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Enzyme Commission (EC): Isomerases altering macromolecular conformation

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   root [root] <7>
+ 1:   Isomerases [5] <7>(128|160) (128|76|32)
0:   Isomerases altering macromolecular conformation [5.6] <2>(20|21) (20|22|10)
- 1:   Enzymes altering polypeptide conformation or assembly [5.6.1] <8>(6|7) (6|3|1)
- 1:   Enzymes altering nucleic acid conformation [5.6.2] <2>(14|14) (14|19|9)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
P-loop containing nucleoside triphosphate hydrolases0Direct
DNA topoisomerase IV, alpha subunit0Direct
DNA breaking-rejoining enzymes0Direct
Type II DNA topoisomerase0Direct
ABC transporter transmembrane region0Direct
Eukaryotic DNA topoisomerase I, dispensable insert domain0Direct
GyrA/ParC C-terminal domain-like0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
Prokaryotic type I DNA topoisomerase0Direct
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment0Direct
Ribosomal protein S5 domain 2-like0Direct
GroEL equatorial domain-like0Direct
Hedgehog/intein (Hint) domain0Direct
DNA topoisomerase I domain0Direct
Zinc beta-ribbon0Direct
GroEL-intermediate domain like2.565e-16Direct
GroEL apical domain-like5.098e-16Direct
Homing endonucleases0.00000000000001749Direct
MIT domain0.000000000002496Direct
S13-like H2TH domain0.00000000003137Direct


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
GroEL-like chaperone, intermediate domain0Direct
Eukaryotic DNA topoisomerase I, dispensable insert domain0Direct
Eukaryotic DNA topoisomerase I, catalytic core0Direct
ABC transporter ATPase domain-like0Direct
GroEL-like chaperone, apical domain0Direct
ABC transporter transmembrane region0Direct
Type II DNA topoisomerase0Direct
Topoisomerase VI-B subunit middle domain0Direct
Prokaryotic type I DNA topoisomerase0Direct
GroEL chaperone, ATPase domain0Direct
DNA gyrase/MutL, N-terminal domain0Direct
Extended AAA-ATPase domain0Direct
Prokaryotic DNA topoisomerase I, a C-terminal fragment0Direct
DNA topoisomerase IV, alpha subunit0Direct
DNA gyrase/MutL, second domain0Direct
Helicase-like "domain" of reverse gyrase0Direct
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment0Direct
Vaccinia DNA topoisomerase I, 9 kDa N-terminal fragment0Direct
GyrA/ParC C-terminal domain-like0Direct
Intein (protein splicing domain)0.000000000008118Direct
MIT domain0.00000001917Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Hedgehog/intein (Hint) domain0Direct
Type II DNA topoisomerase0Direct
Eukaryotic DNA topoisomerase I, dispensable insert domain0Direct
Ribosomal protein S5 domain 2-like0Direct
ABC transporter transmembrane region0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
DNA topoisomerase IV, alpha subunit0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
GyrA/ParC C-terminal domain-like0Direct
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment0Direct
DNA breaking-rejoining enzymes0Direct
Prokaryotic type I DNA topoisomerase0Direct
GroEL equatorial domain-like0Direct
DNA topoisomerase I domain0Direct
Zinc beta-ribbon0Direct
GroEL-intermediate domain like1.778e-16Direct
GroEL apical domain-like3.545e-16Direct
Homing endonucleases0.00000000000001235Direct
MIT domain0.000000000001801Direct
S13-like H2TH domain0.00000000002288Direct

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57783,57783
  • 57783 - Zinc beta-ribbon
  • 57783 - Zinc beta-ribbon
  • 0Direct
    56349,46596
  • 56349 - DNA breaking-rejoining enzymes
  • 46596 - Eukaryotic DNA topoisomerase I, dispensable insert domain
  • 0Direct
    54211,56719
  • 54211 - Ribosomal protein S5 domain 2-like
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    56719,55608
  • 56719 - Type II DNA topoisomerase
  • 55608 - Homing endonucleases
  • 0Direct
    51294,56719
  • 51294 - Hedgehog/intein (Hint) domain
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    56719,101904
  • 56719 - Type II DNA topoisomerase
  • 101904 - GyrA/ParC C-terminal domain-like
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    56741,56349
  • 56741 - Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
  • 56349 - DNA breaking-rejoining enzymes
  • 0Direct
    52540,56712
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    55608,56712
  • 55608 - Homing endonucleases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    55608,56719
  • 55608 - Homing endonucleases
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0Direct
    56719,56719
  • 56719 - Type II DNA topoisomerase
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    55874,46946
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 46946 - S13-like H2TH domain
  • 0Direct
    56712,51294
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    55874,56719
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    56712,57783
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 57783 - Zinc beta-ribbon
  • 0Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    46946,54211
  • 46946 - S13-like H2TH domain
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    55869,56349
  • 55869 - DNA topoisomerase I domain
  • 56349 - DNA breaking-rejoining enzymes
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 1.778e-16Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0000000004373Direct

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    56741,56349,46596
  • 56741 - Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
  • 56349 - DNA breaking-rejoining enzymes
  • 46596 - Eukaryotic DNA topoisomerase I, dispensable insert domain
  • 0Direct
    56712,57783,57783
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 57783 - Zinc beta-ribbon
  • 57783 - Zinc beta-ribbon
  • 0Direct
    55874,54211,56719
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    52540,56712,51294
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    55874,46946,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 46946 - S13-like H2TH domain
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    52540,52540,56712
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    57783,57783,57783
  • 57783 - Zinc beta-ribbon
  • 57783 - Zinc beta-ribbon
  • 57783 - Zinc beta-ribbon
  • 0Direct
    56719,55608,56719
  • 56719 - Type II DNA topoisomerase
  • 55608 - Homing endonucleases
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    51294,56719,55608
  • 51294 - Hedgehog/intein (Hint) domain
  • 56719 - Type II DNA topoisomerase
  • 55608 - Homing endonucleases
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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