosphatase-like0Direct
DNA topoisomerase I domain0Direct
Cobalamin (vitamin B12)-binding domain0Direct
YjeF N-terminal domain-like0Direct
DNA breaking-rejoining enzymes0Direct
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment0Direct
TPR-like0Direct
Thioesterase/thiol ester dehydrase-isomerase0Direct
GyrA/ParC C-terminal domain-like0Direct
Prokaryotic type I DNA topoisomerase0Direct
Alanine racemase C-terminal domain-like0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
Ribulose-phoshate binding barrel0Direct
Cyclophilin-like0Direct
Cobalamin (vitamin B12)-dependent enzymes0Direct
Kelch motif0Direct
Aspartate/glutamate racemase0Direct
Nudix0Direct
Ribose/Galactose isomerase RpiB/AlsB0Direct
Phosphoglucomutase, first 3 domains0Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)1.777e-16Direct
Alpha-L RNA-binding motif0.000000000000001057Direct
ClpP/crotonase0.00000000000006992Direct
Lipocalins0.000000000006425Direct
6-phosphogluconate dehydrogenase C-terminal domain-like0.0000000000148Direct
Thioredoxin-like0.0000000001996Direct
ABC transporter transmembrane region0.000000002277Direct
RNA-binding domain, RBD0.0000001488Direct
GroEL-intermediate domain like0.0000002037Direct
GroEL apical domain-like0.000005666Direct
beta-Roll0.0000776Direct
MAPEG domain-like0.0002131Direct
AraD/HMP-PK domain-like0.0003814Direct
Hedgehog/intein (Hint) domain0.0006676Direct
ADC synthase0.0008269Direct
MIT domain0.0009725Direct
Homing endonucleases0.001252Inherited
Terpenoid synthases0.004673Inherited
FumA C-terminal domain-like0.0067Inherited
Galactose mutarotase-like0.02338Inherited
WW domain0.02587Inherited
HSP20-like chaperones0.04953Inherited
Growth factor receptor domain0.07059Inherited
ACP-like0.1183Inherited
CoA-transferase family III (CaiB/BaiF)0.1607Inherited
Di-copper centre-containing domain0.1806Inherited
NTF2-like0.2237Inherited
Chondroitin AC/alginate lyase0.2535Inherited
WD40 repeat-like0.2691Inherited
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0.34Inherited
Nucleotide-binding domain0.4202Inherited
GST C-terminal domain-like0.4384Inherited
CBS-domain pair0.5014Inherited
Metallo-dependent hydrolases0.5259Inherited
FAH0.5353Inherited
Lipoxigenase0.7348Inherited
Six-hairpin glycosidases0.8333Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.9738Inherited
ACT-like1Inherited
Periplasmic binding protein-like II1Inherited
(Trans)glycosidases1Inherited
Nucleotide-diphospho-sugar transferases1Inherited
CoA-dependent acyltransferases1Inherited
Enolase N-terminal domain-like1Inherited
Radical SAM enzymes1Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes1Inherited
Cytochrome P4501Inherited
Tetrahydrobiopterin biosynthesis enzymes-like1Inherited
L-aspartase-like1Inherited
Ribosomal protein S5 domain 2-like1Inherited
S13-like H2TH domain1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
HAD-like1Inherited
RuBisCO, large subunit, small (N-terminal) domain1Inherited
Phosphoenolpyruvate/pyruvate domain1Inherited
Heme-dependent peroxidases1Inherited
UDP-Glycosyltransferase/glycogen phosphorylase1Inherited
Enolase C-terminal domain-like1Inherited
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain1Inherited
Ribokinase-like1Inherited
Class I glutamine amidotransferase-like1Inherited
Acetyl-CoA synthetase-like1Inherited
FAD-linked reductases, C-terminal domain1Inherited
RuBisCo, C-terminal domain1Inherited
FAD/NAD(P)-binding domain1Inherited
Glycosyl hydrolase domain1Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
Pectin lyase-like1Inherited
EF-hand1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55608,56712
  • 55608 - Homing endonucleases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    64153,53613
  • 64153 - YjeF N-terminal domain-like
  • 53613 - Ribokinase-like
  • 0Direct
    51126,51120
  • 51126 - Pectin lyase-like
  • 51120 - beta-Roll
  • 0Direct
    50891,48452
  • 50891 - Cyclophilin-like
  • 48452 - TPR-like
  • 0Direct
    64158,53649
  • 64158 - 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    56349,46596
  • 56349 - DNA breaking-rejoining enzymes
  • 46596 - Eukaryotic DNA topoisomerase I, dispensable insert domain
  • 0Direct
    109998,54534
  • 109998 - Triger factor/SurA peptide-binding domain-like
  • 54534 - FKBP-like
  • 0Direct
    55174,55120
  • 55174 - Alpha-L RNA-binding motif
  • 55120 - Pseudouridine synthase
  • 0Direct
    143856,53649
  • 143856 - DeoB insert domain-like
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    53697,54631
  • 53697 - SIS domain
  • 54631 - CBS-domain pair
  • 0Direct
    53681,53681
  • 53681 - Aspartate/glutamate racemase
  • 53681 - Aspartate/glutamate racemase
  • 0Direct
    56712,51294
