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Enzyme Commission (EC): Acid--amino-acid ligases (peptide synthases)

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children) EC term [EC ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   root [root] <7>
+ + 2:   Ligases [6] <6>(96|123) (95|112|69)
+ 1:   Forming carbon-nitrogen bonds [6.3] <5>(59|78) (58|59|38)
0:   Acid--amino-acid ligases (peptide synthases) [6.3.2] <63>(18|25) (18|18|11)
- 1:   4-phosphopantoate--beta-alanine ligase [6.3.2.36](0|0) (0|0|0)
- 1:   Aerobactin synthase [6.3.2.39](0|0) (0|0|0)
- 1:   Carnosine synthase [6.3.2.11](0|0) (0|0|0)
- 1:   Coenzyme F420-0:L-glutamate ligase [6.3.2.31](2|2) (2|1|0)
- 1:   Coenzyme F420-1:gamma-L-glutamate ligase [6.3.2.34](2|2) (2|1|0)
- 1:   Coenzyme gamma-F420-2:alpha-L-glutamate ligase [6.3.2.32](0|0) (0|0|0)
- 1:   Cyanophycin synthase (L-arginine-adding) [6.3.2.30](0|0) (1|1|1)
- 1:   Cyanophycin synthase (L-aspartate-adding) [6.3.2.29](0|0) (1|1|1)
- 1:   Cyclopeptine synthase [6.3.2.40](0|0) (0|0|0)
- 1:   D-alanine--D-alanine ligase [6.3.2.4](2|2) (2|2|2)
- 1:   D-alanine--D-serine ligase [6.3.2.35](0|0) (0|0|0)
- 1:   D-alanine--alanyl-poly(glycerolphosphate) ligase [6.3.2.16](0|0) (0|0|0)
- 1:   Dapdiamide synthase [6.3.2.47](0|0) (0|0|0)
- 1:   Dihydrofolate synthase [6.3.2.12](0|2) (0|0|0)
- 1:   Enterobactin synthase [6.3.2.14](0|0) (0|0|0)
- 1:   Fumarate--(S)-2,3-diaminopropanoate ligase [6.3.2.46](0|0) (0|0|0)
- 1:   Gamma-glutamylhistamine synthase [6.3.2.18](0|0) (0|0|0)
- 1:   Glutamate--cysteine ligase [6.3.2.2](1|2) (1|1|0)
- 1:   Glutathione synthase [6.3.2.3](2|5) (2|3|0)
- 1:   Homoglutathione synthase [6.3.2.23](0|0) (0|0|0)
- 1:   ISG15--protein ligase [6.3.2.n3](0|0) (0|0|0)
- 1:   Indoleacetate--lysine synthetase [6.3.2.20](0|0) (0|0|0)
- 1:   Jasmonoyl--L-amino acid synthetase [6.3.2.52](0|0) (0|0|0)
- 1:   L-2,3-diaminopropanoate--citrate ligase [6.3.2.54](0|0) (0|0|0)
- 1:   L-alanine--L-anticapsin ligase [6.3.2.49](0|0) (0|0|0)
- 1:   L-arginine-specific L-amino acid ligase [6.3.2.48](0|0) (0|0|0)
- 1:   N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase [6.3.2.38](0|0) (0|0|0)
- 1:   N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase [6.3.2.26](4|3) (4|5|5)
- 1:   N-acetylaspartylglutamate synthase [6.3.2.41](1|1) (1|0|0)
- 1:   N-acetylaspartylglutamylglutamate synthase [6.3.2.42](0|0) (0|0|0)
- 1:   Pantoate--beta-alanine ligase (ADP-forming) [6.3.2.44](0|0) (0|0|0)
- 1:   Pantoate--beta-alanine ligase (AMP-forming) [6.3.2.1](1|2) (1|1|0)
- 1:   Phosphopantothenate--cysteine ligase (ATP) [6.3.2.51](0|0) (0|0|0)
- 1:   Phosphopantothenate--cysteine ligase (CTP) [6.3.2.5](2|2) (2|1|0)
- 1:   Phosphoribosylaminoimidazolesuccinocarboxamide synthase [6.3.2.6](2|2) (2|1|0)
- 1:   Staphyloferrin A synthase [6.3.2.57](0|0) (0|0|0)
- 1:   Staphyloferrin B synthase [6.3.2.56](0|0) (0|0|0)
- 1:   Tenuazonic acid synthetase [6.3.2.50](0|0) (0|0|0)
- 1:   Tetrahydrofolate synthase [6.3.2.17](2|2) (2|1|0)
- 1:   Tetrahydrosarcinapterin synthase [6.3.2.33](0|1) (0|0|0)
- 1:   Transferred entry: 2.3.2.23, 2.3.2.27 and 6.2.1.45 [6.3.2.19](0|0) (0|0|0)
- 1:   Transferred entry: 2.3.2.27 and 6.2.1.45 [6.3.2.21](0|0) (0|0|0)
- 1:   Transferred entry: 6.3.1.14 [6.3.2.22](0|0) (0|0|0)
- 1:   Transferred entry: 6.3.1.19 [6.3.2.n2](0|0) (0|0|0)
- 1:   Transferred entry: 6.3.2.10 [6.3.2.15](0|0) (0|0|0)
- 1:   Transferred entry: 6.3.2.37 [6.3.2.n1](0|0) (0|0|0)
- 1:   Transferred entry: 6.3.2.38 and 6.3.2.39 [6.3.2.27](0|0) (0|0|0)
