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Enzyme Commission (EC): DNA topoisomerase (ATP-hydrolyzing)

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   root [root] <7>
+ + + 3:   Isomerases [5] <7>(128|160) (128|76|32)
+ + 2:   Isomerases altering macromolecular conformation [5.6] <2>(20|21) (20|22|10)
+ 1:   Enzymes altering nucleic acid conformation [5.6.2] <2>(14|14) (14|19|9)
0:   DNA topoisomerase (ATP-hydrolyzing) [5.6.2.2](7|8) (7|12|6)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
DNA topoisomerase IV, alpha subunit0Direct
Type II DNA topoisomerase0Direct
GyrA/ParC C-terminal domain-like0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
Ribosomal protein S5 domain 2-like0Direct
Homing endonucleases2.565e-16Direct
S13-like H2TH domain0.00000000000003521Direct


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Type II DNA topoisomerase0Direct
Topoisomerase VI-B subunit middle domain0Direct
DNA gyrase/MutL, N-terminal domain0Direct
DNA topoisomerase IV, alpha subunit0Direct
DNA gyrase/MutL, second domain0Direct
Helicase-like "domain" of reverse gyrase0Direct
GyrA/ParC C-terminal domain-like0Direct
Intein (protein splicing domain)0.0000000000002781Direct


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Type II DNA topoisomerase0Direct
Ribosomal protein S5 domain 2-like0Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0Direct
DNA topoisomerase IV, alpha subunit0Direct
GyrA/ParC C-terminal domain-like0Direct
Homing endonucleases1.778e-16Direct
S13-like H2TH domain0.00000000000002489Direct

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54211,56719
  • 54211 - Ribosomal protein S5 domain 2-like
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    56719,55608
  • 56719 - Type II DNA topoisomerase
  • 55608 - Homing endonucleases
  • 0Direct
    51294,56719
  • 51294 - Hedgehog/intein (Hint) domain
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    56719,101904
  • 56719 - Type II DNA topoisomerase
  • 101904 - GyrA/ParC C-terminal domain-like
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    52540,56712
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    55608,56712
  • 55608 - Homing endonucleases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    55608,56719
  • 55608 - Homing endonucleases
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    56719,56719
  • 56719 - Type II DNA topoisomerase
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    55874,46946
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 46946 - S13-like H2TH domain
  • 0Direct
    55874,56719
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    46946,54211
  • 46946 - S13-like H2TH domain
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55874,54211,56719
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    52540,56712,51294
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    55874,46946,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 46946 - S13-like H2TH domain
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    52540,52540,56712
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 56712 - Prokaryotic type I DNA topoisomerase
  • 0Direct
    56719,55608,56719
  • 56719 - Type II DNA topoisomerase
  • 55608 - Homing endonucleases
  • 56719 - Type II DNA topoisomerase
  • 0Direct
    51294,56719,55608
  • 51294 - Hedgehog/intein (Hint) domain
  • 56719 - Type II DNA topoisomerase
  • 55608 - Homing endonucleases
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)