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    56529,56529
  • 56529 - FAH
  • 56529 - FAH
  • 0Direct
    51735,74650
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 74650 - Galactose mutarotase-like
  • 0Direct
    48239,48239
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 0Direct
    56719,56719
  • 56719 - Type II DNA topoisomerase
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    56712,57783
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 57783 - Zinc beta-ribbon
  • 0Direct
    54506,54506
  • 54506 - Diaminopimelate epimerase-like
  • 54506 - Diaminopimelate epimerase-like
  • 0Direct
    53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    54534,109998
  • 54534 - FKBP-like
  • 109998 - Triger factor/SurA peptide-binding domain-like
  • 0Direct
    57783,57783
  • 57783 - Zinc beta-ribbon
  • 57783 - Zinc beta-ribbon
  • 0Direct
    56719,55608
  • 56719 - Type II DNA topoisomerase
  • 55608 - Homing endonucleases
  • 0Direct
    55608,56719
  • 55608 - Homing endonucleases
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    55869,56349
  • 55869 - DNA topoisomerase I domain
  • 56349 - DNA breaking-rejoining enzymes
  • 0Direct
    52242,52540
  • 52242 - Cobalamin (vitamin B12)-binding domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51366,51366
  • 51366 - Ribulose-phoshate binding barrel
  • 51366 - Ribulose-phoshate binding barrel
  • 0Direct
    52540,56712
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    54928,50891
  • 54928 - RNA-binding domain, RBD
  • 50891 - Cyclophilin-like
  • 0Direct
    102735,54534
  • 102735 - Trigger factor ribosome-binding domain
  • 54534 - FKBP-like
  • 0Direct
    52096,51735
  • 52096 - ClpP/crotonase
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    51703,52242
  • 51703 - Cobalamin (vitamin B12)-dependent enzymes
  • 52242 - Cobalamin (vitamin B12)-binding domain
  • 0Direct
    100950,75445
  • 100950 - NagB/RpiA/CoA transferase-like
  • 75445 - D-ribose-5-phosphate isomerase (RpiA), lid domain
  • 0Direct
    51419,50621
  • 51419 - PLP-binding barrel
  • 50621 - Alanine racemase C-terminal domain-like
  • 0Direct
    55874,46946
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 46946 - S13-like H2TH domain
  • 0Direct
    51294,56719
  • 51294 - Hedgehog/intein (Hint) domain
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    51045,54534
  • 51045 - WW domain
  • 54534 - FKBP-like
  • 0Direct
    52833,47933
  • 52833 - Thioredoxin-like
  • 47933 - ERP29 C domain-like
  • 0Direct
    53743,50443
  • 53743 - FucI/AraA N-terminal and middle domains
  • 50443 - FucI/AraA C-terminal domain-like
  • 0Direct
    54211,56719
  • 54211 - Ribosomal protein S5 domain 2-like
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    48179,48179
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    54534,48452
  • 54534 - FKBP-like
  • 48452 - TPR-like
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0Direct
    53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    54534,47473
  • 54534 - FKBP-like
  • 47473 - EF-hand
  • 0Direct
    48600,51735
  • 48600 - Chorismate mutase II
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0Direct
    55874,56719
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    48600,53850
  • 48600 - Chorismate mutase II
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    55120,88697
  • 55120 - Pseudouridine synthase
  • 88697 - PUA domain-like
  • 0Direct
    56719,101904
  • 56719 - Type II DNA topoisomerase
  • 101904 - GyrA/ParC C-terminal domain-like
  • 0Direct
    46946,54211
  • 46946 - S13-like H2TH domain
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    47027,52096
  • 47027 - Acyl-CoA binding protein
  • 52096 - ClpP/crotonase
  • 0Direct
    56741,56349
  • 56741 - Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
  • 56349 - DNA breaking-rejoining enzymes
  • 0Direct
    52317,51366
  • 52317 - Class I glutamine amidotransferase-like
  • 51366 - Ribulose-phoshate binding barrel
  • 0.000000000003232Direct
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0.00000000001161Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000000001987Direct
    51120,51120
  • 51120 - beta-Roll
  • 51120 - beta-Roll
  • 0.00000004876Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.0000002037Direct
    56801,47336
  • 56801 - Acetyl-CoA synthetase-like
  • 47336 - ACP-like
  • 0.0000032Direct
    47336,52777
  • 47336 - ACP-like
  • 52777 - CoA-dependent acyltransferases
  • 0.000005666Direct
    48179,52096
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 52096 - ClpP/crotonase
  • 0.00002229Direct
    53850,55021
  • 53850 - Periplasmic binding protein-like II
  • 55021 - ACT-like