- 1:   Transferred entry: 6.3.2.41 [6.3.2.n6](0|0) (0|0|0)
- 1:   Transferred entry: 6.3.2.43 [6.3.2.n4](0|0) (0|0|0)
- 1:   Transferred entry: 6.3.2.44 [6.3.2.n5](0|0) (0|0|0)
- 1:   Transferred entry: 6.3.2.49 [6.3.2.28](0|0) (0|0|0)
- 1:   Tubulin--tyrosine ligase [6.3.2.25](1|0) (1|0|0)
- 1:   Tyrosine--arginine ligase [6.3.2.24](0|0) (0|0|0)
- 1:   UDP-N-acetylmuramate--L-alanine ligase [6.3.2.8](3|3) (3|3|3)
- 1:   UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase [6.3.2.9](3|3) (3|3|2)
- 1:   UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase [6.3.2.53](0|0) (0|0|0)
- 1:   UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [6.3.2.13](3|3) (3|2|1)
- 1:   UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase [6.3.2.37](0|0) (0|0|0)
- 1:   UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase [6.3.2.7](3|3) (3|2|1)
- 1:   UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [6.3.2.10](3|2) (3|2|1)
- 1:   [Amino group carrier protein]--L-2-aminoadipate ligase [6.3.2.43](0|1) (0|0|0)
- 1:   diaminoheptanedioate ligase [6.3.2.45](0|0) (0|0|0)
- 1:   hydroxypropanoate synthase [6.3.2.55](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
CoaB-like0Direct
Glutathione synthetase ATP-binding domain-like0Direct
CofE-like0Direct
MurE/MurF N-terminal domain0Direct
MurD-like peptide ligases, catalytic domain0Direct
MurD-like peptide ligases, peptide-binding domain0Direct
SAICAR synthase-like0Direct
Glutamine synthetase/guanido kinase0Direct
PreATP-grasp domain0Direct
MurCD N-terminal domain0Direct
Nucleotidylyl transferase0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0.000000000002386Direct
FMN-dependent nitroreductase-like0.000000004767Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0.00000006253Direct
ACP-like0.0003761Direct
CoA-dependent acyltransferases0.09353Inherited
Acetyl-CoA synthetase-like0.3735Inherited
alpha/beta-Hydrolases1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Folylpolyglutamate synthetase, C-terminal domain0Direct
Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC)0Direct
ATP-binding domain of peptide synthetases0Direct
Folylpolyglutamate synthetase0Direct
Eukaryotic glutathione synthetase ATP-binding domain0Direct
MurCD N-terminal domain0Direct
Prokaryotic glutathione synthetase, N-terminal domain0Direct
Glutamate-cysteine ligase family 2 (GCS2)0Direct
Lysine biosynthesis enzyme LysX ATP-binding domain0Direct
CofE-like0Direct
MurCDEF0Direct
MurCDEF C-terminal domain0Direct
SAICAR synthase0Direct
D-Alanine ligase N-terminal domain0Direct
Eukaryotic glutathione synthetase, substrate-binding domain0Direct
MurE/MurF N-terminal domain0Direct
CoaB-like0Direct
Glutamate-cysteine ligase0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0.000000000002589Direct
NADH oxidase/flavin reductase0.00000006877Direct
Thioesterase domain of polypeptide, polyketide and fatty acid synthases0.0000001976Direct
Peptidyl carrier domain0.0000003096Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0.0000006597Direct
Acetyl-CoA synthetase-like0.6895Inherited
Nucleotide and nucleoside kinases1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
MurCD N-terminal domain0Direct
Glutathione synthetase ATP-binding domain-like0Direct
MurD-like peptide ligases, catalytic domain0Direct
SAICAR synthase-like0Direct
Glutamine synthetase/guanido kinase0Direct
MurD-like peptide ligases, peptide-binding domain0Direct
Nucleotidylyl transferase0Direct
CofE-like0Direct
CoaB-like0Direct
PreATP-grasp domain0Direct