  • 0.00004972Direct
    53448,51182
  • 53448 - Nucleotide-diphospho-sugar transferases
  • 51182 - RmlC-like cupins
  • 0.00009924Direct
    48239,48576
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 48576 - Terpenoid synthases
  • 0.0002415Direct
    52777,56801
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 0.002348Inherited
    51971,54373
  • 51971 - Nucleotide-binding domain
  • 54373 - FAD-linked reductases, C-terminal domain
  • 0.006357Inherited
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.08134Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.3307Inherited
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.608Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 1Inherited
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 1Inherited
    54966,51649
  • 54966 - RuBisCO, large subunit, small (N-terminal) domain
  • 51649 - RuBisCo, C-terminal domain
  • 1Inherited
    54826,51604
  • 54826 - Enolase N-terminal domain-like
  • 51604 - Enolase C-terminal domain-like
  • 1Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    51735,48179,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    52096,51735,48179
  • 52096 - ClpP/crotonase
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    48239,48239,48576
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 48239 - Terpenoid cyclases/Protein prenyltransferases
  • 48576 - Terpenoid synthases
  • 0Direct
    53738,53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0Direct
    51294,56719,55608
  • 51294 - Hedgehog/intein (Hint) domain
  • 56719 - Type II DNA topoisomerase
  • 55608 - Homing endonucleases
  • 0Direct
    56741,56349,46596
  • 56741 - Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
  • 56349 - DNA breaking-rejoining enzymes
  • 46596 - Eukaryotic DNA topoisomerase I, dispensable insert domain
  • 0Direct
    57783,57783,57783
  • 57783 - Zinc beta-ribbon
  • 57783 - Zinc beta-ribbon
  • 57783 - Zinc beta-ribbon
  • 0Direct
    52317,51366,51366
  • 52317 - Class I glutamine amidotransferase-like
  • 51366 - Ribulose-phoshate binding barrel
  • 51366 - Ribulose-phoshate binding barrel
  • 0Direct
    52540,56712,51294
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0Direct
    54534,54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    54534,54534,48452
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 48452 - TPR-like
  • 0Direct
    109998,54534,54534
  • 109998 - Triger factor/SurA peptide-binding domain-like
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    51126,51120,51120
  • 51126 - Pectin lyase-like
  • 51120 - beta-Roll
  • 51120 - beta-Roll
  • 0Direct
    55874,46946,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 46946 - S13-like H2TH domain
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    52540,52540,56712
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    55874,54211,56719
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    52833,52833,47933
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 47933 - ERP29 C domain-like
  • 0Direct
    56712,57783,57783
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 57783 - Zinc beta-ribbon
  • 57783 - Zinc beta-ribbon
  • 0Direct
    48600,53850,55021
  • 48600 - Chorismate mutase II
  • 53850 - Periplasmic binding protein-like II
  • 55021 - ACT-like
  • 0Direct
    102735,54534,109998
  • 102735 - Trigger factor ribosome-binding domain
  • 54534 - FKBP-like
  • 109998 - Triger factor/SurA peptide-binding domain-like
  • 0Direct
    56719,55608,56719
  • 56719 - Type II DNA topoisomerase
  • 55608 - Homing endonucleases
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    48600,51735,48179
  • 48600 - Chorismate mutase II
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0Direct
    53738,53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0Direct
    54534,54534,47473
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 47473 - EF-hand
  • 0Direct
    51120,51120,51120
  • 51120 - beta-Roll
  • 51120 - beta-Roll
  • 51120 - beta-Roll
  • 0.00000004876Direct
    56801,47336,52777
  • 56801 - Acetyl-CoA synthetase-like
  • 47336 - ACP-like
  • 52777 - CoA-dependent acyltransferases
  • 0.000000161Direct
    47336,52777,52777
  • 47336 - ACP-like
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.000005666Direct
    48179,48179,52096
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 52096 - ClpP/crotonase
  • 0.00002229Direct
    52777,52777,56801
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 0.000142Direct
    52777,56801,47336
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 47336 - ACP-like
  • 0.0002666Direct


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