MurE/MurF N-terminal domain0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0.000000000001721Direct
FMN-dependent nitroreductase-like0.000000003587Direct
N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)0.00000004774Direct
ACP-like0.0003068Direct
CoA-dependent acyltransferases0.08155Inherited
Acetyl-CoA synthetase-like0.3384Inherited
alpha/beta-Hydrolases1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
56059,53623
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 0Direct
    53244,52440
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 52440 - PreATP-grasp domain
  • 0Direct
    56104,52255
  • 56104 - SAICAR synthase-like
  • 52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
  • 0Direct
    52374,52540
  • 52374 - Nucleotidylyl transferase
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    63418,53623
  • 63418 - MurE/MurF N-terminal domain
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 0Direct
    51984,53623
  • 51984 - MurCD N-terminal domain
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 0Direct
    55931,56059
  • 55931 - Glutamine synthetase/guanido kinase
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    53623,53244
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 0Direct
    51735,53623
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 0Direct
    52507,102645
  • 52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD
  • 102645 - CoaB-like
  • 0Direct
    52777,53474
  • 52777 - CoA-dependent acyltransferases
  • 53474 - alpha/beta-Hydrolases
  • 0Direct
    144010,55469
  • 144010 - CofE-like
  • 55469 - FMN-dependent nitroreductase-like
  • 0Direct
    52777,56801
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 0.000000002973Direct
    56801,47336
  • 56801 - Acetyl-CoA synthetase-like
  • 47336 - ACP-like
  • 0.0000002061Direct
    47336,52777
  • 47336 - ACP-like
  • 52777 - CoA-dependent acyltransferases
  • 0.0000003127Direct
    56059,52440
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 52440 - PreATP-grasp domain
  • 0.00008848Direct
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.001203Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    51984,53623,53244
  • 51984 - MurCD N-terminal domain
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 0Direct
    53244,52440,56059
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    52777,52777,53474
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 53474 - alpha/beta-Hydrolases
  • 0Direct
    63418,53623,53244
  • 63418 - MurE/MurF N-terminal domain
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 0Direct
    56059,53623,53244
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 0Direct
    53623,53244,52440
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 52440 - PreATP-grasp domain
  • 0Direct
    51735,53623,53244
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 0Direct
    52777,52777,56801
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 0.000000002503Direct
    52777,56801,47336
  • 52777 - CoA-dependent acyltransferases
  • 56801 - Acetyl-CoA synthetase-like
  • 47336 - ACP-like
  • 0.000000006124Direct
    56801,47336,52777
  • 56801 - Acetyl-CoA synthetase-like
  • 47336 - ACP-like
  • 52777 - CoA-dependent acyltransferases
  • 0.00000002578Direct
    47336,52777,52777
  • 47336 - ACP-like
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0.0000003127Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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